2012年4月4日星期三

Irinotecan plus cisplatin can be used in treatment of cervical cancer

Cervical cancer is one of the most common gynecological tumors. Cervical cancer surgery is indicated for patients in early stage of I a-II b, and II b late stage patient who lose the chance of operation. Irinotecan plus cisplatin chemotherapy in the treatment of cervical cancer can reduce cervical cancer stage and increase the chance of operation.
Acute cholinergic syndrome patients have short-term and severe acute cholinergic syndrome, such as sweating, chills, nasal congestion, dizziness, watery eyes, blurred vision, abdominal pain, muscle contraction, spasm, limbs and somatosensory abnormalities. Chemotherapy should look carefully at the patient have a history of glaucoma, the day of treatment to avoid eating lactose, caffeine, fried foods and soy ingredients drug. Because of use of irinotecan in patients with acute acetylcholine syndrome, prophylactic use of atropine. Intensive care during chemotherapy. Irinotecan plus cisplatin by the liver, renal excretion, renal toxicity. Patients with liver and kidney dysfunction, attention to urine output change, encourage the patient to drink plenty of water to give a hepatoprotective drugs, regular monitoring of liver and kidney function indicators.
Decrease of white corpuscle is referring to the dose-limiting toxicity. It is reversible. Neutropenia to the lowest point is 8 days after treatment, the incidence rate of 78.7%. In order to prevent bone marrow suppression, chemotherapy guidance of patients with oral the Burnet l white film, the WBC is lower than 4.0 g / L with not medication. The WBC is less than 3.0 g / L. It considers a moratorium on the medication while the WBC is lower than 1.0g / L with protective isolation, intramuscular injection of granulocyte colony stimulating factor WBC. Prevent infection, chemotherapy patients into one ward, to keep the ward air flow and avoid the crowd flow. Glutathione has daily ultraviolet disinfection, guiding the patient to keep warm, observe good personal hygiene, increase nutrition and enhance the body resistance.
The observation of abdominal pain and diarrhea and the number of characters can prevent the occurrence of pseudomembranous colitis, water and electrolyte disturbance. Instruct patient to pay attention to food hygiene, bed rest, to prevent collapse, severe diarrhea, occasional fasting, diarrhea alleviate those into the light digestible food; do the skin around the anus clean and dry to prevent the perianal skin and mucous membranes due to moisture repeated stimulation and injury, the patient anus of each will be required to use warm water and wipe dry. 18% of patients with constipation, and guide the patient appropriate activities, crude fiber foods eat, drink honey and water.
After using the irinotecan, hair loss incidence is 95%. After stopping, it can have self-healing. Giving the patients necessary psychological counseling is necessary. Help patients ready for a wig or hair cut short and avoid the force pulling on hair. People can use good shampoo to keep hair straightened; medication 10 min before the ice cap or head intermittent tourniquet tie can reduce head blood circulation to prevent the shedding of hair have some preventive effect.
Comparing to the common anticancer drugs, adverse reactions of irinotecan plus cisplatin treatment have a certain degree of particularity. To do all the preparatory work before the plant extracts medication to strengthen psychological care and allow the active participation of patients and their families are right behaviors. In drug use time, people should observe closely to prevent the occurrence of anaphylactic shock and timely treat acute acetylcholine syndrome. For the care of bone marrow suppression, monitoring of white blood cells and liver kidney function, people can start from the disinfection and isolation, strict aseptic technique to be effective in preventing infection. For gastrointestinal reactions, it includes nausea, vomiting, abdominal pain, and diarrhea. The timely detection and timely treatment can reduce the incidence. Source:http://www.cospcn.com