Rapid development reasons of abamectin

Abamectin in recent years has a very good development, experts said that avermectin also has a very good development space and development prospects in the future, then why abamectin can get such a good development? The avermectin rapidly developing is based on what?

Abamectin is a natural fermentation mixture of component, occupy a more important position in Chinese pest control system. Avermectins in China, currently has more than 10 enterprises production. The currently commercially available Avermectins Series pesticide has abamectin, ivermectin, the acetamido abamectin and methyl abamectin benzoic acid salt and so on. Boutique Abamectin is a white crystalline powder, melting point is 155-157°C, due to there is not acidic or basic functional groups on its structure, its stability under normal conditions, when the PH is 5-9  will not decompose(see the light will decompose).

Avermectin is a nerve agent, its mechanism is acting on the insect neuron synapses or neuromuscular synaptic GABAA receptors, interference the information delivery of insect nerve endings, that stimulate nerve release neurotransmitter inhibitor γ- amino butyric acid (GA-BA), prompted the GABA-gated chloride channel prolong opening, to the chloride channel have activation effect, a large number of chloride ions influx cause nerve membrane potential hyperpolarization, resulting in nerve membrane in an inhibitory state, thus blocking off nerve and muscle contact, make insects benumbed, poor feeding, death. Because of its unique mechanism of action, so it’s no cross-resistance with commonly used agents.

According to reports, in addition to the chloride channel controlled by GABA receptor, avermectin also can affect other ligand-controlled chloride channel. At the same time, avermectin has good layer-shift activity, a layer shift activity refers to the avermectin can penetrate into the crop leaf tissue after spraying, forming a sachet within the parenchyma cells of the epidermis, long term storage, so the avermectin has preferable persistence period. Because of its good layer shift activity, abamectin to spider mites, leaf miner and borer pests or sucking pests and other pests which conventional agents is difficult to control have a good effect. Avermectin is easy to biodegradable in soil and water, and absorbed by soil in the soil, not leaching, no residue, will not pollute the environment; also not accumulation and persistent residue in vivo, so abamectin should belong to pollution-free pesticides.

Abamectin can also be decomposed by edaphon to be higher activity derivatives, such as the insecticidal effect on plant nematode. Chinese existing avermectin manufacturers have more than a dozen, the annual production capacity is 200-800t/Y, but the technical level of the various manufacturers are not the same, the gap is mainly the bacterial contamination rate and titer in the fermentation. The titer of Chinese manufacturers generally around in 3500μg/ml, individual manufacturers over 4000μg/ml. Bacterial contamination rate is generally below 10%, individual manufacturers below 3%. According to reports, a research institute new cultivated more active strains, the potency can be achieved 8000μg/ml, various manufacturers were highly concerned about it, if this technology industrialization will make Chinese abamectin’s overall production technology level greatly improved, and is expected to reach the international advanced level.

The China produced avermectin have 50% for the downstream products production, 30% for exporting, 20% for preparing a variety of preparations. Abamectin as a major biological pesticide varieties presented in short supply status, so that directly led to the rising price of avermectin. Now the new formulation development of avermectin become the hotspot of international research and development, its dosage form have many different types, such as the missible oil, micro-emulsion, soluble granules, microcapsules, etc., and the use of its preparations has huge increase, has been recognized by the international market, especially the developing countries, such as Thailand, Pakistan, India, those countries’ imports show a upward trend annually, it is visible that abamectin has extremely broad prospects for development.

Source:http://www.cospcn.com