It is well known that tretinoin has serious teratogenic effects on human, including craniofacial deformities, central nervous system abnormalities, cardiovascular malformations and so on. The pregnant women, women who are ready to be pregnant or lactating women should not use the kind of drugs. Childbearing women need to make a pregnancy test before using tretinoin. They should ensure that they are not pregnant before starting the medication. During the medication period and three months after using drugs, women in childbearing age and their spouses should take strict contraceptive measures to ensure no pregnancy.
Although tretinoin is a cosmetic raw material and widely applied in cosmetics, it may have an impact on blood lipid levels, serum triglyceride and cholesterol levels, very low density lipoprotein and low density lipoprotein levels and high density lipoprotein decreased. In foreign clinical trials, emergences of triglycerides on about 25% patients who receive accntane were significantly increased. Existence of predisposing factors for incidence of hyperlipidemia, such as diabetes, obesity, alcoholism, smoking, familial hyperlipidemia, patients should be weighed against the acid medication pros and cons of different dimension A long-term use of retinoic acid in patients with lipid levels should be monitored regularly.
The use of retinoic acid and benign intracranial hypertension related to the tetracycline class of anti-infective drugs may increase the occurrence of adverse reactions. Patients, such as headache, nausea, vomiting, visual disturbances and other symptoms, seek medical attention immediately for investigation. In order to prevent false brain tumor, fat should be avoided while using the tetracycline class of drugs. Retinoic acid Other adverse reactions include: lips and dry skin, cheilitis, desquamation, rash, itching, skin fragility, allergic reactions, hearing and visual impairment, osteoporosis, elevated liver enzymes, inflammatory bowel disease, acute pancreatitis. Patients should be in accordance with the instructions or your doctor prescribed Dosage and administration, carefully read the instructions, adverse reactions should consult a doctor, serious adverse reactions should be discontinued immediately.
Before people plan to buy tretinoin, they need to realize that tretinoin is an effective drug for the treatment of acne, but its potentially serious adverse reactions can not be ignored. Advised physicians to learn more about the retinoic acid contraindications, adverse reactions, attention to issues, interactions and other safety information, ask questions in detail before the prescription retinoic acid in patients with a history of allergies, history of disorders, combination therapy and women pregnancy. They need to communicate with patients about potential risks of the drugs and weigh medication pros and cons.
Tretinoin is the prescription drug. Patients should use the drug under the guidance of doctors without over dose or drug treatment. In medication course, the occurrences of adverse reactions need to be observed, especially for the skin reactions and mental status changes. In the event of serious adverse reactions, they should be discontinued immediately and begin the treatment. At the same time, drug manufacturers need to further improve the risk message in the product instructions and labels. They must pass the information to medical staffs and patients. Meanwhile, they need to strengthen the monitoring of adverse reactions and adopt effective risk management measures to minimize the occurrence of adverse reactions.
Source:http://www.cosprm.com
