Plant extracts industry in China needs to improve its value

A worldwide boom of return to nature makes the new emerging plant extracts industry quickly grew up and developed into global annual sales of nearly $ 100 billion dollars. If China wants to make greater achievements in this emerging market, it must change the traditional export-dependent model of development. China should start from the control of product quality to achieve sustainable development of the whole industry.

Plant extracts are derived from the material containing the active ingredient. Plant extracts, herbal preparations, the main raw material, and can be used in nutritional supplements, health food, cosmetics and other industries, the core product of natural medicine and health products market. "Pesticide residues, heavy metals, microorganisms and other requirements in the improvement of trade barriers increase; the new demands of the enterprise product certification; labor costs, herbal medicine prices increase the cost of doing business and the new requirements by the state production of corporate environmental, etc., are plant extracts industry in China the next step in the development of new challenges. Chinese plant extract industry is facing the biggest challenge or industry, which includes both the external environment for industrial development, including the problems faced by the industry itself.

The key to the development of plant extracts on product quality control. Product quality, but off as well as fake and shoddy products if you can not put an end to the industrial development will be a deadly threat. Product quality problems of consumer confidence is fatal violence, and from the international development trend, the United States and other Western countries on the quality of supervision of the plant extracts, but also was more rigorous trend.

At present, the world's plant extracts market development speed is very alarming. Statistics show that herbal or plant products, the field of global market size of nearly $ 83 billion, and in all areas of growth is relatively stable, an increase ranging from 3% to 12%. Among them, herbal health care products market, accounting for 1/3 share, including herbal dietary supplements, and herbal functional foods; global herbal products industry contribution of $ 44 billion; herbal beauty products occupy the market's remaining $ 14 billion. Plant products market can be described as a huge global market.

The health industry is known as the fifth technological revolution and the industrial revolution is sweeping the world. China will become the heart of global pharmaceutical raw materials industry. Nutrition industry is the core of the health industry, the plant extract is an important guarantee for the development of nutrition industry, and plant extracts to improve the key to the functions of nutritional products, traditional Chinese medicine plant extracts and nutritional industries laid a solid the basis of the theory and practice.

China's industrial development of the plant extracts, should strive to improve product quality, to expand its influence and improve their international competitiveness. Quality problems is the biggest obstacle of the internationalization of Chinese medicine, extracts industry should speed up the standardization of traditional Chinese medicine production process, strict good quality. Extract production management practices promotes the production of extract standardization and institutionalization of quality standardization. It further expands the market.

The standard construction of plant extracts in China has made good progress. Industry regulatory, policy support and guidance, establishing a standardized planting base, fostering sustainable development of products operating model, improving quality standards and integrating by product and industry to strengthen the industry self-regulation will make the whole industry’s development healthy and orderly.

Source:http://www.cospcn.com

Cosmetic raw material: hypoallergenic and preservative alternative will become an industrial direction in future

With continuous expansion of the daily chemicals market in China, many multinational raw materials enterprises have joined the market to gain a position. The presence of multinational enterprises greatly squeezed the living space of Chinese local raw materials enterprises. At the same time, they have brought significant raw materials, technology and management experience of which the local raw materials enterprises is in urgent shortage.

The main cosmetics market mainly pushes the two kinds of products. A class is a security-based raw materials, focus on improving the safety of the product formulation to prevent the ingredients to stimulate and ingredients to stimulate the allergy. Provide appropriate preventive solutions for different skin irritation skin redness, itching, burning sensation, molting, drying. Other products are mainly for preservative alternative, preservatives is more controversial topic, the preservatives alternative will no doubt be the future development trend, the more developed regions of Europe and the United States and Japan, Korea and other cosmetics have been to start the preservative alternative This trend is bound to apply to the future of the Chinese market. Chinese market gradually introduces this type of concept products.

The preservatives alternative does not mean that the role of alternative preservatives. The preservative is a versatile alternative to the functional demands the general cosmetics such as moisturizing, while both anti-corrosion and anti-oxidation, corrosion is only an auxiliary function, such formulations are more moderate than the usual formula. For example, formaldehyde is gradually replaced preservatives because of the long-term use may cause cancer. The Chinese cosmetics market, anti-allergic materials and preservatives alternative raw materials is no longer just a trend, but a trend. Because the trend is in the future, but the trend is current.

Previously, forced by cost pressures, many cosmetic raw material suppliers use the main raw material for the price, rather than functional considerations, but in recent years, cosmetics allergy and preservatives debate in the media are common. This shows that consumer demand for these two types of products is already very obvious, and consumer demand must be in the direction of the cosmetics industry, the market launch of these products are only advantage of the opportunity.

Cosmetics raw materials security includes a lot of contents. The first of many risky ingredients will be able to provide consumers with the protection of product substitution; Secondly, more and more natural, organic, and other more secure ingredients to be used, and this is moment more concept of suppliers of raw materials and finished product suppliers; security, there is an important sensitive skin, regardless of the future of cosmetics development for sensitive skin, it will become an important issue in the future of the industry, or even to account for 50% of the overall market share.

Overall, the cosmetics glutathione market in China is relatively stable 20% average annual growth from 2004 to 2011, 2011 growth rate of the active ingredients of the moisturizer, sunscreen, etc. is as high as 37%, the extract increased by 30%. This data, a significant increase compared to previous years. The development of China's cosmetics market is gradually mature, Chinese enterprises have gradually given up the cost of the supremacy of ideas, began to select the quality raw materials.

The Chinese cosmetics market has gone through the early stages and develops into the stage that brands are the king. Only good brand gets consumers. Differentiation will be the important ideas and opportunity for enterprise rising. Skin care, makeup, mask, and cosmeceutical market have large potentials. Even the without added anti-allergy concept will become an important trend for cosmetics development in China. Raw material suppliers must adapt to this change. The changes in finished enterprise determine the changes in raw materials companies. Raw materials should develop products according to requirements from specific groups.

Source: http://www.cosprm.com

Docetaxel can treat advanced non-small cell lung cancer for elderly patients

The incidence of lung cancer in China increases significantly. The incidence of non-small cell lung cancer accounts for about 70% of lung cancers. 60% -70% of patients are diagnosed in late period. At the same time, about 50% of such patients are over the age of 65. Combination chemotherapy of platinum drugs and local radiotherapy are the main ways for advanced NSCLC. But the drugs in combining chemotherapy are cytotoxic. There are clear and synergistic adverse reactions. In addition to elderly patients with body conditions are deteriorating, and they often have other basic disease, so some patients can not tolerate or refused to combination chemotherapy because of fear. In clinical trials, they can only have support, symptomatic and palliative care. The treatment method is negative.

Before the treatment, the head, chest CT or MRI, bone scan, abdominal ultrasound, blood, liver and kidney function, ECG and other tests need to be taken. During chemotherapy on a regular basis to review the ultrasound, blood, liver and kidney function, ECG and other tests. Every two cycles of measurable lesions, CT scan or MRI. Unified assessment of the objective criteria of efficacy according to the WHO criteria: complete remission, partial remission, stability and progress. Effective rate of CR + PR; efficacy need to maintain more than four weeks. Duration of remission for the first time to evaluate the time of the PR or CR until disease progression, time to tumor progression for the start of treatment until the time of tumor progression, overall survival to begin treatment until the time of death from any cause. Evaluation of adverse reactions were classified into the degree of 0-IV according to the WHO anti-cancer drug toxicity.

Docetaxel is a semisynthetic taxane pharmaceutical raw material. It is cell cycle-specific drug by promoting tubule polymerization stabilized microtubules, and inhibition of its solution of poly to make the number of free small tube of a significant reduction, inhibition of tumor cell division, will The cells were blocked at M phase; its mechanism of action the same role in stabilizing microtubules paclitaxel. Induction of apoptosis may be an important mechanism of chemotherapy drug-induced cytotoxicity, ble-2 protein is an apoptosis inhibitor, docetaxel is an effective phosphorylation induced by agents, including lung cancer in induced entity within the protein over-expression of tumor cell apoptosis; docetaxel for the overexpression of p-glycoprotein in many human tumor multidrug resistance associated protein with anticancer activity. In the clinical treatment of NSCLC, docetaxel as second-line treatment of recurrent or metastatic lung cancer, with good effect. In part as first-line treatment, docetaxel single-agent’s efficiency is from 21.7% to 38%.

Docetaxel’s efficiency in patients with single-agent first-line chemotherapy is about f 25.0%. A median time is 6.5 months, median rrP is5.6 months. The median 0s is 11.4 months, one year survival rate was 38.2%. KPS and weight gain and pain relief also shows that single-agent chemotherapy of docetaxel significantly improves the quality of life of elderly patients with NSCLC. Common adverse reactions are allergic reactions. In recent years, regular preventive doses of dexamethasone, such reaction can be controlled. Followed by bone marrow suppression, gastrointestinal reactions, and liver function damage and nervous system response, are to a lesser extent, symptomatic treatment can be alleviated.

In summary, single-agent docetaxel chemotherapy for elderly NSCLC can prolong survival period and improve quality of life. There are less adverse drug reactions. Compliance and safety of the patients are also guaranteed.

Source:http://www.cospcn.com

Research progress of biotin nutrition

Biotin involves in the metabolism of body's three major nutrients as a cofactor for carboxylation, decarboxylation and dehydrogenation enzymes. It is a necessary and important nutrient foe human and animal body. Only σ-biotin in a variety of isomers has biological activity. Under normal circumstances, the biotin is quite stable. It will be damaged only in acids, alkalis, formaldehyde, and UV. Avidin is a glycoprotein in egg white. It can combine with biotin so that it can not be absorbed in the intestine. After the heat treatment, biotin is able to be reused.

Biotin as a cofactor of many enzymes of the body, play an important role in the metabolic process of carbohydrates, lipids, proteins and nucleic acids. The biotin enzymes in mammals are: pyruvate carboxylase, acetyl coenzyme A carboxylase, propionyl coenzyme A carboxylase and β methyl butene coenzyme A carboxylase are dependent on the activation of ATP and Mg2.

In carbohydrate metabolism, biotin enzyme catalyzed carboxylation and decarboxylation, is an essential component of the citric acid cycle, to participate in food metabolism and gluconeogenesis to maintain stable blood sugar. Biotin as a coenzyme of pyruvate carboxylase, pyruvate carboxylation to oxaloacetate, and impact of oxalyl succinic acid is converted to α-ketoglutaric acid, Ping check the acid converted to pyruvic acid, succinic acid, and pyruvate mutual changed.

Biotin as a coenzyme of acetyl coenzyme carboxylase involved in fatty acid synthesis. As propionyl carboxylase, coenzyme, and odd carbon fatty acid β-oxidation of essential substances. In addition, biotin and acetylcholine synthesis and cholesterol metabolism. Biotin in protein synthesis, amino acid deamination, drift methotrexate synthesis and leucine, tryptophan metabolism plays an important role for a variety of amino acids necessary for the transfer of decarboxylation.

Higher biotin utilization in yeast, bread, meal, corn and other feed, fish meal, meat and bone meal and wheat, barley, sorghum, bran and other cereal feed biotin was combined with the state, the utilization is very low. Diet containing more carbohydrates, especially glucose ingredient, can promote the growth hormone absorption. When the feed contains raw egg, which avidin binding, thus affecting its use. Antibiotics (such as sulfa, etc.) will affect the intestinal bacterial synthesis of biotin.

Biotin is an important cosmetic raw material. It can not only be used in human cosmetics, but also improve the reproductive performance of sows. Diets supplemented with biotin may improve the reproductive performance of sows. Addition of biotin can increase the number of sows. Biotin can shorten the time of weaning and interval. In different types of diet, the supplement of biotin will improve daily gains of growing pigs and feed’s efficiency.

Source:http://www.cosprm.com

Chinese API observation: only establishing trust relationships can achieve win-win situations

China's economy maintained a rapid development in 10 years. The most important reason is the low labor costs in China. Japan and other developed countries have set up factories in China. China has already become the factory of the world. In this case, China as the production of pharmaceutical raw materials and intermediates arouses more and more attention. In addition to a small number of factories, the types of raw materials and production capacity have an increasing trend every year.

Japan also medicine raw materials from abroad, but the scale is relatively small. Since the amendment to the Pharmaceutical Affairs Law, the forms of Japanese pharmaceutical companies do significant adjustment is divided into manufacturing sales, and manufacturing sectors. As pharmaceutical raw materials suppliers of medicines and other products and sales of the businesses, it needs to assume the quality of its production and drugs and ultimately guarantees security responsibility. At the same time, the factory of pharmaceutical raw materials to reach the level of GMP management to assume supervision of the manufacture and sale of businesses obligations.

Quasi-drugs, etc. shall comply with GQP Act, but the pharmaceutical raw materials do not belong to the object of the GMP management, at this stage of the Act does not stipulate the obligations recognized in the factory. However, for countries such as China, India, known as the "high country risk, to manage the departure from the point of view to ensure quality and safety of pharmaceuticals raw materials, corporate responsibility, is also very important from this perspective, corporate protection.

The so-called country risk, it is not just the aspect of production management methods, including the various elements of the working environment of employees, employment conditions, living habits, the income gap. Deal with these problems, starting from the point of view of considering the individual analysis of each reason for processing is necessary. In Japan, usually used in production management, quality management, the security issues are avoided, the Chinese economy sustained and rapid development, still need some time to improve this deficiency.

In addition, when it comes to mixing the generality of foreign matter mixed with foreign pharmaceutical raw materials, quality assurance is very important. As we all know, in the treatment of foreign body-related issues, foreigners in general than the Japanese tolerance. Similarly, in all aspects of plant facilities and equipment maintenance and chia seed production management, Japanese are more concerned about health. In Japan, sales of imported raw materials preparation, then the concern in this regard is essential. By Japanese company’s frequent inspections of Chinese factories in recent years, this problem is gradually improved.

Trust relationship is the quality assurance of the origin. Do not go to great fanfare with Japanese pharmaceutical regulations of the factory audit, but in the audit process with sincere attitude, the urge to see the factory of its attention and related documents, in recognition of documented seriously.

The audit is to have strict complete examination for equipment and machine, the project management and documentation. On this basis, made it clear about the imperfect parts of level of production management and health management. And them make description and accurately convey specific improvement strategies out. Unceremoniously approach can obtain each other's trust. Moreover, in the final review stage of audit, when talking about the proposal to improve countermeasures, if it needs to spend the high cost, if possible, the replacing program needs to be worked out to have best savings for funds. This is not just to ensure quality. From comprehensive aspects, considering the problems with plants benefits is an important step to build a relationship of trust.

Source:http://www.cospcn.com

Can minoxidil be added into shampoos?

Minoxidil is a name well known to the many people with hair loss. Minoxidil is a vasodilator for the treatment of hypertension. But for the mechanism of hair loss treatment, it is not primarily the function of dilate blood vessels. The literature shows that minoxidil is a clinical oral drug for lowering blood pressure.

Minoxidil can direct relax vascular smooth muscle. There is a strong expansion of the role of small arteries and peripheral resistance decreased, the blood vessels to dilate, blood pressure, had no effect on the capacitance vessels, it can promote venous return. At the same time, due to the reflex regulation and positive frequency effect, cardiac output and heart rate can increase, but does not cause orthostatic hypotension. At present, minoxidil is a clinical second or third line blood pressure-lowering medicine. It can be used for the treatment of refractory hypertension and renal hypertension.

Minoxidil is a drug and naturally there are adverse drug reactions. The main side effects of oral minoxidil: reflex sympathetic excitement caused palpitations and arrhythmia, hirsutism. The main side effects of topical formulations skin irritation, medication site dermatitis, erythema, itching and other reactions. Although the uptake in the topical formulations are very small, but can not rule out an impact on heart disease patients with a history of the disease. Suffering from cerebrovascular disease, and non-hypertension-induced heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases, must be careful in minoxidil allergy persons and pheochromocytoma patients to be disabled.

In the hair follicles in vitro, by adding minoxidil can increase the cultivation time of growth of hair follicles. The hair follicle hepatocyte growth factor and vascular endothelial cell growth factor is the dermal papilla of the two major growth factor, an important role in the regulation of hair growth cycle. The present study suggests that minoxidil can directly stimulate the proliferation and differentiation of hair follicle epithelial cells, promote angiogenesis and increase local blood flow.

At present, there are sufficient clinical trials confirmed that minoxidil for androgenetic alopecia, alopecia areata has a good effect, but requires long-term medication to maintain efficacy. The shorter the hair loss, the smaller the area, the better the prognosis. High concentrations of the efficacy of low concentrations of large-scale clinical trials have confirmed that topical minoxidil hair loss treatment is safe.

The major adverse event of minoxidil solution is hirsutism. In clinical use of minoxidil, cosmetic raw material suppliers find that patients have varying degrees of hirsutism. In addition, minoxidil solution may cause irritation or allergic contact allergic reactions. Some patients have the symptoms of itching and scalp desquamation. But patch tests in patients with allergic contact dermatitis show that, for most patients, the propylene glycol solvent is true allergens rather than minoxidil itself. So replacement of solvents should prevent some allergic reactions. It is worth mentioning that minoxidil is approved in indications for androgenic alopecia (also known as male pattern hair loss) and alopecia areata. Consumers should also consult the dermatologist before buying. They should ask about using details from physician or pharmacists.

Source:http://www.cosprm.com

Treatment of docetaxel’s drug leakage

Docetaxel is also known as yew, patel and taxotere, docetaxel. It can promote tubulin to form microtubules and inhibit depolymerization of the latter. Thus it enhances the dimer assembly of microtubules, prevents its poly and eventually leads to the spindle abnormalities to inhibit mitosis. It has a good effect on ovarian cancer, breast cancer and non-small cell lung cancer. At the same time, it has a certain effect on the head neck cancer, small cell lung cancer, stomach cancer, melanoma and soft tissue sarcoma.

Chemotherapy drugs outside the leakage has been the Oncology most afraid of, what, the most likely to cause patient suffering and cause of nursing disputes. Docetaxel solution ph value of about 6.5, a weak acid. Leakage caused by chemical stimulation, causing inflammation of the organization to the organization. medication instructions and pharmacopoeia no adverse reactions and handling of drug leakage outside race. Only the emphasis on the processing of PVC material infusion to prevent allergic reactions. According to the classification of chemicals extravascular leakage, will be divided into stimulant medications. The so-called irritant drugs outside leakage can cause burns or mild inflammation without necrosis.

After outside leakage of docetaxel, the local skin feels blisters, itching and pain. If it is not handled properly, secondary infection can cause serious adverse consequences. During docetaxel treatment, the doctors and nurses should be first in patients with vascular assessment of the master puncture technique, and to inform patients of precautions to reduce the puncture by the movements, but should also step up inspections, ask the patient infusion local with or without pain or tingling in the application of normal saline infusion is completed, rinse the blood vessels, and the timely detection of problems and timely processing.

Nurses should distinguish the difference between extravasation and leakage of the past, leakage, infiltration collectively referred to extravasation. In fact, extravasation is due to the hardening of the arteries in patients with increased fragility, age and long input strong irritant drugs and other factors, causing the permeability of blood vessels increases, the slow penetration of liquid by a blood vessel to the organization. While the leakage due to puncture of the technical problems or activities and the needle puncture site in patients with fixed wrong, cause the needle the prolapse extravascular or perforation of blood vessels caused by liquid leakage into the organization.

There are methods and treatments for blistering pharmaceutical raw materials (refers to the outside leakage causing local tissue necrosis) and its local external leakage. But it dose not specify the frequency and time of partial closure. According to clinical experience in handling, after leakage of blistering drug, the partial closure is necessary. It should be taken once a day. After three days in a row, it does not appear the leakage of local necrosis. If the partial closure of stimulant medication has not been taken for three days, whether the patient’s blisters are related to closure need further study.

Source:http://www.cospcn.com