Analysis of the pros and cons of capsaicin to human body

The unit standard use of spicy is Scoville units. There is not capsaicin in bell pepper, so the Scoville units 0; jalapeno’s capsaicin content is 5000 Scoville units; Havana pepper capsaicin content is 300,000 Scoville units. Considered to be the world's hottest chili, produced from the East Indies jolokia's capsaicin content is more than 1 million Scoville units.

For most people, the spiciness of the pepper is just the feeling of the taste organs, but in fact, the spiciness is linked with nutrition. Rich in vitamin C, carotene, folic acid, magnesium, and potassium; capsaicin contains in pepper is one kind of pharmaceutical raw materials, have anti-inflammatory and antioxidant effect, helping to reduce heart disease, certain tumors and other risk of chronic diseases with aging; human studies found that frequent eating chili meals can increase the body's energy consumption, and help you lose weight; effectively delay the development of atherosclerosis and lipoprotein oxidation in the blood. In addition, people will think that often eat chili may irritate your stomach, even cause ulcers. But the fact is opposite. Capsaicin not only does not cause increased gastric acid secretion, it will inhibit gastric acid secretion, stimulate the secretion of alkaline mucus, and contribute to the prevention and treatment of gastric ulcers.

However, a news reported recently may be let people fear to eat chili, it is said that a British man, in weekdays with good health, penchant for spicy food, one day he ate a pot of homemade chili sauce, sudden death the next day, The autopsy found that he did not have any chronic disease. Does the pepper can also cause dead? Experts pointed out that the capsaicin in the pepper, and eat a lot is really harmful to the body. First, capsaicin stimulate the gastrointestinal mucosa, so that damage to the gastrointestinal tract. Second, capsaicin is absorbed by the body into the blood, can also affect the conduction of the heart and cardiovascular disease. In addition, capsaicin also damage the kidney, thus affecting renal function.

Some people think that drink cold water or hot drinks can be solution while eating spicy food, in fact it is wrong. Drink water or drinks only alleviate the spicy tongue nerve stimulation, but does not neutralize capsaicin, also can not reduce the capsaicin toxicity to the body's internal organs. Capsaicin supplier remain that love spicy food friends do not due to love spicy and then eat a lot of spicy food, even challenge the so-called metamorphosis spicy, while enjoy the spicy food, we must control the scale at the same time, do not try to be brave to eat spicy. And gastrointestinal chronic diseases, chronic kidney disease and cardiovascular disease friends need to pay attention to eat the right amount of spicy food.

Milk and beer can dissolve spicy well than water, when you eat chili, you will feel very hot, and will naturally want to drink water or eat the staple food to dilute the spicy. But the effect of doing that is not very satisfactory. In fact, capsaicin combined closely with the nerve receptors in the taste organs, and capsaicin is a non-water-soluble substances, it can only be combined with fats, oils and alcohol. It is not difficult to explain why beer is easier than water to dilute the spicy. The best mitigation spicy food is milk, especially skim milk. Although previously considered milk lipids can better combine with capsaicin, but now the study found that truly effective ingredient is casein in milk.

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Researches about antioxidant properties of astaxanthin

The astaxanthin is kind of widely used carotenoid, astaxanthin manufacturer conducted extensive studies about its antioxidant and anti-oxidation efficiency. Using blood cells in vitro to study the efficiency of several carotenoids exterminate the singlet oxygen, found that the lycopene’s effective is the best, the following is astaxanthin, β2 carotene is the worst. The efficiency of astaxanthin scavenging free radical is as good as angle zeaxanthin, and 50% higher than the β2-carotene, Clear hydrogen peroxide free radicals and prevent lipid peroxidation is significantly better than zeaxanthin, canthaxanthin and β2 carrots. Astaxanthin in the antioxidant process, each individual is not the strongest, but the capacity of antioxidant is the highest. Like vitamin E, astaxanthin is fat-soluble antioxidant, performance excellent oxidation resistance in the biofilm and lipid-rich tissues.

Human health is largely dependent on the body control free radicals, reduce the damage of oxidation to the organization of cells and DNA. Many human diseases and the aging process is associated with free radicals, although they are not the only factors of these diseases, but free radicals makes the body more sensitive to the pathogenic factors or inhibit the body's own defense and repair process, these diseases are more susceptible and exacerbate, these diseases are associated with free radicals: cancer, aging (including immunodeficiency and premature aging), inflammation (such as vasculitis, glomerulonephritis and autoimmune disease), Alzheimer's disease, Parkinson's disease, ataxia telangiectasia syndrome, emphysema, pneumoconiosis, arteriosclerosis, Keshan disease, myocardial disease, kidney transplant rejection, rheumatoid arthritis, pancreatitis, contact dermatitis, depending on age-related macular degeneration, retinal disease, radiation damage alcohol damage and other pollutants poison. A lot of experimental evidence show that astaxanthin can prevent age related macular degeneration and central nervous system diseases. Different from β2-carotene, astaxanthin easily through the blood-brain barrier.

The astaxanthin security, in many daily foods contain large quantities of astaxanthin farmed Atlantic salmon containing astaxanthin of 10 mg / kg, wild silver salmon containing an average of 14 mg / kg, a large red salmon, astaxanthin mass concentrations up to 40 mg / kg. People taking 316 mg / d, 712 mg of / d, 1414 mg / d dose of astaxanthin are no adverse reactions, and plasma LDL oxidation rate slow down with the increasing dose.

Application of astaxanthin, astaxanthin is a carotenoid, a brown-red crystals. Compared with β2-carotene and vitamin E, astaxanthin has a more biologically active hormone, can be used as cosmetic raw materials or pharmaceutical raw materials. Currently, the commodity astaxanthin mainly the chemical compounds, natural astaxanthin processing by haematococcus pluvialis, crustaceans, aquatic products and red yeast production. According to some market research studies show that: global carotenoids market volume in 1999 was approximately $ 786 million, $ 935 million in 2005, an average annual increase of 2.9, the biggest selling is carotenoids, astaxanthin and β2 carotene, they all account for 28% of the total sales volume. This shows that people are constantly know astaxanthin, accept the astaxanthin and enjoy the new opportunities of astaxanthin on human health. I believe, in the near future, there will be more and more people choose astaxanthin, a new era of anti-oxidation is opening.

Source:http://www.cosprm.com

Anti-cancer and resist disease eight fruits and vegetables

In recent years, due to people pursuit and emphasis on healthy and natural life, some of the great health benefits of fruits and vegetables and their products also be attention too. Here, it is necessary to from the view of emphasizing immunomodulatory, anti-aging anti-cancer, remove free radicals and against chronic health, and taking into account its popularity to elect the most popular eight healthy fruits and vegetables, as the basis for choosing a healthy diet. Those eight fruits and vegetables are tomatoes, carrots, watermelon, strawberries, kiwi, yam, sweet potato, asparagus.

Lycopene in tomatoes can reduce the risk of developing prostate cancer and gastrointestinal cancer; the role of suppressing nicotine and alcohol also better than β-carotene. Glutathione in tomatoes also have an important role on anti-cancer, when the human glutathione concentration rising, the cancer incidence decreased. In addition, glutathione can inhibit the activity of tyrosinase, so have the hypopigmentation, anti-aging effect.

Β-carotene in carrots help fight free radical destruction of insulin. Subjects with normal blood sugar, and its blood concentration of β-carotene is the highest; glucose poor tolerance or diabetic subjects, the β-carotene in the blood, is reduced sequentially. The study showed that foods rich in β-carotene can enhance immune function, reduce the risk of cancer.

Researches by glutathione supplier, watermelon is rich in glutathione, lycopene and carotene, these are powerful anti-oxidant, with anti-cancer function. The lycopene contained in the watermelon is more than tomatoes, every per 100g of tomatoesm containing 3.1g lycopene and every per 100 grams of watermelon contains 4.1 grams, and the antioxidant activity of lycopene is twice higher than the β-carotene. Scientists have over a decade in researching twenty-six thousand adults, the results show that those likely to suffer from low blood lycopene in pancreatic cancer, and the lycopene content in the blood of patients with pancreatic cancer is relatively poor.

Ellagic acid in strawberries have efficient inhibitory effect on carcinogens polycyclic aromatic hydrocarbons, nitrosamines, aflatoxin and aromatic amines. Human experiments show that ellagic acid can prevent esophageal cell gene from damage, prevention of esophageal cancer. Strawberry contains aspartic acid, a natural dehydrating agent, a natural gentle way to remove the excess water in the body, and thus to achieve weight loss.

Kiwi juice can block the synthesis of N-nitrosamines, have anti-cancer effect. The experiments show that the continuous feed kiwi food to the child for three months, can promote intellectual development. According to cosmetic raw material suppliers, kiwi also contains a variety of amino acids, pantothenic acid, folic acid and Black tyrosine and other substances which nourish hair, and containing synthetic black particles of copper, iron and other minerals, and magnesium which has a cosmetic effect, beauty effect.

Yam contains amylase, polyphenol oxidase enzymes and other substances, which is good for spleen and stomach; also contains saponins, mucilage, lubrication, nourishing role. Yam contains large amounts of mucus protein, trace elements and vitamins, can prevent lipids precipitate in the blood vessel wall, prevent cardiovascular disease; mucus proteins also have a role in reducing blood sugar, can be assisted treatment of diabetes.

Sweet potato contains large amounts of mucus protein, which is a substance composed of collagen and mucus polysaccharide. It can prevent fat precipitate in the cardiovascular system, to maintain the elasticity of arteries, preventing premature atherosclerosis; but also to prevent the atrophy of the liver and kidney tissue, to prevent the occurrence of collagen disease, keep the digestive tract, respiratory tract and intra-articular lubrication. Sweet potato contains dehydroepiandrosterone (DHEA), it is an anti-cancer substances that can prevent breast cancer and colon cancer.

Asparagus contains a particularly rich set of proteins, folic acid, nucleic acid, selenium, etc, and there are having anti-cancer effects. Asparagus is rich in asparagines that can enhance the body's immune function. In addition, scholars isolated some saponin compounds from the edible part of the asparagus, and the vitro experiments showed that it can significantly inhibite P388 leukemia cells. Asparagus can also be used as a means of assisted treatment, can mitigate radiotherapy-induced loss appetite, nausea, vomiting, dry mouth and so on.

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Resveratrol and cardiovascular disease

Resveratrol regulated mitochondrial antioxidant manganese superoxide dismutase, manganese superoxide dismutase is an important intracellular antioxidants. Resveratrol used in vitro cultured human cells two weeks, the oxidation of manganese superoxide dismutase protein levels increased six-fold, the activity increased 14-fold, while the other major cellular antioxidants (glutathione peroxidase, catalase) found to be affected or decrease in activity. Resveratrol by regulating manganese superoxide dismutase to part of extend the mitochondrial life, thereby protecting mitochondrial away from the free radical damage, to complete the task of its own capacity.

In animal studies, resveratrol shows it can through a large number of mechanisms to protect the cardiovascular system, including inhibit the oxidation of low-density lipoprotein cholesterol (oxidation is the first step leading to atherosclerosis), protect and maintain the endothelial cells (artery wall cells) complete, promote small artery vasodilation, inhibit platelet aggregation, as well as protection from ischemia - reperfusion injury (to reduce heart attack scale). Endothelial progenitor cells are adult stem cells produced by the bone marrow, through the blood circulation, then divided into the endothelial cells of repairing the artery wall. Diabetes, high blood pressure, high LDL cholesterol and cardiovascular disease in patients with endothelial progenitor cells circulate volume decline. Resveratrol can increase the amount of endothelial progenitor cells, enhance its functionality, what you need to do is suitable drinking the right amount of red wine.

According to several human epidemiology studies, minor or moderate drinking red wine is related to reduce cardiovascular disease, as well as the reduction of total mortality from all causes have contact. Some studies have shown that drinking red wine can more reduce the incidence of cardiovascular disease and mortality than beer. A Dutch study of middle-aged men show that, people who daily drink half a cup of red wine with the lowest mortality, heart attack mortality lower 48%, while 40% reduced all-cause death compared with non-drinkers. In addition, the drinkers’ average life is 3.8 years longer than nondrinkers.

In another study of pharmaceutical raw materials suppliers, 30 patients with coronary heart disease in men taking a red grape polyphenol extract, their endothelium-dependent vasodilation improved, studies show that after 60 minutes their arm rear of the brachial artery flow mediatedguide diastolic function get 73% improvement. This indicates that the red grape extract can also be beneficial for people.

Mice fed a high-fat and added resveratrol, the risk of death is 30% lower than high-fat diet mice fed only. Resveratrol with the high-fat diet-induced 144 in 155 set of genes sang a rival show. Blood glucose and insulin levels in rats fed a high-fat diet have adverse change, and fed added the high-fat diet of resveratrol animal the glucosyl level (and sometimes insulin levels) is close to the normal diet of mice. Obese mice taking resveratrol also reduced the weight, and the ischemic function is more powerful, the ventricular fibrillation reduced 83% and 20% reduction in infarct size (the size of the organization) of cardiac death. Here raises the question of whether resveratrol can effectively prevent and treat diabetes?

What most exciting is resveratrol has the effectiveness of its anti-aging and slow down life, studies by resveratrol supplier show that resveratrol extend the life span of yeast by 70%. In addition, resveratrol extended the life of short-lived fish up to 50%. Resveratrol also show the efficacy in extending the life of the insects. These studies were used high doses of resveratrol, and through modest to moderate consumption of red wine, what dose required to achieve the effect of prolonging life remains to be determined.

Source:http://www.cospcn.com

The strongest natural antioxidant - astaxanthin

In marine skincare ingredients, the most widely used is none other than seaweed. As one of the oldest biological, seaweed has a very strong vitality. It is rich in minerals and vitamins, can also promote tissue regeneration to bring powerful moisturizing effect to the skin, increase cell viability. In hundreds of years ago, the Oriental women had been found that the cosmetic effect of the seaweed, they crushed and cooked seaweed then coating in face and head to make the skin fit, make hair shiny. In recent years, with the seaweed to protect the skin further explore, you can see the shadow of algae in moisturizing or whitening, anti-aging field.

From the name of view it is easy to misunderstand astaxanthin from shrimp ingredients, in fact, it is produced by several algae and plankton. According to astaxanthin suppliers, natural astaxanthin is the most powerful antioxidants ever discovered in nature, the raw materials of many skin care products in recent years. At present, most of the natural astaxanthin extract from haematococcus pluvialis, and astaxanthin content in haematococcus pluvialis is 1.5% to 3.0%, as natural astaxanthin concentrated product.

Haematococcus pluvialis often in the form of a blood-red shell, attached to the edge of water altar or the sea periodic Repulse, its life course is roughly divided into three stages: dormant stage red, green swimming stage, followed by a red dormant stage. It can be seen haematococcus pluvialis has been found long time ago. But what is the use of haematococcus pluvialis? Scientists specializing haematococcus pluvialis do an experiment: two groups of salmon on a different environment, in nurture haematococcus pluvialis environment, salmon life twice than ordinary waters; use shrimp, crab do the experiment, the result is still the same as the former. This phenomenon make scientists very surprised, they began to study the red substance haematococcus pluvialis, the study found that this substance has a super antioxidant capacity; Japanese life expectancy is longer than the life of the people in most countries in the world , one of the reasons, just as they often eat algae containing astaxanthin.

End of the 20th century, the natural astaxanthin in haematococcus pluvialis concerned by more countries of the biosphere, after years of research, scientists have discovered the antioxidant capacity of natural astaxanthin in haematococcus pluvialis, exceed any species known in the world, and is completely non-toxic and harmless, so some enterprises have a strong research capacity, began to research to put haematococcus pluvialis in health care products, cosmetic raw material and food. As we all know, cause the people skin aging substance is "radical" and want to "anti-oxidation, anti-aging", the points is the free radical scavenging. The research results show that haematococcus pluvialis the scavenging ability of free radical is 1000 times than coenzyme Q10, 10 times than natural β-carotene, 17 times than grape seed, 200 times than rosecranine, 150 times than OPC, 200 times than tea phenol, 10 times than natural β-carotene, become the most popular antioxidants on the market.

Source:http://www.cosprm.com

The development direction of Chinese plant extracts

With the rapid development of bio-medicine in the 21st century, under the influence of the new medical model, with favored activity or function plant extracts are widely recognized in the world, has a broad market space.

Currently, the plant extract industry development faster and faster, the rate has exceeded the speed of drug development, and become an independent emerging industry, is widely recognized in the world. With the rise of the worldwide plant extracts markets, Chinese plant extracts industry will also become a strategic pillar industry.

China plant extract industry production and sales demand and forecast report shows that the plant extracts are the main force of Chinese exports, exports accounted for the total exports of Chinese medicine products more than 40%. Although the plant extract industry is an emerging industry, but over the past decade, it develops rapidly. According to plant extract supplier, in 2002 plant extracts exports only $ 190 million, but in 2010, exports have reached $ 815 million, an average annual growth rate is 19.65%. Not only that, the plant exports extract in recent years more showing a trend of volume and price increases, especially the average export prices rose significantly.

The data show that the first half of 2011, China’s exports of plant extracts is $ 525 million, a year-on-year growth of 47.68%, plant extracts in the proportion of the export of Chinese medicine products increasing gradually. Used as a natural medicine and homeopathy products, plant extract has a very stable sales in the international market.

Current challenges of Chinese plant extract products in the international market mainly from the safety testing. In recent years, the European Union, the United States, Canada, Japan and other countries and regions have been gradually established organic agriculture regulations, standards, regulations, to certify the health products. Therefore, in the case of increasing testing standards of the international market, Chinese enterprises are rapidly growing and adapting to environmental changes.

It is worth noting that China has accelerated the standardized of plant extract building material industry, establish and improve relevant laws and regulations, and give appropriate support. In future, China plant extract industry should also extend the industrial chain to the end-products such as herbal medicine, health food, cosmetics, and other aspects of development, improve the technological content of products, expanding profit margins. Special attention the development of some wolfberry, sea buckthorn, Rhodiola, Ganoderma lucidum, Angelica, Pueraria and other new resource types plant extracts, these products are expected to become the future plant extracts market "high demand".

In addition, more than 80% of Chinese plant extracts enterprises export their products. However, with the change of the exchange rate, as well as the growth of the Chinese market, more open up cooperation between the enterprises, also the future development direction of plant extracts enterprises. The plant extract is a core raw materials and products of biomedicine, is widely used in the field of pharmaceutical raw materials, food additives, functional food, cosmetics and other field of production.

Source:http://www.cospcn.com

The function structure and application of astaxanthin

Astaxanthin is a red pigment widespread in organism, although the word “astaxanthin” is not commonly used in everyday life, but astaxanthin exists in many kinds of human food. Most crustaceans, such as: shrimp, lobster, crab and so on showing red is because astaxanthin accumulation, in some fish, such as salmon, the flesh-colored is also results in astaxanthin accumulation. In actual production, astaxanthin is often used as feed additives for fish and other aquaculture animals, in order to make up for the lack of astaxanthin in human dietary, while improving the quality of aquaculture products. Astaxanthin is a safe additive, add up to 80 mg / kg. Absorption and accumulation of fish and crustaceans in astaxanthin is much more effective than other carotenoids such as canthaxanthin, lutein and zeaxanthin.

Astaxanthin is a carotenoid, produced by plants and microalgae in nature, animals can not synthesize carotenoids, only through the food chain from plants or algae. In recent years, the development of astaxanthin manufacturer from the haematococcus pluvialis producing astaxanthin is very soon, because haematococcus pluvialis grow fast, with high mass concentration of astaxanthin, the other way to get natural astaxanthin is: red yeast production; extracted from crustaceans such as the Antarctic krill processing by-products. The majority of currently astaxanthin is chemical synthetic products.

The molecular structure of astaxanthin is similar to β2 carotene, but the chemical properties and biological activity is quite different, in vitro experiments showed that the antioxidant activity of astaxanthin is much stronger than the β2 carotene, the beneficial place of astaxanthin for aquaculture has been known for many years, but the researches about its potential antioxidant properties on human health has only just begun.

Astaxanthin in its distal end cyclic structure having a hydroxyl group respectively, this free hydroxy group can be formed with a fatty acid ester. If a hydroxyl group and a fatty acid forming ester, called astaxanthin monoester; if two hydroxy groups and a fatty acid forming ester, it is called astaxanthin diester. Astaxanthin can according to stereoisomers, geometric isomers, the degree of esterification and whether esterification or not divided into many kinds. The stereoisomers of astaxanthin in haematococcus pluvialis is 3S, 3'S, the monoester is account for about 80%, the diester is about 15%, the main fatty acid has oleic acid, elaidic, ricinoleic acid and arachidic acid.

Natural astaxanthin exists in 3 S, 3'S or 3 R, 3'R form, and tend to form complexes with proteins to produce different colors, such as: lobster blue, green and yellow; also soluble in fat, such as the red in snow plant is resulting in its cytoplasmic liposomes accumulated astaxanthin; or forming esters with fatty acids. Astaxanthin in the cells rarely exist in free state, because of free astaxanthin is instability. Most of the geometrical isomers of synthetic astaxanthin and natural astaxanthin all in E structure, but stereoisomers is different from the mentioned earlier, the ratio between the synthetic astaxanthin stereoisomers is fixed, and racemic accounted for 50%, natural astaxanthin is mainly as 3 S, 3'S esterification structure, astaxanthin monoester accounting for more than 90% in haematococcus pluvialis, diester accounts for about 8%, free astaxanthin is about 1%. Comparison of synthetic astaxanthin and natural astaxanthin in the effect of rearing rainbow trout: result is quite different, rainbow trout were fed with feed containing the same amount of synthetic astaxanthin and natural astaxanthin, with natural astaxanthin fed rainbow trout accumulated more astaxanthin. Astaxanthin is a carotenoid, crystal is brown red. Compared with β2-carotene and vitamin E, astaxanthin has a more biologically active hormone, can be widely used in feed, food, pharmaceutical, cosmetics material and other industries.

Source:http://www.cosprm.com

Eat chili is popular in the world

A small town only have 1200 residents in New Mexico of America, but during the chili festival held annually, people go to there sharply increased 100 times. New Mexico is a state rich in chili, the small town is the center of the pepper, where farmers produce some special pepper, and then take a fashion name for them, such as "Spain Nale", "new ink Paker" and the "lander 21 ".

In recent years, peppers are very popular, not only in this small town, just a few years, the number of Mexican restaurants in the United States increased by 50 percent, while the Indian and Oriental supply chili restaurants increase more, so, peppers became future commodity crops. Not only popular in the diet, but also can be used as pharmaceutical raw materials. Many people who do not like to eat chili though that pepper will damage the taste, but in fact, it opposite, the mouth taste receptor cells exposed to capsaicin in the pepper, will be more sensitive to the flavor of food, and make the food more delicious.

Malaysians eat chili with fish sauce; Mexicans eat chili began 8,000 years ago, sometimes the whole meal are all chili; roast beef plus red spicy fish soup and potato is specialties food of Hungarian. Hungary’s rose pepper famous by fragrance scent, bright colors, most cherished by gourmet. Indian chefs is best know how to cook with chili dishes, the first put the dry chili into the hot oil, then add a few spoons of chili powder, and finally put the point chili mud or a few slices of fresh chili. Southeastern of India have a popular snack that use yogurt and pickled pepper fried crisp, students go to school with it in the pocket, sprinkle red chili powder when they are eating.

Thais eat chili is more than any country in the world, they average eat 5g per person per day, twice as many than the Indian average amount, even their broth also very spicy. Korean eat chili amount is close to the Thai people, they like to eat dried chili, the main seasoning of kimchi.

Japanese like to scatter red pepper powder over the dish, but some cooks put the carrot peelings, dig four holes, put red pepper into the hole, then ground together, to make dressing, scattered in the fish will be a cool spicy. As for the Chinese eat chili, would not have to elaborate on, Hunan can claim to be the Kingdom of spicy, Sichuan is hot in hot, many spicy eating methods have everything that one expects to find.

What is the reason make people who like to eat chili are ready to spicy mouth, have a fever, tears, pant like a bull? There are explained that it is related to the brain on Pepper's burning feeling. Psychologists said, when the body tries to protect themselves from the pepper invasion, the brain thinking that the body is injured then quickly release endorphins, which is a natural painkiller. If one more bite, the brain will think there is pain strikes again, release more endorphins. Continuing release endorphins will make people feel relaxed and happy, produce pleasure after eat chili.

Open the pepper and have a look, the spicy source is capsaicin, in capsicum, the spicy hot pot, chili powder are containing it. Capsaicin supplier make chili into six parts, from little spicy to the most spicy. In addition, in red, yellow pepper, sweet pepper, exist another component is capsorubin, also one of the most popular antioxidants.

Source:http://www.cospcn.com

Healthy foods promote the synthesis of glutathione

Glutathione is the body's main antioxidant and antidote, is one of the commonly used cosmetic raw materials. Glutathione levels can not rely on increased oral intake dose to improve clinical effects, this is because it is generated by the early form of glycine, glutamate and cysteine ​​amino acids in the cell. Therefore, healthy food is the premise to increase glutathione, or through other means to promote its production. And secretion of intracellular glutathione is also affected by the impact of the sulfur-containing amino acid and homocysteine ​​levels.

Cysteine ​​as a free amino acid may be existed toxicity, it is natural metabolites formed in the gastrointestinal tract and the plasma decomposition process. But cystine ​​is relatively more stable than cysteine. Intake healthy food rich in sulfur amino acids help to raise glutathione levels. Here are some sources of health food and nutritional supplements, which can naturally increase the levels of glutathione in the blood. It derived from amino acids, and as a pre-form of glutathione. Once the N-acetyl-L-cysteine ​​into the body can be rapidly metabolized and converted into glutathione. Scientific research and clinical trials have proved that the healthy food containing it can increase the production of the intracellular glutathione. It commonly used in the treatment of lung diseases, such as fibrosis cysts, bronchitis and asthma.

Silymarin, milk thistle is a powerful antioxidant, support and prevent liver glutathione depletion. Silymarin is the active compound of milk thistle, which is a natural liver detoxification agent, can protect the liver from many industrial toxins such as carbon tetrachloride damage.

Alpha lipoic acid is naturally acquired in human cells, and as a by-product of energy release, alpha lipoic acid increase intracellular glutathione levels, is a natural antioxidant with free radical scavenging ability. It has the regenerative capacity of the antioxidant, such as vitamin C and E, and to improve their effectiveness. Alpha lipoic acid can also help improve the absorption of glucose, and to prevent cell damage associated with diabetic complications caused. In addition, it has a certain degree of protection of the efficacy of the brain.

According to glutathione supplier, asparagus is a main source of glutathione. Healthy foods such as cabbage, avocado and spinach also thought that can increase the levels of glutathione. Raw eggs, garlic and fresh unprocessed meats also contain high concentrations of sulfur-containing amino acids, and helps to maintain optimal levels of glutathione.

Whey protein contains sulfur amino acids. However, heating or pasteurization destroyed milk disulfide bonds, make these proteins lost the biological activity. Whey protein is a non-heated product, therefore maintain the biological activity of cystine and other amino acids. Much of the scientific research and clinical trials, it has been proven that can optimize glutathione levels.

Curcumin has the role of treating brain cells, astrocytes. Have been found that put Indian curry spices with it can increase the glutathione S - transferase and protect neurons contact with oxidative stress. Platycodon root, can greatly reduce the oxidative damage to liver cells and reduce cell death and lipid peroxidation. Selenium supplements have become a popular health food, because some studies have found that they are likely to reduce the risk of certain types of cancer, and have the function of improving the immune system and thyroid. However, too much selenium will cause some side effects, including gastrointestinal upset, brittle nails, hair loss and mild nerve damage and so on.

Source:http://www.cosprm.com

Traditional Chinese medicine treat advanced gastric cancer

Incidence of gastric cancer is ranked fourth in the most common malignancy in the world, there are about 1 million of the new cases annually. Ranks second in male cancer mortality, fourth in the ranks among women. As we all know, the adequacy of local control is the key to treat gastric cancer. The incidence rate of the incidence of primary gastric cancer liver metastases is 4% to 14%. Gastric cancer liver metastases is still incurable, patients with 5-year survival rate is only 10%.

Gastric cancer liver metastases, often accompanied with peritoneal dissemination, lymph node metastasis or tumor direct violation of other organs, so few reports about the resection of liver metastases of gastric cancer. Compared with colorectal cancer, the vast majority of gastric cancer liver metastases often prompts the disease has been widely spread. A report shows that in gastric cancer patients with liver metastases, only 1/5 of the patients line liver metastases resection. The survival rate of liver resection is relatively poor, 2/3 of patients with intrahepatic recurrence. Such a high relapse rate in surgery within 2 years means that there is a potential intrahepatic metastases in hepatectomy.

According to pharmaceutical raw materials suppliers, many new drugs such as oxaliplatin, taxane, irinotecan and S-1 and so on for patients with advanced gastric cancer provide a more effective and safe treatment option. Studies have shown that the effective rate of 5-FU + calcium folinate (CF) with oxaliplatin combination chemotherapy is 38% to 54%, overall survival is 8 to 11 months, and good security. The effective of taxane treat advanced gastric cancer was 11% to 24%. Another study showed that single-agent irinotecan in the treatment of gastric cancer was 20%. Various chemotherapy containing irinotecan showed a better relieve rate. What’s more, the irinotecan price is moderate, can be widely used.

S-1 is a fluorouracil derivative oral anticancer drug, compared with 5-FU has the following advantages: (1) can maintain a high blood concentration and improve anticancer activity; (2) significantly reduce drugtoxicity; (3) getting drugs convenient. In Japan, S-1 in 1999, has been approved it in the treatment of advanced gastric cancer. In Japan, more than 80% of the advanced gastric cancer chemotherapy use the S-1, its efficiency up to 44.6%. Clinical trials have shown that the effective rate of S-1 for gastric cancer with liver metastasis was 25% to 31%.

Recently, a clinical trial conducted by oncologists show that S-1 single-agent efficacy was not inferior to 5-FU alone drug; irinotecan combined with cisplatin was no better than use 5-FU alone. Analysis showed that irinotecan can significantly prolonged progression-free survival and overall survival associated with liver metastasis or lymph node metastasis in patients with irinotecan plus cisplatin. In addition, studies have shown that the first-line treatment for advanced gastric cancer, S-1 plus cisplatin is more effective than the S-1 single drug. Therefore, S-1 plus cisplatin has become one of the standard first-line treatment of advanced gastric cancer program in Japan. In S-1 combined with docetaxel clinical trials, types and histopathological types of gastric cancer involving the organ does not affect the efficacy of the program, wherein the overall response rate of gastric cancer liver metastases was 64.7%.

In addition, countries in the treatment of advanced gastric cancer chemotherapy are not the same. Such as the United States is often used docetaxel + cisplatin +5- FU, Europe often used epirubicin + cisplatin +5- FU or epirubicin + oxaliplatin + capecitabine, while South Korea is recommended cisplatin + capecitabine. But the efficacy of the above methods in gastric metastasis has not been reported.

Source:http://www.cospcn.com

Biotin is a good anti-hair loss drug

Friends with hair loss may have seen a news that a guy feeding cattle in farm, cattle lick under the head of hair loss, and after that it grows a lot of hair. After the European mad cow disease, scientists have discovered a new vitamin have excellent effect on mad cow disease prevention and treatment, this new biotin plagued human hair loss have good therapeutic effect. This vitamin called biotin.

Biotin, also known as vitamin H, is a water-soluble vitamin. A coenzyme constitute carboxylase, maintain hair, skin and nails healthy, involved in fatty acid, the genetic material (DNA) and adenosine triphosphate (ATP, the direct source of the body's energy, need to be constantly synthesis) anabolism and catabolism of amino acids. Biotin is an important nutrient fortifier, Britain thought that biotin reference nutrient intake per person per day is 10 ~~ 20 μg, United States recommended adult intake 30 ~ 100μ g per person per day. Biotin is also a biological catalyst which essential for animal growth and development process and gain weight, the quality of meat, fur and so on are influential. The dosage of biotin in Chinese market is small, and only used in the medicine, and other feed additives in very small quantities.

Biotin is an important and indispensable substance in the fats and amino acids metabolism, in preventing gray hair, hair loss prevention and treatment, ease muscle pain, relieve eczema, dermatitis symptoms have an important role. Biotin is synthesized by intestinal flora. The raw protein will hinder the body's absorption of biotin. Biotin and vitamin B2, B6, A, niacin (vitamin B3) have complementary roles to keep the skin healthy. Sparse hair male taking biotin can anti-hair loss; the man who lack of biotin, the facial and body will show up eczema, feel extreme fatigue, hinder fat metabolism, loss of appetite, hair loss, depression.

Biotin is a vitamin, it is necessary to prevent hair loss and promote hair growth. Through multiple case demonstrates, biotin greatly help to prevent hair loss. It can promote the growth of healthy hair, but also to maintain the health of the skin, can be used as cosmetic raw material. If the body lack of biotin, will not only cause hair loss, there are likely to lead to other skin diseases.

Supplemental biotin in addition to a balanced diet, also can through supplements to make the body's biological interaction returned to normal levels. In order to maintain the healthy growth of hair, be sure to pay attention to the skin calorie consumption, biotin manufacturer recommend that it preferably through diet to supply biotin, liver and egg yolk are rich in biotin. In daily, should choose shampoo containing biotin ingredients. Some cereal crops rich in biotin, such as green peas, soybeans, oats, walnuts, sunflower seeds, brewer's yeast, bulgur wheat and brown rice, etc.. Also to be noted that less drinking, because the beer will decompose biotin, reduce the body's absorption capacity, resulting in hair loss.

If you have stomach problems, especially the heartburn, you must be careful observe. Because some stomach problems with acid reflux, will prevent the body from absorbing biotin, that’s why a lot of stomach friends have hair loss. So friends have stomach problem should intake stomach antacids to promote the body absorb biotin, in order to avoid hair loss.

Source:http://www.cosprm.com