Capsaicin impact on the gastrointestinal tract

There is a big controversy on the reports about capsaicin on gastrointestinal cancer, and some studies by pharmaceutical raw materials suppliers suggest that capsaicin can inhibit tumor cell, also some researches found that the capsaicin can promote tumor cell proliferation, there are some reports show that capsaicin has no effect on tumor cells. Researchers doing more researches about capsaicin on gastric motility, most of them reported that small doses the capsaicin can promote gastric motility, large dose of capsaicin on gastric motility have inhibition role.

Effects of capsaicin on gastric mucosa, in recent years, there are many international studies have shown that the right amount of capsaicin on gastric mucosal have protective effect. The probability of Chinese people in Singapore suffering from gastric ulcer is three times than Malaysians and Indians, and may be related with Malaysians and Indians eat more chili. Capsaicin, capsaicin-sensitive afferent nerves and capsaicin receptor and gastric mucosal injury and repair are closely related. Capsaicin-sensitive neuron cell body is able to synthesize tachykinins of substance P (substance P, SP), neurokinin peptide A (neurokinin A) to the axon terminals transport of these peptides. Stomach CSSN through the release of calcitonin gene peptide (calcitonin gen related peptide, CGRP) increased gastric mucosal blood flow, and a series of reactions mediated by CGRP, thereby increasing the gastric mucosal resistance to maintain gastric mucosal integrity. Acid-induced gastric ulcer, congestive reaction capsaicin sensitive afferent neurons by regulating CGRP release to promote the role of the acid treatment of the gastric mucosa, thereby treating gastric ulcer.

The functional activity of the CSSN gastric acid and gastric mucosal blood flow is more important to the regulation of gastric mucosal blood flow. Intragastric perfusion with peptone, causing an increase in gastric acid secretion and gastric mucosal blood flow; terms of the capsaicin afferent denervation weakened the intragastric peptone caused an increase in gastric acid secretion effect, increase in gastric mucosal blood flow effects almost completely disappeared. The surface mucosal growth factor by capsaicin-sensitive afferent nerve play the congestive role and protecting the stomach and gastric mucosa. Gastric mucosa dominated by the vagus nerve and spinal afferent, when gastric mucosa stimulated by harmful chemicals, these afferent nerve though increased gastric mucosal blood flow to protect and repair the gastric mucosa.

Capsaicin have certain effects on gastric acid secretion, the majority of studies by capsaicin supplier have shown that small doses can inhibit gastric acid secretion, large doses may promote gastric acid secretion, also some reports chain that a certain dose of capsaicin has no effect on gastric acid secretion. Capsaicin may through directly stimulate the central, peripheral capsaicin-sensitive sensory nerve and Pik cells capsaicin receptor, causing calcitonin gene-related peptide, P substance, neurokinin A, vasoactive intestinal peptide neurotransmitter release to participate in the regulation of gastric acid secretion.

Capsaicin on gastric cancer cells have significant growth inhibition and induction of apoptosis in a dose-and time-dependent manner, mainly through the regulation of Bax, Bcl-2 and C-myc protein expression to achieve. Capsaicin dose relationship manner to reduce the cell viability of the human colon, capsaicin also cause the fragmentation of the changes in cell morphology and DNA, DNA content decreases, phosphatidylserine shift, wherein phosphatidylserine of the shift marks cells apoptosis. The mechanism of capsaicin-induced apoptosis may be semi-caspase 3 (a major apoptosis-inducing enzyme) activity is enhanced. At present, the international community about the effects of capsaicin on gastrointestinal health research relatively large, but its mechanism of action is relatively weak, especially affect the outcome of colorectal cancer and its mechanism should be further explore.

Source:http://www.cospcn.com

Discussion on the role of vitamin A acid

Recently, a relative researches reported that isotretinoin can cause a rare and serious skin damage. The experts pointed out that this report is not meant isotretinoin will not be used to treat acne, but to remind patients with moderate to severe acne use any drugs must be ask the doctor, or it will be harmful to health.

Isotretinoin is called the "ultimate weapon" in the treatment of acne. Experts said that isotretinoin is one kind of vitamin A acid, is a derivative of vitamin A. According to reports, the vitamin A acid is the recipe for treating skin diseases, such as psoriasis can use vitamin A acid drugs to treat. Careful consumers will find that in some skin care products have an ingredient called vitamin A acid. Vitamin A acid used as cosmetics material may be instead of acid which dominate the world in the past few years, vitamin A acid can penetrate the skin cell nucleus, to really improve the skin from the inside to the outside, make skin have a healthy glow luster, and tretinoin almost does not exist discomfort issues that must be considered.

Vitamin A acid on skin have the following three advantages: promote skin metabolism, improve skin rough, dry, make dull skin looks a shiny. Perfect the organization of the skin stratum corneum, strengthen the skin's elasticity, a sense of transparency, so that the skin looks soft, white, and more healthy. Clear accumulation of dirt in the pores, shrink pores, has an antibacterial effect. The feeling of different skin use the skin care products containing vitamin A acid is different. But is this good medicine, with very large toxicity. Long-term use of vitamin A acid drugs are toxic, so that patients even in strict accordance with the instructions to medication should also regularly check blood and liver function. Since oral toxicity, then does the topical use will be more secure? Though topical use isotrenoin ointment did not cause a lot of toxicity to body, but caused larger skin irritation, for some thin skin people even will cause part of the exfoliation after run out.

Tretinoin manufacturer pointed out that, in the treatment of severe acne, sometimes it may need to use this drug, so must be used under the guidance of a doctor, should not purchase this medicine by your own. Special reminder, due to a lot of acne treatment drugs in the early development stage, children less experience in the application, even if some minors with serious acne should use carefully. In addition, to prepare pregnant women should want the baby after six months they run out the medicine, otherwise it may cause fetal malformations.

Patients need to be reminded that the face acne since pustule, it is better to go to the hospital to deal with, but not to squeeze it yourself, because this is likely to cause the surrounding tissue infected destruction, even cause serious intracranial hemorrhage. For the early acne, only need to wipe some outside medicine, such as some antibiotics, simple vitamin A acid and Chinese medicine. If developed to a certain extent, such as more pustule, it need to identify the cause, for some serious acne may need oral medication to treat.

Source:http://www.cosprm.com

The lure of chili

Do not know what time does it start, Chinese people is more and more love spicy. Today, nearly half of the world’s peppers are produced by china; chili acreage has more than turnips and tomatoes in China, second only to cabbage, it becomes Chinese second largest vegetable.

When the pepper burning stimulate the taste buds; whether summers or winters, North or South, both men and women were falling in love with that eat profuse sweat, hooked feeling, "spicy" is unwittingly become the taste that most people can not live without it. It allows us to increased appetite, hearty, quietly took away the pressure of a busy day accumulated. In the end, what kind of charm does the chili have, whether you can eat spicy food truly?

Spicy charm is a kind of "pain", the researchers had been research peppers for up to 5 years, the first division of the Chinese territory of spicy food spiciness: "hot zone" in the upper reaches of the Yangtze, including Sichuan, Hunan, Hubei, Guizhou, Shaanxi, southern, spicy Index 151-25; northern "mild area, including Beijing, Shandong, Shanxi, northern Shaanxi and Gansu most, Qinghai to Xinjiang, spicy index 26-15; southeast coast, south of Shandong, Jiangsu, Shanghai, Zhejiang, Fujian, Guangdong, compared to avoid spicy "light zone" spicy Index 17-8. the most favorite to eat spicy food is Sichuan, the second is Hunan, the third is Hubei.

Why pepper make people more eat more addictive? Pepper charm comes from a " pain ". And the sweet, bitter, salty, sour, strictly speaking, " hot" is not a taste, but the body burning irritation. The stimulation sense brings pain, let the body to secrete large amounts of endorphins to resist, and the EP also can let a person produce the feeling of pleasure. Therefore, when the pain stimulus fading, the body's stress also releasing slowly.

Eat spicy not only make people feel happy, in fact, as pharmaceutical raw materials, pepper itself is rich in nutrition, has many health benefits. First of all, in the hot pepper, various vitamins and content is extremely rich. A small pepper include vitamin A, vitamin B, vitamin C, vitamin E, vitamin K, carotene, folic acid adn all kinds of vitamin. Secondly, pepper also contains calcium and iron and other minerals and dietary fiber.

Peppers including stem pepper, fresh pepper, pickled pepper, capsaicin supplier recommend that it is better to eat fresh pepper, because it contains more nutrients. In addition, peppers had better cooked to eat. Because chili contains a large number of capsaicin, may have on oral and gastrointestinal mucosa irritation. After heating, the gastrointestinal stimulation will decrease.

Although eat spicy is fun, but eating too much also make people can’t stand it. Experts teach you solution hot method: eat more sweet and sour food. Sweet can cover and interference with spicy, acid and alkaline of capsaicin. Feel too hot, dipped in vinegar to drink a bowl of cold, sweet drinks, eat a cool fruit are very useful. If you are doing at home again, try to choose nourishing Yin, dry down, pours hot food to match, such as the duck, shrimp, crucian carp, bitter gourd, sponge gourd, cucumber, you can also cook cool mung bean porridge, lotus leaf porridge to relieve inflammation. The pepper, due to personal physical fitness is different, the bear level is different. Cold hands and feet, easily anaemic person can eat more. Have gastric ulcers, esophagitis, hemorrhoids, and hyperactivity of fire due to yin deficiency, often constipation, acne people should eat carefully.

Source:http://www.cospcn.com

The new method and its advantages of biotin remove wrinkles

Many people who pursuit beauty feel that new method of biotin remove wrinkles should have better effects, and this is the way it should be, Although these materials of wrinkle injections is the same as usual, but the development of science and technology making these methods have the improved efficacy and safety, you can chose it trustingly. And compared to the traditional method, there are many advantages of this new method, which has a non-invasive, and not need to rest, does not affect the work; effect immediately. But the maintaining time is short, need to regularly repeated injections. The clinical effect of botulinum toxin injection generally can be maintained for 3 to 6 months. Cosmetic raw material suppliers pointed out that the materials of medical biotin remove wrinkles new method used are as the following:

The hydrogel: Is the chemical synthesis of macromolecular polymer. Disadvantages: it is a foreign body, prone to rejection. Hyaluronic acid: the inherent human body composition, methods of operation, safe use, fast effect. It applies to any part of the body, no rejection, repeated injection. Currently very popular in the world. Collagen: extracted from calf or human placenta, only filling the role. Disadvantages: is an allogeneic or xenogeneic protein may occur rejection, but also maintain a relatively short time. Goat embryo essence: China is almost no the pure product, it is the separation of the different components in the sheep embryo, which may contain thymosin, growth hormone and other ingredients and cellular debris. Different people use different preparations. Biotin remove wrinkles new method generally refers goat embryo essence wrinkle. Botulinum toxin: botulinum toxin secreted by a muscle contraction inhibitor, for functional wrinkles work.. Disadvantages: applicable eyelids, orbital and cheilogramma.

However, biotin supplier also said that biotin remove wrinkles new method has now been used very widely, and its operation still have a certain degree of risk, so it should be doing some considerations. Prior to use should clean the face. Prohibition against alcoholic drinks a week. Two weeks before surgery should not use aspirin or other antipyretic analgesics. Learn more about the patient history of major diseases, allergies, facial cosmetic surgery history. Postoperative care work: 4 hours after injection, quiet rest. Keep the body upright. Within 24 hours, not to do strenuous activities. Do local massage, to prevent liquid enters the orbit causing ophthalmoplegia.

As for the advantages of bio-wrinkle injections plastic surgery, Experts pointed out that the main advantages of the following four points: 1. Biological injection can be absorbed by the body, do not need recovery period, after the bio-wrinkle injections you can work immediately. This method is to achieve the purpose of treating wrinkles, its domination nerve paralysis role biologics, this biological rhytidectomy do not need recovery period, just a few minutes you can go straight home or to the office; this method can remove wrinkle accurately, quick effectiveness. Facial subcutaneous injection of trace amounts of biological agents in a short period of time accurately eliminate facial intensive fine wrinkles, such as the outer canthus in the forehead, between the eyebrows, eyes, cheeks, mouth, neck wrinkles, make the skin shiny and elastic; side effects better conditioning of the human body, promote circulation, improve the immune system. Has a role in health care. Finally, experts say the final advantage of bio-wrinkle injections plastic surgery is no need to perform an operation, no adverse reactions also an advantage of biological rhytidectomy.

Source:http://www.cosprm.com

Resveratrol is a potent antioxidants can protect the heart and brain

According to the information supplied by resveratrol manufacturer, the highest content of resveratrol is Aster plants in Japan, followed by grape skins. Red wine, pure grape juice, peanuts, cranberries, blueberries, bilberries and some the pine also contain resveratrol, the concentration is slightly lower than the first two things. Grapes and other plants manufacturing resveratrol is for fighting fungal infections, injury, stress; is part of their natural resist system. The amount of resveratrol in red wine is different from geographical production areas, cultivation conditions, fungal infections, as well as red wine and grape skins mixed time. The content of resveratrol in red wine is from less than 1 mg per liter to more than 20 milligrams per liter.

Red wine contains strong and effective polyphenol antioxidants: resveratrol, anthocyanins (the pigmented substances in grape skin), proanthocyanidins (common in grape seed), catechol and quercitrin. Use mice as experimental research show that resveratrol in the prevention of prostate cancer, colon cancer, and thymic carcinoma. Resveratrol showed multiple stages in the development of cancer, including tumor initiation, tumor induction period, the period of tumor development and metastatic the antagonism can play. Allegedly a week often drink three glasses of red wine and even more among the 3% of colon polyps or colon cancer, while drinking more than 3 cups white wine (white wine grape skin fermentation time is shorter, containing resveratrol week the amount of alcohol is less), the ratio is 9%. Compared the results of no drinking and the results of people drinking white wine is similar.

Resveratrol as pharmaceutical raw materials also can be called red wine or pure grape juice, the suffering Alzheimer's mouse experiments showed that they can protect the brain and cognitive function, and alcohol (equivalent to the percentage of ethanol in wine) or water without protection function. Red wine in the protective effects of alcohol on the brain and cognitive function has no effect. One of the mechanism of Alzheimer is β-amyloid produce excessive, and subsequently cause brain damage. Resveratrol motivated a sirtuin protein, people found sirtuin protein can protect neurons against beta-amyloid - induced free radical damage of DNA. Resveratrol promote dangerous beta-amyloid diminishes. It is thus assume that resveratrol may prevent age-related neurodegenerative diseases, such as Alzheimer's disease.

Compared with nondrinkers aging population older persons of Chinese nationality, little product or moderate alcohol consumption make the risk of suffering from Alzheimer's disease lower 37%, and vascular dementia is as low as 69%. In contrast, excessive alcohol consumption will be increased the risk of dementia. Slightly moderate alcohol consumption may significantly reduce the risk of dementia. Compared with people who never drink beer and slightly moderate drinking beer, the risk of dementia may be significantly higher. In a study from France, the daily consumption of 3-4 glasses of wine, the risk of suffering from Alzheimer's disease fell by 75%, and drink less than one glass of wine a day is reduced by 45%.

Sirtuin protein manage gene silencing, DNA repair, mitochondrial function, control of cell aging and arrange for their deaths. 95% of our cellular energy from mitochondrial manufactured end product of adenosine triphosphate (ATP), ATP is the energy chemical repository. The number of mice treated with resveratrol increases, the mitochondrial energy produced increases, oxygen capacity increases.

Source:http://www.cospcn.com

The high risk of isotretinoin induced depression

Recently, the researchers said in a statement, the hospitals often abuse a drug called isotretinoin to treat acne, but the side effects of this drug is very obvious, even some patients suffer from depression and suicide. According to tretinoin manufacturer, isotretinoin and tretinoin were using in treat acne. Dermatologist reminded acne patients that medication should according to doctor’s instruction, do not overdose or drug treatment. Skin damage, mental disorders and other symptoms during treatment should be discontinued immediately and seek the physician medication guide or correct.

Topical isotretinoin cream or gel, after 5-12 days medication will cause slightly skin irritation, such as local flushing, desquamation, tight or burning sensation, but gradually disappeared. Therefore, you should start using from the low concentration, using one time per night, avoid increased drug irritating after exposure. There are five major risk of oral isotretinoin, teratogenic, mental disorder, severe skin damage and so on.

Serious teratogenic effects of isotretinoin is known to mankind, including craniofacial deformities, central nervous system abnormalities, cardiovascular malformations. Already pregnant, prepare for pregnant and lactating women disabled to use this drugs. Women in childbearing age before using isotretinoin should take pregnancy test to ensure not pregnant before starting medication. During medication and after withdrawal within three months, childbearing women and their spouses should take strict contraceptive measures (many countries recommends two measures of contraception) to ensure that no pregnancy.

Isotretinoin may cause mental disorders. Rare adverse reactions can occur in patients with emotional instability, mental abnormalities, and may exhibit aggressive behavior, depression, suicidal ideation, suicide attempts or suicide. Therefore, before the doctor taking isotretinoin should be asked whether patients with a history of mental disorder, express may cause severe mental disorders and the consequences to the patients clearly.

Isotretinoin is related to benign intracranial pressure (also known as pseudotumor cerebri) elevated, and use tetracycline class of anti-infectives may increase the incidence of adverse. Patients, such as headache, nausea, vomiting, visual disturbances and other symptoms, seek medical attention immediately for investigation. In order to prevent the occurrence of pseudotumor cerebri, should avoid the simultaneous use of tetracycline drugs.

According to cosmetic raw material suppliers, Isotretinoin may also cause serious damage to the skin, such as dry lips and skin, cheilitis, desquamation, rash, itching, skin fragility increased allergic reactions. In addition, the drug, as well as hearing and visual impairment, osteoporosis, elevated liver enzymes, inflammatory bowel disease, acute pancreatitis and other side effects. Patients should according to dosage and administration in the instructions or your doctor prescribed, carefully read the instructions, adverse reactions should consult doctors, once show up serious adverse reactions should be immediately discontinued.

Isotretinoin is effective drugs for the treatment of acne, but potentially serious adverse reactions can not be ignored. Physicians are advised to learn more about the isotretinoin’s contraindications, adverse reactions, precautions, interactions, and safety information, before prescription isotretinoin asked in detail about the patient's allergy history, disorder history (such as mental disorders, hyperlipidemia, liver damage), a joint drug use, female pregnancy, the potential risks of medicines information to communicate with patients, weigh the pros and cons of medication.

Source:http://www.cosprm.com

Eat chili help anti-cancer

Recently, the scientists have found that often eat spicy foods which are rich in capsaicin can prevent or control cancer. As pharmaceutical raw materials, capsaicin has been used to treat psoriasis and other diseases, is expected to become a core component of the next generation of anti-cancer drugs.

Pepper’s origin and its history in China: chili also known as Capsicum, originating in South America. It is an annual herb Solanaceae. Is a perennials tropical regions in the south. Pepper’s fruit shape is diversity, Longhorn, ellipse, oval, spindle; peel colors are red, green, yellow, purple; the spicy is different with the fruit overturned or down to the other. The pepper’s vitamin C content is the best in vegetables: bright color, aromatic flavor, moderate spiciness horn peppers in Ningdu, one hundred grams of pepper content 10.54% protein, 8.2% fat; seeds containing protein 16.83%, fat 21.15 %, the vitamin C content is up to 172 mg, lysine content is also more abundant. So people call it bag of nutritional spicy. The chili is warm and invigorating stomach, insecticidal efficacy, attending to the stomach to spot present, indigestion, rheumatism, lumbago, mumps, multiple boils swollen embolism. Capsaicin is also a potential anti-cancer substances, and antioxidants.

The chili has important medicinal value: The dinner is not fragrant, reduce appetite, put some pepper in the food can improve appetite, increased appetite. Alone with a little pepper decoction taken orally, can cure the poor appetite cause by cold, abdominal distension and abdominal pain. Drink the soup with chilli and ginger also can cure cold; particularly suitable for both dyspepsia patients.

Why pepper can invigorating stomach and help digestion? That it contains an ingredient called capsaicin, oral and gastrointestinal irritation, they are able to enhance gastric peristalsis, promote secretion of digestive juice and appetite improved, and can inhibit the intestinal abnormal fermentation, exclude the accumulation of gas in the digestive tract. Eating proper chili, is good for the people live in damp abode to prevent of rheumatism and frostbite.

Chili has strong refreshing effect, according to the study of capsaicin manufacturer: capsaicin, the chili’s spicy source, can stimulate the area of the skin and tongue feel pain and heat, the brain produces the spicy feeling of burning pain. Pepper stimulates the production of endorphins and serotonin, the "endorphin" is a "pain killer", it can lead to emotional upsurge.

Pepper can prevent heart disease: the chili can promote blood circulation, increase the flexibility of blood vessels, reduce the risk of hardening of the arteries, help prevent cardiovascular disease. Pepper is rich in vitamin C, with antioxidant effect, not only can enhance the body resistance, but also anti-aging.

Who is not suitable to eat chili: chili is a pungent and hot food, eat more will make inside exuberant inflammation, so those people deficient of yin should not eat pepper. Stomach problems, high blood pressure, eye disease patients also not to eat pepper; hepatitis, nephritis, pneumonia, sore throat, swollen boils patients should eat less. Pregnant women also should not regularly eat spicy food.

Source:http://www.cospcn.com