Application of Biological Technology In The Resveratrol Research

For the first time got resveratrol from wool leaf hellebore (VeYatYuD? Grandiflo - rtua) root in 1940. In 1960 Nonomura and other people come up with Res is some herbal medicine treatment of inflammation, lipid metabolism and heart disease of the effective components. In 1977, found in grapes Res as plant resistance to toxin exist. In 1989 WHO hold an epidemiological survey, the results show that the "French Paradox" (French Paradox), namely: high fat diet and coronary atherosclerosis low incidence was significantly consistency. Through further research, people found by drinking wine intake Res is French cardiovascular morbidity one of the main reasons for low: red wine for belt leather fermentation, peel and juice contact time long, make the skin a considerable amount of Res can enter the wine, which has good lipid peroxidation, known lipid peroxidation in atherosclerosis and other cardiovascular disease plays an important role. In 1992, the commercial wine found resveratrol the first time, the same year the academic circle further confirmed on wine rich in resveratrol. In recent years, many pharmaceutical raw materials suppliers learning function of resveratrol biological in deep research, these studies including lipid metabolism, arachidonic acid metabolism, etc., prove it has many important physiological activity, such as: cancer, protecting cardiovascular system, estrogen-like effect, influence bone metabolism, etc.

People to resveratrol natural resources have been studied extensively, at least has been in grape families, liliaceae, polygonaceae, leguminosae, myrtle, apiaceae, cyperaceae, palmae, buy a horse TengKe etc 21 families and genera and 72 species of plants found white hellebore alcohol. Its main exist in buckwheat fleece-flower root root, buckwheat giant knotweed roots, stems, grape family plant vitis peel, stone, liliaceous plant hellebore of roots, stems, leaves, leguminous plant groundnut roots, stems and the flowers. Especially in fresh grape skin of content is higher, about 50 ~ i00 > g/g, and with trans primarily. Grape cultivars, growth location, climate, planting technology, fungal infection degree and so on all affect the content of resveratrol. Made method to the influence of the content of resveratrol in grape wine was particularly remarkable, red wine the average contents of resveratrol to 4. 37 mg/L, and white wine only 0.68 mg/L. In improving content also had a lot of research, such as: use before harvest ultraviolet pulse radiation method improve the grape resveratrol content]; With recombinant yeast strain as a tool to improve the content of resveratrol in grape wine was white, natural including RS genes in plants suffer stimulation, can stimulate the gene transcription and translated into RS, then instantaneous synthesis of resveratrol. In grapes, peanuts, pine trees and other plants with induction type stilbene synthase gene expression mechanism, but most plant cells despite STS enzyme substrate, but lack of STS genes, and thus lack in the induced factor synthesis under the action of this kind of plant protection element ability.

Because the content of resveratrol in plants is very low, generally exist in glycosides. Many domestic scholars and resveratrol manufacturer are using chemical methods to make it. Generally speaking, chemical synthesis method with low cost, but from the food safety point, more and more scholars advocate getting it from natural plant extract, especially in foreign resveratrol biological extraction are more attention, and have a deep research.

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