Traditional Chinese medicine treat advanced gastric cancer

Incidence of gastric cancer is ranked fourth in the most common malignancy in the world, there are about 1 million of the new cases annually. Ranks second in male cancer mortality, fourth in the ranks among women. As we all know, the adequacy of local control is the key to treat gastric cancer. The incidence rate of the incidence of primary gastric cancer liver metastases is 4% to 14%. Gastric cancer liver metastases is still incurable, patients with 5-year survival rate is only 10%.

Gastric cancer liver metastases, often accompanied with peritoneal dissemination, lymph node metastasis or tumor direct violation of other organs, so few reports about the resection of liver metastases of gastric cancer. Compared with colorectal cancer, the vast majority of gastric cancer liver metastases often prompts the disease has been widely spread. A report shows that in gastric cancer patients with liver metastases, only 1/5 of the patients line liver metastases resection. The survival rate of liver resection is relatively poor, 2/3 of patients with intrahepatic recurrence. Such a high relapse rate in surgery within 2 years means that there is a potential intrahepatic metastases in hepatectomy.

According to pharmaceutical raw materials suppliers, many new drugs such as oxaliplatin, taxane, irinotecan and S-1 and so on for patients with advanced gastric cancer provide a more effective and safe treatment option. Studies have shown that the effective rate of 5-FU + calcium folinate (CF) with oxaliplatin combination chemotherapy is 38% to 54%, overall survival is 8 to 11 months, and good security. The effective of taxane treat advanced gastric cancer was 11% to 24%. Another study showed that single-agent irinotecan in the treatment of gastric cancer was 20%. Various chemotherapy containing irinotecan showed a better relieve rate. What’s more, the irinotecan price is moderate, can be widely used.

S-1 is a fluorouracil derivative oral anticancer drug, compared with 5-FU has the following advantages: (1) can maintain a high blood concentration and improve anticancer activity; (2) significantly reduce drugtoxicity; (3) getting drugs convenient. In Japan, S-1 in 1999, has been approved it in the treatment of advanced gastric cancer. In Japan, more than 80% of the advanced gastric cancer chemotherapy use the S-1, its efficiency up to 44.6%. Clinical trials have shown that the effective rate of S-1 for gastric cancer with liver metastasis was 25% to 31%.

Recently, a clinical trial conducted by oncologists show that S-1 single-agent efficacy was not inferior to 5-FU alone drug; irinotecan combined with cisplatin was no better than use 5-FU alone. Analysis showed that irinotecan can significantly prolonged progression-free survival and overall survival associated with liver metastasis or lymph node metastasis in patients with irinotecan plus cisplatin. In addition, studies have shown that the first-line treatment for advanced gastric cancer, S-1 plus cisplatin is more effective than the S-1 single drug. Therefore, S-1 plus cisplatin has become one of the standard first-line treatment of advanced gastric cancer program in Japan. In S-1 combined with docetaxel clinical trials, types and histopathological types of gastric cancer involving the organ does not affect the efficacy of the program, wherein the overall response rate of gastric cancer liver metastases was 64.7%.

In addition, countries in the treatment of advanced gastric cancer chemotherapy are not the same. Such as the United States is often used docetaxel + cisplatin +5- FU, Europe often used epirubicin + cisplatin +5- FU or epirubicin + oxaliplatin + capecitabine, while South Korea is recommended cisplatin + capecitabine. But the efficacy of the above methods in gastric metastasis has not been reported.

Source:http://www.cospcn.com

Biotin is a good anti-hair loss drug

Friends with hair loss may have seen a news that a guy feeding cattle in farm, cattle lick under the head of hair loss, and after that it grows a lot of hair. After the European mad cow disease, scientists have discovered a new vitamin have excellent effect on mad cow disease prevention and treatment, this new biotin plagued human hair loss have good therapeutic effect. This vitamin called biotin.

Biotin, also known as vitamin H, is a water-soluble vitamin. A coenzyme constitute carboxylase, maintain hair, skin and nails healthy, involved in fatty acid, the genetic material (DNA) and adenosine triphosphate (ATP, the direct source of the body's energy, need to be constantly synthesis) anabolism and catabolism of amino acids. Biotin is an important nutrient fortifier, Britain thought that biotin reference nutrient intake per person per day is 10 ~~ 20 μg, United States recommended adult intake 30 ~ 100μ g per person per day. Biotin is also a biological catalyst which essential for animal growth and development process and gain weight, the quality of meat, fur and so on are influential. The dosage of biotin in Chinese market is small, and only used in the medicine, and other feed additives in very small quantities.

Biotin is an important and indispensable substance in the fats and amino acids metabolism, in preventing gray hair, hair loss prevention and treatment, ease muscle pain, relieve eczema, dermatitis symptoms have an important role. Biotin is synthesized by intestinal flora. The raw protein will hinder the body's absorption of biotin. Biotin and vitamin B2, B6, A, niacin (vitamin B3) have complementary roles to keep the skin healthy. Sparse hair male taking biotin can anti-hair loss; the man who lack of biotin, the facial and body will show up eczema, feel extreme fatigue, hinder fat metabolism, loss of appetite, hair loss, depression.

Biotin is a vitamin, it is necessary to prevent hair loss and promote hair growth. Through multiple case demonstrates, biotin greatly help to prevent hair loss. It can promote the growth of healthy hair, but also to maintain the health of the skin, can be used as cosmetic raw material. If the body lack of biotin, will not only cause hair loss, there are likely to lead to other skin diseases.

Supplemental biotin in addition to a balanced diet, also can through supplements to make the body's biological interaction returned to normal levels. In order to maintain the healthy growth of hair, be sure to pay attention to the skin calorie consumption, biotin manufacturer recommend that it preferably through diet to supply biotin, liver and egg yolk are rich in biotin. In daily, should choose shampoo containing biotin ingredients. Some cereal crops rich in biotin, such as green peas, soybeans, oats, walnuts, sunflower seeds, brewer's yeast, bulgur wheat and brown rice, etc.. Also to be noted that less drinking, because the beer will decompose biotin, reduce the body's absorption capacity, resulting in hair loss.

If you have stomach problems, especially the heartburn, you must be careful observe. Because some stomach problems with acid reflux, will prevent the body from absorbing biotin, that’s why a lot of stomach friends have hair loss. So friends have stomach problem should intake stomach antacids to promote the body absorb biotin, in order to avoid hair loss.

Source:http://www.cosprm.com

Capsaicin impact on the gastrointestinal tract

There is a big controversy on the reports about capsaicin on gastrointestinal cancer, and some studies by pharmaceutical raw materials suppliers suggest that capsaicin can inhibit tumor cell, also some researches found that the capsaicin can promote tumor cell proliferation, there are some reports show that capsaicin has no effect on tumor cells. Researchers doing more researches about capsaicin on gastric motility, most of them reported that small doses the capsaicin can promote gastric motility, large dose of capsaicin on gastric motility have inhibition role.

Effects of capsaicin on gastric mucosa, in recent years, there are many international studies have shown that the right amount of capsaicin on gastric mucosal have protective effect. The probability of Chinese people in Singapore suffering from gastric ulcer is three times than Malaysians and Indians, and may be related with Malaysians and Indians eat more chili. Capsaicin, capsaicin-sensitive afferent nerves and capsaicin receptor and gastric mucosal injury and repair are closely related. Capsaicin-sensitive neuron cell body is able to synthesize tachykinins of substance P (substance P, SP), neurokinin peptide A (neurokinin A) to the axon terminals transport of these peptides. Stomach CSSN through the release of calcitonin gene peptide (calcitonin gen related peptide, CGRP) increased gastric mucosal blood flow, and a series of reactions mediated by CGRP, thereby increasing the gastric mucosal resistance to maintain gastric mucosal integrity. Acid-induced gastric ulcer, congestive reaction capsaicin sensitive afferent neurons by regulating CGRP release to promote the role of the acid treatment of the gastric mucosa, thereby treating gastric ulcer.

The functional activity of the CSSN gastric acid and gastric mucosal blood flow is more important to the regulation of gastric mucosal blood flow. Intragastric perfusion with peptone, causing an increase in gastric acid secretion and gastric mucosal blood flow; terms of the capsaicin afferent denervation weakened the intragastric peptone caused an increase in gastric acid secretion effect, increase in gastric mucosal blood flow effects almost completely disappeared. The surface mucosal growth factor by capsaicin-sensitive afferent nerve play the congestive role and protecting the stomach and gastric mucosa. Gastric mucosa dominated by the vagus nerve and spinal afferent, when gastric mucosa stimulated by harmful chemicals, these afferent nerve though increased gastric mucosal blood flow to protect and repair the gastric mucosa.

Capsaicin have certain effects on gastric acid secretion, the majority of studies by capsaicin supplier have shown that small doses can inhibit gastric acid secretion, large doses may promote gastric acid secretion, also some reports chain that a certain dose of capsaicin has no effect on gastric acid secretion. Capsaicin may through directly stimulate the central, peripheral capsaicin-sensitive sensory nerve and Pik cells capsaicin receptor, causing calcitonin gene-related peptide, P substance, neurokinin A, vasoactive intestinal peptide neurotransmitter release to participate in the regulation of gastric acid secretion.

Capsaicin on gastric cancer cells have significant growth inhibition and induction of apoptosis in a dose-and time-dependent manner, mainly through the regulation of Bax, Bcl-2 and C-myc protein expression to achieve. Capsaicin dose relationship manner to reduce the cell viability of the human colon, capsaicin also cause the fragmentation of the changes in cell morphology and DNA, DNA content decreases, phosphatidylserine shift, wherein phosphatidylserine of the shift marks cells apoptosis. The mechanism of capsaicin-induced apoptosis may be semi-caspase 3 (a major apoptosis-inducing enzyme) activity is enhanced. At present, the international community about the effects of capsaicin on gastrointestinal health research relatively large, but its mechanism of action is relatively weak, especially affect the outcome of colorectal cancer and its mechanism should be further explore.

Source:http://www.cospcn.com

Discussion on the role of vitamin A acid

Recently, a relative researches reported that isotretinoin can cause a rare and serious skin damage. The experts pointed out that this report is not meant isotretinoin will not be used to treat acne, but to remind patients with moderate to severe acne use any drugs must be ask the doctor, or it will be harmful to health.

Isotretinoin is called the "ultimate weapon" in the treatment of acne. Experts said that isotretinoin is one kind of vitamin A acid, is a derivative of vitamin A. According to reports, the vitamin A acid is the recipe for treating skin diseases, such as psoriasis can use vitamin A acid drugs to treat. Careful consumers will find that in some skin care products have an ingredient called vitamin A acid. Vitamin A acid used as cosmetics material may be instead of acid which dominate the world in the past few years, vitamin A acid can penetrate the skin cell nucleus, to really improve the skin from the inside to the outside, make skin have a healthy glow luster, and tretinoin almost does not exist discomfort issues that must be considered.

Vitamin A acid on skin have the following three advantages: promote skin metabolism, improve skin rough, dry, make dull skin looks a shiny. Perfect the organization of the skin stratum corneum, strengthen the skin's elasticity, a sense of transparency, so that the skin looks soft, white, and more healthy. Clear accumulation of dirt in the pores, shrink pores, has an antibacterial effect. The feeling of different skin use the skin care products containing vitamin A acid is different. But is this good medicine, with very large toxicity. Long-term use of vitamin A acid drugs are toxic, so that patients even in strict accordance with the instructions to medication should also regularly check blood and liver function. Since oral toxicity, then does the topical use will be more secure? Though topical use isotrenoin ointment did not cause a lot of toxicity to body, but caused larger skin irritation, for some thin skin people even will cause part of the exfoliation after run out.

Tretinoin manufacturer pointed out that, in the treatment of severe acne, sometimes it may need to use this drug, so must be used under the guidance of a doctor, should not purchase this medicine by your own. Special reminder, due to a lot of acne treatment drugs in the early development stage, children less experience in the application, even if some minors with serious acne should use carefully. In addition, to prepare pregnant women should want the baby after six months they run out the medicine, otherwise it may cause fetal malformations.

Patients need to be reminded that the face acne since pustule, it is better to go to the hospital to deal with, but not to squeeze it yourself, because this is likely to cause the surrounding tissue infected destruction, even cause serious intracranial hemorrhage. For the early acne, only need to wipe some outside medicine, such as some antibiotics, simple vitamin A acid and Chinese medicine. If developed to a certain extent, such as more pustule, it need to identify the cause, for some serious acne may need oral medication to treat.

Source:http://www.cosprm.com

The lure of chili

Do not know what time does it start, Chinese people is more and more love spicy. Today, nearly half of the world’s peppers are produced by china; chili acreage has more than turnips and tomatoes in China, second only to cabbage, it becomes Chinese second largest vegetable.

When the pepper burning stimulate the taste buds; whether summers or winters, North or South, both men and women were falling in love with that eat profuse sweat, hooked feeling, "spicy" is unwittingly become the taste that most people can not live without it. It allows us to increased appetite, hearty, quietly took away the pressure of a busy day accumulated. In the end, what kind of charm does the chili have, whether you can eat spicy food truly?

Spicy charm is a kind of "pain", the researchers had been research peppers for up to 5 years, the first division of the Chinese territory of spicy food spiciness: "hot zone" in the upper reaches of the Yangtze, including Sichuan, Hunan, Hubei, Guizhou, Shaanxi, southern, spicy Index 151-25; northern "mild area, including Beijing, Shandong, Shanxi, northern Shaanxi and Gansu most, Qinghai to Xinjiang, spicy index 26-15; southeast coast, south of Shandong, Jiangsu, Shanghai, Zhejiang, Fujian, Guangdong, compared to avoid spicy "light zone" spicy Index 17-8. the most favorite to eat spicy food is Sichuan, the second is Hunan, the third is Hubei.

Why pepper make people more eat more addictive? Pepper charm comes from a " pain ". And the sweet, bitter, salty, sour, strictly speaking, " hot" is not a taste, but the body burning irritation. The stimulation sense brings pain, let the body to secrete large amounts of endorphins to resist, and the EP also can let a person produce the feeling of pleasure. Therefore, when the pain stimulus fading, the body's stress also releasing slowly.

Eat spicy not only make people feel happy, in fact, as pharmaceutical raw materials, pepper itself is rich in nutrition, has many health benefits. First of all, in the hot pepper, various vitamins and content is extremely rich. A small pepper include vitamin A, vitamin B, vitamin C, vitamin E, vitamin K, carotene, folic acid adn all kinds of vitamin. Secondly, pepper also contains calcium and iron and other minerals and dietary fiber.

Peppers including stem pepper, fresh pepper, pickled pepper, capsaicin supplier recommend that it is better to eat fresh pepper, because it contains more nutrients. In addition, peppers had better cooked to eat. Because chili contains a large number of capsaicin, may have on oral and gastrointestinal mucosa irritation. After heating, the gastrointestinal stimulation will decrease.

Although eat spicy is fun, but eating too much also make people can’t stand it. Experts teach you solution hot method: eat more sweet and sour food. Sweet can cover and interference with spicy, acid and alkaline of capsaicin. Feel too hot, dipped in vinegar to drink a bowl of cold, sweet drinks, eat a cool fruit are very useful. If you are doing at home again, try to choose nourishing Yin, dry down, pours hot food to match, such as the duck, shrimp, crucian carp, bitter gourd, sponge gourd, cucumber, you can also cook cool mung bean porridge, lotus leaf porridge to relieve inflammation. The pepper, due to personal physical fitness is different, the bear level is different. Cold hands and feet, easily anaemic person can eat more. Have gastric ulcers, esophagitis, hemorrhoids, and hyperactivity of fire due to yin deficiency, often constipation, acne people should eat carefully.

Source:http://www.cospcn.com

The new method and its advantages of biotin remove wrinkles

Many people who pursuit beauty feel that new method of biotin remove wrinkles should have better effects, and this is the way it should be, Although these materials of wrinkle injections is the same as usual, but the development of science and technology making these methods have the improved efficacy and safety, you can chose it trustingly. And compared to the traditional method, there are many advantages of this new method, which has a non-invasive, and not need to rest, does not affect the work; effect immediately. But the maintaining time is short, need to regularly repeated injections. The clinical effect of botulinum toxin injection generally can be maintained for 3 to 6 months. Cosmetic raw material suppliers pointed out that the materials of medical biotin remove wrinkles new method used are as the following:

The hydrogel: Is the chemical synthesis of macromolecular polymer. Disadvantages: it is a foreign body, prone to rejection. Hyaluronic acid: the inherent human body composition, methods of operation, safe use, fast effect. It applies to any part of the body, no rejection, repeated injection. Currently very popular in the world. Collagen: extracted from calf or human placenta, only filling the role. Disadvantages: is an allogeneic or xenogeneic protein may occur rejection, but also maintain a relatively short time. Goat embryo essence: China is almost no the pure product, it is the separation of the different components in the sheep embryo, which may contain thymosin, growth hormone and other ingredients and cellular debris. Different people use different preparations. Biotin remove wrinkles new method generally refers goat embryo essence wrinkle. Botulinum toxin: botulinum toxin secreted by a muscle contraction inhibitor, for functional wrinkles work.. Disadvantages: applicable eyelids, orbital and cheilogramma.

However, biotin supplier also said that biotin remove wrinkles new method has now been used very widely, and its operation still have a certain degree of risk, so it should be doing some considerations. Prior to use should clean the face. Prohibition against alcoholic drinks a week. Two weeks before surgery should not use aspirin or other antipyretic analgesics. Learn more about the patient history of major diseases, allergies, facial cosmetic surgery history. Postoperative care work: 4 hours after injection, quiet rest. Keep the body upright. Within 24 hours, not to do strenuous activities. Do local massage, to prevent liquid enters the orbit causing ophthalmoplegia.

As for the advantages of bio-wrinkle injections plastic surgery, Experts pointed out that the main advantages of the following four points: 1. Biological injection can be absorbed by the body, do not need recovery period, after the bio-wrinkle injections you can work immediately. This method is to achieve the purpose of treating wrinkles, its domination nerve paralysis role biologics, this biological rhytidectomy do not need recovery period, just a few minutes you can go straight home or to the office; this method can remove wrinkle accurately, quick effectiveness. Facial subcutaneous injection of trace amounts of biological agents in a short period of time accurately eliminate facial intensive fine wrinkles, such as the outer canthus in the forehead, between the eyebrows, eyes, cheeks, mouth, neck wrinkles, make the skin shiny and elastic; side effects better conditioning of the human body, promote circulation, improve the immune system. Has a role in health care. Finally, experts say the final advantage of bio-wrinkle injections plastic surgery is no need to perform an operation, no adverse reactions also an advantage of biological rhytidectomy.

Source:http://www.cosprm.com

Resveratrol is a potent antioxidants can protect the heart and brain

According to the information supplied by resveratrol manufacturer, the highest content of resveratrol is Aster plants in Japan, followed by grape skins. Red wine, pure grape juice, peanuts, cranberries, blueberries, bilberries and some the pine also contain resveratrol, the concentration is slightly lower than the first two things. Grapes and other plants manufacturing resveratrol is for fighting fungal infections, injury, stress; is part of their natural resist system. The amount of resveratrol in red wine is different from geographical production areas, cultivation conditions, fungal infections, as well as red wine and grape skins mixed time. The content of resveratrol in red wine is from less than 1 mg per liter to more than 20 milligrams per liter.

Red wine contains strong and effective polyphenol antioxidants: resveratrol, anthocyanins (the pigmented substances in grape skin), proanthocyanidins (common in grape seed), catechol and quercitrin. Use mice as experimental research show that resveratrol in the prevention of prostate cancer, colon cancer, and thymic carcinoma. Resveratrol showed multiple stages in the development of cancer, including tumor initiation, tumor induction period, the period of tumor development and metastatic the antagonism can play. Allegedly a week often drink three glasses of red wine and even more among the 3% of colon polyps or colon cancer, while drinking more than 3 cups white wine (white wine grape skin fermentation time is shorter, containing resveratrol week the amount of alcohol is less), the ratio is 9%. Compared the results of no drinking and the results of people drinking white wine is similar.

Resveratrol as pharmaceutical raw materials also can be called red wine or pure grape juice, the suffering Alzheimer's mouse experiments showed that they can protect the brain and cognitive function, and alcohol (equivalent to the percentage of ethanol in wine) or water without protection function. Red wine in the protective effects of alcohol on the brain and cognitive function has no effect. One of the mechanism of Alzheimer is β-amyloid produce excessive, and subsequently cause brain damage. Resveratrol motivated a sirtuin protein, people found sirtuin protein can protect neurons against beta-amyloid - induced free radical damage of DNA. Resveratrol promote dangerous beta-amyloid diminishes. It is thus assume that resveratrol may prevent age-related neurodegenerative diseases, such as Alzheimer's disease.

Compared with nondrinkers aging population older persons of Chinese nationality, little product or moderate alcohol consumption make the risk of suffering from Alzheimer's disease lower 37%, and vascular dementia is as low as 69%. In contrast, excessive alcohol consumption will be increased the risk of dementia. Slightly moderate alcohol consumption may significantly reduce the risk of dementia. Compared with people who never drink beer and slightly moderate drinking beer, the risk of dementia may be significantly higher. In a study from France, the daily consumption of 3-4 glasses of wine, the risk of suffering from Alzheimer's disease fell by 75%, and drink less than one glass of wine a day is reduced by 45%.

Sirtuin protein manage gene silencing, DNA repair, mitochondrial function, control of cell aging and arrange for their deaths. 95% of our cellular energy from mitochondrial manufactured end product of adenosine triphosphate (ATP), ATP is the energy chemical repository. The number of mice treated with resveratrol increases, the mitochondrial energy produced increases, oxygen capacity increases.

Source:http://www.cospcn.com