Resveratrol and cardiovascular disease

Resveratrol regulated mitochondrial antioxidant manganese superoxide dismutase, manganese superoxide dismutase is an important intracellular antioxidants. Resveratrol used in vitro cultured human cells two weeks, the oxidation of manganese superoxide dismutase protein levels increased six-fold, the activity increased 14-fold, while the other major cellular antioxidants (glutathione peroxidase, catalase) found to be affected or decrease in activity. Resveratrol by regulating manganese superoxide dismutase to part of extend the mitochondrial life, thereby protecting mitochondrial away from the free radical damage, to complete the task of its own capacity.

In animal studies, resveratrol shows it can through a large number of mechanisms to protect the cardiovascular system, including inhibit the oxidation of low-density lipoprotein cholesterol (oxidation is the first step leading to atherosclerosis), protect and maintain the endothelial cells (artery wall cells) complete, promote small artery vasodilation, inhibit platelet aggregation, as well as protection from ischemia - reperfusion injury (to reduce heart attack scale). Endothelial progenitor cells are adult stem cells produced by the bone marrow, through the blood circulation, then divided into the endothelial cells of repairing the artery wall. Diabetes, high blood pressure, high LDL cholesterol and cardiovascular disease in patients with endothelial progenitor cells circulate volume decline. Resveratrol can increase the amount of endothelial progenitor cells, enhance its functionality, what you need to do is suitable drinking the right amount of red wine.

According to several human epidemiology studies, minor or moderate drinking red wine is related to reduce cardiovascular disease, as well as the reduction of total mortality from all causes have contact. Some studies have shown that drinking red wine can more reduce the incidence of cardiovascular disease and mortality than beer. A Dutch study of middle-aged men show that, people who daily drink half a cup of red wine with the lowest mortality, heart attack mortality lower 48%, while 40% reduced all-cause death compared with non-drinkers. In addition, the drinkers’ average life is 3.8 years longer than nondrinkers.

In another study of pharmaceutical raw materials suppliers, 30 patients with coronary heart disease in men taking a red grape polyphenol extract, their endothelium-dependent vasodilation improved, studies show that after 60 minutes their arm rear of the brachial artery flow mediatedguide diastolic function get 73% improvement. This indicates that the red grape extract can also be beneficial for people.

Mice fed a high-fat and added resveratrol, the risk of death is 30% lower than high-fat diet mice fed only. Resveratrol with the high-fat diet-induced 144 in 155 set of genes sang a rival show. Blood glucose and insulin levels in rats fed a high-fat diet have adverse change, and fed added the high-fat diet of resveratrol animal the glucosyl level (and sometimes insulin levels) is close to the normal diet of mice. Obese mice taking resveratrol also reduced the weight, and the ischemic function is more powerful, the ventricular fibrillation reduced 83% and 20% reduction in infarct size (the size of the organization) of cardiac death. Here raises the question of whether resveratrol can effectively prevent and treat diabetes?

What most exciting is resveratrol has the effectiveness of its anti-aging and slow down life, studies by resveratrol supplier show that resveratrol extend the life span of yeast by 70%. In addition, resveratrol extended the life of short-lived fish up to 50%. Resveratrol also show the efficacy in extending the life of the insects. These studies were used high doses of resveratrol, and through modest to moderate consumption of red wine, what dose required to achieve the effect of prolonging life remains to be determined.

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