The health care function of wine

Wine contains a variety of nutrition: amino acid, protein, vitamin C - B1, B2 - B12 and the nutrition of grapes from natural ingredients and brewing process of ingredients can reduce cholesterol, prevent arteriosclerosis and heart vascular disease French people like to eat fatty foods, such as fat goose liver, but the French atherosclerosis and the prevalence of vascular disease in Europe countries lowest, this is due to the French wine. Can help digestion and promote metabolism. Drinking wine while eating can improve gastric acid content, promote human body in food calcium, magnesium, zinc and other absorption of mineral.

Wine is rich in phenolic substances, which have antioxidant effect, the prevention and control of degenerative diseases, such as aging, cataract, immune disorder and some cancers. With the advance of science and technology, with the instrument analysis precision degree of enhancement, the researchers can analyze more and more compositions in wines. In 1950 people can analyze wine only 50 kinds of component; 1986 can analyze 600 ingredients. Wine contains abundant nutritional ingredients, they mainly is all sorts of saccharide, organic acid kind, inorganic salts and trace elements, nitrogen material and a variety of amino acids, all sorts of vitamins. From the perspective of nutrition, wine itself contains rich nutrients, is a ideal nutritional drink wine. Not only that, some of red wine efficacy composition, have obvious health care function, red or the best health care sex drink wine. Red wine, has the health care function of many components, the most popular subject at present, is the resveratrol in red wine. resveratrol exist widely in nature plant body. Fine out in the eucalyptus, peanuts, tiger branches and more than 70 kinds of plants.

In the grape and grape juice, contains resveratrol, but the content is very low, in micrograms/liter order of magnitude, resveratrol manufacturer found that in the fermentation of grape juice, containing beta - glucose livor glucosidase, with fermentation process production of resveratrol reed alcohol quantity increase abruptly. High quality dry red wine, the content of resveratrol can reach 5 ~ 10 mg/L, from health care medical point of view, it have already with the therapeutic dose.

As one of pharmaceutical raw materials, resveratrol has a variety of health care and medical function, its main function is; (1) control atherosclerosis, coronary heart disease, ischemic heart disease and the role of hyperlipidemia. (2) has obvious antioxidant, clear free base, anti-aging effect. (3) antiplatelet aggregation, with the antithrombotic function. (4) resist cancer, inhibiting tumor and so on.

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The effect of astaxanthin protect skin

Now skin protection had become the popular trend, whether minor or adults and even the elderly, are in whitening skin. So do you know as a Cosmetics material, how does astaxanthin work in skincare efficacy? Let us have a look.

First of all, astaxanthin have the effect of prevent you from the sunlight, it has unique molecular structure, the physical absorption peak is about 470 nm, is just like it’s the most perfect unique natural sunscreen, if in the outdoor it can rapid recovery from ultraviolet burn damage skin, astaxanthin is also the best products protect the human body skin from uv damage .

Secondly, astaxanthin can dispel spot and whitening skin, astaxanthin can effectively restrain the formation of melanin, and can significantly reduce melanin precipitation, let you can away from obscure blind spot skin, rather than spend a lot of money to beauty parlour to whitening skinor why not spent your money to buy astaxanthin health care products, can let you rest assured edible and won't have side effects and bad harm, astaxanthin’s whitening effect is more than many other  products. Astaxanthin capsule, there still did not find out any kinds of material which can have such a good prevent melanin precipitation effect in the same concentrations so far, so you can imagine how good it is, sometimes while doing mask we can also with a drop astaxanthin in the mask., insist to use astaxanthin capsule can achieve a very good effect.

What’s more, astaxanthin can also anti-wrinkle, our skin is comsist of the skin layer and the dermis and subcutaneous fat structure, the dermis contains collagen, elastin, and some other constitute which let our skin smooth and elastic, but these same element is also very easy to damage, and thus our skin also appeared wrinkles, the directly reason to prevent skin oxidized is not eat collagen, but edible astaxanthin, astaxanthin is the most strong antioxidant in all food, so if you want to prevent wrinkles just eat astaxanthin.

However where to get natural astaxanthin? The astaxanthin manufacturer tell us that the salmon contains one kind of powerful antioxidant components - astaxanthin. Salmon is the most effective in whitening  in all the deep sea fish. Because it contains unsaturated fatty acid in the moist skin, plays an important role in preventing and removing wrinkles. The unsaturated fatty acid is the skin barrier component, the supplement can help skin lock moisture, achieve moisturizing effect. In addition, it also has strong antioxidation, can effectively prevent skin aging and wrinkles, and the salmon contains the most aliphatic acid in all the fish. In the salmon there is another powerful antioxidant components astaxanthin, salmon orange red is derived from it. Astaxanthin’s ability of antioxidant is 550 ~ 1000 times than common vitamin E, can effectively combat free radicals, postpone skin aging, also can protect the skin from uv damage at the same time.

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The Role of Biotin In The Glutamic Acid Fermentation

As a cosmetic raw material, biotin has important influence to glutamic acid biological synthesis methods. At present, the application of glutamic acid produce bacteria in industrial have glutamic acid corynebacterium, lactose fermentation short bacillus, scattered branches short bacillus, yellow short bacillus, bite ammonia short bacillus, etc.

The strains in common use in our country are Beijing rod rod bacteria, pure tooth corynebacterium, etc. Glutamic biosynthetic pathway is roughly by glycolysis of glucose (EMP approach) and hexose phosphate branch (HMP way) generation pyruvic acid, then oxidized to acetyl CoA (acetyl CoA), and then enter the Krebs cycle, generating alpha ketoglutarate. Alpha ketoglutarate in glutamate dehydrogenase catalytic and NH + 4 existence condition, generation glutamic acid. In the glutamic acid fermentation process, the influence factors of strains metabolic pathway. Glutamic acid produce bacteria need growth factor biotin. When biotin are lacking, strains grow very slowly, When biotin excess, the converted to lactic acid fermentation. Therefore, usually control the biotin in the moderate conditions, to get high yield of glutamic acid.

In the glutamic acid fermentation industry, corn steep liquor is an important source of biotin, also it is one way of biotin manufacturer produces biotin. But the composition of corn steep liquor different with the sources of the raw materials and processing methods. So the glutamic acid fermentation production process, corn pulp raw material should be decided according to the production condition.

In the glutamic acid fermentation, if it can change the permeability of cell membrane, make the glutamic acid row to cell outside continuously, it can get a lot of glutamic acid accumulation. Research shows that what affect the cell membrane permeability is the main factor in the cell membrane phosphatide content. Therefore, the produce of glutamic acid bacteria breeding, often from the control of the phospholipids in cell membranes of synthesis or damaged, such as biotin defect type strains breeding. Biotin is not saturated fatty acid synthesis process for acetyl CoA of CoA. Biotin defect type strains for not synthetic biotin, thus inhibiting the unsaturated fatty acid synthesis. And the unsaturated fatty acid is one of the components of phospholipids. Therefore, the synthesis of phospholipid quantity also reduced correspondingly, this would lead to cell membrane structure is complete, improve cell membrane to glutamic permeability. In fermentation process, the adjust and control of oxygen, temperature, pH and phosphate, etc are as follows: (1) the oxygen. Glutamic acid produce bacteria is aerobic bacteria, ventilation and mixing will influence not only strains source of nitrogen and carbon sources utilization,but also affect the synthesis of glutamate fermentation period and quantity. Especially the fermentation period, the increasing ventilation to glutamic acid synthesis. (2) the temperature. The growth of bacteria’s optimum temperature is 30 ~ 32 ℃. When bacteria growth to stationary phase, increasing temperature to produce acid, therefore, in the fermentation period, the temperature can be increased to 34 ~ 37 ℃. (3) pH. Glutamic acid bacteria fermentation produced the optimum pH in 7.0 ~ 8.0. But in the fermentation process, with the use of nutrients, metabolite accumulation, nutrient solution of pH changes continually. With the use of such as nitrogen source, release ammonia, pH will rise; When sugar is used generating organic acid, pH will decline. (4) phosphate. It is in the process of glutamic acid fermentation must be, but concentration too much, otherwise you will turn to valine fermentation. After the fermentation, commonly used ion exchange resin method of extraction. Glutamic acid in addition to used in the manufacture of monosodium glutamate outside, still can be used to treat neurasthenia and nutritional injection preparation, etc. Although the glutamic acid fermentation have greatly improved in quality and other aspects in China, but compare with the foreign advanced level, There are still exists a certain gap between compared. Mainly displays in: the old equipment, the scale is small, the automatic control level, the conversion and extraction efficiency is low, vulnerable to phage pollution, waste water pollution problem has not been fully resolved, etc.

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Application of Biological Technology In The Resveratrol Research

For the first time got resveratrol from wool leaf hellebore (VeYatYuD? Grandiflo - rtua) root in 1940. In 1960 Nonomura and other people come up with Res is some herbal medicine treatment of inflammation, lipid metabolism and heart disease of the effective components. In 1977, found in grapes Res as plant resistance to toxin exist. In 1989 WHO hold an epidemiological survey, the results show that the "French Paradox" (French Paradox), namely: high fat diet and coronary atherosclerosis low incidence was significantly consistency. Through further research, people found by drinking wine intake Res is French cardiovascular morbidity one of the main reasons for low: red wine for belt leather fermentation, peel and juice contact time long, make the skin a considerable amount of Res can enter the wine, which has good lipid peroxidation, known lipid peroxidation in atherosclerosis and other cardiovascular disease plays an important role. In 1992, the commercial wine found resveratrol the first time, the same year the academic circle further confirmed on wine rich in resveratrol. In recent years, many pharmaceutical raw materials suppliers learning function of resveratrol biological in deep research, these studies including lipid metabolism, arachidonic acid metabolism, etc., prove it has many important physiological activity, such as: cancer, protecting cardiovascular system, estrogen-like effect, influence bone metabolism, etc.

People to resveratrol natural resources have been studied extensively, at least has been in grape families, liliaceae, polygonaceae, leguminosae, myrtle, apiaceae, cyperaceae, palmae, buy a horse TengKe etc 21 families and genera and 72 species of plants found white hellebore alcohol. Its main exist in buckwheat fleece-flower root root, buckwheat giant knotweed roots, stems, grape family plant vitis peel, stone, liliaceous plant hellebore of roots, stems, leaves, leguminous plant groundnut roots, stems and the flowers. Especially in fresh grape skin of content is higher, about 50 ~ i00 > g/g, and with trans primarily. Grape cultivars, growth location, climate, planting technology, fungal infection degree and so on all affect the content of resveratrol. Made method to the influence of the content of resveratrol in grape wine was particularly remarkable, red wine the average contents of resveratrol to 4. 37 mg/L, and white wine only 0.68 mg/L. In improving content also had a lot of research, such as: use before harvest ultraviolet pulse radiation method improve the grape resveratrol content]; With recombinant yeast strain as a tool to improve the content of resveratrol in grape wine was white, natural including RS genes in plants suffer stimulation, can stimulate the gene transcription and translated into RS, then instantaneous synthesis of resveratrol. In grapes, peanuts, pine trees and other plants with induction type stilbene synthase gene expression mechanism, but most plant cells despite STS enzyme substrate, but lack of STS genes, and thus lack in the induced factor synthesis under the action of this kind of plant protection element ability.

Because the content of resveratrol in plants is very low, generally exist in glycosides. Many domestic scholars and resveratrol manufacturer are using chemical methods to make it. Generally speaking, chemical synthesis method with low cost, but from the food safety point, more and more scholars advocate getting it from natural plant extract, especially in foreign resveratrol biological extraction are more attention, and have a deep research.

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Plant extracts analysis of international market

Market of plant extracts is a developing market and has enormous growth potential, in 2005 the global market size of plant extracts at around 33 billion dollars, main plant extract suppliers are from India, and Brazil and China, United States, Asia, Europe is the world's third-largest market of plant extracts. According to United Nations estimates, annual industry growth rates between 10~20%.

Plant extracts export prices have been volatile, prices showed an upward trend in the early 1990s, the downward trend from 1996 later, from 1996 $ 20/kg down to 11.26/kg in 2003, a 40% decrease, from 2004 onwards, the price was stable and rapid rises, from $ 11.26/kg in 2003 rose to $ 19.12/kg in 2005, an increase of 68%, largely restored to the 1996 price level, especially in the Asian market recovery in prices faster, mainly due to the fast rising demand of the international market for natural medicines, another reason, China plant to industrial development for many years, as the international market to raise the threshold, their competitive capacity is also rising.

North American plant extracts more than 90 percent of the market depends on the United States, and the United States is the world's largest herbal market. According to statistics, each year in the United States to spend $ 6 billion for nutrition and health food, and this market is the increasing rate of nearly 20% per year. About 5% of patients taking natural medicines, of which 80% of the people taking traditional Chinese medicine in the treatment process. Plant extracts currently sold in the U.S. market may be divided into two categories: one is a standard extract usually extract such a clear and uniform quality standard system molecular biology research such as Ginkgo biloba extract (24% ginkgo flavonoids and 6% ginkgolide); other crude plant extract, such extracts are often only extraction ratio without a clear common standards, such as Equisetum extracts. Plant extracts accounted for more than 95% of the U.S. market for herbal medicines, raw herbs and other products account for less than 5%. In the last three years, Chinese exports to the U.S. plant extract 20-30% of the total export volume. The greater demand for varieties of Ginkgo biloba, Hypericum lotus Alice, soybeans, ginseng, etc.

Asian plant extracts market mainly Japan, South Korea and China, the current size of the market for about $ 3 billion, China accounted for 15%. Japan and South Korea are China's major exporting countries of the plant extract. Japan, South Korea, the source of plant extracts from traditional Chinese medicine, the last century 70's, Japan, South Korea vigorously develop Kampo and Korean medicine, Kampo and Korean medicine from Chinese medicine. Japan current pharmaceutical companies more than about 200. Japan Kampo formulations have more than 20,000 kinds of varieties. The majority of the pharmaceutical companies in Japan passed the GMP. The size of the Korean pharmaceutical ranked 10 in the world, the 80 pharmaceutical companies, accounting for 22.2% of the total number of Chinese and Western pharmaceutical companies. In developed countries, on the other hand, the production lines are gradually migrating to Asia, to promote the development of the Asian plant extracts industry.

Europe more prevalent as the raw material of herbal products, plant extracts, is currently the world's largest herbal medicine market, accounting for 45% of the global herbal medicine market, the market size of more than 10 billion U.S. dollars in 2005. Europe is the world's largest cosmetics and health food market and production research and development center. Since 1995, the European plant extract was relatively large market growth, most countries in more than 10% annual growth rate, individual countries or even as high as 16% (such as the United Kingdom, the Netherlands). Fastest growing herbal plant extracts into three categories: First, the role of preventive pharmaceutical raw materials, such as garlic, ginseng; medical institutions recognized the old products, such as the treatment of insomnia and neurological products; Third, is the discovery of a new treatment the role of the old products, such as evening primrose oil and ginkgo preparations. European governments and the academic community have a positive attitude on the plant extracts to strengthen the study of medicinal plants and traditional medicine, herbal ginkgo has been widely welcomed.

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Astaxanthin is the most potent anti-aging foods

Although there is no one can live forever, and no one can stop what age left on the face, but we can retard the rate of aging, delay teh sking aging, wrinkles. In real life, there are many kinds of food can reach the effect, such as narural vitamin E, grape seed, β – carotene and so on, are good antioxidants, adequate intake per day you can achieve this effect. This is the one reason why people used it as cosmetic raw material and become more and more younger now.

In the fight against aging, and fight free radicals in the great war, people often say that those are not the most powerful, the most potent is astaxanthin. The word for perhaps many people unfamiliar, perhaps some people know, so let me introduce simple.  Astaxanthin is a red pigment, ornamental fish, salmon, shrimp and flamingo pink color can be given. Their chemical structure similar to the β-carotene. Astaxanthin is a carotenoid group. Highest level product is also carotenoids synthesis, beta-carotene, lutein, canthaxanthin, lycopene daily antioxidant, anticancer star only carotenoid synthesis intermediate, so in nature, astaxanthin has the strongest antioxidant activity against free radicals.

Someone will ask what is the free radicals. In general, radicals are the root causes of human aging and illness, the reason aging, physical deterioration, the skin loses its luster and flexibility, addition to age irresistible factors, the main too many free radicals in the body, the young man body better and the system to eliminate free radicals and reduce the harm it causes; However, with age, the body's ability to repair free radical decline; Failure to timely supplemental antioxidants, cell injury, disease arose, more and more evidence found by astaxanthin suppliers shows that the higher the content of free radicals in the body, the shorter the life.

Not only the presence of free radicals in the human body, but also from the outside of the body, such as smoking, car exhaust, then, there are two ways to reduce the free radicals harm: First, remove excess free radicals in the body, using the body's own free radical scavenging systems; The second is to explore exogenous antioxidants - radical detergent, blocking the invasion of free radicals on the human body, which is supplement can antioxidant foods, such as vitamin C, vitamin E, carotenoids and son on.

When body movement muscles will release free radicals, these radicals if not to be antioxidants in time, it will produce oxidative stress, resulting in muscle soreness or muscle tissue damage. Astaxanthin can act as an antioxidant to inhibit free radical oxidative damage to the body. Increase muscle strength and muscle endurance, alleviate sports fatigue quickly, reducing delayed muscle pain after strenuous exercise.

From the point of view of a healthy diet, away from the human food chain, the closer the food organisms containing astaxanthin astaxanthin content is lower, their food source is complex, the byproduct bring harm to human health (such as paragonimiasis more avian flu), food chain, the farther away from the human food organisms containing astaxanthin astaxanthin content, the higher, the more secure. So pure astaxanthin extracted from algae is the highest content of the safest food containing astaxanthin.

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The health benefits of red wine and resveratrol

We all know that drinking a glass or two of red wine a day is good for health. In fact, that is true. For the Frenchman diet study found that, despite their daily food contains large amounts of animal fat and butter, but fat diet-related incidence of heart disease is not so high, which has a certain relationship with the hibit of drinking red wine. That is very similar to the asian one day one pack of igarettes but little risk of lung cancer. This phenomenon is also considered a puzzling thing. The study found that women drink a day, men drink two glasses of wine a day is safe intake.

Scientists believe that red wine contains resveratrol play the role of prevention of heart disease. In many research reports of resveratrol supplier have referred to the resveratrol effect, prevention of diseases other than heart disease, but also involving other diseases such as cancer and diabetes. In addition, anti-aging ability of this compound is higher than other nutrients. The following are several anti-aging mechanism: DNA damage. Human cells suffered millions of attacks every day, which will undoubtedly lead to DNA damage or an error, while resveratrol contribute to healthy cell regeneration. In addition, it can determine whether the cells need to be replaced as a gene regulator. The cell mitochondria to produce energy will die, resveratrol helps to provide more energy to produce more mitochondria. Resveratrol itself can affect the process of cellular senescence of the first three, but can not affect the fourth protein aging mechanism. Scientists has found that the polyphenol resveratrol mixed than they are individually more effective, and can have an impact on the fourth mechanism.  

However, some researchers believe that it needs to drink 100 glasses of red wine to play the anti-aging effect, unless drunk, otherwise it is impossible to reach this number. Therefore, resveratrol nutritional supplements are considered to be the only way to get the daily requirement. However, most of these nutritional content of only 50% purity, and therefore is not able to anti-aging truly effective way.  

Natural foods that contain resveratrol usually only provide a small amount of this antioxidant, a cup of boiled peanuts contain a maximum of 0.32 to 1.28mg of a glass of red wine provides fewer, only 0.25 and 1.25mg. The resveratrol content of grapes, berries and other plants. And all fruits and vegetables have different nutrients. You to read the vitamin content is purely average, the actual ingestion of food containing the nutrients may be less. Understand why plants contain antioxidants and similar compounds, they begin to close to the truth. These are the natural defenses of plants to produce these substances against bacteria or fungi, to prevent the sun's ultraviolet radiation, and even to resist insects. For example, tea, coffee and cocoa plant contains caffeine is a natural insecticide.  

Logically, if the plants are protected from disease and insect damage, they will produce less natural defense mechanism. This also is to contain resveratrol in food vary considerably in composition. It is the antioxidants of grapes and other plants used to combat fungal and bacterial infections. Many farmers have other means of protection of plants, especially for large farms. Resveratrol red wine from Spain typically contain the highest content of 145 grams of red wine is far from the same amount of peanut or grape content is high, only 0.29 and 1.89mg.  

The resveratrol as pharmaceutical raw material in the nutritional supplements is relatively high, this source of resveratrol whether can be normal absorpted of by blood is doubtful. The researchers tested for drinking after changes in blood in a glass of wine and the intake of nutritional supplements. In both cases, the amount of resveratrol in the blood did not change significantly. Some natural health advocates believe that people should eat more natural food to increase resveratrol, and avoid nutritional supplements. But most people rely solely on the diet, nutritional supplements, it is difficult to get all the vitamins and minerals. In addition, there are many chinese medicines and plant extracts help to maintain good health, prevent life-threatening diseases.  

Source: http://www.cospcn.com