Eat peppers can ease chest and belly cold pain in winter

In human’s impression, the spicy food may be harmful to human health. However, according to the latest study pointed out that these harmful food in people’s stereotype, in fact may produce considerable help to human body, every hectogram pepper content vitamin C up to 198 mg, ranking first in vegetables. Vitamin B, carotene, calcium, iron and other mineral also have rich content. Medical experts believe that peppers can ease the chest and belly cold pain, stop diarrhea, inhibit intra-abdominal parasites, control of heart disease and coronary artery disease; can stimulate oral mucosa, causing gastric peristalsis, promote saliva secretion, increase appetite, promote digestion. Spicy products because of its sterilization, preservation, seasoning, nutritional, and fend off the cold and other functions, played a positive role in human disease prevention, medical treatment, genetic improvement and promoting human evolution. Therefore, add a little pepper in the winter daily recipes, have a great benefit to the health of the body. The chili is the master of antioxidant, has always been considered to stimulate food pepper, in fact, contains a very high antioxidant content, and the content even 42 times than apple, 12 times than oranges, and four times than grapes, is a very good anti-aging medicine. pharmaceutical raw materials suppliers said, in fact, every kind of spice or pepper are contain a certain effect.

Pepper slimming effect, the reasons why people can not refuse the pepper is that: burn fat, Slim plastic body. The key to burning fat chili is that the capsaicin, the role of capsaicin is to stimulate the body produce heat, speed up metabolism. Fast heat systems can improve the efficiency of the body, like the fast-running machines can consume large amounts of hydrocarbon fuels. After eating a meal of spicy, can consume more than 25% of calories. When hot, drink a cup of caffeine-rich black tea in the belly burning, the effect is even more obvious. The chili can promote the production of two enzymes in the body, in the process of burning fat, they can convince the fat cells side unloading, while preventing excessive accumulation of fat. This way to lose weight without any diet rules companion, the capsaicin stimulates production of endorphins and serotonin, at the same time will allow you to have a good mood.

Pepper can prevent heart disease, the chili can promote blood circulation, increase the flexibility of blood vessels, reduce the risk of hardening of the arteries, help prevent cardiovascular disease. Pepper content rich of vitamin C, have the effect of antioxidant, while enhancing the body’s resistance also anti-aging. Special reminder by capsaicin manufacturer: chili should not eat too much. Due to the pepper heat is toxic, excessive eating can make the body wet from the heat, manifested as skin acne, high blood pressure, hemorrhoids increased, epistaxis and so on. If eat lots of chili for a long time will cause poisoning performance, such as epigastric burning sensation, abdominal distension, abdominal pain, nausea, vomiting, dizziness, and even vomiting blood, blood in the urine, high blood pressure or decline.

Source:http://www.cospcn.com

The extensive application of glutathione

According to the study of glutathione manufacturer, glutathione as one of the most important antioxidants in body, can directly through for H + antagonistic toxicity of oxygen free radicals, remove the superoxide ions and other radicals in body, to prevent damage to the liver cells.

The pharmacological effects of glutathione: reduced glutathione is a tripeptide composed of glutamic acid, cystine and glycine, it is a cofactor of glyceraldehyde dehydrogenase, also the coenzyme of ethanediyl aldehyde enzymes and triosephosphate dehydrogenase which can involve in the in vivo TCA cycle and glucose metabolism, make the body get the high energy. Glutathione can activate a variety of enzymes, such as the body’s mercapto group (-SH) enzyme, coenzyme, etc. thereby contributing to the carbohydrate, fat and protein metabolism, and can also affect the metabolic processes of the cells, is an intracellular important regulator of metabolic substances.

In addition, glutathione in the body exist in two forms of reduced glutathione and oxidized glutathione, its active ingredient is glutathione, can participate in vivo redox processes. Under the action of glutathione transferase, glutathione can combine with the peroxides and free radicals to anti oxidants destruct mercapto, protection of cell membrane protein containing a mercapto group and a mercapto group-containing enzyme is not destruction against free radical damage to vital organs. Reduced glutathione is widespread in the animal and plant’s cells, and content in the liver and lens more. Now can be produced by chemical synthesis or fermentation.

Reduced glutathione is cofactor of glyceraldehyde phosphate dehydrogenase and the coenzyme of glyoxal enzymes triosephosphate dehydrogenase, involved in the body of the citric acid cycle and glucose metabolism, make the body get high energy. Can activate and protect a variety of enzymes, such as sulfhydryl (-SH), in vivo cholinesterase enzyme, so that the body against iodoacetic acid, mustard gas, free radicals (such as superoxide anion), heavy metals (such as mercury, lead), poisoned epoxide and other harmful substances, thereby contributing to the carbohydrate, fat and protein metabolism, can also affect the cell's metabolic processes. Promote eye tissue metabolism, inhibit crystal protein thiols instability, prevent the development of cataracts and retinal disease, which can be used to keratitis, corneal trauma. These diseases before reaching old age, began regular use of such antioxidants can play a preventive role. There are also good increasing role in vision.

Glutathione suitable for a variety of liver diseases, especially alcoholism, liver disease, drug-induced liver disease (including anti-cancer drugs, anti-tuberculosis drugs, neuropsychiatric drugs, antidepressants, acetaminophen and Chinese medicine) positive effect on the infectious liver disease - hepatitis B, chronic active hepatitis C also improved the symptoms, signs, and recovery of liver function. Used for poisoning rescue for heavy metals, organic solvents. Prevention and treatment of radiation injury, leukopenia disease and radiation-induced bone marrow tissue inflammation. It can also be used as cosmetic raw materials, used for facial pigmentation, sweat stain and a variety of causes pigmentation. For eye drops to treat early age-related cataracts, can also be used for corneal ulcers, corneal epithelial peeling, keratitis.

After the reduced glutathione treatment, it may cause rash, stomach pain, nausea, vomiting, injection of local mild pain. A small number of patients using the drug drops may occur itching, irritation, ocular hyperemia, blurred vision and other symptoms, after drug withdrawal it will disappear.

Source:http://www.cosprm.com

Capsaicin can make of antidote and tear gas

Ordinary people feel the more red chili the more spicy, but purified capsaicin is white! In fact, the red is capsanthin, it is not spicy, the extracted pigment can added to foods. The capsaicin manufacturer said that capsaicin purification is very difficult, previously only can purified to about 10%, and now after years of research, it has been improved. Preparation of capsaicin is a very complex process, star the pepper acquired from the market to become white crystalline capsaicin, even if the various steps incessantly row to do should spend a day. Capsaicin extract, first of all should shatter the pepper, screen pepper seeds, then ground into powder, made of granules, last adding to an organic solvent to extract, all in all it by the various extracts, separated manners to get this crystalline.

According to the content of capsaicin, 1 kg of capsaicin needs at least 34 pounds of pepper extract. At present, many scientists are researching red dried chili, because this type of pepper can both extract capsaicin and capsanthin. High purity capsaicin should not touch the skin, it will burn skin. The studies show that if the capsaicin accidentally gets on the hands, wash your hands many times will still feel hot and pain. Because capsaicin belongs to lactam substances, it will burn the skin.

Capsaicin is an extremely spicy vanilla amide alkaloids, it is the main source of chili has a spicy flavor and drug function. Capsaicin is white crystals, melting at 65 ° C to 66 ° C; soluble in methanol, ethanol, acetone, chloroform, benzene and ether, and soluble in alkaline aqueous solution, produce irritating gases at high temperatures. Natural capsaicin composed by a series of congeners: capsaicin, dihydro-capsaicin, drop dihydro capsaicin, high dihydro capsaicin, capsaicin and so on, the most important of which is capsaicin, dihydro-capsaicin.

The application of capsaicin, medical treatment, weight loss and make drug rehabilitation tear gas: as far as I know the use of capsaicin is very extensive. The high purity of capsaicin has many physiological activities, such as capsaicin can be used for biological and chemical pesticides, sprayed it on the plant’s leaves, neck, fruit and flowers can be effectively expelled aphids, spiders, leaf-eating insects and fleas; capsaicin can also used as pharmaceutical raw materials, these drugs can be used for analgesia and treat skin diseases, arthritis, etc; in addition, capsaicin can also be used to do the diet food, even for giving up drug. Capsaicin also have a very wide range of uses in other areas. For example, capsaicin can be used to produce functional coatings, coated in a shell of the ship to prevent the adhesion of algae and marine life, coating the surface of the cable and wood can also prevent rats chewing on. In addition, many of the tear gas is also made of capsaicin, which is that it can as a function of defensive weapons materials.

Source:http://www.cospcn.com

Astaxanthin can inhibit acute inflammation

Natural astaxanthin can regulate the immune response, inhibit the growth of cancer cells, reduce bacterial infection and gastritis, against oxidative damage induced by ultraviolet ray. Everyday life, we will be more or less show up some physical illness, small to fever and big to cancer as well as hard-to-cure diseases. As the saying goes: Blocked have means to resist. We will do this by taking drugs to treat these diseases. However, how many people will get to know the real reason why you will be sick ? For example, you catch a cold, you are just thought the weather was cold yesterday, you wear less clothes. You did not expect to find the root cause of the disease, enabling to prevent the occurrence of disease in advance, rather than when the disease was occured, and then spend money on medicines to treat it.

Rely on oxygen, our body is full of vitality. We breathe in oxygen, and use it to burn fuel (food consumption) and produce energy. However, when cells use oxygen waste produced as a by-product - in the form of high-energy oxygen molecules. These reactive oxygen molecules have a name, called free radicals. Free radical damage to human tissue and cell structure, such damage called oxidative stress - the body utilize oxygen to impose their own pressure.

Most of the aging-related health problems, such as wrinkles, heart disease and Alzheimer's disease are related about the oxidative stress. As the cosmetic raw material supplier noted: "Few people can live up to their potential maximum life span. They often die of various diseases earlier, including a large part of radical initiator." Despite those research results have been half a century ago, but people understand these concepts until recently.

In fact, almost all the organs of the body are very susceptible to hurt by oxidative stress, there are numerous symptoms, such as fatigue, general weakness, muscle and joint pain, indigestion, anxiety, depression, pruritus, headache, and difficulty concentrating and hard to cure infection. The most common diseases induced by elevated levels of oxidative stress are heart disease, cancer, osteoarthritis, rheumatoid arthritis, diabetes, and neurodegenerative disorders such as Alzheimer's, Parkinson's disease.

We also found that oxidative stress and inflammation are closely linked. In body’s everywhere, as long as there is one phenomenon there will be another phenomenon attendant. Take the example of the lungs of smokers, the existence of a large number of oxidative stress in the region. The smoke is an oxidant, with a high oxidative capacity. When inhaled this oxidized tobacco, lung tissue damage occurs, quickly causing inflammation. Therefore, smokers are mostly suffering from bronchitis.

Astaxanthin is a super natural extracellular antioxidants first separated from the lobster in 1938. according to the surveys by astaxanthin suppliers, it is the only antioxidants can retard aging function of organs and tissues. It can clear excess of free radicals in the body to reduce oxidative stress, thereby enhancing our body's immune function, prevention of inflammation and disease occurrence.

Source:http://www.cosprm.com

The modern production and applications of chili

Capsanthin is both pharmaceutical raw materials and cosmetic raw material, in industrial, it commonly used ethanol or n-hexane extract of red pigment from the red chili powder, due to the complex chili ingredients, low solvent selectivity, the purity of the product obtained and spicy, smell, so it must be approved by de-spicy, deodorized refined before use. Because of capsanthin oily characteristic makes the removal of residual solvent in the product is difficult to reach the required standard, it greatly affect its use and export.

In recent years, a high-tech industrial application of the separation technology - supercritical fluid extraction to solve these problems. Carbon dioxide is the most common solvent in the supercritical fluid technology, its critical temperature is 31.05C, SCFE technology operation can achieved at around room temperature, in order to save energy, and its critical pressure is not very high. Processing equipment is not difficult. Most of its solute having greater solubility, while the solubility of water in the carbon dioxide was small. Carbon dioxide also has a non-combustible, non-toxic, chemical safety, cheap and easy to get the advantages. Using SCFE-CO2 can be directly extracted no spicy ingredients, odor component and yellow pigment-free taste of the high capsanthin from chili.

The impact of the extraction conditions to extract: the lower the pressure, the smaller the color value extract, mainly because of pepper pigment solubility less than spicy ingredient in chili oil resin, fatty acids and Triglycerides.

The application of modern biotechnology in enhance capsaicin, capsaicin was crystallized in the water as a white monoclinic rectangular plate crystals, crystallized in petroleum ether is scaly. Soluble in alcohol, ether, benzene, chloroform, fats and alkaline aqueous solution. High temperatures produce irritating vapors.

Capsaicinoids have been widely used in the pharmaceutical industry and the food industry. The different pepper varieties contained the different amount of capsaicinoids, differences generally dried chili 0.2% -2% capsaicin matter content, have an important role to improve the chili quality and value.

The capsaicinoids belongs lactam compounds composed of vanilla amine and branched lipid intestinal acid. Vanilla base amine part derived from phenylalanine. Because of capsaicin synthetic phenolic precursors - coumaric acid, phenylalanine, cinnamic acid, caffeic acid, vanillin synthetic precursor of the protein, alkaloids, flavonoids, and lignin, therefore pepper biosynthesis to the existence of the problem of competition with other biosynthetic pathways Community. Through metabolic regulation or gene regulation best to promote the biosynthesis of capsaicin. It is of great significance to the industrial production of capsaicin.

The enzymes involved in the capsaicinoid biosynthesis pathway have: phenylalanine lyase, cinnamic acid hydrolase, coumaric acid hydrolysis enzymes, capsaicin synthase is capsaicin last enzyme in the synthesis process, is a critical the rate-limiting enzyme. Of capsaicin synthase gene cloning, the use of genetic engineering and modern biotechnology prompted capsaicin synthase gene expression in pepper fruit and plant cell culture fully screened the high capsaicin prominent body, excellent cultivating transgenic yield capsaicin content of pepper varieties, will greatly improve pepper quality, which will effectively promote capsaicin industrial development. Source:http://www.cospcn.com

The side effects of topical vitamin A acid in the treatment of acne

Usually skin disease acne is common among adolescents, can be significantly improved by treatment, several mainstream drug treatments including isotretinoin and antibiotic treatment, and other cosmetic skin care products for acne often contain hormone ingredients which harmful to the human body.

Use vitamin A acid to treat acne will cause a lot of side effects: topical vitamin A acid, which is derived from vitamin A acid topical formulations. Main ingredients include Vitamin A acid, isotretinoin, adapalene, the major role is to increase the metabolism of the cells of the epidermis, make keratosis abnormal situation can be improved, the anti-inflammatory response, regulating the growth and differentiation of epidermal cells, promote collagen production, improve sebaceous gland function, reverse photoaging, inhibit melanin generation, promote thickening of the dermis layer, the treatment of acne. Of course the vitamin A acid can cure the acne, but vitamin A acid is a drug that contains the ingredients of skin irritation, also have a lot of side effects. Vitamin A acid promote angiogenesis, the outermost layer of horny slightly thinner. If patients redness of the skin, should be used it carefully. Its skin irritation is larger, thin skin, or even run out will cause part of the exfoliation.

The cosmetic raw material suppliers remind that vitamin A acid has two sides, has both advantages and disadvantages, and must not blindly use. Especially pregnant women must be used with caution. A new study found that the drug must be used under the guidance of a doctor, pregnant women can not use this drug, because the drug can cause birth defects of the baby. And retinoic acid-related drugs pregnant women should be banned.

Scientists do a small study show that pregnant women used retinoic acid appeared habitual abortion or born infants have serious defects. The study found that people can easily buy the retinoic acid. And tretinoin manufacturer do not follow the standard drug dose.

In addition, in order to be effective in preventing the occurrence of acne, except for drugs, you should pay attention to the conditioning of everyday life, including eating less animal fat, high-sugar, spicy, fried food, avoid liquor, coffee and other stimulating drinks, eat more vegetables fruit and light food, drink more water; regular cleaning of the skin with warm water or sulfur soap wash the affected area, but do not use too irritating soap, do not use oily cosmetics. Recurrence or worsening of acne is often associated with mood swings, etc., should maintain ease of mind, eliminate stress, anxiety, worry, ensure adequate rest and sleep; do more exercise, prompting the body's waste excreted in a timely manner, the skin constantly sweating keep pores open in the process, and then promptly cleaned.

Source:http://www.cosprm.com

Depth development outlook of chili

According to the effective ingredients of chili can develop all kinds of peppers emerging products.

1. Pain and topical agents: chili can be made into ointment for cold pain, skin reflex from the local blood vessels dilate, promoting strong local blood circulation, so it has the effect of removing stasis and lee joints. Topical use can cure rheumatoid arthritis.

2. Drug treatment analgesics: as pharmaceutical raw materials, the medical effects of capsaicin, recently received a lot of special attention. The scientists found that capsaicin does not produce drug dependence of neurological drugs, has a powerful drug and analgesic efficacy. Use high purity capsaicin to make of the injection of the drug treatment is a broad-spectrum efficient new drugs, in drug treatment has a powerful role for almost all drug addiction, so it has a broad space for development, the analgesic injection made with capsaicin for the massive trauma, produced by advanced cancer pain has a strong blocking effect. The analgesic efficacy and heroin considerable, but it does not produce the drugs dependence like heroin.

3. As a digestive drugs: pepper can stimulate the oral mucosa, increase the movement of the stomach naturely, increasing the activity of digestive enzymes, which promote appetite, and improve digestion.

4. Natural red pigment: With the constant discovery of synthetic pigment toxicity, countries in the world to use synthetic pigment varieties dwindling, the use of non-toxic harmless natural materials to extract food coloring has become an inevitable trend. Prohibit the use of chemical pigment agreement signed with the EU countries, capsanthin has been the product of choice as a red pigment.

Pure capsanthin is a deep rouge red needle-like crystals are naturally exist in the four terpene natural pigment of ripe red pepper fruit, which polar red component is capsanthin and Capsorubin of (Capsorubin) is 50% -60% of the total, and the other is the polarity tiny yellow components, the main component of the B-carotene (B-Carotene), the zeaxanthin (Zenxanlthin), and pepper flavin (Crytoxanthin ), they are with vitamin A activity. Capsanthin not only bright colors, good thermal stability, safe and reliable, and can be widely used in the pharmaceutical industry, such as tablets coated coloring. Health drugs, cosmetics and so on.

5. Natural preservative

Pepper pericarp contained capsaicin and other substances can inhibit many bacteria, as a natural preservative, safer than chemical synthesis of anti-corrosion and have nutritious.

The studies by capsaicin supplier shows: capsaicin have strong inhibition of Staphylococcus aureus, Escherichia coli, Bacillus subtilis, yeast, Hansenula, Aspergillus niger have to prove that it can not suppress the bacteria can inhibit fungal. Therefore, the chili is a broad-spectrum antibacterial material. Fresh pepper because of its low cost, high yield, is the extraction of natural preservatives have a good raw material, developed for the food industry preservatives. Not only with good economic but also have social benefits of healthy, green, environmental protection. It has been reported that capsaicin strong inhibition of Bacillus cereus and Bacillus subtilis, but the effect is lighter to Staphylococcus aureus and Escherichia coli.

6. Slimming and beauty drugs: chili can improve the capacity of fat metabolism, the role of the liquid solution fat to achieve weight loss goals.

7. Natural antioxidants: the body's disease, aging, is closely related to the restore and oxidation imbalance in the body, in recent years, the rapid development on the research and development of anti-oxidants, its related chemically synthesized antioxidants is severely restricted source. The natural antioxidants in plants has caused great concern.

The chili has a strong antioxidant capacity, mainly due to polyphenols and vitamins contained in the pepper pericarp.

Source:http://www.cospcn.com

The physiological role of glutathione in the body

Glutathione is a small molecule, composed of three amino acids, is exist in almost every cell. However, glutathione must produce cells and their precursors (vitamin C and alpha lipoic acid) to work effectively in the body. The glutathione can maintain normal immune system function.

Glutathione strengthen the human immune system, the body's immune activity, smooth lymphocyte and antibody production needs glutathione maintenance. It also as an antioxidant and free radical scavenger: glutathione has a protective effect, preventing the impact of hazardous substances, including the affects of bacteria, viruses, pollutants and free radicals.

Another major physiological role of glutathione in the body is as an important anti-oxidant, and its can rip the body’s free radicals, cleansing and purifying the body’s environmental pollution, thus enhancing people's physical and mental health. As an antioxidants, it also widely used in the cosmetics industry, to be cosmetic raw materials can effectively delay aging. Glutathione itself susceptible to oxidation of certain substances, in the body it can protect many proteins and enzymes not to be oxy-genated by mercapto in the molecule, such as free radicals and other harmful substances oxidation, so that protein and enzyme molecules to exert its physiological function. Human erythrocyte glutathione content, the protection of the red blood cell membrane protein thiol keep reducing state prevent hemolytic significance, but also can protect hemoglobin is not subjected to the oxidation hydroxide radicals and other oxidation so that it continues to function properly in play the ability to transport oxygen. Part of hemoglobin in red blood cells in the role of hydrogen peroxide and other oxidants, the oxidation of ferrous iron to ferric iron to make hemoglobin into methemoglobin, thus losing the aerobic capacity. Glutathione both directly in combination with an oxidizing agent such as hydrogen peroxide, to generate water and oxidized glutathione, but also can restore methemoglobin to be hemoglobin.

In addition, vitamin C is also an important anti-oxidants in body. Because vitamin C can reversibly hydrogenation or dehydrogenation, so vitamin C have an important role in the reduction reaction in vivo oxidation. For example, many enzymes in the active group is a mercapto group (-SH), vitamin C, while maintaining the activity of the enzyme-SH can be maintained in a reduced state; vitamin C can be oxidized glutathione into reduced glutathione (GSH restore), hydrogen peroxide metabolism; Vitamin C also protects the vitamins A, E and some B vitamins from oxidation. Therefore, the use of glutathione and vitamin C is possible to improve their effectiveness.

Currently, glutathione manufacturers has been developed glutathione drugs and widely used in clinical, in addition to use its sulfhydryl binding heavy metals, fluoride, mustard gas poisoning, also used in hepatitis, hemolytic diseases, as well as keratitis, cataracts and retinal disease and so on, to be an adjuvant therapy drugs.

Source:http://www.cosprm.com

Why the chili so hot

Pepper is not only delicious, but also can prevent food spoilage and extend the function of the storage time. The ancient Mayans used a mixture of pepper drugs to heal infected wounds, gastrointestinal diseases, and ear pain. The experiment proved that the pepper extract is a pharmaceutical raw material that can inhibit the growth of some microbial pathogenicity. But these are clearly not reason why chili evolved spicy.

The pepper’s spicy is from capsaicin. Capsaicin can stimulate the nerves on the tongue and skin sensor. These nerve sensors also responsible for the feelings of temperature rise. View on neurons and brain, the feeling of your mouth is not much different with fired. When the temperature rises to a certain extent, it will stimulate the secretion of adrenaline, resulting in rapid heart beat. The scientists say these the reaction is precisely the reason why people fascinated with pepper.

Human use pepper as spices have been at least 8,000 years. At the beginning, they used wild pepper. Adding some while in the production of potatoes, corn and cereals. Ancient Americas began planting pepper as early as 6000 years ago. But for the main purpose of pepper also controversial at that time. Human beings began planted peppers very early, and it spread to far away places, and the reason is very simple, because it is delicious, are you like the sweet potato pot insipid, or put pepper sweet potato? Researchers have different views, they feel that human beings are aware that peppers can prevent food spoilage for a long time, with he function of extending the storage time. Some researchers believe that the pepper has medicinal value. The ancient Mayans used a mixture of pepper drugs to heal infected wounds, gastrointestinal diseases, and ear pain. The experiments show that the pepper extract can inhibit the growth of some microorganisms pathogenic body, capsaicin was also used for local anesthesia.

In the process of research different varieties of pepper containing spiciness, the capsaicin manufacturer found that the lower the capsaicin concentration the higher the degree of fungal infections. In addition, the fungus in wet environments is the most active, but Bolivia’s pepper spiciness seems as the humidity changes: the environment is humid, the higher the degree of local capsaicin. In the laboratory, the discovery of the fungus in a spicy pepper easily trace capsaicin suppression, while in the high degree of spicy chili, fungus can withstand a higher concentration of capsaicin.

The capsaicin show the beauty of evolution. Plants with a special chemical substances against microbial --- human use of pepper borrow the same principle to preserve food --- but capsaicin does not prevent the birds dispersing seeds. Sometimes, the nature select to ask conflicts to species, in results, it evolved with a truly wonderful solution. The method of pepper against an enemy is a classic example.

Source:http://www.cospcn.com

The inoxidizability and integrate detoxification of glutathione

Reduced glutathione plays an important role in the process of our efforts to safeguard the health, helps white blood cells to kill bacteria and prevent vitamin C and E being oxy-genated, prevent the formation of stroke and cataract, and can help skin whitening. However, due to the accelerated pace of modern life, liver is hard to meet the demand of human, and can not guarantee always secrete enough of reduced glutathione, so we are required reduced glutathione to give adequate attention and timely supply.

Glutathione widespread in animals, plants, the baker's yeast, wheat germ and animal liver are with the pretty high level. Also the glutathione with reduced and oxidized, the reduced glutathione occupied majority under physiological conditions. It can strengthen the immune activity of the body's immune system, for radiation, radioactive drugs or leukopenia caused by anticancer drugs and other symptoms can have a protective effect, from oxidative damage, prevent red blood cell hemolysis and promote the reduction of methemoglobin, anoxemia, nausea and discomfort caused by liver disease mitigation. More as a functional food base material, widely used in anti-aging, enhance immunity, anti-tumor and other functional food.

Reduced glutathione is a peptide in the cytoplasm of human natural synthesis, consists of  glutamic acid, cysteine ​​and glycine, containing a mercapto group, is widely distributed in various organs of the body, show the important role for the maintenance of cell biological functions. Reduced glutathione antioxidant integrate the role of detoxification, antioxidants counteract free radical damage to the human body. Free radicals are the contributing factors that lead to aging and disease. We contact free radicals with every day from diet, environment, household chemicals, and other aspects of sources. Reduced glutathione glyceraldehyde phosphate dehydrogenase cofactor glyoxal enzymes triose dehydrogenase coenzyme involved in the body of the citric acid cycle and glucose metabolism. Can activate a variety of enzymes, thereby contributing to the sugar, fat and protein metabolism, and can affect the metabolic processes of the cells; Through the combination of thiol and free radicals, can be converted into easy metabolic acid material so as to accelerate the excretion of free radicals, which helps to reduce the side effects of chemotherapy and radiotherapy.

Reduced glutathione has two important effects: antioxidant and detoxification integration. Because it easy to combined with iodoacetic acid, lead, mercury, arsenic and other heavy metals, and has a very important physiological role is the integration of detoxification, involved in the biotransformation of some drugs, which transformed into the body of harmful poisons harmless substances excreted.

Glutathione applicable to a variety of liver diseases, for liver disease caused by alcoholism, drug-induced liver disease have a more noticeable effect, the role of chronic active hepatitis B, hepatitis C, improve symptoms and liver function. In addition, due to the amino acid is a key ingredient for skin whitening agents, reduced glutathione also can be used as cosmetic raw material, which contains vitamin C can also make the skin smooth, flawless and wrinkles.

Chemotherapy in patients with drug injection, should be advance 15 minutes to put 1.5g/m2 of this product dissolved in 100 ml of normal saline, intravenous infusion within 15 minutes, 2-5 days of daily intramuscular injection of this product 600mg. For the prevention of urinary system damage, it is recommended that immediately after intravenous injection of the goods in the cyclophosphamide injection infusion is completed within 15 minutes; Shun chloride platinum chemotherapy, the recommended amount of this product should not exceed 35mg/mg cis chloride platinum , so as not to affect the effect of chemotherapy. Alcoholic liver injury: intravenous saline the 250ml plus FDA 1200mg once a day.

The glutathione manufacturer reminded that, reduced glutathione should be used under medical supervision, must be completely dissolved before injection, the appearance is clear, colorless; dissolved this product can be stored at room temperature for 2 hours, 0 ~ 5 ℃ save 8 hours. Do not mixed use with vitamin B12, the menadione, Calcium Pantothenate, orotic acid, antihistamines preparations, sulfa drugs and tetracycline.

Source:http://www.cosprm.com 

The effectiveness of pepper

As one kind of pharmaceutical raw materials, Chili has important medicinal value: Pepper with the temperature stomachia and insecticidal efficacy, attending stomach cold and inappetence, indigestion, rheumatism, lumbago, mumps, multiple boils swollen embolism. Capsaicin is also a potential anti-cancer substances, antioxidants. No pleasure in eating, reduce appetite, put some pepper in the food can improve appetite, increased appetite. Alone with a little pepper decoction taken orally, can cure catch cold cause poor appetite, abdominal distension and abdominal pain. Also can cure cold soup with chilli and ginger; particularly suitable for both dyspepsia patients.

Why pepper can invigorate stomach, help digesting? That’s because it contains an ingredient called capsaicin, have irritation to oral and gastrointestinal, they are able to enhance gastric peristalsis, promote secretion of digestive juice, make appetite improved, and can inhibit the intestinal abnormal fermentation, exclude the accumulation of gas in the digestive tract . Proper eating chili, damp abode, is also good for prevention of rheumatism and frostbite.

Chili with strong refreshing effect: According to the researches of capsaicin manufacturer: capsaicin, is the source of the chili spicy, can stimulate the area of skin and tongue feel pain and heat, then the brain produces burning pain spicy feeling. Pepper stimulates the production of endorphins and serotonin, one of the "endorphin" is a "pain killer", it can lead to emotional upsurge. Eat chili, it has a strong refreshing effect.

The chili is a good supplements to women's health: Many women believe that eat chili is easy to get angry, appears small acne on his face, for beautiful, although many people like to eat pepper, also restrained appetite, at arm's length. However, the study conducted by the Medical College of Nutrition of the German Nutrition Habitat show that the pepper in addition to taste endearing, the contain of vitamin C is the richest in all the vegetables, vitamin B, carotene and calcium, iron and other nutrients is also very rich. What more special is peppers contain a substance called capsaicin, can promote hormone secretion, accelerate metabolism, can make eating people sweating, thereby increasing the energy consumption of the body, burn body fat, Slim plastic body, The skin becomes smooth, so it has the role of weight loss and beauty. And chili ingredients are natural and reliable, in some areas which mainly eat spicy foods, local women not only rare acne problems, but also have the multi-slippery skin. The Korean girl liked spicy kimchi, good skin, acne less, this is coincide with fair-skinned Chongqing girls in China.

Chili also has slimming effects: According to scientific analysis, after eating a meal of spicy can consume 25% of the intake of calories more than in one meal. When spicy in the belly burning, drink a cup of caffeine-rich black tea, the effect is even more obvious. The chili can promote the production of two enzymes in the body, they can in the process of burning fat side "convince" Uninstall fat cells, while preventing excess fat accumulation. This way to lose weight without any diet rules companion, the capsaicin stimulates production of endorphins and serotonin, at the same time will allow you to have a good mood.

Pepper can prevent heart disease: the chili can promote blood circulation, increase the flexibility of blood vessels, reduce the risk of hardening of the arteries, help prevent cardiovascular disease. Pepper also with rich vitamin C, have the effect of antioxidant, not only can enhance the immunity of body, but also anti-aging.

Source:http://www.cospcn.com

Astaxanthin, a natural sunscreen

Excessive exposure to the sun have devastating damage to human skin. Such as slight sunburn, melanoma, skin cancer and so on, exposure to the sun for a long time can even lead to a fatal disease, everything is possible. For this reason, the prevention of excessive exposure to the sun is being the most important things in the minds of people for many years. Although for most individuals, stay away from the sun is completely impossible, use sunscreen can significantly reduce the impact of direct sunlight, but it also can damage the skin. Astaxanthin, as an antioxidant, researches by astaxanthin manufacturer show that it is a natural skin protection agents, can minimize the damage caused by the sun's UV rays.

Astaxanthin is a member of carotenoid family, a plant chemical group used to adjust many species of flora and fend off the sun's destructive influence. Natural sunscreen, astaxanthin has been protect the plants for thousands of years. Many animals eating plants, especially algae to get astaxanthin. These animals include seafood, such as salmon, shrimp, crab, lobster, also including flamingos. But unfortunately for humans, only eat the astaxanthin-rich foods is not enough to prevent sunburn, The antioxidants can be taken as a dietary supplement, astaxanthin is very beneficial to the human body.

As such a powerful substance, astaxanthin can penetrate into the body of each part of the cells (brain, nervous system, eyes, tissue and skin), astaxanthin can cross the blood-brain barrier and penetrate into the bloodstream and provide good protection to every cell in the body, anti-oxidation, prevent sunburn, especially the sun's rays (UV) through free radical damage our skin, which can cause premature delivery, aging and certain cancers. Activities of anti-oxidants and free radicals can prevent skin from damage such as sunburn. What is important, the astaxanthin is one of the most powerful antioxidants. Obtain enough astaxanthin in vivo can effectively prevent sun damage, but may take several weeks, which also prompted many people to rely on expensive sunscreens; However, the over-the-counter cosmetics brands contain a lot of harmful chemicals, will lead to free radical damage. Astaxanthin is a mature natural prevention of sunburn products can provide reliable protection to the body. Taken natural astaxanthin supplements can improve the ability of our body to prevent sunburn, but if you decide to take this method to protect you from damage, first you must according to the different circumstances of each person's determined to take the number of doses of astaxanthin, and then determine how long you can stay under the sun and would not hurted by the sunlight. For anyone, who want to use a natural sunscreen to protect the skin from damage, as a cosmetic raw material, astaxanthin is a good choice, it can take the place of many chemical products sold in most stores. The benefits of astaxanthin is obvious, However, if it is to implement into your diet routine, be sure to pay attention to your level of antioxidants can allow you under the sun for how long. Then you need to be based on your level of antioxidant and decide the dose of taking astaxanthin.

Source:http://www.cosprm.com

Pepper and capsaicin extraction method

Pepper is fruit of solanaceae pepper. Pepper’s stems, roots also for medicinal purposes. Picking fruit usually in 7-10 months. Pepper as the drugs and spices have been hundreds of years history. Nearly 1/4 of the world's population often eat it. China is one of the earliest country use the pepper as pharmaceutical raw materials. Chinese medicine use chili to treat stomach cold, rheumatism embolism. Pepper’s cultivation throughout the world. Collectively referred to as Capsicum, due to the different origin of its name there are many different names, strong spicy in Africa, India and China called chillies, produced in Spain, Hungary, the low degree of spicy chili called paparika, spiciness between the two is known as red peppers. The Chinese pepper planting large country, there are five to six million acres of peppers. In China, there are divided Fujian millet chili, Sichuan pod pepper, southern claw pepper, Henan cherry pepper, Shandong red peppers, etc. Its spicy content due to the different origin of chili and the different parts of pepper are different. Generally the fruit endodermal block organization and diaphragm organizations. The high content of peel middle, and picking time and save different methods in different periods can influence the content of capsaicin. Spicy ingredients contained in the pepper fruit of capsaicin, is dihydro-capsaicin, high capsaicin, high-dihydro capsaicin, octanoyl of Vanilla amine, pigment cryptoxanthin, capsanthin the trace Capsorubin, carotene, containing vitamin C, citric acid, tartaric acid, malic acid and so on. The depth development of new products about chili and applications in medicine and health care is gradually being recognized. In Mexican, a chili enterprise with annual sales of up to 4 billion RMB. In the United States, researchers extract capsaicin from the pepper, can be used for anti-inflammatory, analgesic, anesthetic, and drug treatment. The price of one kilogram of high purity capsaicin can reach tens of thousands of dollars.

The preparation method of capsaicin manufacturer extract capsaicin: (1) extract from natural Pepper system, early capsaicin extract from dry red pepper, extraction with an organic solvent after crushing, and concentrated to give a dark red to orange red oily liquid. Ether extract color darker than ethanol extraction of color, a little sticky. This oil collectively called as capsicum oleoresin in the international market. Its main ingredient is capsaicin, dihydro-capsaicin, Are two dihydro capsaicin, high dihydropyridine capsaicin, capsanthin, carrot pigment, and citric acid, tartaric acid, malic acid, and other ingredients. Usually accounts for about 1% of the weight of dried fruit. The Oleoresin Capsicum through diethyl ether, dilute ethanol, and an aqueous alkaline solution, or concentrated further extracted with petroleum ether, dichloroethane, etc. solvent, crystallized from petroleum ether or n-oxide crystallization can be obtained crude capsaicin. Using gas chromatographic to analysis the crude capsaicin crystalline component. Which accounted for 76% -96% capsaicin and dihydro pepper alkali content. The researchers used high-concentration ethanol extraction capsanthin, a low concentration of ethanol extract of capsaicin. Capsaicin of 6% to 8% and 3% to 4% of capsanthin were extracted from the dried chili. First they use a low concentration of ethanol extracted from dried chili powder, pepper oleoresin capsaicin solution. The capsaicin solution was concentrated to give the crude product of capsaicin. The process is simple, low cost, the use of acetone, petroleum ether, 95% Ethanol capsicum oleoresin and the solvent as a result, and then ether to give the crude crystalline capsaicin, and purified by column chromatography on silica gel to give the pure product of capsaicin. Was also a direct high yield capsaicin extracted from fresh green chili. The fresh chilli powder pulverized frozen, and dried with acetone, ether, aqueous methanol, and an aqueous alkaline solution extract capsicum oleoresin, get a capsaicin crude in ether. Get pure capsaicin from Petroleum ether and recrystallized. Yield was 1.12% of the dried chili. (2) Preparation from biological cell cultivating. The capsaicin research in many countries was no longer satisfied with the system from natural pepper capsaicin, but use of a biological cell technology to produce more and faster capsaicin. Researchers from natural pepper meat-like body, the cells will be taken by its embedding and fixed, was suspended in 5 liters of an aqueous culture liquid, after 32 days the pepper alkali content is achieve a high degree, if extend the incubation time, chili alkali content will increase. (3) chemical synthesis methods take high purity capsaicin is very difficult due to the natural pepper have many analogues of capsaicin. People trying to get a successful synthetic capsaicin. Researchers use triphenylphosphine and 6 - bromo-acid as raw materials. Through four-step reaction, the synthesis of a sample of the extract obtained is identical to the pure capsaicin. The total yield is 26.6%.

Source:http://www.cospcn.com

The detoxification role of glutathione

Glutathione is a small peptides compound of three amino acids, as an important anti-oxidant and free radical scavenger in body, such as in combination with free radicals, heavy metals, etc, make the harmful poisons turn into harmless substances in body and excreted out of body. Glutathione is now been widely recognized as a whitening ingredients in the international market, mainly by blocking the of tyrosinase synthesis of melanin pathway to inhibit melanin production, so as to achieve the whitening effect. Glutathione’s whitening effect is significant, in recent years it has also been widely used as cosmetics material.

Glutathione is a tripeptide combine of glutamic acid, cysteine ​​and glycine, mercapto group-containing, has detoxification of anti-oxidation and integration. The mercapto group on the cysteine ​​glutathione active group (glutathione often abbreviated as G-SH), easy has integrated detoxification with certain drugs (such as paracetamol), a toxin (such as free radicals, iodoacetic acid, mustard, The combination of lead, mercury, arsenic and other heavy metals). Therefore glutathione (especially glutathione in liver cells) can be involved in the biotransformation, and thus the machine body of harmful poisons into harmless substances, and excreted. Glutathione also helps to maintain normal immune system function.

Glutathione not only removes the body of free radicals, but also can improve the body's immune system. The glutathione in maintaining health, anti-aging, the efficacy of cells in slow elderly play better than the young. Glutathione also can protect the hemoglobin not to be oxidated by oxidation hydroxide radicals and other oxidation so that it continued normal functioning of the ability to transport oxygen. Part of hemoglobin in red blood cells under the action of hydrogen peroxide and other oxidants, the oxidation of ferrous iron to ferric iron to make hemoglobin into methemoglobin, losing the aerobic capacity. Glutathione can directly in combination with an oxidizing agent such as hydrogen peroxide, to generate water and oxidized glutathione, but also be able to methemoglobin reduction is hemoglobin. The content of glutathione in human erythrocyte is high, it has important implications for protecting the red blood cell membrane protein thiol in a reduced state and preventing hemolytic.

Glutathione to protect the enzyme molecules in the-SH group, is beneficial for the enzyme activity play its role, and can restore the activity of the-SH group which has been damaged by the enzyme molecule, to resume the enzyme activity. Glutathione can also inhibit ethanol against fatty liver. Glutathione a strong protective effect for the leukopenia symptoms caused by radiation, radioactive drugs. And enter the body of toxic compounds, heavy metal ions or carcinogen glutathione and promote excreted, play a role in detoxification.

The glutathione manufacturers remind that taking glutathione seldom show up nausea, vomiting and headache, rare rash. Glutathione couldn’t use in allergy, and shall not be used in combination with vitamin B12, menadione, Calcium Pantothenate, orotic acid, anti-histamine preparations, sulfa drugs and tetracycline and so on.

Source:http://www.cosprm.com

The scientists found that capsaicin against muscle and joint pain

Cooking a delicious meal of spicy, a lot of people may have to pay over the price! Whenever you cut Mexico green chili pepper seeds and plucked with bare hands, you will feel intolerable pain. This feeling of pain is caused by a fat-soluble substance, this substance is called capsaicin. People in all peppers are found capsaicin. It is the capsaicin let pepper so delicious to eat, it is also the capsaicin bring the pain to our skin. But what we should appreciate is that capsaicin will not damage body tissue. If your hands feel like being burned, the best way is to grab the ice packs and do not let go, then you might not feel how much pleased with this argument. But in-depth study will bring us into a strange world, this world is consisted by neurotransmitters, pain signals and brain.

When you eat hot peppers or encounter peppers, capsaicin particles will penetrate the skin, through the organization, and touched a deep nerve in the body. This sounds a bit technically! Capsaicin plays the role of a neurotransmitter, combined with the capsaicin receptor and make it disintegrating. Normally, when the temperature reaches or exceeds 42 degrees Celsius, the capsaicin receptor will change. When capsaicin receptor disintegration, it will be released to the nerve cells of charged particles, that is the ion, signal transmission to the brain through the nerves. Such signals with capsaicin receptor feel the heat signal is the same. The brain and can not distinguish the difference between them, the feelings of chili been brought to our feelings is the same as being burned. Now, we should tell the most interesting part. The scientists have discovered the way how to make capsaicin, this liar deceive our taste buds into a "hero". As pharmaceutical raw materials, capsaicin can be used to combat muscle and joint pain, such as the long-term pain caused by diseases such as osteoarthritis and rheumatoid arthritis.

First of all, you have to know that the doctors divided the pain into two kinds, physical pain and neuropathic pain. The physical pain is that when we are injured, we will soon be able to feel very severe pain. For example, when our hands touched the red-hot wok, let us handle the pain come back quickly. Neuropathic pain is slowly accumulated long-term pain. This chronic pain does not subside in a short period of time. As isolated nerve conduction pathological pain unlike nerve conduction physiological pain, pathological pain will be very slow conduction. Pain itself is composed of a protein called substance P. Substance P is a neurotransmitter, its appears is show the generation of neuropathic pain and stimulate inflammation.

When the capsaicin touched nerves, it will lead to all media pass neuropathic pain (P substance) to pass on to the nociceptive nerve. These substance P soon exhausted, before the generation of the new substance P molecule, nervous system have no way to return conduction neuropathic pain - that is, there is no substance P, there won’t chronic pain.

Briefly, capsaicin ointment smear 1-4 weeks, a capsaicin ointment can gradually decrease the supply amount of the substance P, and ultimately reducing the persistent pain. There is a drawback of this method in treating pain, that is patients have to endure the burning sensation produced by capsaicin. And this feeling is going to limit them to withstand pain to a certain extent, it will not feel again. This will take some time, but very worth it. Ultimately the pain patients feel will be greatly reduced. This is very good, isn’t it?

But you probably did not have arthritis, just the fate let you get into the red pepper, and you hope that the pain can get over soon. However, once the capsaicin through the skin, it is impossible to seep from the skin. Capsaicin is a very tenacious substance, can survive in the pan, but also resist the low temperature, even thought in the harsh environment of the human gut also could not anti it. Well, you have to remember that not to intake too much capsaicin, or you’ll feel hard to excrete! Prevention is the best defense. Capsaicin manufacturer suggest us to wear gloves while cut peppers or wipe oil in hands before cutting. After cut peppers with soap and water to wash your hands, and painted on the skin of lemon juice. If you do not take timely measures but has begun to feel the pain, then try the handle dipped in oil or vinegar, or the handheld ice pack waiting for the pain subsides. Not to touch the hot things, because that would make more capsaicin receptor decomposition.

Source:http://www.cospcn.com

   

The biological function of astaxanthin and its application

The astaxanthin had been separated from shrimp and crab shells as early as in the 1930s, but it was not until the mid-1980s, an extensive study of its biological function had been started. Studies have shown that astaxanthin has many important biological functions and broad application prospects.

The Astaxanthin widespread in the biosphere, especially in aquatic animals of shrimp, crab, fish and bird feathers, have effects on the color. The astaxanthin was bright red, when it is added to the feed of aquatic animals, the aquatic animals’ body color can be becomes bright. Usually add astaxanthin supplement as a pigment in aquatic animal’s feed, can greatly increase the market value of the product. Astaxanthin not only can be used as the aquaculture animals colorants, there are more and more evidence prove that the astaxanthin also have an extremely important role on normal growth, healthy farming, improve survival and reproductive rates of aquatic animals. In addition, to add astaxanthin in aquaculture feed can also prevent processed aquatic products such as rainbow trout lipid oxidation and deterioration, and provide a rich source of astaxanthin for human food.

Astaxanthin is a non-vitamin carotenoids can not be converted to vitamin in animals’ body. However, in the molecule of astaxanthin, there is a very long conjugated double bonds, and has a hydroxyl group and the conjugated double bond chain end unsaturated ketone, wherein the hydroxyl group and a keto group and a hydroxy ketone, these structures have a more lively electronic effects can provide free radical electronic or attract free radicals unpaired electron, so that it can easily react to free radical and scavenging free radical, and thus play a role of antioxidant. Animal experiments showed that astaxanthin can remove sulfides, disulfides. The astaxanthin in the free radical scavenging, its capacity is more than 10 times of the carotenoid and more than 100 times than the vitamin. At the same time, the astaxanthin can inhibit or reduce the role of lipid peroxidation, to protect phosphatidylcholine lipids from oxidation. Therefore, astaxanthin can be applied to pharmaceutical products, as anti-aging drugs and food, health care products.

Astaxanthin can effectively clear the free radicals generated by UV irradiation in the body, to reduce the harm caused by the photochemical, therefore, the UV-induced skin cancer prevention and treatment effect. In addition, researches by cosmetic raw material suppliers show that the astaxanthin mixed with cosmetics, can form a new sunscreen daily cosmetics.

As a immune agents: in recent years, some studies by astaxanthin manufacturer have shown that astaxanthin has important physiological functions to promote the production of antibodies, enhanced host immune function. Singlet oxygen having a cytotoxic effect on the animal's immune system, it catalyzes the production of free radicals can accelerate the degradation of the macrophage cell membrane, resulting in phagocytic efficiency and dysfunction. Astaxanthin clear singlet oxygen, can significantly affect the animal's immune function. The experiments show that in the presence of an antigen, the astaxanthin can significantly promote the spleen cells to produce antibodies, thereby enhancing cell stimulation of human blood cells in vivo production of immunoglobulin. Etc. by experimental observation found that astaxanthin can significantly promote the thymus-dependent antigen stimulation of antibody production, secretion and increase the number of cells. Supply astaxanthin also can partially restored the humoral immune system in aged mice. Thus, astaxanthin has important immunoregulatory action, can be used as immunostimulants.

Many experts study the physiological and biochemical functions of the natural carotenoid. Found astaxanthin has a strong anti-cancer effect. Can inhibit the mutagenic effects caused by aflatoxin, diethyl nitrite nitropropane, butyl, hydroxybutyl, nitrosamines and cyclophosphamide. Therefore, astaxanthin can effectively prevent liver cancer, oral cancer, colorectal cancer, bladder cancer, and breast cancer. The use of astaxanthin can develop a drug for the treatment and prevention of tumor.

The application of astaxanthin is more than what we said above, it can also for the prevention of atherosclerosis and related diseases, it should be attributed to the inoxidizability of astaxanthin. Astaxanthin can reduce or inhibit the oxidation of LDL in the blood, make the vessel wall deposits reduce, thereby reducing the occurrence of atherosclerosis. In addition, the astaxanthin can also be a characteristic for the prevention and treatment of eye disease similar to vitamin. Especially have  a significant effect to reduce the incidence of diabetic eye disease, can be used as a supplementary drug for treatment of diabetes.

Source:http://www.cosprm.com

The medicinal value of chili

Chili contains rich vitamin E and C, in addition, it also contain some capsaicin which only exist in pepper, and in red, yellow pepper still have a kind of capsorubin, the two components are only exist in pepper, capsaicin exist in chili pulp, and capsorubin is in the pepper skin, its action is similar to carotene, have a very good antioxidant effect, so those people who like to eat peeling pepper may not eat capsorubin.

The hot of chili in addition to remove thermal pain, because of it can promote the secretion of epinephrine, improve metabolism, so it also be made into weight loss products, and capsaicin as a kind of pharmaceutical raw materials also have good effect of reducing platelet sticky, therefore also become a good composition of maintaining cardiovascular health care food, but because of its strong irritating, those people who have intestines and stomach ulcer or heart pain, chest distress should avoid eating.

When the chili hot stimulus tongue and the nerve endings in the mouth, the brain would immediately command the whole body "alert" : rapid heartbeat, saliva, or sweat secretion increase, intestines and stomach double "work", and at the same time release endorphins. If eat more, the brain will thought that more pain is coming and release more endorphin. Continuous release of endorphin, can make the person feel exciting, produce hot after the "pleasure". Another factor of people get addictive to eat chili is the capsaicin. When taste sensory cell contact to capsaicin will be more sensitive, thus feel the food is delicious.

when people eat chili, as long as not hot injury oral, taste is sensitive. In addition, while edible pepper, saliva in the mouth, gastric juice secretion increased, gastrointestinal peristalsis acceleration, person without incense in eating, and reduce appetite will produce the idea of eating chilies. In fact, whether get addiction to eat spicy or not, right amount to eat chili is a good effect to human body to have certain food therapy.

First, invigorating stomach, helping digestion. As what we said, pepper on oral and gastrointestinal have stimulation effect, can strengthen enterogastric peristalsis, promote digest fluid secretion, improve appetite, and inhibit the intestinal abnormal fermentation. Some Chinese medicine, nutrition experts to HuNan and SiChuan provinces to investigate, found that these generally like to eat hot provinces, the incidence of gastric ulcer is far lower than other provinces. This is because the chili can stimulate human body prostaglandin E2 release, promote gastric mucosa regeneration, maintain gastrointestinal cell function, prevention and control of gastric ulcer.

Second, the prevention of gallstones. Often eat green pepper can prevent gallstones. Green pepper contains rich vitamin, especially vitamin C, can make the excess cholesterol turn into bile acid, thus preventing gallstones, had gall-stone person eat more rich in vitamin C green pepper, to alleviate illness have certain effect. Red apple and red pepper can control breast cancer - researchers recently discovered that red apple and red chili "red one" fruits and vegetables, have prevention and cure function to breast cancer and tumor diseases.

Third, improve cardiac function. With chilli as main raw materials, compounding with garlic, hawthorn extract and vitamin E, make "health food", after eating can improve cardiac function, promote the blood circulation. In addition, often feed chili can reduce blood fat, reduce thrombosis, have a protective effect on the cardiovascular system diseases.

In addition, pepper also can reduce blood sugar, relieve skin pain, chili have effect reducing weight, prevent colds, resist radiation, encourage shou, warm the stomach cold, promote the blood circulation, skin beauty, lipid-lowering effect such as weight loss.

Chemical analysis of capsaicin: capsaicin is alkaline through PH value test, the advantages of eating pepper, first of all, it can reduce the acid content in the human body. Because of the human diet are like to eat acid foods, so the acid content is higher in the body, make the body of toxins can't expel from body effectively. In order to make the body of acid-base food chain to keep a balance state, also want to eat a small amount of contains spicy meat food and vegetables, ensure acid-base value was basically in a state of balance. If the diet is spicy vegetables, can be in cooking Fried hot vegetable add contain acidic substances, in order to reduce the content of hot meal. We often eat eggs that partial acid, eggs with chilli taste is very good, that is not too spicy is still very delicious, the intestines and stomach will also bring too much stimulation. In modern society, the human diet can not ensure the body's ph balance, resulting in the frequently occurring disease state, eating more alkaline food is beneficial to the health of the body.

Source:http://www.cospcn.com

Glutathione’s widely application

Glutathione is a kind of three peptide which including amide linkage and thiol, comsisit of glutamic acid, cysteine and glycine. In almost every cell of the body. Glutathione can help maintaining the normal immune system function, and has the antioxidation and integration detoxification. Glutathione have a broad spectrum of detoxification, not only can be used for drug, but also as a functional food makings, have a wide application on delaying senescence, enhance immunity, antitumor and functional food. Glutathione widely exists in animals and plants, has an important role in organisms.

At present, it have already artificial developed many glutathione drugs, widely used in clinical, in addition to use its sulfhydryl with chelating heavy metal, fluoride, mustard gas toxins and so on to be poisoned, also used in hepatitis, hemolytic disease and keratitis, cataract and retina disease and so on, as a treatment or auxiliary treatment drugs.

Glutathione protect - SH base in enzyme molecules, be helpful for enzyme activity of the play, and to restore the damage of enzyme molecules - SH base active function, make enzyme recover its activity. Glutathione can also inhibit ethanol enroach on liver generated fatty liver. In recent years, the western scientists, especially Japanese scholars found that glutathione have the function of inhibiting HIV.

The latest study also shows that, glutathione can correct acetylcholine, cholinesterase imbalance, have the effect of anti allergy, still can prevent skin aging and pigmentation, reduce the formation of melanin, improve skin antioxidant capacity and make the skin produces burnish, in addition, glutathione in the treatment of corneal disease and improve the sexual aspect also has a very good effect. Glutathione exist in many fruits, such as tomatoes (commonly known as tomato), cherry, cherry tomatoes (commonly known as small tomato)and so on. So, we should eat more fruit in daily life, be beneficial to slow the aging and prolong life.

Today, glutathione already applied to the beauty industry, as a cosmetics material glutathione’s another major physiological function is to be a kind of important antioxidant in the body, it can remove body’s free radicals, clean and purify the body environmental pollution, so as to enhance the people's physical and mental health. Make the glutathione and vitamin C using together can improve the efficacy.

Glutathione supplier remind that glutathione can be used as a functional food base. Add glutathione can have unexpected effects: 1, add to flour product, can have a reduction. Not only make the time of manufacturing bread reduced to one half and one third of the original, improve the working conditions, and have food nutritional reinforcement and other functions. 2, add to yogurt and baby food, is equivalent to vitamin C, can have the effect of stabilizing agent. 3, mix to fish cake, can prevent color deepened. 4, add to the meat and cheese in the food such as, has the effect of strengthening flavor.

Source:http://www.cosprm.com

Cardiovascular and resveratrol

While the researchers analyse the heart disease found that in cell level there are many different things to happen. Cholesterol and other materials which relate to fat were just a small part of many factors that influence heart disease. Fortunately, many of the heart disease can be controlled through the diet method. Resveratrol is a kind of pharmaceutical raw materials, have all kinds of significant efficacy to heart and vascular disease.

"The French paradox" is that people eat a lot of fat but not heart disease. Why? One of the reasons is that the wines they drink contains resveratrol, this is a kind of powerful antioxidants. Up to now, many people know that the low density lipoprotein is one of the reasons lead to heart attack. This is why vitamin E can prevent heart disease: it can be through the oxidation lipoprotein to eliminate free radicals. However, the free radicals removed by vitamin E is not the only kind of free radicals people worried about. There are many different kinds of free radicals. A study published in the free radical research, use resveratrol and vitamin E together with other a synthetic antioxidants for test, these 3 kinds of substance were very well in clearing damage the artery of the role of free radicals, but resveratrol showed the best effect to defense a particular of free radicals. This study points out that use a variety of compound antioxidant is very important.

Atherosclerosis is one of the most serious illness caused by freedom radical destroys. This is the a "vicious circle" of free radical, artery is destroyed, and because of scar tissue make it become narrow, which in turn lead to more radical activities, causing more damage. Resveratrol, melatonin and probucol was used to treat the progressive disease. The oxidation function of resveratrol can prevent free radical damage and by increasing the content of nitric oxide open clogged arteries.

Nitric oxide is the heart artery function key material. It can make blood vessels "relax", increase blood flow. Recently, according to the study of resveratrol manufacturer show that high cholesterol diet can reduce about one third of nitric oxide. Supplementary resveratrol can obviously reverse this trend. From this aspect, the role of resveratrol is similar with viagra, viagra can also influence the content of nitric oxide. However, viagra can only affect small blood vessels, but resveratrol can affect the aorta.

Finally, resveratrol can also prevent vascular of artery blood vessels become narrow cell proliferation, also can prevent blood stick together. These two action is very important to prevent heart attacks. The function of resveratrol prevent blood stick together is found by a Canadian researcher, he wants to know if other components in wine works in the process, what it is action. He found that alcohol itself can restrain a promote clot formation material (clotting enzyme), and Shuo fine (another polyphenol) can inhibit another (12 - hydroxyl eicosane four enol acid), but in the detection, except for resveratrol, no other substances have any effects in the treatment of heart disease, it can be not only inhibit thrombin, also can inhibit many other materials that promote clot formation.

Source:http://www.cospcn.com

Astaxanthin is a good antioxidant product

Every person's life were had to go through birth, growth, aging, aging is unwilling to everyone, but it always happen all the time, from a medical point of view, why people are aging is because the basic composition of unit cells appeared decay, while people reach to 25 years old, cells regeneration split become more and more slow, the accumulation of aging cells make organ function decreases, happened ageing or even pathological changes, people will be increasingly aging, the astaxanthin anti-aging is amazing, let us come to know about it together.

Astaxanthin is the strongest nature known antioxidants, often referred to as "the super vitamin E", "super antioxidant". The antioxidant ability is 6000 times higher than vitamin C, 800 times higher than coenzyme Q10, 550-1000 times higher than green tea catechins and vitamin E, 10 times higher than beta carotene, 20 times higher than the whole forming astaxanthin.

Astaxanthin is the most powerful antioxidants currently found in the field of natural, oxidation to produce free radicals, free radicals is a radical, in order to let oneself not disorderly down will grab other material of electronic, so will hurt various organs in our body, lead to early aging and other related diseases. These diseases including cardiovascular disease, cancer, etc., theoretically, astaxanthin have better prevention effect for these diseases.

Astaxanthin has the effect of protect skin healthy. Reactive oxygen species and pyrrolidone, these two kinds of material is the culprit that damage collagen and elastin, causing the skin coarse, the root cause of wrinkles, but astaxanthin is able to significantly weakened ROS and NMP to dermal layer collagen, elastin, damage, protect the skin health, reduce wrinkles.

For many years research, scientists finally clear that today have many chronic diseases bothering people, such as high cholesterol, diabetes, coronary heart disease, atherosclerosis, cerebrovascular disease, gout and metabolic disease, and chronic poisoning pathogenesis is caused by "oxidative stress", as many astaxanthin manufacturers said: oxidation damage is the root of all damage. If we can prevent oxidative damage effectively at the beginning of the disease, it is expected to end and delay the disease and its development. Astaxanthin cell oxidation is like the penicillin against bacterial infection, thus it can be concluded: as astaxanthin cognition and application of the chronic diseases are expected to get effective control in this century.

In addition, animal studies show that astaxanthin in the body has significant effect to increased HDL and drop LDL, so speculation astaxanthin can reduce apolipoprotein oxidation, can be used to prevent arteriosclerosis, coronary heart disease and ischaemic injury.

Now, as a cosmetic raw material, astaxanthin are widely used in the field of cosmetics and skincare, almost a line of cosmetics brand in globle are added astaxanthin as its super antioxidant components, astaxanthin capsule can not only improve the rough skin, fade fine lines and splashes, repair facial ministry skin dark heavy, alsol can restrain the formation of melanin, improve the skin grease, stop the Uv radiation; Rapidly repair sun burn, sunburn, skin weather-shack, peeling and so on.

Source:http://www.cosprm.com

Plant extract make Chinese medicine internationalization development find the new way

As goods categories of Chinese traditional medicine import and export trade, plant extract export developing rapidly. Customs statistics show that in the first quarter of this year, China plant extract import and export maintain the high speed growth, imports and exports is up to 310 million dollars, increase about 46.4%. Among them, the export volume is 270 million dollars, up 53.4% increase, accounting for 48.4% of exports of traditional Chinese medicine products, plant extracts in the proportion of traditional Chinese medicine product export increase gradually. Next year the plant extract is expected to export in a new record.

Plant extract as the pharmaceutical raw materials, it combined with modern pharmaceutical technology, become natural medicine health care products on the market core products, the huge market space of natural health medicine for plant extract become the international market products which sell like hot cakes. When Chinese traditional medicine because of "identity" problem and difficult to open the market of developed country, plant extract because of its "return to nature", "green consumption" becomes fashion, it is highly valued in western developed countries, opened up a new path for traditional Chinese medicine in the international market.

Because of China plant extracts industry in the guidance of traditional Chinese medicine theory, the development have its unique advantages. At present, China plant extract has formed a certain scale of the industry, and the mainstream enterprise in production equipment and technology ability can completely and the world main extract producers Germany, Italy, Spain, etc).

Although in recent years in China plant extract industry has made a great progress, industrial concentration have significantly improved, but the industry enterprise still exist the small scale, product innovation ability is low, the international market development ability is weak and shortage. In order to improve the Chinese plant extract enterprise and product international competitiveness, promote extract industry internationalization level of ascension, the Chinese medicine health products import and export chamber of commerce to carry out a lot of fruitful work. The year before last year, the ministry of commerce by China's foreign trade company’s entrust, Chinese health-care chamber of commerce and plant extract manufacturer compiled a book about the plant extract export guide , the paper focuses on market environment of the main target market, policy and regulations, quality control standards and enterprise quality management system requirements, the relevant enterprises to improve product quality plays a guiding role.

While in the guidance of enterprises to promote product quality, Chinese health-care chamber of commerce also organizations enterprises to participate in the exhibition in the domestic and foreign country, held various training, BBS, fully enhance the level of trade, and platform structures for enterprise internationalization operation.

Chinese health-care chamber of commerce actively organize enterprises to participate in the world pharmaceutical raw materials exhibition, Asian food ingredients exhibition, the United States natural products exhibition, Japan international health products exhibition, South Korea natural health products exposition, the United States plant extract professional supplier of western exhibition, European food exposition at home and abroad such as plant extracts exhibition. This year's world pharmaceutical raw materials, Chinese exhibition plant extract zone of the participating enterprises reached 180, surpass last year's scale, become a feature of the exhibition.

Every year 5 ~ 10 months that the Chinese health-care chamber of commerce will host more than a relevant plant extracts of the BBS, help enterprise familiar with policy, pulse market trend. In may this year for the first time held in Beijing "Chinese antioxidant berries and super fruit industry development BBS", introduces the latest international market situation for the enterprises, and discuss the Chinese antioxidant berries industry opportunities and development trend with practitioners.

Source:http://www.cospcn.com

Effective treatments of tretinoin for many diseases

People on the lack of vitamin A will cause a lot of skin problems, but if taking large doses and effective doses of vitamin A, will appear poisoning symptoms, such as excessive drowsiness, excitement, have A headache, systemic skin is dry, peeling, etc. In other words, the effective dose of vitamin A is poisoning dose, namely effective dose and poisoning dose is very close. In order to reduce the side effects of vitamin A, improve its effective function, in 1962, researchers do a rial that change vitamin A terminal groups, make it become all trans vitamin A acid, referred to as vitamin A acid or tretinoin.

As a cosmetic raw material, the role of tretinoin is various, and can treat a lot of diseases. For example it can inhibit the epidermal cells hyperkeratosis, cell proliferation, has the antineoplastic effect; Also can restrain sebaceous glands secretion, reduce or remove the skin surface and acne related pathogenic bacteria, in order to reduce acne inflammation reaction; Can fight ageing of the skin, make the skin tender, reduce wrinkles, remove excessive calm pigment; It can inhibit proliferation of skin, regulate immune function. Used in the treatment of acne, chloasma, psoriasis, keratin abnormal sex skin disease, light aging skin, skin cancer and many other diseases.

The use of retinoic acid, common vitamin A acid drugs have oral and external use clinically, such as amine ester. For the oral, because they with side effects, so the requirement of indication is strictly. Usually use in clinical treatment of psoriasis, keratin sexual disease, had better not use for mild acne, only use in moderate to severe acne. Treatment of the disease can oral, also can be for external use. But for senile wart, flat wart, the use of vitamin A acid can be only use for external.

Use such drugs that should be noticed that retinoic acid can increase blood fat, therefore, high blood fat and people with diabetes should be use it carefully, Liver and kidney function person should be banned; Pregnancy and lactation women can not be used, and taking vitamin A acid, should not pregnant after 2 years, because it will led to teratogenic baby; Teenagers under 18 years of age also suggest not to use.

For external use of vitamin A acid use in inflammatory diseases, skin have certain irritation and with the drug concentration and the number of drug in the treatment of the first few weeks will cause varying degrees of skin irritation reaction, such as lupus, desquamation, itching, burning, clinical go up those who say to vitamin A acid reaction. While the skin appear this kind of reaction, you should reduce the number of drug and the dosage, if the reaction is serious, stop using immediately, and to the hospital’s dermatological department to consult the doctors. Vitamin A acid for external use, can produce photosensitization, sun can increase vitamin A acid to hurt skin, so during the day these drugs should not be used, and should be avoid sun exposure.

According to the researches of tretinoin manufacturer, tretinoin with a lot of side effects, such as dry skin, peeling, cracked lips, etc, even cause hair loss, so it should be used under the guidance of doctors. While you are use it, you should see its indications, according to the patient's specific situation, if used it properly, the effect will be very good.

Source:http://www.cosprm.com