What is the plant extract

Plant extract refers to the use of appropriate solvent or method from plant (plant part or as a whole) as raw material extraction or processing of substances that can be used to improve health or other purposes.

The plant extract industry is developed in the last 10 years, is the chief in the pharmaceutical, fine chemicals, agricultural sector between the edge of the industry. Its definition is stated as follows:

The plant extract is based on plants as pharmaceutical raw materials in accordance with the need for the use of the extract of the final product, after the physical and chemical extraction and separation process, directed to obtain and concentration plants in one or a variety of active ingredients, without changing its active ingredient structure and the formation of the product. At present, the plant extracts in the product concept is quite broad. Accordance with the extracted plant ingredients are different, the formation of glycosides, acid, polyphenols, polysaccharides, terpenes, flavonoids, alkaloids and other vegetable oils, extracts, powder, lens, etc.; in accordance with the different characters of the final product can be divided into.

Chinese plant extracts are in general intermediate products, currently uses a very wide range, mainly for drugs, health food , tobacco, cosmetics, raw materials or accessories, etc. . Types of plants for the extraction of raw materials is also very much into the industrial extraction plant varieties in more than 300 kinds.

Well known in the history of human civilization, most of the time about 200 years ago, mankind has been dependent on traditional medicines (including botanicals) struggle with the disease for more than 90%. Major ancient civilization and a certain degree of civilization of the nation almost has its own national medical care system, especially China's most comprehensive Chinese medicine system, the biggest achievement. It can be said that the Chinese medicine system in China is the highest expression of the ancient medical science.

The progress of science and technology, creating a chemical drugs and new biological drugs. After World War II, the entire pharmacy, technology, production technology to professional management techniques have gained considerable progress. At the same time, have long-term relative stagnation of herbal with advances in technology and management to obtain a new development. So far, the herbal preparation has been three stages of development. The first stage, the traditional red, pill, cream, scattered. The second stage, based on the method of water alcohol or alcohol-water extraction method based crude processing technology and modern industrial preparation technology is a combination made ​​of proprietary Chinese medicines. The third stage is the application of modern botanicals for modern separation and detection techniques refined and quantitative. Botanicals in three stages, but they have produced in chronological order, does not mean that a later stage will replace or cancel the previous stage. As the chemical drugs can not be canceled natural medicines, biological medicines, chemical drugs can not be canceled. But after the level more than the previous levels reflected or the use of modern technology.

Plant extracts and botanicals in the connotation of the concept of cross-cutting each other with each other part. Modern herbal medicine is the plant extract is the main raw material and components of the modern herbal extract -based, to a large extent; and some items of plant extracts were directly as a medicinal. In worldwide, there is no uniform definition of plant medicine. But the plant extract suppliers are accustomed to herbal medicine known as a natural medicine. Natural medicine refers to everything from nature, for the treatment of diseases without chemical treatment drugs, traditional Chinese medicine, herbal medicine should bear its areas.

Modern herbal medicine refers to Germany in the treatment of selected plant extracts, both the extract of the plant as a whole, can also be part of the extract, usually a composite of chemical substances. Germany from 1976 to herbal medicines. This definition has been using the American Botanical Council.

EC -defined herbal products are not just a single medicinal plant may be a variety of herbal compatibility ( HERBAL MEDICAL PRODUCTS), containing the active ingredient of specific plants or plant extracts, herbal plants have been used in medical the purpose of medical supplies. Herbal medicine and its products is considered to be an active ingredient or ingredients of the therapeutic effect is not very clear of pharmaceutical products. Herbal preparations will crumble into a powder plant extract, coloring, oil or liquid of pressure rolling plant juice processing plant production, purification or concentration of single compounds or mixtures isolated from plants, which when no longer seen as a herbal medicine is seen as chemical drugs such as atropine.

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Biological characteristics of astaxanthin

Natural astaxanthin is the strongest anti-oxidants ever discovered in nature, and is the only one can get through the blood-brain barrier of a carotenoid. Only algae, yeast and certain bacteria can produce astaxanthin. The astaxanthin in nature is mainly generated by the plants and microalgae. The animals can not synthesize carotenoids, they only can get them from plants or algae in food chain. The molecular structure of astaxanthin and β2-carotene are very similar, but vert different in chemical properties and biological activity. It can quenching singlet oxygen, remove free radicals and effectively ending the peroxidation chain reaction, remove free radicals and effectively ending the peroxidation chain reaction, thereby protecting cells from oxidation damage, known as "super vitamin E", "super antioxidants" as cosmetic material. Only natural L astaxanthin has the antioxidant extraordinary capacity!

Astaxanthin with super antioxidant capacity that we talking about, only with left-spin structure of natural astaxanthin, is by algae that astaxanthin synthesis in the body. Artificial chemical synthesis, its antioxidant capacity is extremely low, basic is negligible, as industrial pigments used and not a good role in health and disease treatment, prevention.

Astaxanthin structure with two symmetric centers, which are molecules in both ends of the ring structure of C - and C - 3 '. An asymmetric center can have two conformations, astaxanthin two asymmetric carbon atoms, C - 3, C -3 ' can be R or S form of existence, so there are three kinds of stereoisomers : 3 S, 3 'S, 3 S, 3'R and 3 R, 3'R, 3 S, 3 'S and 3 R, 3'R isomers are mirror images of each other enantiomers, each enantiomer has the opposite optical rotation, enabling plane polarized light to the left or right rotation, 3 S, 3 'S structure of polarized light to the left, called L; 3 R, 3'R structure of polarized light to the right called the right rotation, 3 S, 3'R no optical activity, called racemic.

The test confirmed that only L astaxanthin has a superior antioxidant capacity, the dextral astaxanthin low capacity, racemic astaxanthin pigment basically do not have the antioxidant capacity.

In one study by astaxanthin manufacturer, to the three middle-aged smoking men, respectively, taking 100 mg L, the right hand, racemic astaxanthin , 10 times in the taking of blood samples within 72h, analysis by HPLC high performance liquid chromatography method for quantitative analysis. Six hours after taking the plasma of subjects of natural L- astaxanthin, astaxanthin concentration up to 1124 mg / L, and taking the right hand of astaxanthin, plasma astaxanthin concentration must rise, while taking racemic astaxanthin in the blood, and its content did not change significantly. Body prawn astaxanthin bioavailability and its structure is closely related to.

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Role of glutathione

Do you know glutathione to promote the role of the immune system healthy? This means that the amount of glutathione in human cells has a direct impact on the number of right to resist the virus and reduce disease. The body's immune system is very complex, difficult to make it clear that only one article. The latest studies have shown that glutathione is an effective nutritional supplements can boost the immune system. Here I will share the results of these studies by glutathione supplier.

Distinguish the innate immune system, the difference between the adaptive immune system, and the acquired immune system is very important. The latest medical research report , glutathione contribute to the adaptive immune system health. Therefore, raising glutathione levels is very important to maintaining good health and disease prevention.

Glutathione is a balancing agent, an immune deficiency, the body's immune system will be strengthened. Glutathione promote the production of white blood cells, especially T lymphocytes responsible for resistance to infection. If you suffer from autoimmune diseases, glutathione helps the body regain the balance of the immune system. To protect the structure of the body's immune system is very complex and precise cooperation of a variety of factors to maintain normal work. Eating, proper rest and exercise, as well as to raise glutathione levels can make the immune system more robust. Let us understand the research results of some medical professionals on the effects of glutathione on the immune system.

We are not like to know the heart and lungs as clear as glutathione, but life is inseparable from this peptide. We strive to maintain good health, glutathione also plays an important role.

Glutathione is produced in the liver, the primary antioxidant for the body to counteract free radical damage, free radicals is a contributing factor that lead to aging and disease. Contact with every day from the diet, environment, tobacco smoke, household chemicals, and other aspects of free radicals. Even health campaign will generate free radicals. If you do not have enough glutathione, unimaginable radicals will give the body what kind of destruction.

According to the report of pharmaceutical raw materials suppliers, glutathione helps white blood cells kill bacteria and prevent vitamin C and E oxidation, prevention of stroke and cataract formation. In addition, glutathione binding carcinogens through urine excreted.

Unfortunately, due to the fast pace of modern life and the pressure to lead to faster depletion of glutathione, the liver is difficult to meet the needs and always maintain secrete enough of glutathione. In addition, aging also decreased secretion of glutathione.

How to make up for lack of glutathione? In addition to control the pressure and clear the factors that deplete the glutathione, taking nutritional supplements may be a good solution. However, because the body can not effectively absorb them, the better choice is N - acetylcysteine ​​supplements, bio- available, can be effectively transformed into glutathione.

Source: http://www.cospcn.com

Vitamin H applications and production profiles

Vitamin H (Biotin), also known as Coenzyme R, which is a water -soluble B vitamins, and is  is a colorless crystalline powder. Nature vitamin H is widely exist in the kidney, liver, pancreas and other organs of the animals as well as egg yolk, yeast, milk. In recent years, the international market demand for Vitamin H is continuously strong growth, which push the production. The increase in the production and export of vitamin E, which shows bright maket prospects.

Vitamin H is mainly used in medicine and health, nutrition fortifiers, feed additives, cosmetics material and health products, as well as drinks and so on. Vitamin H has a wide range of physiological effects, it is an important coenzyme of body fat metabolism and other carboxyl reaction, a certain role in fat metabolism and nucleic acid and protein synthesis. Lack of vitamin H may cause hair loss, dermatitis, and weight loss. Mainly used in clinical vitamin H deficiency and the prevention of skin diseases.

Vitamin H is an important nutrient supplement, the United Kingdom Vitamin H reference nutrient intake per person per day 10μg-20μg. U.S. adult recommended intake per person per day 30μg-100μg. China Fortified Food hygiene standards under the Vitamin H is used in foods for infants and young children when 0.1mg-0.4mg/kg drink liquid of 0.02 mg of -0.08 mg / kg.

Vitamin H is also an important feed additive, it is essential for livestock growth and development of a biological catalyst, livestock and poultry during growth and development of a number of factors, such as weight gain, feed conversion, meat production, meat quality, fur, egg and so influential. General per kilogram of feed required to add 0.15μg vitamin H. Vitamin H is usually used as feed additives, processing into the preparation of 2%.

Vitamin H, more complex structure, the production of technical difficulty. The production method of extraction, fermentation and chemical synthesis. Due to the natural vitamin H is a wide range of egg yolk, milk and animal liver, kidney, pancreas and other organs, it can be extracted from these substances, vitamin H, alumina chromatography extraction by distillation under vacuum refining derived. However, the production of small, high cost, the products are mainly used in the production of biological reagents, for teaching and research. Available microbial fermentation, the fermentation of this method is not easy, the yield is not high, the quality is not stable enough. Over the years, biotin manufacturers have been studying the chemical synthesis method for the production of vitamin H, until the early 1980s, this problem was able to break. Chemical synthesis method is based on 2 - Amino-3-- SH sodium propionate as the starting material, condensation of chloro-acetic acid, and then after acylation, esterification, hydrolysis, decarboxylation, condensation, oximation, hydrogenation, hydrolysis, cyclization, etc. many reactions in the system.

For the process of Vitamin H production is complex, needs long time, and the technique is difficult, now only several enterprises master the production process, and can industrial production, also the annual production is very rare in the world. At the end of 20 century, the world annual production is  about 45 tons, and now has reached about 60 tons.

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Chia seed multifunctional

Speaking of eggs, the chia seed which is gelatinous, after dissolved can be an egg substitute for cooking and baking. Chia seed sub-gel can sva half of salad dressing and reduce 50% calories, and meanwhle can better improve texture of salad. It also can be used as thicken soup. But better not eat dry chia seed directly, cause it can dehydration. To provent this problem, we need to eat plenty of liquid. Chia seed can be made into oil and the oil can be used in cooking.

In order to increase the consumption of nutritional value, it can be added to honey. Chia seed promoter contains natural fibers can overcome problems of constipation. A lot of sports products can be designed to increase energy and endurance of athletes. Because the calcium content per gram which chia seed than milk, some people, especially milk intolerance buy chia seed instead of milk, and the gel mingled bread dough, hot cereal or soup. There are some people use Hungariana sub-gel instead of egg white. The gelatinous chia seed is an ideal integration into the roasted corn dough and can be used in the dried fruit butter. By virtue of its high content of chlorogenic acid, caffeic acid and flavonol glycosides, chia seed sub-gel is an ideal anti-oxidants can be added to the pre-packaged good food. It can also be mixed in fruit juice, mineral water or yogurt. Inspired from the ancient Mayans and Aztecs, a person from the gelatinous chia seed invented a variety of beverages. In Mexico, people are still the gelatinous chia seed is added to orange juice, lime juice or lemon juice - two to add some honey. Cooling, which is a refreshing and nourishing beverage.

In addition to uses in food, chia seed oil can be added to cosmetics. chia seed a large number of dietary fiber - especially water-soluble - is a very important source of the thickener used in cosmetics. Some entrepreneurs have to consider the refining and sale of chia seed oil is used to polish furniture and antiques. Inherited in the ancient Aztec people, others are planning to use preservatives chia seed oil as a coating to protect the painting, to prevent years later due to oxidation and loss of color and gloss.

For the Chia seed has acted as an indigenous food for centuries, some pharmaceutical raw materials suppliers are considering make it into pharmaceutical products. Surely, chia seed can provide many essential medicated products. Chia seed used as food,drink,cosmetic and other products, that is like a person with unlimited imagination.

Source:http://www.cospcn.com

The principle of treatment for hair loss about minoxidil

Minoxidil was a drug used to treat hypertension originally in the 1970s, classified as Potassium Channel Openers, and has effects on expansion of peripheral vascular, such study of potassium channel openers was doing for many years. Minoxidil is the only widely used drugs in the human body. Hirsutism, hair or non-expected growth was originally the side effects of this drug, but also because of the inspiration of such side effects, minoxidil is imported for the treatment of male and female alopecia. Today, Cosmetics material minoxidil is develop into two forms of drugs, oral minoxidil is used to treat high blood pressure; and topical minoxidil was used in the treatment of hair loss and baldness. Concentration of 2% topical minoxidil in the United States in 1986, after seven years, the concentration of 5% also be listed.

Through animal experiments confirmed that the stump-tailed macaque body minoxidil can shorten the hair follicle resting stage, the static in the hair follicles to enter the growing season earlier, minoxidil can really add a certain percentage of hair follicles in the histological study of these primates display enter the growth phase, and reduce the number of telogen hair follicles; can also increase the size of the hair follicle itself, so the hair becomes more coarse. In human trials, minoxidil for hair growth cycle have the same effect, increasing hair diameter is also possible to happen.

Why minoxidil germinal efficacy? In fact minoxidil is not the function of anti-androgen, in animal studies, minoxidil does not stimulate testosterone or adrenal androgen secretion; on human experimentation, the serum testosterone concentration will not change because of the use of minoxidil. However, according to the results of clinical trials, with male pattern baldness hair loss in men and women, hair re-use minoxidil, hair quantity and weight are significantly increased. Because minoxidil can make the tiny hair follicles to produce a reversal of the role of renewable and let the hair to accelerate growth and promote the key to enter the growth phase of hair follicles from the telogen. If minoxidil resolution as a vasodilator, with so increase the flow of blood flow to the hair follicles to stimulate hair growth results

The composition of the skin from the outside, mainly three parts of the epidermis, dermis, subcutaneous tissue. The epidermis is the outermost layer, the thickness is only about 0.5mm. It is mainly composed of layers of keratinocytes, and keratinocytes can protect the body from intrusion by the external environment or micro-organisms and maintain a certain humidity and moisture. We have confirmed that the minoxidil is good for the growth of keratinocytes, primate and human hair regeneration, and have the positive effect. Germinal effects, buy minoxidil and the use of products containing minoxidil, usually 6-8 weeks, you can begin to see the increase of hair, can see noticeable results in 12-16 weeks. But not everyone is applicable to the above effective period, sometimes after the first out of the hair increased, and increased hair is not always grow to the general coarse hair types, there are likely to grow finer hair.

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Emerging pharmaceutical markets: Brazil

In recent years, the rapid development of the emerging pharmaceutical raw materials market has attracted extensive attention in the global pharmaceutical industry, its rapid growth and huge development potential, to attract investment interest of many multinational pharmaceutical companies. The IMS report shows the number of emerging pharmaceutical market from the past 7 to 17. China is still the largest emerging market, Brazil, Mexico, India, Russia and other markets followed, showing the huge market potential for development.

Many multinational companies want their products and services sold to emerging markets, especially the growing middle class in these countries, it is estimated that this part of the market will involve a population of nearly 2 billion, its market size is a whopping $ 7,000,000,000,000 . Based on this huge market potential, these middle-class population has been pushed to the center of the global corporate strategy. According to a recent research report, the world's leading pharmaceutical companies in the emerging pharmaceutical market performance is still not ideal: ranks among the top five pharmaceutical companies, their sales in these markets accounted for the total global sales accounts for less than 20%.

Among them, the world's second largest emerging pharmaceutical markets - Brazil market research show that global pharmaceutical company that is being missed an important opportunity to profit from the provision of medical services for the Brazilian middle class. According to statistics, the middle class in Brazil has reached 120 million people and growing rapidly; the value of prescription drug consumption in 2010 reached $ 8,000,000,000, of which the majority of drugs are generic drugs. This also means that, increasingly prosperous and growing middle class will be the development of Brazil's pharmaceutical industry to bring new market opportunities. However, for drug discovery led global pharmaceutical company and plant extract supplier, the number of million Brazilian families the ability to provide high-quality patented drugs have not been brought into full play.

According to the preference of people for health care and public services, the Brazilian middle class is divided into two categories. Among them, a class of people (accounting for 53%) are more likely to rely on public services, the purchase of cheaper generic drugs. The other groups (accounting for 47%) more willing to pay additional costs in order to obtain better medical services, they argue, wait for the phenomenon can be avoided in the process of medical examination or laboratory, and they believe that drug prices there is a strong direct link between the efficacy. They are more willing and better for those efficacy, well-known brand name drugs with fewer side effects and more pay.

For family members with chronic diseases in elderly patients with middle-class families, their investment in health care than middle-class average of 15% invested in drug spending will be 10% higher than average. These patients generally require multiple medications, but usually can not afford to buy high-quality drugs and make a choice, so you need medication. This will also become an important factor to affect the pharmaceutical companies to develop their development strategies. In addition, the incidence of chronic diseases in the emerging markets have shown a rapid growth momentum; For example, it is expected that within the next 20 years, Brazil is expected to become one of the countries with the highest incidence of diabetes in the world. Chronic disease of the enormous needs for drugs, but also the development of the brand of patented drugs will open up a new world.

Source:http://www.cospcn.com

The latest features to prevent eye fatigue Ingredients: Astaxanthin

Eye fatigue is a common disease of eye, it is caused by dry eyes, eye astringent, eye soreness, blurred vision and even vision loss which directly affects people in working and living. When we concentrate to see the computer screen in usually, the eyes blink is reduced which resulting in tears secretion corresponding decrease, at the same time flashing screen is strongly irritating to the eyes caused visual fatigue. It will lead to corresponding parts of the neck, shoulder pain, but also lead to nuclear aggravate a variety of eye disease.

Commonly those have visual fatigue are: computer users, students, drivers, who often reading books, or watching television, the eyes often fatigue, itching, dryness, young people who often in outdoor sports, and who accepted the myopic lasik surgery.

Senior nutrition experts recommend that visual fatigue should actively supplement beneficial to the eyes of nutrients, thus preventing further serious fatigue and lead to the occurrence of eye disease. In addition to β-carotene is the most common seductive nutrients, nutrition experts  expecially introduce to the people who care about eyes that the latest seductive functional components - astaxanthin.

Nine clinical studies conducted in Japan and other countries show that the daily 4 mg astaxanthin (rain pluvialis extract) continued to consume four weeks, 46% of the test are the main eye fatigue alleviate; those who use visual monitor the test subject eye fatigue by a big margin reduction; can reduce eye pain, dry eye and eye fuzzy symptoms. If buy astaxanthin and get the consumption of 6-12 mg in daily the effect will be better.

In addition to the treatment drug was identified as eye fatigue, astaxanthin may also have eye fatigue prevention role. A clinical trial of eye health, no signs of fatigue of the population were studied, the results show whether it is taking the the astaxanthin test the main test subject or the placebo group, only will appear in the intensity of visual stimuli under the premise eye fatigue, and the results found that the use of astaxanthin in the experimental group recovered faster. Obviously, natural astaxanthin healthy people can prevent eye fatigue status (Takahashi and Kajita, 2005).

The mechanism of action of astaxanthin on the eye: to improve the retinal blood flow, inhibit inflammation of the eye, and adjust the visual sensitivity. Astaxanthin to reduce or prevent eye fatigue principle of diversification. Of course, astaxanthin antioxidant and anti-inflammatory properties which on the one hand. Astaxanthin is by inhibition of nitric oxide synthase inhibition of inflammation of the eye occurred (Ohgami et al, 2003); study also astaxanthin super antioxidant activity but also to prevent the rat's eye cataracts (Wu , et al, 2002). Astaxanthin comfortable retinal blood circulation also played a role.

With the eye of the worldwide scientific research, visual fatigue syndrome is expected to be completely resolved. However, astaxanthin has been able to resolve about 50% of these patients the weal and woe, the effect is far stronger than lutein and blueberry anthocyanin factors, the effect of astaxanthin on the eye is 200 times that of lutein, which is 150 times the anthocyanins. It is certain that astaxanthin can relieve eye ciliary muscle of the long-term under pressure to help improve the focusing function of the eye, in addition, cosmetic raw material natural astaxanthin can also improve blood circulation within the eye, prompting more nutrients delivered to the ciliary body and retina, thereby significantly improving the visual fatigue syndrome.

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The export of chinese pharmaceutical raw material keeps downroll

The international economic continous downturn, especially the European debt crisis hit the price of drug and pharmaceutical market. As the API exporter, the phamaceutical industrial suffers a lot, not only on the export amount, but also on the export price of partial pharmaceutical raw material. The performance of different pharmaceutical material appears bigger differentiation.

The issue has always been lingering overcapacity, rising costs, coupled with new contradictions of international raw material drug regulatory tighter, increasing pressure on raw material drug companies in China. Most of the materials drug industry, science and technology content less low threshold for the pursuit of profit is often adopted of scale to expand production capacity can be compression costs, resulting in production can be excess, and ultimately enable enterprises lose the price right to speak, into a passive situation; In addition, raw materials, water, electricity the implementation of the transport as well as a new version of Good Manufacturing Practices (GMP) of directly increasing the cost pressures; At the same time, increasingly stringent international supervision, the international environment becomes more complex, and the RMB exchange rate constraints are leading Chinese chemical raw materials enterprises "go out facing increasingly complex inspection preparedness program, the requirements become more stringent, competitive advantage in price is gradual loss of these factors the business of export enterprises to huge pressure, resulting in bulk drugs export volume and price or phenomenon.

Chinese Medicines and Health Products Import and Export Chamber of Commerce recently released data show that from January to May 2012, the number of vitamin products and traditional Chinese medicine exports shrink, product prices also showed a larger decline in According to reports, May vitamin products exported 75,800 tons, down 6.34%, of which the export volume of the two main single varieties of vitamin C and vitamin E were reduced by 14.2% and 11.62%, while a variety of product prices a sharp decline. It is understood that different export target countries, the impact on differences in demand for bulk drugs. European drug prices in the first half of 2012, a larger decline in the performance of domestic exports of bulk drugs is the most obvious. January to May, China's number of bulk drugs for export to the EU decreased by 26.41%, which German exports fell 36.67 percent; U.S. and Japanese markets remained relatively stable, while the emerging market countries to maintain a certain growth. Chinese Medicines and Health Products Import and Export Chamber of Commerce data show that India is the largest country in export growth of China's API.

Current Chinese chemical raw materials still faces may unfavorable factors, inculding the pressure comes from external  market and internal enterprise. But viewing from from the favorable factors, chinese medicine industry overall still keep stable, that makes good environment for developing chemical material. In addition, economic growth and policy guarantee will promote medical consumption rapid growth, and continue to be the development of Chinese medicine industry endogenous power. For now, the international market for chemical raw materials there still rigid demand, China chemical API positions in international market in the short term will not be replaced, vitamin, penicillin, citric acid, antibiotics, acetaminophen and other large sums of apis still has a certain price competitive advantage. Moreover, characteristics by relying on technology advantage apis will continue to expand the international market share, emerging market demand is also active pharmaceutical ingredients (apis) will continue to expand, but some traditional API enterprise performance may last optimistic.It is reported, emerging markets such as China plant extract API present a price rise, statistics from plant extract supplier show that in 2012 January to March, Chinese plant extracts export quantity for 10,238 tons, 7.5% year-on-year drop; Export value of $ 298,571,500, up 11.71%; Export price $29.16 / kg, a 20.77% increase year-on-year. But overall, Chinese domestic market is still active pharmaceutical ingredients (apis) failed to respond, especially some traditional API performance.

Source:http://www.cospcn.com

Basic knowledge of the minoxidil solution

Minoxidil solution is for external use hair loss treatment, generally used to treat male hair loss such as: male pattern alopecia, alopecia areata. Minoxidil's main role is to stimulate the blood circulation of hair follicles, improve hair follicle. Here with the simply introduce a few basic knowledge when using cosmetic raw material  minoxidil solution to cure the  male hair loss.

The initial hair loss: topical minoxidil solution can cause initial mild hair loss to increase, because minoxidil already in the telogen hair loss, usually on the scalp hair in the telogen last 100 days fall, 10% of hair in telogen increased to 20%, but in the area of ​​male pattern baldness, shrinking of hair follicles in the telogen, when minoxidil work for thinning hair, can explain why Minoxidil can cause hair loss, hair fall will be the repose of the end of the thicker, healthier hair to replace the other hand, the treatment of male pattern baldness will result in hair follicles gradually narrowing.

On minoxidil resistance, misunderstanding, minoxidil will help restore the hair follicles, again in about two years (sometimes years) to grow thicker hair, more than this time, minoxidil to Seoul will continue to help hair remain in the growing season, the new long hair will be thicker, and longer growing season to maintain, however, because most patients do not see in a few years a significant sustained improvement. so they thought that minoxidil caused a resistance, and will not work, unfortunately, they stop using minoxidil solution therapy, their new long hair will be in 3-4 months again fall.

Minoxidil side effects: patients with any history of heart disease patients should not use 12.5% ​​Minoxidil solution, and known to cause a negative reaction to minoxidil or propylene glycol should be avoided 12.5% ​​minoxidil solution, only a very small number on minoxidil the Ermin sense of patients will feel rapid heart rate, so they will feel headache, dizziness, chest pain and / or ankle swelling, if these symptoms occur, patients should stop using any formula containing minoxidil, according to our experience, these side effects occurrence rate of less than 0.1% of patients.

Minoxidil preservation methods: buy minoxidil and placed under room temperature, avoid direct sunlight when not in use be sure the cap tightly closed. Because ethanol is volatile, so the cap should be closed when you don't use it. The solution is very stable in a wide range of temperatures and has been tested from zero to 149 degrees Fahrenheit (65 degrees Celsius) will not be affected.

If continuous increasing hair loss after using minoxidil solution, one should better go to see doctors for checking.

Source:http://www.cosprm.com

The benefits of eating chia seed

Chia seed provide sufficient calcium and protein. This kind of seed contains boron, which could help  absorption of calcium. This kind of nutrition also help to keep the brain function well. The chia seed also contains 20 kinds of amino acids. Among which, there are 8 kinds are necessary to human but cann't compose by body itself (Leucine, isoleucine, lysine, armour sulfur acid, phenylalanine, threonine, tryptophan valine). The abundance ratio of amino acid of protein in chia seed is very close to human neccessary, which of high-usage. All sorts enzyme, each organ are so mean to the proportion of amino acid. If lack of any kind of amino acid ,other amino acid will be waste. That likes a barrel, consist of many lathes. If any one shorter than others, others will be limited to function.

Let's make an interesting experiment, buy chia seeds then put a spoonful chia seeds in a glass of water and stir. A few hours later, you can find what will happened. Chia seed rich in dietary fiber can absorb more than 10 times its own weight of water. This feature makes it possible to maintain the electrolyte balance, prevent dehydration, when strenuous exercise is particularly useful sub Hungariana so long-distance food "reputation. When the seeds in your body, the same physical process can help you lasting moisture and maintain the electrolyte balance of body fluids.

Even swallowed the whole seed, the shell is also very easy to digest. This is an improved compared with flax seed, we had to flax seeds are crushed for easier to digest. If you eat a whole flax seed, it will be directly discharged.

Chia seed has strong water absorption ability, its absorption capacity could reach as much as 10times of its own weight ,then it expands, gets heavier, stimulating bowel movement. General speaking, Gastric emptying time is 4-6 hours, then, be intended to soon have combined fecal sufficient water, loosely soft, not take much effort can be quickly eliminated from the body, constipation, easy to solve, to avoid the intestinal absorption of toxic substances or theirdamage, reducing the risk of suffering from intestinal cancer.

Unlike other seeds, as a pharmaceutical raw material chia seed's taste is very light. Its light taste, fit into the soup, made milkshakes, bread stuffing, mix the pudding, as well as the seasoning of food you want. It will not change the taste, but increase you more nutrition.

Source:http://www.cospcn.com

Special effects of astaxanthin

Nature astaxanthin has most comprehensive “high antioxidant" effect as a cosmetic material. Gereral antioxidant such as beta carotene, lycopene, etc. are just neutralize free radicals. And neutralize molecules will stay in the bodies, and then become help antioxidant. But astaxanthin can stable the cell membrane, subsidiary in free substrate, terminate free radicals destroy chain reaction forever, and itself won't be help antioxidant.

Natural astaxanthin can penetrate the blood-brain barrier and the blood pancreas barrier and blood testis barrier of the three human barrier, and is the only carotenoids that can penetrate the blood-brain barrier, so it is possible to act on brain cells and the eye retina CD eleven types of carotenoids.

Organisms cell membrane phospholipid bilayer, natural astaxanthin can cross the cell membrane phospholipid bilayer, to prevent the phospholipid molecules are oxidative damage, good safeguard the stability of the cell membrane, thereby significantly extend the life of the cell.

The astaxanthin small molecular weight, even if coupled with both ends of the ester group is not to 1000 dalton, can easily be absorbed by the body, and it will reach each organs of the human body just in 20 minutes .

It is proves that nature astaxanthin is the most strongest antioxidant, what is offen called "super vitamin E", "super antioxidant", its antioxidant capacity as much as 6000 times of vitamin E, 800 times of coenzyme Q10, 550 times of green tea catechins, 10 times of beta carotene, 3 times of lutein, nature astaxanthin has a charactiristic. It is a unique  kind of carotene that can break through the blood brain barrier, that is, it can transmit all sorts of antioxidant to brain and central nervous system. It is suitable to buy astaxanthin for those who are sub-health, atherosclerosis, atherosclerosis, coronary heart disease and ischaemic injury patients, middle, and low immunity, joint inflammation crowd, myopia, pseudo myopia, retinopathy, all kinds of eye disease, chronic disease of people, disease and released need to regulate the crowd, auxiliary regulate various infectious disease, inflammation  infected .

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Glutathione nutritional yeast powder

Glutathione nutritional yeast powder is a kind of health products designed for the function disorders caused by nutritional deficiencies. Glutathione is an effective substance for detoxification. It is an important antioxidant and free radical scavenger. The substance has a very important role in biotransformation and integrating detoxification. It excretes harmful poison and substances from human body.

Yeast is considered to s complement for a variety of nutrients. It is one of the best medicines and it is a natural inexpensive antidote. Yeast has a low-calorie, low fat, low cholesterol, high-quality protein, high-quality B vitamins, high-quality minerals, quality dietary fiber. The yeast protein contains more than 18 kinds of amino acids, yeast, a dozen minerals containing calcium, magnesium, potassium, iron, zinc, selenium, chromium, copper, manganese and other every two yeast containing these minerals to meet the body day demand, and these minerals and yeast cells, proteins and polysaccharides in combination, in the organic form, the body's absorption and to avoid the adverse effects of the inorganic state minerals, digestive tract irritation. Many people buy glutathione to provide nutrients for organ cells and resist hazardous substances for normal cells.

In daily life, people are inevitable exposure to various toxins. Not even have water bottle is safe enough and valuable, and a clean air, a cabbage without pesticide, a hormone-free eggs, one rest assured of pork. A variety of hormones, heavy metals exist in our use of cosmetics, drugs and a variety of beverages and processed foods. On the table, furniture, floors, ceilings, blankets, clothes, toothpaste, soap, washing powder, detergents and other daily use items, without exception, are likely to lurk a variety of toxins. Varying nature of the toxins, the body will result in different injury. The water-soluble toxins will damage the kidneys and lungs; fat-soluble toxins, resulting in liver, skin, and cardiovascular and cerebrovascular damage. That does not dissolve in water, not dissolved in the fat toxins microcirculation system, the nervous system, causing irreversible damage.

Variety of the body of toxins and hazards are also aspects of the human body. When toxins from the body less, may not have any symptoms, if the toxin is excessive accumulation, there will be some of the symptoms of certain diseases and even lead to drinking water. The neurotoxin can lead to common symptoms, people often do not understand. At a fixed time such as morning and can not naturally wake up, wake up the limb weakness; often feel fatigue, drowsiness, aches; often feel physical fatigue, chest tightness, shortness of breath; often insomnia, dreams, mental anguish; great anger for no apparent reason, often quarrel with the people, the result of these are neurotoxins. Toxins in the blood can cause many problems as it can with the blood circulation to reach throughout the body. For example, will lead to obesity, fatty liver, often bad breath and body odor, increasing weight, waist and abdomen fat, hair, hair loss too much blood sugar, blood pressure, decreased immunity.

In addition to the detoxifying effect, glutathione nutritional yeast powder has a high nutritional value. Its market price is expensive. A large number of scientific trials prove that protein, vitamins, minerals and dietary fiber of pharmaceutical raw materials are essential substances. Their contents are significantly higher than that of cordyceps and other traditional rare medicinal herbs. They are able to be quickly digested and have a positive recovery. They have effects of disease prevention, anti-aging and improving immune system.

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Topical minoxidil may cause headaches

The main treating methods for hair loss are hair loss products, cultivation of hair follicle cells, surgical transplant surgery, physical therapy and weaving hair replacement. The follicle cells cultivation use the cell biotechnology and molecular biology techniques. It has a broad application prospects, but there is no clinical breakthrough. Surgical autologous hair transplantation needs the high cost. Its effect is significant different with the germinal growth speed. It also has the non-rehabilitation injury and other defects. While physical therapy is to alleviate the hair loss and its effect is not obvious. Woven hair replacement is purely in cosmetic covering up areas. Therefore, most people choose to buy minoxidil which is economical and easy to operate in hair loss treatment.

Minoxidil is the world's only one pair of hair loss have significant effect of topical chemical drugs. The suppliers claim that minoxidil composition in itself does not affect the health, topical no obvious toxic side effects. This drug is taken orally is used to lower blood pressure. If the external high doses, the drug will be absorbed through the skin to penetrate into the body, may cause headaches, low blood pressure. If you accidentally drip onto his face, may cause the drop at the excess hairs growth. Minoxidil in the hospital tend to concentrations above 2% will be effective. It will be useless if the adding volume doesn’t reach 2%.

Now the streets of germinal bodies, both Chinese medicines germinal do signs Showmanship. In fact, many products contain minoxidil, because they do not master the technology of Chinese medicine treatment of hair loss, often by western medicine to achieve the desired effect. In fact, Chinese medicine treatment of hair loss need to keep in tune, governance means, it is not just simple in some germinal fluid.

The cosmetic raw material suppliers declare that hair growth and hair restorer products belong to special purposes and cosmetics in China. They must go through the special approval of health supervision. But regulators only for its safety assessment of security you can pass, can achieve the germinal role in hair restorer, the role of propaganda is not assess what kind of ways to achieve. Chinese medicine is relatively safe; some companies tend to use traditional Chinese medicine formula to regulatory reporting, to pick up the special cosmetics approvals. But to the pursuit of efficacy, it is entered, add some chemical drugs into not only the flicker of consumers, but returned to the health of consumers pose a threat, many users have found that using minoxidil after there will be headaches, dizziness and other symptoms.

The metabolism of hair is divided into stationary, growth and regression periods. The normal hair loss is a natural expression of hair metabolism. Daily hair loss is normal. There are more reasons for hair loss in summer. It may due to the inadequate rest and sleep. And hot weather, work stress and other unhealthy habits such as too spicy diet may also cause the hair loss. In addition, the incorrect hair washing and hair combing are the reasons for hair loss in summer. Of course, in normal circumstances, people can make less hair shedding. While using minoxidil in treating hair loss, people should develop good habits in daily life.

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Chinese herbal medicine will accelerate the entrance of global health care system

International herbal regulations and regulatory cooperation organization is established by the essential drugs and traditional medicines of technical cooperation department of world health organization and national governments. Its members are national or regional drug regulatory agencies. They are committed through the improvement of herbal medicine regulatory regulation, health and safety of public.

Globalization has brought great convenience to the Chinese, but also to bring new challenges. A national production of drugs may reach the hands of patients of any country in the world, R & D, production and supply of drugs is also possible that the different countries to complete the supply chain not only established in a country or a continent, so the drug regulatory may rely on a national, and global cooperation to become necessary.

Troubled by traditional plant extracts in the worldwide promotion of doping to become concerned about the focus of one substance detection for traditional plant extracts drugs is not indicated in advance, including the ban added Western drug ingredients and pesticides, heavy metal residues and other countries attach great importance, also hopes to strengthen exchanges of experience and cooperation. In addition to the technical detection, plant extract manufacturer also called for the establishment of the warning mechanism before or after the traditional herbal medicinal products listing.

China including the sources of Chinese herbal medicines for quality control of Chinese medicine, the traits of the finished product, Indications, contraindications, and the production process introduced, especially for the production of traditional Chinese medicine injection process introduced a wide range of information. But in many countries, traditional plant extracts category management, but in accordance with OTC to manage, therefore, it is recommended that relevant countries can be involved in the supervision of the traditional plant extracts more information. In addition to strengthening the international regulatory cooperation and information sharing, international herbal medicine and regulations, and regulatory cooperation organization next year, two important task is to promote the application of traditional medicine in basic health care as well as from political and economic dimensions of global strategy to promote traditional medicines to speed up the traditional medicines integrated into the process of the six plates of the world health system.

At present, China, Japan, Myanmar, Mongolia and other Asian countries in the plant extracts used in basic health care has been made a better experience, including Chinese massage, acupuncture and promotion, international herbal medicine regulations and regulatory cooperation organizations hope worldwide Promotion of the exemplary experience of these countries. Therefore, the international botanicals regulations and regulatory cooperation organizations from the technician, diagnostic methods, and intellectual property to improve the management practices of traditional medicines, to lay the foundation for the next step to promote the use.

Some pharmaceutical raw materials suppliers regard traditional plant extracts as national health care products. They also begin to regulate management, including the specification of the functions declared and labeling. In order to shorten the registration time of the related drugs, Canada and other countries to establish the mechanism of pre-licensing information and simplify the registration approval process. Currently, the world health organization in traditional herbal drug classification and quality control related to the two institutions to cooperate, the aim is to promote and standardize the international classification of traditional medicines, branch, traditional medicine included in the International classification of diseases ICD-11 version.

China and India have listed the traditional medicine into basic medical insurance system. The promotion of these experiences will provide the reference value for other countries. ASEAN has also set up experts committee for traditional medical standards development. They eliminate technical barriers for traditional medicines entering into the health insurance system. At present, some traditional medicines as well as some alternatives and supplements have been included in the health care system in ASEAN.

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Vitamin A compounds include vitamin A and its derivatives. Tretinoin is one of the compounds. It plays an important role in the prevention of tumor including the incidence of breast cancer and a variety of cell differentiation. They mainly work through tretinoin receptors and related receptors of steroid hormone nuclear receptor family.

Studies from cosmetics material have shown that RARα plays a key role for tretinoin to inhibit the growth of breast cancer cells. It can be used as an indicator to guide the clinical application of retinoic acid treatment of breast cancer, and its mRNA expression is related to the estrogen receptor. Retinoic acid plays an important role in the proliferation and differentiation of breast cancer, its combination with retinoic acid receptors and related receptors) play a role. The study found that retinoic acid on breast cancer cell growth inhibition associated with ER. Retinoic acid of the ER-positive breast cancer cell growth can be inhibited and ER-negative breast cancer cells to retinoic acid tolerance.

ER-positive breast cancer cells of RARα mRNA expression was significantly higher than the ER-negative cells, the expression of other receptor subtypes was no significant difference between the two cell types. RARα and there is a certain relationship between the ER and retinoic acid. RARα and mRNA high expression of retinoic acid inhibits breast cell growth is directly related to, play a key role of RARα in retinoic acid inhibit the growth of breast cancer cells. RARα also permit the application of retinoic acid treatment and prevention of breast cancer as guide clinical indicators.

In addition, Chinese scientists first discovered that cheap tretinoin can inhibit lung transplant rejection. The key to solve the problem of immune regulation after organ transplantation is the tregs cells, which also known as regulatory T cells. It is not only in maintaining immune homeostasis and prevention of autoimmune diseases play an important role, it can effectively inhibit organ transplant rejection after the reaction rates. However, Tregs cell lung transplantation ineffective, mainly because the lungs and the outside world of hollow organs, easy to produce a more severe inflammatory response in patients after lung transplantation. In this inflammatory environment, Tregs can be transformed into Th17 cells, which can be accelerated obliterative bronchiolitis occurrence of severe cases lead to death of lung transplant patients.

All-trans tretinoin can stabilize the tregs cells and inhibit its conversion to Th17 cells in the inflammatory environment. Even in the environment of inflammation after lung transplantation in human body, tregs can still maintain its immunosuppressive function and inhibit conversion to Th17 cells. All-trans tretinoin has been widely used in the treatment of cancer, leukemia, bone marrow dysplasia disease. The research has opened up new opportunities for prevention and treatment of lung transplant rejection reaction in the field of transplantation immunology. It lays an important theoretical basis for the worldwide research of regulatory T cells and clinical application of allogeneic organ transplants.

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Nutritional benefits of chia seeds

There are 180 grams of omega3 fatty acid and 27.6 grams of fiber in 1000 grams of chia seeds. Omega 3 fatty acids can promote cardiovascular sound, increase concentration, relieve stress and make the skin young and healthy. Chia seed is considered ad the food which contains highest content of omega-3. Soluble fiber of chia seeds can take away the food debris in the gut and effectively clean up the intestinal wall.

There are 6310 mg of calcium in 1000 g of chia seeds. In 1000 grams of milk, there are 1200 mg of calcium. Content in chia seed is five times, and more easily absorbed. The chia seeds contain 19% - 23% protein and amino acids are much higher than traditional cereals. Chia seed with high saturated hydraulic and can contain up to 9-12 times more water than its own weight. This feature can be severe-intensity exercise in humans, helping to effectively retain water and electrolytes. Chia seed can also prevent muscle fatigue and soreness after exercise. It contributes to muscles recover and flexibility. Due to its multifunctional effects, chia seeds purchase becomes a popular trend.

Chia seed can be added in the diet. Chia seeds have the highest content of fatty acids. Omega3 has been proved to have potent anti-inflammatory function. To alleviate arthritis, muscle pain, joint pain, old injuries, and other similar pain caused by aging also has a significant effect. Chia seeds effectively reduce the effect of hypertension. In addition, intake of chia seed in ten weeks, the cholesterol content was significantly lower. Chia seed is recommended for maintaining heart health, can improve the patients with heart disease. Diet containing a-linolenic acid groups, significantly lower risk of heart attack;

The pharmaceutical raw materials chia seeds form a barrier between carbohydrates and digestive enzymes, thereby reducing carbohydrates converted to sugar. It reduces blood sugar levels and moderate blood sugar peaks and troughs. Chia seed is useful in solving problems of skin dry, itchy dermatitis, eczema, psoriasis. It can promote the healing of skin wounds. Chia seed can improve the role of colorectal bipolar disorder, intestinal disease and other digestive diseases. It starts the colorectal bipolar disorder and other digestion and intestinal inflammation in patients with small doses of eating chia seeds, initially one teaspoon, gradually increase to 2-3 teaspoons a month later. Chia seed is a kind of high fiber food. It can regulate intestinal uniform manner until it returns to normal situation.

Chia seed doesn’t contain gluten. So it is suitable for celiac disease. In particular, the high-fiber will significantly reduce the side effects of drugs. The chia seeds can help to improve concentration, improve depression, autism, children attention deficit and hyperactivity disorder symptoms. Chia seed may adjust the balance of hormone levels in body. It alleviates the suffering of female premenstrual stress disorder, dysmenorrhea and menopausal period. Chia seed can help to boost energy and reduce sense of tiredness. It is not like caffeine to make people excited at the same time.

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Research progress of traditional medicine and modern medicine on seborrheic alopecia

Seborrheic alopecia is progressive hair loss on head and frontal areas. Seborrheic alopecia is a clinical common disease in dermatology. It is also one of refractory diseases. The disease impedes and affects face beauty. It often gives patients a great deal of mental stress and psychological burden.

The etiology and pathogenesis of seborrheic alopecia is complex. It is an androgen-dependent autosomal dominant multi-genetic alopecia. The genetic susceptibility and scalp hair follicles partial androgen metabolic abnormalities are the leading factors. Treatment of seborrheic hair loss is through inhibition of androgen metabolizing enzymes or the role of androgen receptors. It blocks androgen activity in the target organ expression.

There are some commonly used clinical medicines a synthetic finasteride group compounds is currently only approved for clinical 5a-reductase inhibitor, can specifically inhibit 5a-reductase type Ⅱ the same testosterone on the competitive enzyme binding sites, blocking testosterone conversion to DHT, thereby reducing the concentration of DHT in the blood, promote hair growth, so it is a specific competitive inhibitor of 5a-reductase type Ⅱ.

Minoxidil is currently the only approved listing non-prescription drug in the treatment of hair loss. The hair follicles in vitro experiments showed that minoxidil can promote hair growth is to stimulate the hair follicles, increase the proliferation and differentiation of hair follicle epithelial cells, promoting the growth of the hair follicle epithelium. Patients can buy minoxidil to stimulate the true dermal papilla cells overexpressing vascular endothelial growth factor gene transcription control raised the hair papilla cells on protein expression, thereby promoting hair growth.

Seborrheic alopecia belongs to hair moth hair loss in traditional Chinese medicine areas. Chinese medicine believes that hair growth depending upon the essence and blood, the liver stores blood, kidney essence, which in the hair, liver and kidney homologous blood and essence homologous kidney essence is blood to breed with each other, for a total of hair growth the necessary material. Liver and kidney deficiency type patients have a genetic predisposition, common in the mental or infirm, hair loss at the scalp smooth or left over from the sparse, soft, short hair, often accompanied by Yaoxisuanruan nocturia. Expelling nourishing liver and kidney, fill fine hair growth. Type in patients with leukemia hair orifices passionate blog depression, hair loss a long time. Expelling blood of plague, germinal. Commonly used drugs bupleurum, angelica, peony root, peach kernel, safflower, red sage root, motherwort, millettia and so on.

The relatively long time required for drug treatment of seborrheic alopecia due to hair growth characteristics and individual patient factors. Years of clinical observations suggest that most of the western medicine can only reduce hair loss and side effects are more pronounced; certain medications to promote hair regrowth but continue after stopping the hair loss makes its efficacy is difficult to maintain. Variety of Chinese medicine treatment of fat off, focus on treating the symptoms, regulate endocrine function on the whole, to achieve better clinical efficacy in improving symptoms, slow the course of the disease aspect. But cosmetic raw material suppliers have achieved breakthroughs on hair growth.

The treatment of seborrheic alopecia should adopt the combing treatment of traditional and modern medicine and the combination therapy of internal and external governance. It is necessary to attach importance to drug treatment. It also needs appropriate psychological treatment to eliminate neuropsychiatric incentives. Whine the patients need recommendations on diet to appropriately adjust the diets. With the three-pronged approach, it will improve efficacy and shorten the treatment course.

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Technical strength and innovation of Chinese plant extracts

At present, Chinese plant extracts manufactures have the capability in technology development and innovation. The main features are the high planting level, skilled operation of extraction and separation unit, flexible use and rational combination of various technologies and the strong technology development capabilities. They have strong production capacities from the ordinary pharmaceutical raw materials plant extract to active ingredients of natural plant extract. They can have extract production or research in molecular distillation technology, mold separation technology, macroporous resin adsorption technology, industrial chromatography and carbon dioxide supercritical extraction technology. Chinese plant extracts suppliers can control hazardous limited chemicals by reasonable means and technology. At the same time, the detection and analysis level of extract industry has reached the level required by international market, both in equipment and analytical techniques.

Extensive use of fresh herbs as extracts raw materials is a useful complement to traditional Chinese medicine, it should be an important scientific research of the extract of Chinese medicine industry. Chinese herbal medicines in the acquisition, preservation methods or storage conditions meet the requirements, the most likely to lead to the destruction of the active ingredients of herbs, reduce the value of the use of herbs. Echinacea have picked, dried way to dry, contained the polyphenol oxidase can not be quickly destroyed, which contained the acid of the active ingredient chicory and other coffee acids polyphenol substance content decreased rapidly lead to medicine Use the decline in value. The solution is to use fresh herbs as the extraction of raw materials extraction operation, not only the active ingredient content of the product obtained is greatly improved, and extract color, odor and other physical characteristics are significantly improved. The application of fresh herbs is a developed, modern extraction technology and equipment capabilities allow large scale production, extract industry, industry, science and technology characteristics, and need to attract more attention and further study.

Currently, plant extract manufacturer has the ability to study on the detection method. The ability development is also formed the basis of extracts established industry standards. At present, the extract of enterprises in China can study through the ability systematic approach to the analysis of test methods, the ability to ensure that the extract enterprises developed in the international market can be recognized, but also, more and more foreign merchants are now starting the extract enterprises to develop their own methods for the analysis and detection of plant extracts. For example, on the international market objects detection from China extract enterprises.

The application of new materials is mainly reflected the application of excipients in the production process of the extract. Since plants in general sugar high, but more or less contain certain fats, sticky wall, plastic in the process often is not easy molding, easy to dry phenomenon. In addition, the extract market product has a higher use value through technical means, such as to reduce the bad smell or taste of the product, or oily products improved handle for easier processing of solid powder, thereby improving the processing performance of the product. At present, the more new accessories extract enterprises PVP, β-cyclodextrin, hydroxy-β-cyclodextrin, microcrystalline cellulose, pellets, etc. In addition, in production process of pharmaceutical equipment and packaging materials, the application of new materials play an active role.

At present, the plant extract industry has been equipped with new production equipments such as molecular distillation equipment, industrial macroporous resin operating system, the industrial column chromatography equipment, mold separation equipment, freeze-drying equipment, carbon dioxide supercritical extraction equipment and so on. The new testing equipments are LC-MS instrument, diode array detection and evaporative light scattering detector and solid phase extraction. Those new equipments used in the production or testing significantly improve cognitive ability and technical level of Chinese plant extract industry.

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Be alerted to serious skin damage and other risks caused by tretinoin

It is well known that tretinoin has serious teratogenic effects on human, including craniofacial deformities, central nervous system abnormalities, cardiovascular malformations and so on. The pregnant women, women who are ready to be pregnant or lactating women should not use the kind of drugs. Childbearing women need to make a pregnancy test before using tretinoin. They should ensure that they are not pregnant before starting the medication. During the medication period and three months after using drugs, women in childbearing age and their spouses should take strict contraceptive measures to ensure no pregnancy.

Although tretinoin is a cosmetic raw material and widely applied in cosmetics, it may have an impact on blood lipid levels, serum triglyceride and cholesterol levels, very low density lipoprotein and low density lipoprotein levels and high density lipoprotein decreased. In foreign clinical trials, emergences of triglycerides on about 25% patients who receive accntane were significantly increased. Existence of predisposing factors for incidence of hyperlipidemia, such as diabetes, obesity, alcoholism, smoking, familial hyperlipidemia, patients should be weighed against the acid medication pros and cons of different dimension A long-term use of retinoic acid in patients with lipid levels should be monitored regularly.

The use of retinoic acid and benign intracranial hypertension related to the tetracycline class of anti-infective drugs may increase the occurrence of adverse reactions. Patients, such as headache, nausea, vomiting, visual disturbances and other symptoms, seek medical attention immediately for investigation. In order to prevent false brain tumor, fat should be avoided while using the tetracycline class of drugs. Retinoic acid Other adverse reactions include: lips and dry skin, cheilitis, desquamation, rash, itching, skin fragility, allergic reactions, hearing and visual impairment, osteoporosis, elevated liver enzymes, inflammatory bowel disease, acute pancreatitis. Patients should be in accordance with the instructions or your doctor prescribed Dosage and administration, carefully read the instructions, adverse reactions should consult a doctor, serious adverse reactions should be discontinued immediately.

Before people plan to buy tretinoin, they need to realize that tretinoin is an effective drug for the treatment of acne, but its potentially serious adverse reactions can not be ignored. Advised physicians to learn more about the retinoic acid contraindications, adverse reactions, attention to issues, interactions and other safety information, ask questions in detail before the prescription retinoic acid in patients with a history of allergies, history of disorders, combination therapy and women pregnancy. They need to communicate with patients about potential risks of the drugs and weigh medication pros and cons.

Tretinoin is the prescription drug. Patients should use the drug under the guidance of doctors without over dose or drug treatment. In medication course, the occurrences of adverse reactions need to be observed, especially for the skin reactions and mental status changes. In the event of serious adverse reactions, they should be discontinued immediately and begin the treatment. At the same time, drug manufacturers need to further improve the risk message in the product instructions and labels. They must pass the information to medical staffs and patients. Meanwhile, they need to strengthen the monitoring of adverse reactions and adopt effective risk management measures to minimize the occurrence of adverse reactions.

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Biosynthesis of glutathione

Glutathione is the most abundant small molecule thiol compound in the cells. Glutathione is a major component of the intracellular non-protein sulfhydryl groups. It has a variety of important physiological functions in living tissue. Meanwhile, glutathione participates in redox reactions within the cell. It is the coenzyme of some certain enzymes and plays an active role in some sulfhydryl enzyme. It provides with the restored thiol to make sulfhydryl enzyme and protein thiol stabile. It is an antioxidant to protect enzymes and other proteins sulfhydryl group. In addition, it also involves in transportation of transmembrane amino acid by intracellular metabolic cycle.

Glutathione plays an important role in the removal of cells outside foreign body detoxification and hydroxy peroxides, free radicals and electrophilic reagents; protect cells against oxidative damage of the formation of reactive oxygen species in normal and UV light and derivatives. Therefore, GSH is one of the key materials of the cells against damage and metabolic regulation. Although a large number of reports on GSH metabolism and function in mammals, but less for GSH in the body's metabolism and function of microbial research, therefore, research in this area need to be strengthened. GSH clinically for: detoxification of acrylonitrile, fluoride, carbon monoxide, heavy metals, organic solvent poisoning; prevent hemolysis, reduce methemoglobin loss; for radiation, radiopharmaceuticals or oncology drug-induced leukopenia play a protective role, in combination with anticancer drugs that inhibit the liver tumor; to correct the acetylcholine, the imbalance of fat alkaline esterase. It played anti-allergic effects. People may buy glutathione to ease the discomfort caused by anoxemia, nausea and liver disease. It can prevent the development of cataracts, cornea treatment; skin pigmentation and improves skin luster.

Japan and other countries have GSH as a biologically active additives to actively develop GSH health food products and widely used in food processing areas. At present, its growing interest in the food additives industry, clinical and sports nutrition. In recent years, with the extensive application of GSH in various fields, and its manufacturing method has been studied extensively. GSH in manufacturing is divided into chemical synthesis, fermentation and enzymatic. At present, the chemical synthesis and extract rich intracellular GSH in yeast cells, GSH has been industrialized. Enzymatic Synthesis of ongoing extensive research has not yet used for commercial production of GSH. Glutathione synthesis is the need for an effective ATP regeneration system. Activity of the microbial cell synthesis of glutathione is relatively low; enzyme required for synthesis of glutathione intracellular content is generally lower, and the biosynthetic pathway by microorganisms as well as glutathione restore or feedback inhibition of oxidized glutathione; degradation of glycylglycine side effects. Once solved the above problems, the microorganisms can be used in production of pharmaceutical raw materials glutathione.

Strains currently glutathione biosynthesis, a yeast-based, and has made a lot of work for people breeding strains, fermentation conditions. But the mechanism of bacterial synthesis of GSH influence of various factors is still not clear, and intracellular GSH content is not high. As the use of E. coli production of GSH production rate to be higher than the production of yeast extract, acetyl phosphate can be obtained by chemical synthesis, so E. coli is becoming a research hotspot of GSH overproducing strain. GSH in the selection of the strains of E. coli recombinant DNA technology compared to the yeast is much more mature, so the use of E. coli production has its unique advantages.

Of course, works in use of recombinant DNA technology to improve the yield of yeast GSH is also underway. But they have not yet reached the mass production level. Meanwhile, in order to improve the catalytic activity of micro-organisms or enzymes, continuous production and study of immobilized cells or immobilized enzyme are also important directions. In addition, establishing a set of GSH production process, using automatic control technology, detecting and controlling the fermentation process to optimize the production process and obtain the maximum accumulation of GSH will be the focus of future research.
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Harmful additives of shampoo have bad influences on hair health

Blacking hair shampoo mainly relies on p-phenylenediamine, m-phenylenediamine, lead acetate and other hair colorings. The vinegar-soaked lead combcan make hair black. Lead acetate has highest contents in many blacking hair shampoo. The colorings do great harm, on human body. They may cause dermatitis, carcinogenic, teratogenic and eczema. Adding it directly into hair shampoo will do great harm to the body. The officials have banned to use the addictives. And the formal cosmetic raw material suppliers will not use it in their products too.

Undesirable components of the shampoo on the hair damage, mainly from two aspects, external damage to the hair shaft, waterproof layer of the cuticle, the hair shaft moisture to escape dry shampoo again absorbent swelling, long-term repeated down, further damage to the hair dry inner hair cortex, hair medulla, leading to fragile hair dry, easy off, easy off, easy to turn white. Followed by the scalp hair follicles absorb the long-term harmful ingredients compromised, seventh head around the hair follicles in the telogen, the lack of hair root blocking, absorbing more and injured more normal hair follicle metabolic balance of the environment damaged, black melanocytes and dermal papilla, hair matrix cells, the lesions occur, eventually leading to hair dry. It is easy to become white and fall off.

Shampoos containing undesirable components over time, the damage to the hair needs of young people due to metabolism, the sebaceous glands are also strong, will have to make up for repair on hair, short term damage will not soon became apparent, the older people's own repair function is not in strong period, type of shampoo on the hair of the elderly devastating, and even bring disaster to the scalp to accelerate the aging of the skin of the head loss, hair loss faster. Only undesirable components of short-term topical shampoo, shampoo harm to the hair in the bath needs a relatively longer time course, the logic of this causal relationship is difficult to directly associate certification. But the fact that, a century in the history of developed countries, the use of shampoo, hair loss and other problems the universalization of the history of shampoo just two years, just in a period of hair loss, white hair and other hair onset began to have large-scale growth.

In addition to children's shampoo, shampoo sold in the market will contain undesirable components against the hair healthy or containing one or contain many types. For hair healthy of their families, consumers must carefully read the ingredient list in its logo. Anti-off products generally contain some anti-androgen, such as minoxidil; or use the free inhibitor, such as cyclosporine A; and retinoid similar to vitamin A structure A, the hypertension drug diazoxide. In the past, many people would like to buy minoxidil to treat hypertension. Its side effects can increase the growth of hair follicles time. The mechanism is used for the treatment of hair loss.

Commercially available in China, minoxidil tinctures have two concentrations, a concentration of 5% and the other is a 2% concentration. Common clinical adverse reactions were mild dermatitis of the scalp, and also include irritant dermatitis (redness, dander and burning), non-specific allergic reactions, the wind group, allergic rhinitis, facial swelling, allergies, shortness of breath, headache, nerve inflammation, dizziness, syncope, dizziness, edema, chest pain, blood pressure changes, palpitations and pulse rate changes.

There are many requirements for monoxidil in hormonal drugs. Children, pregnant women, lactating women and elderly people who are above 65 years should be cautious in use the drugs. If there are excessive or serious adverse reactions emerge, people should seek medical care immediately. It may burn or irritate yours eyes. And if drug liquid contacts with sensitive surfaces, the region should be flushed with plenty of cold waters. Because of many taboos, once discontinued, the conditions will return to the previous hair loss status like other hormones germinal western medicines. General regular shampoo manufacturers do not add the violating additives. And the official also not allowed adding it in the shampoos as a common ingredient.

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Varieties of Chinese plant extracts

Currently, production technical level and product detection technologies of Chinese plant extracts industry have been able to adapt to requirements of international extracts market. And large plants extracts factories have the ability to extract production and product quality control basing on the relevant standards or enterprise standards of developed countries. There are several hundreds of extract items. The representative extracts species whose raw materials are Chinese herbal medicines are ginkgo biloba extract, green tea extract, ginseng extract, licorice extract, ephedra extract, soybean extract, acanthopanax extracts and ganoderma lucidum extract. They are pharmaceutical raw materials of traditional Chinese medicines which have broad and long-term applications.

Herbal varieties of traditional Chinese medicine herbs as raw materials in China, the varieties have good resources, such as Hypericum perforatum extract, red clover extract, Tribulus extract, grape seed extract and so on. The introduction of species such as Echinacea purpurea extract, the original plant from North America to China. It has large-scale cultivations in Hunan, Shanghai, Anhui, Beijing of China..

Imported processed directly from the imported raw materials, the use of the extract industry technology and equipment to carry out the processing trade of the species, such as imports from South Africa, Ghana, sub can be used for the extraction of 5 - hydroxy tryptophan; yohimbine bark imported from Africa or the Americas can be used to extract yohimbine; imported from North America, Saw Palmetto, or for the processing of Saw Palmetto extract; cranberries imported from Europe used to extract anthocyanins.

Generalized derived from plant varieties, such as natural vitamin E, conjugated linoleic acid, octacosanol category, solanesol, and saponin. Extract manufacturers use technical means to a higher production plant of fine chemicals, such as carbon dioxide supercritical fluid extraction equipment to produce lycopene, as well as the use of molecular distillation technology to produce natural vitamin E products, and also has considerable international competitiveness. There is a small amount of products derived from animals, it is often classified as an extract in the industry, such as chondroitin sulfate extracted from cartilage and D-glucosamine extracted from crustaceans.

Varieties of chaises plant extract are abundant. There are not only plant extracts reflecting valuable wealth of traditional Chinese medicines, but also the other plants extracts processed by rich plant resources or extraction technical capacity. There are success varieties obtained by the introduction and cultivation of plant extract manufacturer, as well as important species which are processed from raw materials of international markets. They are useful supplements for Chinese herbal medicines and plant extracts industry. They promote the exchanges between the Chinese medicine industry and the international herbal industries. In addition, the rich varieties also reflect the more positive way of Chinese plant extracts to participate in the cooperation in international markets. China gradually gets rid of the competing way by cheap labors and resources.
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