Side effects of minoxidil

Minoxidil is a peripheral vasodilator. For local long-term use, it can stimulate hair growth for male pattern hair loss and alopecia areata patients. There are several years’ history for minoxidil using in the treatment of hair loss. The direct role of minoxidil in the hair follicles can increase the proliferation and differentiation of hair follicle epithelium and it will stimulate the hair follicles so that hair after stopping hair medicines does not rely on drugs and can continuous grow. Minoxidil as a potassium channel activator can increase the potassium ion permeability and will prevent calcium ions from entering into the cell. And if the calcium ions exist, epidermal growth factor will inhibit hair growth. Practice has proved that the 5% minoxidil solution is stronger, faster and more efficiently than the role of 2% minoxidil solution.

China is currently in a lack of detailed pharmacokinetic study in minoxidil information. Minoxidil solution skin after topical application of minoxidil absorbed through the skin is poor, and minoxidil Seoul tablets after oral administration, the gastrointestinal tract almost are completely absorbed. 1ml of each dose of 2% minoxidil solution, transportation 20mg minoxidil into the skin, the results of about 0.28 mg minoxidil E1 is absorbed. 1ml of each dose of 5% minoxidil solution, transportation 50mg minoxidil into the skin, the results about 0.70mg minoxidil to Seoul to be absorbed. Whether this absorption effect accompanied by a skin disease is still unknown.

After topical administration of the minoxidil solution, plasma concentrations of minoxidil and biotin are controlled by the drug percutaneous absorption rate. The cessation of the topical application of minoxidil solution, about 95% of minoxidil absorbed into the body within four days cleared. After topical application, the absorption of minoxidil metabolism, conversion is not fully clear, but the absorption by the oral administration of minoxidil mainly by glucuronic acid and send pyridine ring on the N-oxygen combination transformed into a very more a product of, the pharmacological effects of the metabolite is less than minoxidil. Minoxidil does not, and plasma protein binding, and its renal clearance and glomerular filtration rate. Minoxidil can not pass the blood-brain barrier. Minoxidil and its metabolites are mainly excreted though the kidney.

In the beginning, the minoxidil is used as a drug in the treatment of hypertension. Then later it is discovered that after hair loss patients with hypertension use minoxidil, hair loss situation has been improved. Then minoxidil is used in the treatment of hair loss. From above, it can be said that it is the result of side effects for minoxidil in the treatment of hair loss. 5% degree minoxidil solution is non-prescription medicine in the international market. Source:http://www.cosprm.com