Application of abamectin series drugs

In China, abamectin and ivermectin formulation mainly have powders, premixes, capsules, tablets and injections. Recently also developed oral liquid, paste, pouring agent and ointment, but the market application surface is not large. Various formulations have advantages and disadvantages, should be according to the different animal object to apply. In bioavailability, the injection agent is the best, followed by is the pouring agent, again is oral liquid.

At present, in the animal health products market, abamectin and ivermectin have very widespread popularization and application. In drive mites and external parasites drugs, abamectin and ivermectin is the most widely used drug, and the amount is still expanding. With the production technology continues to progress, ivermectin prices will continue to fall, in China, ivermectin will be increasingly replaced abamectin.

The application of abamectin and ivermectin is a big step forward in the breeding technology, is a major contribution of antibiotics on livestock. However, in the process of using abamectin, many users reflected that the effect is not good, even show up poisoning, especially the reflections about the unstablity of using abamectin is more prominent. After investigation and analysis, the researchers think that the cause of these results with the following reasons.

First, the chemical structure of abamectin is inherently instability, susceptible to be oxidized and reduce the activity. This activity decay process can occur in the drug raw material, tablets, powders, premixes and capsules and so on. Secondly, due to the abamectin is a group of compounds, constituent and molecular structure are more complex, if the quality control measures in the production process can not be fully in place, the quality of drugs produced will be severely affected. Third, some abamectin manufacturers use the Afo bacterials mycelium without further purification refined or crude extract as abamectin to sale. This is not only can not play the efficacy, but also likely to cause livestock poisoning and even death. Fourth, different manufacturers produce abamectin and ivermectin injection solvents and accessories (such as co-solvent, antioxidant, analgesic, etc.) is different, make the efficacy discrepancy. Fifth, abamectin and ivermectin have good effect to kill the adult insects, but the efficacy on larvae and eggs is poor or even no efficacy, if oral medication is not continuous or repeated drug use will result in the larvae and insects egg stage parasites develop into adults cause repeated infections. Sixth, did not cooperate with the hogpen cleaning and disinfection measures while deworming with drugs, causing ova and parasites repeated infections in the environment.

For the above, while buying abamectin and ivermectin should note the followings: choose high degree credibility well-known abamectin supplier, so the quality is reliable. Don’t buy the commodity preparations made ​​from mycelium or crude extracts. Qualified abamectin and ivermectin oral preparations are not gray and black, tasteless. If the powder or tablets is black or gray, unpleasant odor is lead to mycelium or crude extracts, can not be purchased to use. In the case of the conditions permit, as far as possible to choose ivermectin preparations, do not use abamectin. As far as possible to choose a relatively new product in the production batch, especially using the abamectin. Ensure adequate dose and duration of drug effect, if necessary, repeated drug use. According to the rearing conditions and different livestock breeds choose the appropriate dosage forms, in the case of operating conditions permit, as far as possible to choose injections. Pay attention to the cleaning and disinfection of environmental health while medicating, to kill the parasite eggs in the environment.

Source:http://www.cospcn.com