Chili was good but could not excessive consumption

Animal experiments showed that the capsaicin can extend longevity, dietary capsaicin can speed up the body's metabolism, so whether dietary capsaicin can protect the cardiovascular system, or reversal of cardiovascular function? The scientists conducted experiments in spontaneously hypertensive rats with hereditary vascular endothelial capsaicin receptor, capsaicin activate the capsaicin receptor, can significantly enhance vasodilation and reduce spontaneously hypertensive rats blood pressure. In addition, capsaicin also makes thinning of the cerebral vascular lumen diameter increased, thus preventing stroke. The study found that stroke type mice fed capsaicin, the average life expectancy of only 70 days, but fed capsaicin, the life span is 100 days. There are many causes of hypertension, dietary factors is just one of the experiments on mice only prove that eating chili no harm. The daily average to eat chili, eat what kind of chili, how to eat in order to prevent high blood pressure, is a very complex issue. Consider many people can not eat spicy food, perhaps structural transformation of capsaicin, the spicy sweet and more generally applicable crowd.

Experts think that capsaicin is useful but should not eat spicy food blindly, scientists mentioned the results of the epidemiological investigation is an objective reality, but does not let people eating spicy food blindly. First of all, we can not definitely determine whether capsaicin determine the incidence of cardiovascular disease in some areas, is the size of the activity, climate factors, other dietary habits different cause these results.

In addition, from the conclusion of the experiment in mice can not directly generalizable to have the same effect on human. The study itself is a good theoretical research, scientists did not recommend blindly eat chili. There was a research about chili and curry prove that capsaicin as pharmaceutical raw materials can promote animal cell metabolism, increase energy consumption, promote blood circulation. Also are many people who love spicy food, no studies have shown that people who love spicy food than people who do not love spicy and leaner. Capsaicin have many effects, such as benefits for cardiovascular disease, but no food is a panacea and perfect, beneficial to the body does not mean you can eat unlimited.

Capsaicin contact with mucosal can cause burning sensation and increased gastric acid secretion, like caffeine good for cardiovascular disease, but it may cause osteoporosis, capsaicin can also cause stomach ulcers, and some skin infections, constipation,hemorrhoids and so on, a place long-term eating habits have its ecological significance and rationality, but transplanted to other places, whether it’s suitable requires further study.

Different races, different groups of people, in the case of different genetic susceptibility, the impact of different outside eating is not the same. The proof capsaicin role in the prevention of cardiovascular disease in the animal experiments, can not be proved in the crowd. The prevention of stroke, cardiovascular and cerebrovascular diseases among the most important measures to limit salt, low-salt diet, especially universal salt intake too much for the Chinese people. Chinese people general lack of folic acid in the diet, Americans benefit of folic acid supplementation is very obvious. Strengthen the control of blood pressure in hypertensive patients, in all hypertensive patients, 50% of patients with hypertension-induced cardiovascular and cerebrovascular diseases, folic acid supplements, eat more fruits and vegetables, and foods rich in B vitamins, as well as emphasis on low-fat low sugar low calorie diet is very important, from the mass level, we do not recommend people to drink vinegar today and eat capsaicin tomorrow.

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The nature of glutathione

Glutathione is an important physiologically active substances, is from glutamic acid, cysteine ​​and glycine through skin key condensation of a tripeptide compound, is a widely used active polypeptide. Half of the γ-L-glutamyl-L phthalate cysteine ​​phthalocyanine glycine by its chemical name, the English name is L- Glutathione.

Glutathione is isolated from the yeast in 1888; in 1921, scientists extracted crystallized and conceived its structure; elucidate its chemical structure and synthesis team in 1935, Enzymatic synthesis of glutathione mechanismexplore in 1953; seventies of the last century, further study of the chemical synthesis of glutathione, focused on process improvements; eighties of the last century, due to the development of genetic engineering technology, glutathione supplier began to study the production of glutathione bacteria and(enzyme) production of glutathione immobilized.

The relative molecular weight of glutathione is 307.33, the melting point is 189 to 193 ° C, the crystal was colorless and transparent elongated granular, the isoelectric point is 5.93. It is soluble in water, dilute alcohols, ammonia, and dimethylformamide and not soluble in alcohol, ether and acetone. Glutathione solid is more stable, with water in the air is easily oxidized, and the two molecules also prototype active mercapto glutathione disulfide oxidative condensation, i.e. the oxidized glutathione. Expressed in ionic form, can be seen as the missing electron oxidation (SH compound is weakly acidic, H + SH group to). This reaction is reversible, so glutathione has redox role. Oxidized glutathione (GSH) and reduced glutathione was having a physiological activity can play an important physiological need to restore oxidized glutathione vivo function. Therefore, when extracting glutathione can be added substances in solution which having a strong reducing such as vitamin C, etc. when there is a strongly reducing material can protect glutathione is not easy to be oxidized.

Glutathione in the distribution of plants and animals, glutathione nature is abundant in many plants and animals. Very high levels in the baker's yeast, wheat germ and animal liver is 100 ∽ 1000mg/100g, 26 ∽ 34mg/100g containing in human blood, with blood containing 58 ∽ 73mg/100g , pig blood containing 10 ∽ 15mg / 100g, tomatoes, pineapple, cucumber, content is also higher (12 ∽ 33mg/100g), sweet potatoes, green bean sprouts, onions, mushrooms, low levels (0.06 ∽ 0.7mg/100g). The glutathione structure containing a reactive sulfhydryl-SH, the easily oxidized deoxidation, the specific structure makes it become the main body radical scavengers. The body metabolism of many free radicals can damage cell membranes, invasion of macromolecules of life, promote aging body and generate induced tumors or atherosclerosis. As a cosmetic raw material, glutathione can scavenge free radicals play a strong protective effect on anti-aging. For example, when cells generate a small amount of H2O2 and glutathione in the role of glutathione peroxidase will reduce H2O2 to H2O, and itself is oxidized to GSSG, GSSG by glutathione in the liver and red blood cells, glutathione under the role of reductase catalytic, accept H reduced to glutathione, a free radical reactions to be sustained. Glutathione is a very special amino acid derivatives, and mercapto group-containing tripeptide, so it plays an important role in vivo.

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The spicy characteristics of pepper

Pepper contains a substance called " capsaicin ", this is a kind of natural, green alkaloids. Different types of chili, the capsaicin content is not the same. Researches by capsaicin manufacturer found that sweet pepper does not contain capsaicin, and some pepper such as Mexico pepper capsaicin content is 5000 units, the Havana pepper capsaicin content is 300000 units, and the new Indian bhut jolokia capsaicin content is more than 1000000 unit. Capsaicin in hot peppers has 5 main components: capsaicin, two hydrogen capsaicin, down two hydrogen capsaicin, high capsaicin and high hydrogen capsaicin, wherein the capsaicin, two hydrogen capsaicin accounted for about 90% of total capsaicinoids, is the main component of pungency degree.

Pepper give the main feeling to human is " spicy ". what is the pepper’s characteristic? Stimulus characteristics. Pepper contains capsaicin and biochemical composition, has a strong irritating, can stimulate the skin and tongue feeling pain and hot region, so that the brain generate searing pain pungent sensation, i.e. when the hot peppery taste stimulate the tongue and buccal nerve endings, the brain will immediately in a general state of alert, such as heartbeat is accelerated, saliva or sweat secretion, gastrointestinal peristalsis accelerates, and the simultaneous release of endorphins. When the food is spicy, endorphins continuously release, will make people excited and have a spicy after " pleasure ". If repeated, taste cells on hot sensitivity increased significantly, spicy will become a kind of dietary habit slowly.

Medicinal properties. The spicy contains of pepper is mainly composed of capsaicin, drop two hydrogen capsaicinoids, high capsaicin, homodihydrocapsaicin, azelaic acid vanillyl amide, capric acid vanillyl amide, and pigment, lutein cryptoxanthine, red pepper, trace capsorubin, citric acid, malic acid are with important medicinal value.

Chinese medicine thought that pepper is spicy, hot, can warm the stomach, promoting blood circulation and relieving pain. Modern medical research shows that capsaicin has anti-inflammatory, analgesic and antipruritic effects, have been widely used for pharmaceutical raw materials. Many countries in the early ninety century have capsaicin compound capsule, both single and compound ointment preparation production. Currently used for analgesia of capsaicin and ointment has been included in the Pharmacopoeia in United States, Japan, Germany, Canada and other countries. Scientists found that red pepper contains large amounts of antioxidants, which can prevent free radical damage to the skin, and the free radical is the cause of premature skin aging and skin cancer. Many medical studies have also documented, capsaicin has the role of cancer prevention.

Adaptive behavior. Hot pepper spicy in taste generated continuously by the people's favorite, because chili spicy and people's physiology and psychology has good adaptability with the characteristics, such as tobacco and pungent material adaptability characteristics. Can better adapt to human's physiology and psychology need, it is an another important reason for chili can spread. It is the special spicy pepper promote human blood circulation, make people energetic; to promote the secretion of saliva, increasing appetite; promote the rich taste, let people enjoy more and better spicy food.

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Indications and precautions of retinoic acid

Vitamin A acid can make early gastric cancer cell changed, early cancer and dysplasia can make it back to normal. For the treatment of acne vulgaris (inhibition of sebum secretion, reduce hair follicles, sebaceous tube abnormal keratosis, is not conducive to bacteria breeding in the epidermis), lichen planus, leukoplakia, multiple verruca vulgaris, seborrheic dermatitis, ichthyosis, hair red rosea, Darier's disease, as well as other abnormal keratinization class skin disease, psoriasis, basal cell carcinoma, malignant epithelial cancer, actinic cheilitis and so on.

The irritation of tetinoic acid is large, but a lot of people use it, you can sum up the experience of others, in short, do a good sunscreen during the day, adapt from low concentration, and with a few weeks after a period of time is the exacerbation stage survived. Through the terrible time, the skin will be fine. According to the surveys by tretinoin manufacturer, some skin care products containing an ingredient called vitamin A acid. Vitamin A acid skin care products successfully developed, instead of tartaric acid which dominate the world’s acid in the past few years, acid A can deeply into the skin cell nucleus and truly improve the skin from the inside to outside, give skin a healthy glow glory, and A acid almost non-existent the discomfort problem that tartaric acid must consider.

Retinoic acid has light sensibility, so can not be used during the day. Otherwise it will make the skin be black. Problem skin: the skin condition is very bad, the acne always inseparable from the face, especially in more severe menstrual period. Despite we do our best to try many refreshing type of skin care products, but the acne still exsist in the face. The first time using tretinoin skin care products, face greasy, a little uncomfortable. But two months later, the skin will improve, the anger will converge, and slightly red dark skin will also become more and more shiny. And this skin care products can be used with other skin care products.

Sensitive skin: the skin is too sensitive, has been always plagued by females. Whenever the breeze on the face, this kind of skin will feel dry and discomfort, and even in the office air-conditioning also make them feel uncomfortable. But use products containing vitamin A acid, originally drying and easy peeling of the facial skin after one week, it start to get the delicate up, nose dander will also improve. After a month, not only the sensitivity of the skin can change a lot, even the yellowish skin will start to gloss, also can make pores shrink.

Oily skin, especially in the T-shaped parts, easy to allergies, and often there will be a small cob blisters, feels quite uncomfortable. Sometimes cheek will feel dry. This kind of skin with vitamin A acid skin care products, although the feeling of use is a bit greasy, but after a week, the skin will be gloss and the cheeks will not feel dry, and have a smooth feeling. Small blisters will also uncommon.

There are many beauty products containing retinoic acid in the market, tretinoin used as cosmetics material can accelerate the shedding of epidermal keratinocytes, keep the skin dry and cure acne, but it must be prescribed by a physician. Such as with peeling after use, can not be exposed to the sun; pregnant women have teratogenic risk of using this drug to treat, so that patients should avoid pregnancy.

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The analgesic applications of capsaicin

As pharmaceutical raw materials, capsaicin has the effect of desensitization, can damage the primary feeling into C-fiber nerves, so capsaicin has been used to treat a variety of neuropathic pain and related symptoms. Which the more mature is that the capsaicin cream use to treat skin pain, itching, such as postherpetic neuralgia, diabetic neuralgia, trigeminal neuralgia, efficacy optimistic. Treatment of neurogenic bladder excesses and hyperalgesia efficacy of the capsaicin solution intravesical infusion been clearly demonstrated in clinical trials in 200 patients. Capsaicin make the density of nerve fibers decreasing in the patient's bladder, so that obtain a longer period of relieving.

Capsaicin acts on the skin peripheral nerve endings, a burning feeling, and caused the local area congestion, even neurogenic inflammatory response. Capsaicin applied to the mucosa causing sneezing, nasal congestion, cough, mucus secretion, watery eyes, bronchoconstriction, breathing difficulties and other symptoms. Chili strong irritant inhalation, capsaicin oil is made ​​from tear gas, spray cans sold as self-defense weapons in some national markets. Capsaicin irritant limit its clinical application. Research directions in clinical application, clear the adverse of capsaicin and retain of its desensitization analgesic efficacy is the research objectives of the clinical application of capsaicin. The following 3 aspects is the most promising breakthrough in direction.

In combination with other drugs, lidocaine and capsaicin combined to use will cause synergistic retarding effect. Lidocaine can block the nerve reflex arc path. Thus easing the capsaicin which can weaken hot allergy symptoms caused by capsaicin. In the study of oral sensitivity to capsaicin, the scientists found that first coated with menthol in a short time (a few minutes), the oral is insensitive to capsaicin.

Change the mode of taking medicine, in addition to the surface of the skin and mucous membranes application, you can try to change the route of taking medicine to avoid the side effects of capsaicin stimulating peripheral nerve endings. Pepper receptor present in the dorsal root ganglia, trigeminal ganglion sensory ganglion cells, the perineurium or ganglia direct application of the theory is valid. The scientists applied capsaicin on nerve bundles membrane selectively block C-wave complex potential of the incoming branch of the superior laryngeal nerve, A wave has no effect. Capsaicin microinjection into the rat arc the beam nuclei caused bradypnea. Inject capsaicin to rat gastrocnemius, halibut intramuscular, nerve reflex is suppressed. Select the capsaicin derivatives the gum resin toxin is one of the very promising capsaicin substitute. Perfusion treatment of bladder detrusor excesses the gum resin toxin bladder pain, have the similar effect with pepper, but no local irritation.

In addition, with the further study of VR1 receptors and the gene mature, people can through VR1 receptors to synthetize VR1 excited or antagonists, or even the synthetic VR1 receptor regulation from the gene level expression, one day, humans will reveal all the secrets about the relationship of capsaicin and pain.

Source:http://www.cospcn.com

Foods containing vitamin H

From the biotin supplier, we know that vitamin H, also known as biotin, is a white compound, heat resisting, but easy to be oxidized and destroyed by acid-base. It is combined with protein can be dissolved in fat, but plants contained vitamin H is soluble in water. Biotin in food is absorbed by the small intestine, distributed by blood flow to the body tissues. Especially liver content the most, followed by kidney and pancreas, the brain also containing biotin enzyme. Vitamin H as one of a complex B vitamins, as a water-soluble vitamin, store enough energy for the human body, the excess can be excreted through the urine. Unlike those vitamins obtained from foods, biotin is a bacteria that live in the large intestine. In our lives, what kind of food containing vitamin H?

The main source of vitamin H is a yeast, so the content of vitamin H in the beer is more abundant. The main source of Vitamin H also includes animal organs such as the liver and kidneys. In beans, bread, chocolate, cooked eggs (especially egg yolks), meat, legumes (including soybeans, black-eyed peas, etc.), dairy products, nuts (almonds, peanuts, pecans, walnuts) and nut butter, bananas, mushrooms broccoli, oatmeal, oysters, peanut butter, poultry, wheat germ and whole grains also rich in vitamin H. Even foods containing omega-3 polyunsaturated fatty acids also contain vitamin H, such as salmon, tuna and eel. In addition, the bacteria in the intestines also produce a small amount of vitamin H may be absorbed, which helps the needs of everyday life.

Biotin is the part of the protein, fat, carbohydrate metabolism necessary carboxylase. Its direct involvement of some amino acids and long chain fatty acid biosynthesis, and also involved into pyruvate carboxylation oxalyl during acetic acid and glucose. Biological factors involved in the synthesis of protein, purine, fatty acids, etc.; involved in the metabolism of folic acid, pantothenic acid, vitamin B12; able to promote the urea synthesis discharge in vitro. It’s worth noting that vitamin H will be influenced by a substance such as raw eggs, raw eggs contain a chemical substance called avidin, and vitamin H with a very strong, and to prevent it from the intestine into the bloodstream to be absorbed, thereby interfering with the use of vitamin H. Therefore, if you want to supply vitamin H, don’t eat with raw eggs. Or it will cause biotin deficiency symptoms.

Vitamin H can also easily damaged, such as food processing technology can destroy vitamin H, not only vitamin H, other vitamins, particularly water-soluble vitamins are more vulnerable to destruction. Due to improper processing, resulting in the loss of many nutrients, it is not conducive to the health. Based on the researches by cosmetic raw material suppliers, we know that human supply vitamin H insufficiently will cause scalp dry, scaly, hair loss, muscle pain, nausea, loss of appetite, skin problems, depression, anemia and even loss of appetite and other symptoms. So usually should be obtained from foods containing vitamin H, because the needs of the human body is a little, so as long as the food supplement properly, we can get the amount of vitamin H we need. Vitamin H exists in most of the food, and the body of its demand is also very small, so the lack of Vitamin H symptoms is very rare. However, this is also establish on the basic of usually eating these foods, if you can not guarantee to absorb vitamin H from these foods, the rare also can be turned into possible or realistic.

Source:http://www.cosprm.com

Eating raw chili can delay human aging

Pepper, also known as die peperoli. Green peppers can be eaten as a vegetable, red pepper is many people’s favorite condiment. India called pepper as “red steak”; Mexican take chili as country food. In China, chili in many areas is very important, even some people did not like to eat without chili, so you can see how people love the chili.

Pepper rich in vitamins, eat peppers can increase appetite, enhance physical strength, improve sensation of chill, frostbite, vascular headache and other symptoms. Peppers contain a special substance which can used as pharmaceutical raw materials, so eat chili can accelerate metabolism, promote the secretion of hormones, health skin. Rich in vitamin C, can control heart disease and coronary artery disease, lower cholesterol. Contains more antioxidants can prevent cancer and other chronic diseases. Can make the airway for the treatment of coughs and colds. The chili can kill suppressing stomach intra-abdominal parasites. The most important is that it can delay aging.

Always for the concerns of healthy, the Europeans do not eat chili. But in recent years, with the Asian food popular in Europe and the people in-depth study of the nutritional value of chili, chili become the table cuisine of Europeans again. The most attractive reasons for Europeans eat spicy is that it can delay human aging.

Eating raw chili is the most healthy ways, the tricks of Europeans eat chili is various, use chili to make sauces fin is the most common method, so no matter what the meals, the Europeans were putting on chili sauce on the table. At the same time, they also like to sprinkle red pepper in a variety of dishes or cooking add green pepper and red pepper to even drink the soup is burning. However, respect for nature, Europeans prefer to eat raw pepper, or take advantage of the fresh raw food, or add salad made side dishes. This practice has won the recognition of the European nutritionists, because raw food chili is beneficial to the body. Because of the vitamin C is unstable due to the peppers stored for too long or cooked ,eat raw food can be best to preserve its nutritional value. Cooking in the pot before adding pepper, so as to avoid the loss of nutrients.

In Europe, the chili is also known as the “red herbs”, the research about chili is endless. Capsaicin manufacturer recently discovered: chili prevention and treatment of breast cancer; capsaicin can induce prostate cancer cells "commit suicide"; pepper can relieve the symptoms of a cold; pepper can also prevent arteriosclerosis; help you to sleep, eat chili. In order to meet the fashion to eat hot peppers to lose weight, many beverage companies also compete with chili as the raw material to produce the new hotness drinks.

The scientists found that red pepper contains large amounts of antioxidants can prevent free radical damage to the skin, while the radicals is the major factors that lead to premature skin aging and skin cancer, which is comparable to large doses of supplements is much more powerful. But the experts also pointed out that the hot and spicy chili, should not eat too much, otherwise not only damage the taste nerve, but also affect the liver and kidney function.

Source:http://www.cospcn.com