Exports of Chinese plant extracts achieve a historic leap

Exports of Chinese plant extracts outstrip exports of Chinese herbal medicine and decoction pieces first time. It accounted for 44.62% of Chinese export value in the first half year of 2011 with an increase of 45.72 percent. It indicates that export structures of Chinese medicine product change from quantity to quality.

With the new understanding of the world on the therapeutic value of traditional Chinese medicine, international trade situation of Chinese medicine gradually becomes optimistic. In the first half of 2011, Chinese medicine import and export trade still maintains a good momentum of growth. Chinese medicine import and export volume reached $ 644 million, an increase of 22.86%. Among them, the imports amounted to $ 137,000,000 with an increase of 9.48%. The export value is $ 507 million with an increase of 27.05%.

Plant extracts become the main force of Chinese exports in recent years, is developing rapidly, with exports rising. The major export markets of the plant extracts have maintained relatively high growth rate. Chinese plant extracts export the largest country in the first half of this year, total exports of $ 47,650,000, and an increase of 26.71%. Plant extracts of Ginkgo biloba, ginseng, soy isoflavones, such as liquorice, a large market share. The Japanese market has been the second largest market for Chinese exports of plant extracts, the first half of total exports to the Japanese plant extract $ 37,180,000, an increase of 26.20%, accounting for 16.42% of the export value of plant extracts export volume of the larger species such as ginseng, licorice, mint and green tea extract.

Since 2005, India continues to import large quantities of extract products. It has leapt to the plant extract products export in China's third-largest market in the first half of this year. The total exports value from plant extracts supplier is $ 19,410,000 with an increase of 363.86%. At the same time, exports to traditional markets such as Korea, Germany, France and Spain also maintained relatively high growth rate.

The import of plant extracts to reverse the downward trend last year. In the first half of 2012, the Chinese plant extract imported a total of $ 25,580,000, an increase of 10.89 percent, but still small amount of imports. The United States, India, France, Turkmenistan and Germany are the main importing countries of the Chinese plant extract products, the main varieties of mint, licorice and blueberry extract.

Little export growth in export of medicines and Pieces continued to decline in the first half of 2011, total exports of $ 180 million, an increase of 7.24%, accounting for 35.53% of the total export value of Chinese medicine, for the first time lower than the plant extracts. Ginseng, Chinese caterpillar fungus, cinnamon, Chinese wolfberry and chrysanthemum ranks the top five export commodities, but the increase was not large. The bulk export of medicinal herbs bitter almond negative growth. The largest increase cordyceps sinensis. The single variety increases by 110.02%.

Chinese medicines continuous maintain a rapid growth momentum. In the first half of 2011, exports value of Chinese pharmaceutical raw materials is about $ 61,620,000 with an increase of 15.51%. All major varieties showed a growing trend in expect aspect. Asia is the major export markets foe Chinese medicines. Export value in the first half year is about $ 44,340,000, accounting for 71.94% of the total export value. It increases by 11.97%. But it is lower than the average increasing rate.

Source:http://www.cospcn.com

A comprehensive analysis of drugs in the treatment of hair loss

With the accelerated pace of life and mental stress increases, the number of penitents with hair loss is also on the rise. Hair loss is becoming a modern trouble. Hair loss is a common skin disease. The genes increase in male hormones. Some people loss their hair because of mental stress, psychological pressure and insomnia. Patients often complain that they felt uneasy, loss self-confidence and even many opportunities due to the hair loss problems. What are the drugs to treat hair loss?

The body content of dihydrotestosterone (DHT) will affect the hair growth. If levels in plasma improve, it can make hair follicles shrink, hair long-term shortened, resulting in hair loss. Finasteride can effectively inhibit the formation of DHT in the blood to prevent the smaller of the scalp hair follicles, and thus reversed the hair loss process.

Finasteride can only used in the treatment of male hair loss, female disabled. 1 mg per day the course of 6-12 months. General three hair loss improved significantly, the effective rate of 60% -90%. Non fewer side effects of finasteride, a few men, decreased libido, and even fewer people will be reduced ejaculation volume. But after stopping the drug, it resumes.

Minoxidil is a peripheral vasodilator. Long-term local use can stimulate the hair follicles and hair growth. People can buy minoxidil to treat alopecia areata and female fat off. The 5% minoxidil tincture is used for male fat off and early bald patients. When the liquid applied to the scalp of the hair loss area, each 1 ml, start painting from the center of the affected area, and hand massage for 3-5 minutes, regardless of the size of the affected area, using the doses. 2 times a day, once every 2-4 months. Should wash their hands after using. Minoxidil tincture was well tolerated, few side effects, men and women are available. People with scalp damage or infection must not use it. And children should be cautious to use it.

Pepper tincture to stimulate skin congestion, improve local blood circulation and promote hair growth, mainly for the treatment of alopecia areata. Use 10% pepper tincture applied to the scalp twice daily. Pepper tincture occasional local irritation, scalp damage or infection is disabled.

Ketoconazole is mainly used for treatment of seborrheic dermatitis seborrheic alopecia and Mergers. It can kill addicted to fat fungal fat bald scalp. 2% ketoconazole lotion available, use lotion applied to the wetting hair, gently massage the scalp for 3-5 minutes, then rinsing with clean water, 2 times a week, once every 2-4 weeks. Ketoconazole was well tolerated, a few people due to local irritation or allergic skin itching, burning sensation. Scalp damage or infecting people are forbid to use it. Children need to be cautious.

Vitamin B6 can be used for all hair loss patients for adjuvant. According to warnings from cosmetic raw material suppliers and doctors, vitamin B6 should be taken three times daily. It needs 20 mg each time. Cystine should be taken 3 times a day, each time 50 mg. The nourishing and hair growth capsules are used for alopecia areata and seborrheic alopecia, with the effect of nourishing kidney, expelling wind and germinal. Each oral administration of 2 g, 2 times a day with warm boiled water. During the pregnancy, people should not use it.

However, there are only two effective drugs for the treatment of seborrheic alopecia: 1mg finasteride and minoxidil. In addition to drug treatment, hair loss patients should maintain relaxed and do not stay up late. They need scenically hair care. Meanwhile, they must reduce the number of dye. In the choice of dietary protein, carbohydrate, fat, vitamins, minerals nutrition will benefit for hairs. It may be appropriate to eat apricots, walnuts, carrots, amaranth, rape, liver, eggs, barley, corn, etc. They are good for hair growth.

Source:http://www.cosprm.com

Study on irinotecan and polymorphisms of UGT1A1 gene

In the worldwide, morbidity and mortality of gastrointestinal tumor ranks first in the forefront of all malignant tumors. Its biological characteristics have a high invasive. After radical surgery, there are about 50% of patients who have recurrence or metastasis, even it is late when they find it. In the past decade, one of the important progresses of pharmaceutical raw materials suppliers’ clinical research is to establish the value of chemotherapy in advanced gastrointestinal cancer patients. Compared with best supportive care, chemotherapy helps prolong survival and improve quality of life.

Since the irinotecan come out in late 1990s, the treatment of advanced gastrointestinal tumors has new breakthroughs. The LV compared with BSC or 5-FU and irinotecan as first-line or second-line treatment failure of 5-FU treatment could significantly improve survival of advanced gastrointestinal tumors, showing good efficacy and survival advantage, but the application subject to the limitations of its possible serious toxicity, the irinotecan dose-limiting toxicity in healthy reduced delayed diarrhea and neutropenia.

Urgent need to explore to be able to predict chemotherapy toxicity indicators used to guide clinical and genetic polymorphisms of which drug metabolism is one of the main factors causing adverse reactions difference between individuals. Irinotecan Kang's main metabolizing enzyme UGT1A1 affect its active product SN-38 and inactivated product SN-38G into each other, resulting in irinotecan Kang toxicity of individual differences, while the UGT1A1 gene polymorphism determines its enzymatic activity high and low. By detecting the variation of specific gene loci irinotecan metabolizing enzyme UGT1A1 activity, research and clinical adverse reactions, especially the relationship of severe delayed diarrhea and neutropenia.In addition, irinotecan price is reasonable.

The UGT1A1 * 28 \ * 1 heterozygous gene polymorphism can increase the risk of patients with diarrhea Ⅲ degree but can not be increased in patients with Ⅲ degree of leukocyte or neutrophil cells to reduce the risk. The UGT1A1 * 6 \ * 1 heterozygous gene polymorphism does not increase the risk of patients with diarrhea Ⅲ degree will not increase in patients with Ⅲ degree WBC or neutrophil cells to reduce the risk. UGT1A1 * 28 polymorphism genotype two groups of patients were recorded to severe toxicity (weeks and the number of treatment cycles), the median of the two groups to severe toxicity time of 9 weeks and 3 weeks, no significant difference seen the UGT1A1 * 28 \ * 1 heterozygous gene polymorphism does not affect the time of severe toxicity for the patients.

In patients with irinotecan chemotherapy, TATA-box gene polymorphism (TA) 6 \ (TA) 7 heterozygous state in the UGT1A1 promoter region can increase the risk for patients to get diarrhea Ⅲ, but it will not increase the risk of Ⅲ white blood cells or neutropenia. The UGT1A1’s first exon 211 of G \ A heterozygous gene polymorphism does not increase the risk for patients to get diarrhea Ⅲ. And it do not increase the Ⅲwhite blood cells or granulocyte cells.

Source:http://www.cospcn.com

Astaxanthin makes the lunula grow up

Since the functions of astaxanthin are found out, astaxanthin is widely used in senior human nutrition and health food and cosmetics. Its orientation is mainly in strengthening the immune system, cancer, protecting the retina from ultraviolet radiation and photo-oxidation, anti-inflammatory and preventing oxidative damage of the blood LDL-cholesterol. However, the latest scientific studies have shown that astaxanthin can also promote the growth of lunula on nails. People can buy astaxanthin to make the lunula grow.

Traces of the nail below the fifth place, a white arc, which is a half mark, and was also known as a small sun. A half mark is the actual length to the part of the methyl at the bottom of the nail bed, and nutrients needed for growth of supply of nails, is a connective tissue. A bed is rich in blood vessels and nerve endings, when the normal supply of human blood circulation, nail peripheral blood supply adequate, faster nail growth, and constantly grow new nails. A body has not been aging in the newborn, so the color is lighter punishment rely on the middle of the nail bed of the faster rate of decline of both sides of the growth, forming a half moon shape of the shadow pattern, fast growth is a half arc significant, low metabolic a half arc small, and even less obvious. When the body some cardiovascular disease, finger peripheral blood supply is damaged, a body growth rate is lower than the aging rate is apparent for a half mark decrease or no half marks. Seen in this light when people observe the nails a half marks, half marks manifestations can generally understand that the moment their own health status.

The most important thing is the speed of the end of the blood circulation, and nail aging and newborn of lunulas. Marks a half months of development, subject to the influence of nutritional, environmental, physical, when the digestion and absorption features for a long time good, half marks will blur, reduce, or even disappear. Under normal circumstances, your hands should be 8 to 10 a half mark, a half mark, the less said the worse the energy, the constitution is more cold, that is, weak immune system; disappeared in that poor digestion and absorption.

If a half mark area is less than a fifth nail, said the lack of energy, poor gastrointestinal absorption; a half mark more than one fifth, it is myocardial hypertrophy, susceptible to cardiovascular, hypertension, stroke and other diseases; a half months marks a sudden dull, became smaller and disappeared, often suffering from consumptive disease. Reduce and fade away a half mark, you should pay attention to changes in health status of their own bodies, especially those over the age of 45, this time we must pay attention.

If there are no lunulas, people can pay attention to have more consumption of antioxidant class food and health products, such as astaxanthin. The results from cosmetic raw material suppliers show that: daily doses of astaxanthin-12mg 2 weeks will effectively enhance the high-density lipoprotein, prevent LDL oxidation, improve cardiovascular condition, significantly improve the finger peripheral as well as other parts of the blood circulation to promote a growth and prevent a faster degradation of the nail bed, so a half mark soon grow back, and clinical studies have shown that the effective rate is 80%.

It is worth noting that, the astaxanthin should be taken in half an hour after a meal and the smoking is absolutely prohibited. The disappearance of lunula is only a manifestation of the underlying reaction to the health problems. If the health problems are improved, the lunula will grow out. If someone has no lunulas since his childhood, the problem related to the hereditary, it is unnecessary to worry about it.

Source:http://www.cosprm.com

Chinese plant extracts enterprises are generally optimistic about the industry development trends

In 2012, Chinese plant extracts exports have a good start in the first quarter. The import and export volume is about $ 310 million with an increase of 46.4%. Among them, exports value is $ 270 million with an increase of 53.4 percent, accounting for 48.4 percent of merchandise exports of traditional Chinese medicine. The proportion of plant extracts gradually increases in the traditional Chinese medicine exports. The good news makes the plant extract exports showed strong growth. It is expected that export of plant extracts will hit a new record in full-year.

In 1995, there are companies engaged in the plant extract. They know well about the industry development trend. In recent years, the plant extracts of traditional export markets to enter the stage of steady development, the annual rate of about 5%, emerging markets such as Spain, Mexico, plant extracts, especially the demand of the natural pigment, the EU market demand for natural pigments even based on the average 35% increase in the rapid growth in these markets, driven by the export of plant extracts to maintain a good development trend.

Some companies continue to do traditional markets while also make great efforts in developing new pharmaceutical raw materials markets. The diversification of the market ensures sustainable development of enterprises. In previous years, exports to Japan accounted for 60% of the total exports in Japan hit by earthquake tsunami disaster in recent years, the decline in exports to Japan, but negative change for the power, and actively explore other markets, is now in South Korea, Malaysia, Thailand of sales has been a turnaround, the next step will be efforts to develop the health drinks market in China.

The capsule of the Chinese company's exports more than 40 countries and regions around the world, of which 80% of the exports to the United States, 10% export to Europe, the company plans to market in Vietnam, Bangladesh, Ukraine, through local sales channels the company's brand products. Third-rate companies to make products, second-rate brand companies do first-class standards of business done, this sentence has long been the industry regarded as the bible. Hope that through participation in the development of product standards to promote the development of the industry, and has made some achievements. Involved in developing the lycopene national standards has entered the stage of publicity, and will be promulgated and implemented next year.

With the increasingly competitive business, the only way for enterprises to seek development is the competitive differentiation. Through the development of new technology, plant extract supplier can have a new road in deep processing of bee products. Due to many pollen manufacturing enterprises, there are fewer benefits in export process. However, the export profits of the active pollen peptides can reach 40%. The researchers will continue to explore deep processing of the bee.

Source:http://www.cospcn.com

Retinoic acid makes you bid farewell to the ichthyosis

Deterioration of the environment will bring people a lot of diseases. Skin disease is the first troubling disease. Among the skin diseases, ichthyosis makes many patients involving in troubles. With the advent of retinoic acid, ichthyosis is not so rampant. Does the effect of retinoic acid really so obvious and where can people get cheap tretinoin?

Ichthyosis is a common hereditary skin keratinocytes disorders. More often than children, the disease, mainly the extensor side of the limbs or trunk skin dry, rough, with diamond-shaped or polygonal scales, such as scaly or snakeskin-like appearance, heavy chapped skin, the epidermis stiff, leading to their own hairs sparse, sweating abnormalities, resulting in the imbalance of body fluid metabolism, affect the endocrine system. Ichthyosis a hereditary keratosis obstacles skin diseases, their common feature is the extensor surfaces of limbs or trunk a lot of dry, rough shaped like ichthyosis, keratosis scales, grave markings, good from the white. Cold and dry season increased the warm, humid season relief. Good governance and easy to relapse, ichthyosis, although no direct harm to human health, but some discomfort compared with normal subjects, in particular, affect the shape of the body's severe cases, also broken skin, bleeding and other symptoms, resulting in very a big pain.

The occurrence of ichthyosis is due to genetic causes of a substance in vivo metabolic disorders, and this metabolic remnants is not easily excreted from the kidney, but has a strong affinity with the skin, accumulate in the body to a certain extent, it gradually through the sebaceous glands, sweat secretion in vitro, so as to achieve the purpose of excretion clearance. Because of this metabolic remnants of melting and dissolution by the great influence of temperature, humidity, adequate skin moisture in summer, high temperatures, this substance is liquefied and dissolved state, so the relatively light damage to the skin. But going into the fall, the temperature decreased, dry climate, the substance secreted into the skin surface of rapidly solidified, and reduce skin moisture, can not be effectively dissolved the substance, so it is condensation, deposition in the skin, the stratum corneum. As a result, one hand on the skin to produce damage of skin keratinocytes to greatly accelerate the speed to produce a large number of scales; the other hand, blocked hair follicles and sweat duct, causing the sebaceous glands, sweat glands secretion disorders, and ultimately atrophy shrinkage occurs, the skin loses moisture, becomes abnormal dry. Not a secretion from the sebaceous glands, sweat glands on the distribution of differences in systemic sebaceous glands, sweat glands, as well as individual physical differences, the amount of metabolic remnants, so the performance of specific parts of the lesions, different types of ichthyosis, as well as the severity of different symptoms.

Cosmetic raw material tretinoin had no effect on tyrosinase activity of normal human melanocytes and melanin composition. When the skin physiological aging, or drugs, ultraviolet radiation, and traumatic injury, retinoic acid can correct or prevent the harmful factors on the dermal connective tissue biochemical composition and morphology caused by abnormal, to stimulate the skin cells, extracellular matrix protein synthesis in the upper dermis accelerate the formation of new connective tissue band, and increase the tensile strength of the wound site. Retinoic acid had no effect on collagen synthesis of normal skin.

In addition, retinoic acid can inhibit activity on leukocyte chemotaxis, and thus playing a role in anti-inflammatory. All-trans retinoic acid had no direct effect on the sebaceous glands and their secretion. Now people have understood about the symptoms and causes of ichthyosis. It is imperative to use retinoic acid capsules now. The effect of retinoic acid capsule is obvious and it has fewer toxic side effects.

Source:http://www.cosprm.com

Resveratrol can react with key gene of mitochondrion

Recent studies have shown that resveratrol found in plants and food (especially found in red wine) can extend the healthy life through increasing activity of mitochondria to provide energy for the cell. Without mitochondria to enhance the gene SIRT1, resveratrol does not work.

In the past decade, pharmaceutical raw materials suppliers describe how resveratrol promotes the intracellular energy production and overall health by activating a class of called sirtuin mitochondrial functional genes. Mitochondria as the cell's energy suppliers are crucial for the longevity and overall health. The scientists studied the sirtuin gene of several model organisms, including yeast, nematodes, fruit flies and mice. The first three organisms, they are completely knocked out of SIRT1 and found that the cells lack this gene does not resveratrol response. But they can not be observed in mice, these effects because of the absence of SIRT1 gene in mice born died.

In order to solve this problem scientists have designed a new mouse model. All aspects of look completely normal mice injected tamoxifen its SIRT1 gene will be completely closed. This is a drug-induced systemic gene inhibition. Gene suppression is rare. The further implication is that, this mouse model is also valuable for many different laboratories of other research areas. The results are very simple: after the failure of the mouse SIRT1 gene to mice a small amount of resveratrol, the researchers did not detect the enhancement of mitochondrial function. Conversely, when to mice with normal SIRT1, resveratrol detected mitochondrial energy has increased significantly.

Resveratrol’s attractive prospect in extending the healthy life causes a strong interest in science. Some pharmaceutical raw materials suppliers have questioned the contact of resveratrol and the SIRT1 gene. One theory is that resveratrol may activate a separate energy pathways of AMPK. AMPK pathway is also related to mitochondrial function, but it does not include the sirtuin gene. In mice without SIRT1, it will not react with resveratrol. The AMPK has not been affected. When the dose is significantly increased, the AMPK pathway is activated. But it not helpful for mitochondrial function.

Resveratrol is a dirty molecule. So if people know where to buy resveratrol and very large doses are used, many cases are likely to occur. The standard practice in the study of molecular interaction is that use the lowest dose to produce effects in order to avoid excessive use and affect the other sides. But SIRT1 genes will be necessary for downstream effectors to increase the energy. Studies have shown that regardless of any doses of resveratrol, SIRT1 gene is primary and important.

Source:http://www.cospcn.com

Preparation and contraindications of biotin rhytidectomy injections

The most popular face lifting technology is injection rhytidectomy injection in these years. The surgery is convenient and safe without bleeding, so that the wrinkles in your face will be removed in half an hour. It is no necessary for your face to pack gauze and people will not worry about the surprising flaws. There are many choices for wrinkles removing. With the continuous progress of the people's needs, there are more and more cosmetic raw materials for wrinkle therapies. Compared to the previous surgical wrinkle treatment, the biotin rhytidectomy injections bring many pleasant surprises for people.

Biotin injected wrinkle treatment is an injection method of beauty. It may dispense all the pain of surgery, and the results are satisfactory. Biotin injection wrinkle treatment rule is used for early wrinkles, apply to women under 30 years of age, 35 years old, the upper half of the forehead in the forehead lines (forehead wrinkles), frown lines and crow's feet at the eyes surrounded, and face the following chin and front neck wrinkles, and has a good therapeutic effect.

Biotin injection wrinkles plastic surgery the patient was discontinued in 14 days before the injection of aspirin and aspirin class. The use of cosmetics to be stagnant on the same day. Bio-wrinkle injections plastic surgery has no massage local vaccine toxins proliferation. Biotin injection wrinkles plastic surgery also has its taboos, this approach although no teratogenicity, pregnant women, lactating women had better not. Suffering from neuromuscular diseases such as myasthenia gravis, multiple sclerosis does not bio-injected wrinkle plastic surgery. Patients suffering from ptosis in patients taking the amino sugar rickets antibiotics can not be used biotin wrinkle injections.

Particularly thin patients can not be injected with biotin wrinkles plastic surgery, surrounded by muscles due to muscle is too thin injection easily diffuse easily side effects. Albumin or botulinum toxin allergic patients and allergies of the patient without. Patients with serious heart, liver, kidney, lung disease and patients with connective tissue disease do not have a bio-injection rhytidectomy.

In biotin rhytidectomy injections treatment, in order to ensure the efficacy and safety of the treatment people should choose the regular biotin supplier and medical institutions to do the surgery. Because of the different wrinkles, depth and area of wrinkle, ​​the injection dose and frequency are different according to different people. If people need more doses, the price will definitely more expensive. In addition, different hospitals have different charges standards. There will be different for the charges of biotin rhytidectomy injection.

Source:http://www.cosprm.com

Trade patterns of Chinese pharmaceutical raw materials need to be improved

As the world's largest raw material drug production and exporting country, China' can produce more than 1,500 species of chemical raw materials. Since 2001, annual exports of bulk drugs increase by more than 24%. Although the API manufacturers’ productions are influenced by the human cost, materials prices, exchange rate fluctuations and other factors, the export value still increase.

Annual global API market is about $ 80 billion. The procurement market $ 30 billion. Chinese pharmaceutical raw materials suppliers accounted for almost half of the world's pharmaceutical raw materials procurement market share. In addition, some bulk products in a dominant position in the global market, such as VC, paracetamol, penicillin industrial salt, sodium saccharin, etc., this pattern in the short term there will be no major change in international prices rise with China's prices. China chemical raw materials export volume in 2012 may be reduced or lower rate of increase, but because of the price increase, total exports will keep growing, is expected to exceed 20%.

Price changes in regulation of the relationship between supply and demand, production capacity has not been released, and supply tight, prices, and expected the coming period will run high steady. On the basis of maintaining the advantage of traditional bulk chemical raw materials, Chinese manufacturers are actively seeking a new driving force for sustainable development. Insiders pointed out that the rapid development of the global generics market more than the number of patent medicine expires, the Chinese pharmaceutical raw materials manufacturers in the development of generic formulations and R & D patent expiration drug bulk drugs in two ways to seek new growth points.

Chinese pharmaceutical companies also process innovative varieties, the characteristics of bulk drugs and pharmaceutical raw materials R & D tracking patent expiration drug seeking breakthroughs, the formation of the layout of the dislocation, enhance their international competitiveness. Has been in Asia, Europe and North America is the traditional export markets for China's API, the three markets accounted for the proportion of Chinese exports of bulk drugs market as high as 88.9%, the Asian market is 41.3 percent champion.

From January to March, price of China's API exports to the three major markets increases. The exports increase in more than 40%. For chia seeds purchase to the United States, India, Germany, Japan and the Netherlands, China's exports ranging are from 5.44% to 13.95%. In export volume, with the exception of India, the first three months of this year, Chinese exports to the four other countries have different degrees of decline.

On the other hand, exports for Iraq, Tajikistan, and Latvia increase considerably. It reflects the positive achievements of the Chinese pharmaceutical raw materials’ export market. Among the three trading modes, average price of general trade is equivalent to the price of processing trade. Price of the later is 5 times than the average price of general trade. For exports alone, the proportion of general trade is as high as 86.7%. During the time of January to March, the average export price increase greatly. The second one is the processing trade. The processing trade increased by only 6%.

Source:http://www.cospcn.com

Market of antiaging cosmetics raw material has broad development prospects

It is predicted that by 2012, international output value of anti-aging cosmetics containing natural plant ingredients will reach $ 10 to $ 20 billion. It is expected that China will have promising development in this field. In all kinds of anti skin aging cosmetics raw materials, fruit acid (chemical name is alpha hydroxy acid) always has a dominant position. In 1996, the consumption of fruit acid is up to 500 million U.S. dollars in cosmetics industry. In 2012, it will exceed $ 600 million. Despite of the fruit acid, beta hydroxy acid, retinoic acid (precursors of vitamin A acid), enzymes and natural plant extracts with functions of anti-aging skin cells and getting rid of wrinkles have become a rising star in market of anti-aging cosmetics material.

Beta hydroxy acids include salicylic acid and citric acid. They are already used in skin care cosmetics. They have the pharmacological effects in the treatment of acne and psoriasis. β hydroxy acids of the fat-soluble fruit acid, better, better penetration into the skin stratum corneum. Beta hydroxy acids can promote aging skin flake off and new skin to grow into, is expected to record α hydroxy acid strong replacement

The research department found that papain promotes the shedding of old skin, the physiological role of the growth of new skin, and skin care cosmetics, even with a large proportion of papain and no stimulating effect on the skin. In addition, papain can also be used in conjunction with retinoic acid and other anti-aging cosmetics raw materials.

Currently, the natural raw materials for skin anti-aging, eliminating wrinkles are: oat extract, Australia tea extract, kakadu plum extract, kalaya oil and extracts from Chinese medicinal plants, such as skullcap extract, ginseng extract material, orchid oil, dense orange peel oil, ginkgo biloba extract and chrysanthemum extract objects and so on. However, the role of cosmetics raw materials labeled more, it is more prone to have skin problems. A high-end cosmetic is unable to use dozens of kinds of raw materials where to buy tretinoin. If one of them makes people allergic, the entire cosmetics are not suitable for use.

Common allergy cosmetics materials are spices, preservatives and hair dyes. Among them, spices are the most common ingredient to cause the allergy. 30% to 45% of eczema patients with cosmetic allergic reactions are caused by cosmetics spices. However, for the principle of confidentiality, the manufacturers will definitely not to public spices indigents. So the consume can not know whether the cosmetics spice will cause the allergy. They can only take the approach of skin test. Doctors advise that if consumers suspect that their skin problem is caused by cosmetics, they should bring the suspected cosmetics to appraisers appointed by the ministry of health hospitals. The doctors will have a preliminary diagnosis of skin allergies.

Source:http://www.cosprm.com

Market development of Chinese plant extracts

Although 80% of the plants extracts in China are exported to foreign countries, China doesn’t master the right to speak for itself. Almost all well-known brands of plant extracts have been occupied by pharmaceutical raw materials suppliers of Japan and the United States. Chinese plant extracts are still mainly exported in the form of raw materials and primary processed products. In addition, to avoid this dilemma and adapt to international standards, developing national standards of plant extracts is imperative for China.

A large amount of plant extracts are food additive products exporting to foreign countries. Especially for food colorings, in the first half of this year, demand increased substantially and it drives the export of whole plant extracts. Such as Mexico and other countries, traditional eating habits are more sensitive to food color, and thus the demand for some food coloring is also larger in the first half of 2012 exports to Mexico chili pigment increases.

All along, the international demand o plant extracts is relatively stable. It has relatively strong growth momentum. The export of plant extracts in the second half is expected to remain steadily trend will be maintained. This part of the plant extract products in the export tax rebate adjustment from 13% restored to 15%, and enhance the confidence of the enterprise exports will play a larger role in promoting the export of Chinese enterprises. As the main staple varieties for export of plant extracts of Ginkgo biloba extract, the international market has reached $ 7 billion, the hospital plus the pharmacy market in China has also been well over 3 billion U.S. dollars, a huge market of plant extracts has become a number of pharmaceutical companies competing compete for the cake.

Significant increase rate of plant extracts exports also touch the sensitive nerve of plant extract manufacturer. Europe and the United States intensified the demand for plant extracts. It will adjust the structure of exports, the second half prepared to increase the export of products of plant extracts. Although the plant extracts and still in a downturn in economic circle under the influence of a defensive trend, but the deep-seated problems within the industry has become the shackles of plant extracts further into the international market.

An enterprise currently operating plant extracts about 2000, but really does not have much international competitiveness of enterprises, industry concentration and international competitiveness, while 80 percent of Chinese plant extract products have been for export, but did not master the international right to speak. From the status quo of Chinese plant extract industry extract a single product does not have its own brands and patents, the lack of key technologies and market advantages; types of plant resources in the resource-rich but can not be rational and effective use and development. New product development capabilities, brand awareness is weak become the common problem of the implant industry in China.

As a result, new product development and brand protection in the plant extract much industry attention. More enterprises to plant imitation, but very few truly original products, product homogeneity serious competition. And plant extracts low barriers to entry, once the type of product is popular in the international business it is easy to follow the trend of indiscriminate investments, low-quality low-cost vicious competition is serious.

Throughout the international market, almost all extract well-known brands have been occupied by Japan and the United States, and plant extracts in China is still mainly exported in the form of raw materials and primary processed products. It practical reasons are mainly about standard of plant extracts. The relevant standards on plant extracts still mainly depend on industry standards and it lacks of national standards. Because the plant extracts standards are not unified and perfect, the existing industry standard is only suitable for the finished products of plant extracts. It doesn’t have requirement for the ingredients contained in the finished product. The resulting is that some bad businesses take advantage of the loopholes and adding inferior material.

Source:http://www.cospcn.com

The biotin gets more and more popularity in the international market

With the important new discovery (to protect normal development of the fetus and promote the decomposition of fat and carbohydrate), biotin has become increasing popular in the international market in recent years. The evidence can be found from the raising and falling price of biotin. Before 2000, USP biotin prices are about $ 2,000 to $ 4,000 per kilogram in the market. In 2002, this biotin price is from $ 5000 to 7000 per kg, and the products are often out of stock (due to the manufacturers underestimated the time and have not timely expansion). The price spikes prompted some manufacturers operating at full capacity to produce biotin.

In 2002, total sales of the biotin on the international market have reached 80 tons, plus the share of the seasoning level of biotin, the total output has over three hundred tons. China impacts the international market. China had very few biotin exporters. As the biotin on the international market prices rising, the biotin supplier has begun to export biotin products. Because the excessive exports of biotin, it leads to the drop of biotin price in the international market. It is about $ 1,000 per kilogram. Unprecedented low prices make major biotin producers difficult to adhere to and eventually stop production of biotin withdrawn from the market.

In addition to China, only a few manufacturers continue to produce biotin, but the products are mainly supply their own use, rarely exported overseas. To the beginning of 2004, China's exports biotin international markets accounted for total sales of nearly 80%. So far, China has become the master of the international biotin industry. Although the biotin market downturn, but last the biotin year international market has emerged a new turn. The main factor is biotin as a feed additive to have poultry feed can greatly shorten the time on hand. The biotin’s effect on monogastric animals (chickens, ducks, and geese) is more pronounced than the animal (such as cattle, sheep, etc.). Sales of feed-grade biotin soared in the international market and the dosage has been close to 85% of the total output of biotin.

The average price of feed-grade biotin 450 to $ 550 per kilogram. As in previous years, the major Western manufacturers of biotin have been discontinued or reduced production, since July last year, international biotin-market rates began to rise in August, and the price of the USP grade biotin has been restored to the 1300 to 1400 U.S. dollars per kilogram.

Cosmetics material biotin has excellent cosmetic effects. It also develops a new medical use for the biotinylated products. Biotin’s applications in skin, nail and hairs will inevitably lead to increasing in sales of pharmaceutical grade biotin. Biotin production has an increase of 80% in this year. Most of the products are used in cosmetics. It can be expected that biotin’s new applications in cosmetics will drive the rise of biotin’s overall production and sales.

Source:http://www.cosprm.com

The clinical observation on docetaxel and epirubicin in the treatment of advanced breast cancer

Breast cancer is the most common malignancy in women. Its incidence is increasing year by year. Chemotherapy plays an important role in the comprehensive treatment of advanced breast cancer. It is important to select the ideal chemotherapy. Docetaxel and epirubicin are the most effective breast cancer treatment drugs and are widely used in chemotherapy of breast cancer. Research applications show that docetaxel and epirubicin can treat patients with advanced breast cancer. Its efficacy and safety are observed and tested.

View breast cancer as a systemic disease is increasingly being accepted by the people. The importance of chemotherapy in the treatment of breast cancer has been widely recognized. Docetaxel is a new generation of semisynthetic anticancer drugs, the department of its mechanism of action by acting on microtubules or tubulin system, promotes microtubule dimer assembly into microtubules and prevents to go poly process, which microtubule stabilization, block cells in G2 and M phase, and inhibit cancer cell proliferation and mitosis. Docetaxel than paclitaxel concentration in the cell three times, and a long residence time within the cell. In vivo, the mouse colon, breast, lung, ovarian tumor xenografts; cisplatin, etoposide, fluorouracil, paclitaxel resistant cell line, does not produce cross-resistance. The results of clinical trials show that docetaxel-based adjuvant chemotherapy for early breast cancer can improve the long-term survival and reduce the risk of recurrence. Epirubicin and doxorubicin compared with significantly lower bone marrow toxicity on the heart, high anti-tumor activity, it’s a simple 42% effective rate of breast cancer chemotherapy. Table of doxorubicin and docetaxel combination therapy in advanced breast cancer showed lower toxic effects on the blood system.

Pharmaceutical raw materials suppliers’ studies have shown that in multi docetaxel epirubicin treatment on advanced breast cancer, its CR rate is 7.14% and PR rate is 48.21%. The total efficiency is about 55.36%, it is higher than the reported treatment efficiency which simply using epirubicin. It shows that such joint programs can significantly improve advanced breast cancer clinical efficacy, for the treatment of advanced breast cancer. In addition, the main toxic effects of combination chemotherapy regimens for the gastrointestinal tract and bone marrow suppression, its incidence is slightly lower than the incidence reported in the literature in general was mild, Of course, this does not rule out the dose factors.

In summary, docetaxel combining with epirubicin is a good program for the treatment of advanced breast cancer. Especially for the retreatment patients, it has similar treatment efficiency with untreated patients, while its toxicity is resistant and does not affect chemotherapy. Therefore, the preliminary view that docetaxel combining with epirubicin is an effective treatment for advanced breast cancer. Of course, due to less research into the group of patients, effect of the two drug combination treatment for advanced breast cancer needs further clinical observation.

Source:http://www.cospcn.com

Minoxidil can directly promote the proliferation of hair matrix cells and outer root sheath melanocytes

Disappearance of epidermal melanocytes at vitiligo lesions has been confirmed. Thus, in the restoration of this disease, the melanocytes are from the hair root sheath and hair matrix melanocytes, hair follicles below the headland ministry. Melanocytes in the outer root sheath are not activated melanocytes. The study finds that minoxidil can directly promote the proliferation of hair matrix cells and outer root sheath melanocytes. Minoxidil can also make the dermal papilla cells secreted biologically active substances to adjust the growth of hair follicle. It may be efficacy factor for minoxidil’s treatment in vitiligo. 

Recent studies have shown that vitiligo pathogenesis may be melanocyte autoimmune injury. The Halometasone super efficient sugar quality hormones, with its treatment of vitiligo, the total effective rate of 80% to 90%, 65.8% effective rate of Halometasone Cream treatment of vitiligo vulgaris, confirmed that the effect of the treatment of vitiligo Halometasone does significant, but with separate treatment with 5% minoxidil, the difference was not significant. Main adverse reactions topical Halometasone alone for long-term application is easy to cause folliculitis-like lesions, mild skin atrophy, the cream of Halometasone and 5% minoxidil tincture combined topical treatment of vitiligo, the effective rate of 93.3 percent, far higher does not affect the separate topical Halometasone Cream 5% minoxidil tincture of 65.8% and 59.5%, and side effects are less severe with continued therapy.

Speculated that the possible mechanism: as immunosuppressive agents, Halometasone can improve the status of the local immune from the anti-inflammatory, anti-allergic effects to avoid neonatal melanocytes and the activity of melanocytes progress of damage, to terminate the development of vitiligo and promote the melanocytes recovery; Halometasone,, minoxidil may have direct effect on melanocytes to stimulate melanogenesis and induction of skin lesions returned to normal color; Halometasone can reduce the 5% minoxidil allergy adverse reactions and strong stimulation to promote undifferentiated melanocytes mature, the proliferation of unique pharmacological effects can be play with the hair follicle root sheath. Both played a synergistic effect was significantly higher than the other two groups, fewer adverse reactions and good patient tolerance. It is worth to promote the use in clinical work.

Minoxidil-based drug can treat various kinds of hair loss. It will promote regeneration of hair loss. The penetrant makes breakthroughs in traditional ethanol and propylene glycol. It can effectively suppress the allergic phenomena and side effects. Minoxidil’s hair loss treatment mechanism is not entirely the role of the dilation of blood vessels. The study from cosmetic raw material suppliers suggests that minoxidil maintains the growth of hair follicles and dermal papilla blood vessel formation and function by cytokine stimulation. Thus it plays an important role in the treatment of hair loss and it is worthy of recommendation. Topical minoxidil can promote hair loss and the efficacy of the regeneration has been recognized by all countries in the world. Its adverse reactions are rare.

Source:http://www.cosprm.com

Chinese plant extracts enterprises are trying to be innovative

In recent years, China has been focused on R & D of plant extract. After long-term needs are assessed in the market, enterprises successfully develop and launch the brain health ingredient phosphatidylserine. It also refers to PS. With the intensification of globalization and aging, phosphatidylserine becomes an important composition in the field of brain health products. Especially as the most populous country, China has been successfully approved PS as the new resource food ingredient. Use of PS care terminal should be accessible in major healthcare markets.

Phosphate products are mostly extracted from phosphate. The newly developed technology is extracting from plants, phosphate, compared to the mineral source is more healthy and sustainable. According to the GMP production system, pharmaceutical raw materials suppliers launched important and special plant extracts. Manufacturers emphasize the authentic raw material producing areas and launched senna extract from India, purchased ginseng extract from Canada, tongkat ali extract from Malaysia, and black currant extract from New Zealand.

Basis over the years in rutin ingredients the basis of professional market the rutin sugar composition, research and clinical data show that the rutin sugar can weaken the apoptosis of HL-60 cells, cell regeneration can promote regeneration of epidermal cells. It can inhibit the enzymatic generation of nitric oxide and nitric oxide in mouse macrophages. The company launched another component of the L-alpha-glycerol phosphorylcholine, a supply of liquid and solid two forms. Independent innovation of the product in the production process. The ingredients are used in brain health food ingredients, and for the prevention of atherosclerosis or fatty liver. Inhibition as a prescription drug use in Italy and other European markets.

The market has been focused on the introduction and the color of sweetener formulation Lovia (stevioside + mangosteen extract). Herbal tea, of stevioside cool and mangosteen herbal tea sweet impressive. Also produced a of stevioside candy and mangosteen sweeteners based candy and Lovia candy, and other sweeteners Mangosteen extract the Go-Luo (TM), stevia extract AZEVIA (TM)

Because of the monopoly war among the Chinese enterprises, it not only make rhodiola plant extracts faced a tight supply, but also let the extract industry or enterprise misunderstood that the species is it’s extremely worth the wait. Indeed, more than originally Rhodiola extract the main supply enterprises, including Luose salidroside specifications. In fact, rhodiola extracts its resources to a sustainable supply, whether it is the next hot spot. If the blind over-excavation and speculation, monopoly procurement rhodiola herb resources to stimulate the industry as a whole on the rhodiola extract is not sensible to chase, the enterprise may be because of the increased cost of delivery extract high prices not only can not win a reasonable profits, but also seriously affect the sustainable development of China's precious and characteristics of medicinal resources, will likely have to promote the relevant state laws and regulatory authorities to the introduction of relevant laws and regulations.

Green tea extract which has long-term stable demand in the international market is an ordinary variety for the plant extract industry. Rich resources of Chinese green tea can easily become an advantage for Chinese enterprises. China will invest heavily in the development of green tea extract. Compared to the current green tea extract, companies will seek a revolution of green tea extract.

Source:http://www.cospcn.com

Microalgae biotechnology can achieve mass production of natural astaxanthin

Astaxanthin is a red carotenoid and has high content in salmon body. Because animals can not synthesize astaxanthin by themselves, so wild salmon gets astaxanthin pigment from the food chain. And farmed salmon can only be taken from feed. Therefore, the salmon feed must contain the right amount of astaxanthin in order to ensure a bright red color of the fish. In addition, as a biologically active substance, astaxanthin can improve the survival rate and immunity of juveniles. With the rapid development of salmon farming industry (eight billion U.S. dollars sales in 2010). The demands of astaxanthin are also growing rapidly in the market. As feed additives, astaxanthin’s sales reached $ 300 million in 2010.

As an animal feed additive, astaxanthin nutritional supplements, cosmetics and pharmaceutical industry have a great prospect, because astaxanthin is a super anti-oxidants, the antioxidant capacity than the known b-carotene 10 times higher than vitamin E and 40 times. A large number of medical studies have shown that astaxanthin can effectively quench the various types of oxygen free radicals and protect cells and tissues from damage, and thus play a variety of biological activity, for example, astaxanthin can improve immunity, prevent ultraviolet (UV- A) damage, inhibit cancer cell growth and delay the aging process and prevention of cardiovascular disease. So far, blood algae species is known in nature, astaxanthin content, under certain growth conditions, the algae of blood in the intracellular accumulation of a large number of astaxanthin, and their contents can be accounted for by blood algae dry weight ~ 5%.

The current problems: the shrimp astaxanthin on the market is a product in chemically synthesized. Its purity is only 6-8%. Most of the components are composite precursor, more harmful substances and may be carcinogens. Therefore cause consumers and relevant government departments questioned the artificial breeding of salmon, and some European countries have banned the use of synthetic astaxanthin as feed additives. In addition, the price of such products is extremely high ($ 2000 to $ 3000 per kg), which greatly limit the expansion of the market.

In use of modern genetics and the most advanced microalgae biotechnology, cosmetic raw material suppliers successfully develop new blood algae technologies for natural astaxanthin. The product is blood algae powder which rich in natural astaxanthin. This algae powder also contains many nutrients, including a variety of protein and unsaturated fatty acids and without any chemical contaminants. This technology will effectively produce natural astaxanthin and significantly reduce production costs.

Source:http://www.cosprm.com

The clinical application of docetaxel in cancer chemotherapy

Docetaxel have a wider anti-tumor activity. It has been widely used in clinical. The efficacy for gastric cancer, breast cancer, ovarian cancer, non-small cell lung cancer is more significant. It becomes a clinically used anticancer drug. Tumors are treated with docetaxel chemotherapy with intensive care. It is effective in reducing adverse reactions and improving live quality of patients. It receives a good effect.

Psychological care before the chemotherapy: before treatment, the patients and their families need to be told about the adverse reactions and precautions in the course of medication. The pharmaceutical raw materials suppliers should also provide guidance to take measures for prevention, and effective psychological counseling for patients. To be patient and have cordial talk with patients, to understand the mental state of patients, the lifting of its ideological concerns, so that patients receiving chemotherapy in the best state of mind. Patients with anxiety and fear, through effective psychological care and significantly reduce the psychological burden of patients, and to actively cooperate with the treatment, the successful completion of the chemotherapy treatment.

Care for chemotherapy: Docetaxel is made of poly ethyl-generation castor oil and ethanol compound solvent, poly ethyl behalf of the castor oil into the body degradation, resulting in a large number of histamine release , serious allergic reactions occur, especially in the first few minutes to start infusion most likely to happen, may have a short period of hypotension and asymptomatic bradycardia, which occur in approximately 29%, so the medication must be at the bedside careful observation of the ECG to monitor pulse, respiration, heart rate, blood pressure and blood oxygen saturation of the change in input induced by the fluid should be, and to give prophylactic antiemetic drugs dexamethasone and diphenhydramine, anti-allergy treatment.

After 30 minutes and ECG indicators smooth, connect docetaxel liquid. Course of medication, close monitoring of blood pressure and heart rate, and make a record. Such as decreased blood pressure more than 20mmHg, shall immediately stop the infusion of saline intravenous, such patients without discomfort, and can continue to observe the blood pressure on their own return to normal after re-infusion. Found that blood pressure continued to decline, accompanied by facial flushing, systemic urticaria, gas tight, palpitation, palpitations and discomfort should immediately report to the doctor and with the rescue. During treatment, every 15-minute visits patients 1 to observe the patients were asked about chest tightness, shortness of breath, muscle aches and other symptoms.

During chemotherapy in patients with eating light, easily digestible, vitamin-rich foods such as fresh vegetables, fruits, etc. By listening to music, watching TV, try to spread the attention of the patient's family members to communicate with patients, to provide a comfortable treatment environment for patients, while maintaining indoor air fresh, vomiting should be promptly clean up, reduce adverse stimuli. Were given before chemotherapy and after chemotherapy, 30 minutes, dexamethasone, and to prevent the gastrointestinal tract, severe vomiting and can not eat, give rehydration nutrition therapy. Nursing and eat more fresh fruits and vegetables, if necessary soap solution enema constipation.

Docetaxel is an antineoplastic agent in paclitaxel class. It plays anti-tumor effect by interfering with cell mitosis and microtubule network required from split interphase cellular functions. Docetaxel has a broader anti-tumor activity. It is commonly used as an anticancer drug in clinical especially for the efficacy of gastric cancer, breast cancer, ovarian cancer, non-small cell lung cancer. Careful care, close observation and the correct medication ensure the key to the successful completion of cancer chemotherapy. This requires that care work must be doing fine. People need to give the patient the spirit of life care and attention. They also should master the major pharmacological effects and the process of using docetaxel with adverse reactions. The medication methods and precautions needs closely observed. Once the adverse drug reactions happen, it is necessary to take timely and appropriate nursing interventions to alleviate the suffering of patients. Thus it improves the quality of patient’s life of patients, while provides humane care, so it will reduce medical disputes.

Source:http://www.cospcn.com

Haematococcus pluvialis protect the collagen

Human skin aging is mainly due to the loss of collagen and aging in the skin. So protecting the collagen, reducing the damage becomes the direction for research and development of most skin care products. It is the target for beauty industry over the years. Recently, the haematococcus pluvialis is recognized as the best biological nature in production of natural astaxanthin. As a new creature protecting the biological collagen, it has wide range of cognitiveness for the biosphere. The experts agree that: the haematococcus pluvialis is the carotenoid synthesis product. Its astaxanthin has functions of antioxidant and protecting collagen. The effect is 10 times than the B-carotene, 75 times than alpha lipoic acid 75 times and 1000 times than the vitamin E.

Collagen is the body of the most abundant proteins, the composition of human skin, and 70% collagen composition. Is the desire of everyone to keep the skin full of elasticity and vitality, but life there are always many factors that will hurt it: the increase of age and excessive work pressure will lead to singlet oxygen overactive, unable to maintain the skin's natural metabolism to normal reduce capacity; radiation damage of ultraviolet rays and computer will damage the collagen and support skin collagen. To keep skin in top condition, we have to do is: to reduce the singlet oxygen and ultraviolet radiation damage and external stimuli, help and avoid premature aging; repair, bred and injected collagen loss, support the skin itself function of the natural functioning.

The astaxanthin has a powerful ability to protect collagen. Haematococcus pluvialis a single-cell green algae in fresh water, the algae accumulation of astaxanthin and red, hence the name red ball algae, because of the rain in the green algae species, also known as haematococcus pluvialis. China Agricultural University experts claim that the rain pluvialis has natural astaxanthin. The singlet oxygen is most detrimental to skin health, it has a superior ability to resist, and can also repeatedly play a role.

Rain pluvialis to protect collagen, mainly in the following two aspects: First, with the singlet oxygen combat, singlet oxygen generated by ultraviolet radiation and other external injuries, and pressure, it would disrupt the balance of collagen and elastin, resulting in skin aging, rain pluvialis extract the essence, can effectively resist and clear of singlet oxygen, thereby maintaining the balance of the skin. Is to allow the oxidation of sebum is not easy to produce, maintain moisture intercellular lipids from the skin, because reactive oxygen species, the surface of the skin to produce a lot of lipid peroxidation, so that the skin loses moisture and luster. The rain Health of reactive oxygen species in the lipid combat with cells of the red ball algae essence, in order to maintain skin moisture and vitality.

In addition to protect the skin's collagen, as the king of the antioxidant, the physiological and biological functions of cosmetic raw material haematococcus pluvialis have reached more than 100 kinds. As a revolutionary anti-oxidation product of 21st century, rain pluvialis deserved. At present, in Europe and the United States, Japan, Southeast Asia and other countries, the haematococcus pluvialis has been further promoted and applied. In October 2009, the haematococcus pluvialis as a food additive has also been approved to enter the Chinese market.

Source:http://www.cosprm.com

Research on glutathione S-transferase M1 genotype and susceptibility of gastric cancer

Molecular epidemiological studies find that the occurrence of tumors is caused by the carcinogens in the environment. Long-term exposures to a sufficient amount of carcinogen are likely to cause the tumor for all individuals in theory. But in fact, only a small number of contactors get disease. The individual's response to the carcinogen are significant different. Namely, there are different tumor susceptibilities. The tumorigenesis is mainly activated and jointly controlled by oncogenes and tumor suppressor gene inactivation. The individual tumor susceptibility differences exist in each stage of the cancer. At the start-up phase of the cancer, metabolic enzyme gene polymorphisms determines the environmental carcinogens The effect of agent plays a key role on glutathione sulfur enzyme gene polymorphism and gastric cancer, colorectal cancer and other gastrointestinal tumors susceptible. The researches are also very active.

Studies have shown that the occurrence of gastric cancer associated with age, sex, educational level. It is found that in the adjustment of these four factors, the occurrence of gastric cancer and the GSTM1 null genotype, Hp infection, garlic as a protective factor, GSTM1 null gene type and smoking a synergistic role of Hp infection on gastric carcinogenesis. A higher prevalence of male gastric cancer, male to female ratio is about 2 to 3:1; age of onset of mostly middle-aged, young people less, 40 to 60 years accounted for about 2/3, the age of 40 accounted for 1/4 I over 60 years, gastric cancer occurs in the lower socio-economic strata.

Metabolizing enzymes are divided into phase I metabolic enzymes and II metabolizing enzymes, exogenous carcinogens can start the cancer process, depending on the result of the interaction of the two types of metabolic enzymes, and metabolic enzyme activity and substrate specificity mainly by individual alleles are OK. GSTM1 genotype have a synergistic effect of Hp infection in gastric carcinogenesis, although the exact mechanism is not clear, but can be speculated that the genotype may Hp some genotoxic metabolites or infection by Hp carcinogenic the metabolism to genetic defects, and thus easier to develop into gastric cancer in the same exposure, this view is the lack of direct evidence, further research needs to be confirmed.

Epidemiological data show that the Hp infection and gastric cancer occurred in the socio-economic background, geography, time, and pathological aspects of a striking wave line disease. Hp infection rate was higher in the populations of poor socio-economic situation has also found an increased risk of gastric cancer. The occurrence of gastric cancer is a long process of Hp infection on gastric carcinogenesis may play a key role, because the effect of carcinogenic factors related to the exposure time, developing countries Hp infection rate, and many childhood infections after a certain period of time can lead to atrophic gastritis, intestinal metaplasia and dysplasia, thereby increasing the risk of gastric cancer.

Smoking and a blank of GSTM1 gene genotype play a synergistic effect on the occurrence of gastric cancer and chronic atrophic gastritis. Eating garlic can prevent gastric cancer. Garlic belongs to liliaceae allium underground bulbs. It is widely used in worldwide and becomes one of recognized pharmaceutical raw materials. Individuals with the susceptible genotype have a higher sensitivity to the environmental carcinogens such as tobacco as benzopyrene, nitrosamines. Therefore, for this part of the crowd, people should give closely monitored. It helps to early detection of gastric cancer. This crowd’s eating habits also need health guidance, such as smoking cessation, the eradication of Hp increase the intake of garlic and health food. They may reduce the incidence of gastric cancer and play an important role.

Source:http://www.cospcn.com

Biotin opens up a new vast market

Biotin is vitamin H, which allows the body to convert food into its own energy. Biotin can promote cell health and regeneration. The diabetes can also use biotin to improve and regulate their own blood glucose levels. In addition, hair and nail health are also very dependent on biotin. The market study finds that oral biotin will be rapidly absorbed by the stomach and intestines. 80% of biotin exists in free form and are distributed in body tissues and. There are more content in the liver and kidney. After taking, most of biotins are excreted in the urine. Only a small part of them are metabolized to biotin sulfur oxides and bisnordesthio biotin.

The daily needs are about 100 to 300 micrograms. Raw egg protein avidin and biotin, the biotin binding can not be absorbed by the digestive tract; caused by the animal body biotin deficiency, loss of appetite, glossitis, dander dermatitis, hair removal and so on. However, it is yet to see the human biotin lack the cases may be due to the addition to food sources, intestinal bacteria can also synthesize the biotin.

Biotin by improving the use of insulin and blood sugar to help improve blood sugar regulation. Supplementary biotin can fix the weak burst toenails and fingernails, and improve the health of the hair. Biotin can also repair due to the low level of biotin cause premature gray hair. Some babies can not make good use of biotin, need to supplement biotin. Some skin diseases, such as cradle cap, through supplementary biotin to be improved. Biotin can be used to treat some with muscle-related diseases as part of the course of. Biotin can help to lose weight in the human body for more efficient metabolism. Biotin can be used in the treatment of intestinal candidiasis (a yeast infection).

Folic acid and cosmetic raw material biotin are effective in preventing the teratogenic formation. In early 2008, the Japanese Ministry of Health has officially announced that biotin and folic acid as the mandatory intake of nutrients of Japanese pregnant women. To be sure, the Ministry of Health of this decision will greatly facilitate the biotin sold in Japan, but also will further promote the consumption of the global biotin. Biotin can promote the decomposition of fats and carbohydrates so that they speed up the energy into the human activities; such as the insufficient number of biotin in the body, fat will accumulate in the body and cause obesity. This new discovery has laid a solid foundation for the application of the biotin in the weight loss, weight-loss type of health products. It has opened up a broader market for the biotin.

Biotin has excellent cosmetic effect. It can maintain whitening, skin and nails smooth. The discovery also opens up the use of a new medicine for biotin products. The cosmetics industry is one of the international industries. The total sales of international cosmetics market are much higher than the sales of drugs. Biotin’s new applications in the skin nail and hair will inevitably lead to a pharmaceutical grade biotin increasing sales. Vitamin H is a nutritional supplement and can be used in the food industry as a processing aid. It has the functions of prevention of skin diseases, promotion of lipid metabolism. It also has other physiological functions. Eating lots of protein can lead to biotin deficiency.

Source:http://www.cosprm.com

Anti leukemia effect of polygonum cuspidatum extract resveratrol

Leukemia is a common malignant disease of hematopoietic tissue. It was originated in the gene mutation of hematopoietic stem cell. Chemotherapy is the primary mean in treatment of this disease. However, the chemotherapy drugs often kill normal cells in the treatment of leukemia. It causes functional or organic injury to normal tissues and organs of the body, especially for bone marrow and digestive tract. In addition, the tolerability of chemotherapy drugs is also one of the main reasons for failure of chemotherapy. Therefore, there is an urgent need to find a better way for the treatment of leukemia and systemic tumor.

Trans-resveratrol obtained from Shaanxi, China. It is a Chinese medicine from polygonum cuspidatum. It has a higher extraction rate of active ingredient resveratrol. The Resveratrol chemical name of the stilbene phenol, is a non-flavonoid polyphenols, plant resistance to outside stimulus such as ultraviolet light, fungus, virus infection or mechanical damage, a phytoalexin. Although the anti-tumor effect of resveratrol have been confirmed in many cell lines, but there are large differences in the specific application of dose in the different studies.

In vitro cell culture, and observed the effect of different concentrations of resveratrol on the cell. Resveratrol treatments, the cells in each group are different degrees of morphological changes and apoptosis. Resveratrol growth inhibition with strong pro-apoptotic effects. And resveratrol in play at the same time on the cytotoxicity of leukemia cells does not affect the growth of normal cells. In view of the anti-tumor chemotherapy drugs on normal cells tend to cause non-specific killing of resveratrol extracted from Chinese herbal medicine or natural plant not only has good anti-tumor effect, but no obvious cytotoxic effect on normal cells. Therefore, the immune deficiency crowd even more important value.

A growing number of studies have found that a considerable portion of the blood system the occurrence of diseases related to abnormal regulation of hematopoiesis. Leukemia is a malignant clonal disease of hematopoietic stem cells, the path of sustained activation of the abnormal proliferation of leukemic cells to apoptosis blocked and is closely related to differentiation obstacles. The STAT family is a group of DNA binding proteins, and tyrosine phosphorylation of signaling pathways coupled to play a transcriptional regulatory role, mediated by a variety of biological effects, play an important role in the process of tumor development. The study confirmed that activation of STAT3 signaling to the tyrosine kinase signal integration, combined with DNA components, the activation and proliferation-related gene transcription, or increase the expression of antiapoptotic proteins, thus affecting cell survival and proliferation, eventually lead to cancer. Resveratrol can pSTAT3 expression in a dose-dependent weakening of cell. Prompt it is blocked by down-regulating the activity of STAT3 tyrosine phosphorylation, its downstream target gene protein Bcl2 expression, thus it inhibits the growth of leukemia cell proliferation and promotes apoptosis.

Many anticancer pharmaceutical raw materials can induce tumor cell cycle arrest. They suggest cell cycle arrest can play a role in tumor cell apoptosis. Resveratrol plays a inhibiting and proliferation role on leukemia cells through interfering with DNA replication. In different cell lines, the ways that resveratrol plays its role are not the same. At present, for how resveratrol affect the cell cycle, scientists from various countries has not yet reached a consensus. Therefore, it is necessary to further study and reveals the exact molecular mechanisms of resveratrol’s anti-tumor effect.

Source:http://www.cospcn.com

Important reasons for men's hair loss

There are many factors for human’s hair loss. The genetic factor is the most direct reason. In some family, some family members have very similar hair types: sparse hair that progressive occurs from the forehead on both sides and top of the head. This alopecia genetic is called as male baldness. Genetic alopecia is difficult to treat, because the gene has already decided everything. However, most of men are not so unfortunately. Their hair loss is often caused by acquired factors. As long as to be able to promptly find the reason and treated it, it is possible for their hair growing back. There are many hair loss drugs on the market today. Among them, minoxidil is one kind of most effective drugs.

A lot of the occurrences of skin or hair loss are related with eating habits. The seeds of some plants, heavy metals, excess vitamin A can lead to hair loss. Even more frightening is that they may cause chronic damage to the body. The hair loss is sometimes a representation of the internal body conditions reflect. The endocrine system diseases often affect hair growth. Such as hyperthyroidism can cause hair loss. The same time, it will be accompanied by some other change in the body, such as sweating, palpitations, emotional irritability. The occurrence of similar symptoms to the hospital to do a comprehensive inspection, effective control of thyroid function, so that the lost hair grows back. When serious illness or high fever a few days later, you may find the hair, this is a temporary phenomenon. It may also spread to other parts of his body hair. However, with the rehabilitation and strong of body functions, the hair will gradually grow.

Receive long-term X-ray radiation exposure, and will accelerate the male hair loss. Long been engaged in radiation medicine doctors are also not spared. It will not only bring disaster to his hair, but also pose a great threat to his health. The protection of scientific, strict isolation and the necessary rest and adjustment is the key to prevention.

In many cases, hair loss is because of its excessive repair. Such as repeated perm, frequent power blowing, or use inferior products. Adequate sleep at any time to ensure that the first element of the quality of hair. A good rest is the best hair tonic. Lack of sleep, even if less than serious point of hair loss, and also make the hair look lack luster, or not enough fluffy. To remind him not in the nervous always nervous to involve their own hair, the shower, the water temperature is not too high, not to it and rubs the hair. Hair in the wet state is most likely to suffer. But do not have to because of fear of hair loss, and dare not touch the hair. Because the accumulation of dirt, dandruff, dust, will stimulate the scalp, caused by inflammation, so that the hair loss.

The main component of hair is sulfur-containing amino acids. It should be ensured that daily intakes are rich in amino acids, protein, vitamin B and vitamin A food. Currently, the most effective cosmetic raw material in treatment of male hair loss is undoubtedly the minoxidil. Male hair loss can use the topical minoxidil. After some months, it will be effective.

Source:http://www.cosprm.com

Docetaxel inhibits the proliferation of MKN45 cells

Docetaxel is a semi-synthetic anticancer drug processing from the European yew needles extract. Its structure is similar to paclitaxel. Sources of docetaxel are more accessible compared with paclitaxel. The killing effect of certain tumor is 2 times than that of paclitaxel. It is still valid to some resistant cells of over-expression of P-glycoprotein. But the role of docetaxel in gastric cancer cells can not be fully understood.

Docetaxel significantly inhibited MKN45 cells with increasing concentrations. The inhibition of MKN45 cells was significantly enhanced. Gastric cancer cells to different concentrations of docetaxel treatment, the cells were collected, respectively, by agarose gel electrophoresis and TUNEL assay results showed that the apoptotic index of treated cells was significantly higher, DNA gel electrophoresis showed obvious ladder map, and concentration-dependent manner.

Docetaxel-treated cells, the cells were collected at different times, respectively, using real-time quantitative PCR and Western blot analysis. The results showed that, compared with the control group, treated mRNA and protein levels were significantly lower. Docetaxel has been used in clinical treatment of gastric cancer, but the mechanism of action of gastric cancer cells is not fully understood. The scientists used to docetaxel treatment MKN45 cells from apoptosis and survival gene.

Apoptosis in the regulation of cell proliferation, plays a key role in tumor formation and development. With different concentrations of docetaxel treatment of gastric cancer cells, cells were collected at different times, respectively, found using TUNEL and agarose gel electrophoresis, treated cells showed significant apoptosis was time-and concentration-dependent manner. At the same time, the malignant proliferation of gastric cancer cells was inhibited, and the concentration of the drug. These results indicate that gastric cancer cell proliferation was inhibited, and may be related to induction of apoptosis.

There are two classic apoptotic pathways, namely the death receptor pathway and mitochondrial pathway. Inhibitor of apoptosis protein family is from the inhibition of apoptosis in apoptosis signal transduction pathways of these two. Survival factors are an important member of the IAP family. The study found that survivin is rarely expressed in the differentiation and maturation of cells and tissues, but highly expressed in embryonic tissue and not fully differentiated tissues, high expression in a variety of tumor tissues, including lung, breast. Survival factors expression and tumor resistance enhancement and patient survival in non-small cell lung cancer, stomach cancer, neuroblastoma, to lower them. High expression of survivin in gastric cancer tissues, while no expression in adjacent tissues. This high expression was positively correlated with apoptotic index decreased, and tumor invasiveness of gastric cancer.

After docetaxel’s treatment on gastric cancer cells, the scientists test the PCR and Western blot analysis of mRNA and protein levels. Pharmaceutical raw materials suppliers find that the in treatment groups, the survival protein and mRNA decrease. In addition to the decreasing of survivin expression, the level of tumor cell apoptosis has a corresponding rise. According to the statistical analysis, they show a positive correlation. Survivin plays an important role in docetaxel-induced apoptosis of gastric cancer. The study declares that in vitro, docetaxel can significantly inhibit the proliferation of gastric cancer cells. Its mechanism may be related to induction of apoptosis and downregulation of survivin gene expression.

Source:http://www.cospcn.com

Biotin and amino acids have impacts on lincomycin biosynthesis

Lincomycin is an efficient broad-spectrum antibiotic. In clinical trials, it is used for the treatment of diseases caused by the anti-gram-positive bacteria. Lincomycin A and lincomycin B have different pharmacological effects. The antibacterial activities of lincomycin B are weaker than lincomycin. But it has stronger toxic side effects. In Chinese market, the B content in the finished product must be less than 5%.

Lincomycin is lincosamides antibiotics, L-tyrosine and the pentose phosphate cycle intermediates condensation of the entire biosynthetic pathway, including two branches: one by the L tyrosine synthesis of C proline (PPL,), another sedum sugar phosphate constitutes α amine methylthio forest. The speculation lincomycin A biosynthetic pathway has been reported in the literature. And it is proposed that tyrosine is the main precursor of first branch.

D biotin is an essential growth factor for many micro-organisms. Biotin acetyl-CoA carboxylase, pyruvate carboxylase, propionyl CoA carboxylase and 3-methyl croton-CoA carboxylase coenzyme composition, its glucose metabolism, fatty acid metabolism and protein and amino acid metabolism have greater impact. L-amino acids has a very important role in growth and metabolism of microorganisms, one hand, they can be generated through deamination. Transamination reaction of substances have a stimulating effect on the growth of microorganisms, such as a branch of fatty acid, on the other hand, after decarboxylation and other multi-step reaction generate pyruvate, oxaloacetate, propionyl CoA and succinyl-CoA such as the strengthening effect of the citric acid cycle.

In low concentration range, lower the biotin concentration is, greater the predictive value will be. Between the biological potency the valine, glutamic acid and valine, leucine and tyrosine, it gas has a significant impact on the biological potency of positive synergies. Valine and methionine has impact on the biological potency of the antagonistic effects of high and low methionine concentration of valine concentration, predict the efficiency of higher value. Low concentrations of biotin Lim Streptomyces glucose metabolism, lipid metabolism and amino acid metabolism, the role; higher demand for forest Streptomyces glutamate may be due to their participation in more deamination and amino transfer reaction to generate more α-ketoglutarate and other intermediate products.

α-ketoglutarate and other intermediates of the citric acid cycle on the one hand strengthen the role, on the other hand the lincomycin generate rich intermediates; valine and leucine for the branch amino acids, their deamination can generate the branched-chain fatty acids, have a stimulating effect on the growth of the lim streptomyces. Cosmetic raw material tyrosine can increase the synthesis rate and yield of the Lincomycin A forest can amphotericin A synthesis of precursors, fill the desired amount of precursor; methionine go A Keeling amine methyl transfer reaction of methyl donor, the synthesis rate of its lincomycin may have greater restrictions on the role of valine lincomycin growth stimulating effect, the bacteria body growth and synthesis of lincomycin in a way that a mutual checks and balances, so that it reflects the performance of antagonism between methionine and valine.

The syntheses of lincomycin require a higher bacterial concentration. So in the medium, it should increase the valine concentration appropriately and reduce the concentration of methionine. In the chemical synthetic, the chain mold fermentation can be used in production of lincomycin. In the two-level factorial design experiments with biotin and amino acids, the scientists find out that there are 6 factors which have significant impacts on biological potency: D biotin, L glutamic acid, L valine, L-methionine, L leucine and L-tyrosine.

Source:http://www.cosprm.com