Capsaicin impact on the gastrointestinal tract

There is a big controversy on the reports about capsaicin on gastrointestinal cancer, and some studies by pharmaceutical raw materials suppliers suggest that capsaicin can inhibit tumor cell, also some researches found that the capsaicin can promote tumor cell proliferation, there are some reports show that capsaicin has no effect on tumor cells. Researchers doing more researches about capsaicin on gastric motility, most of them reported that small doses the capsaicin can promote gastric motility, large dose of capsaicin on gastric motility have inhibition role.

Effects of capsaicin on gastric mucosa, in recent years, there are many international studies have shown that the right amount of capsaicin on gastric mucosal have protective effect. The probability of Chinese people in Singapore suffering from gastric ulcer is three times than Malaysians and Indians, and may be related with Malaysians and Indians eat more chili. Capsaicin, capsaicin-sensitive afferent nerves and capsaicin receptor and gastric mucosal injury and repair are closely related. Capsaicin-sensitive neuron cell body is able to synthesize tachykinins of substance P (substance P, SP), neurokinin peptide A (neurokinin A) to the axon terminals transport of these peptides. Stomach CSSN through the release of calcitonin gene peptide (calcitonin gen related peptide, CGRP) increased gastric mucosal blood flow, and a series of reactions mediated by CGRP, thereby increasing the gastric mucosal resistance to maintain gastric mucosal integrity. Acid-induced gastric ulcer, congestive reaction capsaicin sensitive afferent neurons by regulating CGRP release to promote the role of the acid treatment of the gastric mucosa, thereby treating gastric ulcer.

The functional activity of the CSSN gastric acid and gastric mucosal blood flow is more important to the regulation of gastric mucosal blood flow. Intragastric perfusion with peptone, causing an increase in gastric acid secretion and gastric mucosal blood flow; terms of the capsaicin afferent denervation weakened the intragastric peptone caused an increase in gastric acid secretion effect, increase in gastric mucosal blood flow effects almost completely disappeared. The surface mucosal growth factor by capsaicin-sensitive afferent nerve play the congestive role and protecting the stomach and gastric mucosa. Gastric mucosa dominated by the vagus nerve and spinal afferent, when gastric mucosa stimulated by harmful chemicals, these afferent nerve though increased gastric mucosal blood flow to protect and repair the gastric mucosa.

Capsaicin have certain effects on gastric acid secretion, the majority of studies by capsaicin supplier have shown that small doses can inhibit gastric acid secretion, large doses may promote gastric acid secretion, also some reports chain that a certain dose of capsaicin has no effect on gastric acid secretion. Capsaicin may through directly stimulate the central, peripheral capsaicin-sensitive sensory nerve and Pik cells capsaicin receptor, causing calcitonin gene-related peptide, P substance, neurokinin A, vasoactive intestinal peptide neurotransmitter release to participate in the regulation of gastric acid secretion.

Capsaicin on gastric cancer cells have significant growth inhibition and induction of apoptosis in a dose-and time-dependent manner, mainly through the regulation of Bax, Bcl-2 and C-myc protein expression to achieve. Capsaicin dose relationship manner to reduce the cell viability of the human colon, capsaicin also cause the fragmentation of the changes in cell morphology and DNA, DNA content decreases, phosphatidylserine shift, wherein phosphatidylserine of the shift marks cells apoptosis. The mechanism of capsaicin-induced apoptosis may be semi-caspase 3 (a major apoptosis-inducing enzyme) activity is enhanced. At present, the international community about the effects of capsaicin on gastrointestinal health research relatively large, but its mechanism of action is relatively weak, especially affect the outcome of colorectal cancer and its mechanism should be further explore.

Source:http://www.cospcn.com