Brief introduction of biotin

Biotin, also known as vitamin H, coenzyme R. It is a sulfur-containing water-soluble vitamin, and is widely distributed in animal and plant tissues. Biotin also called biocytin, it is the carrier of carboxyl groups in the carboxylation reaction of many ATP. Animals lack of biotin can cause skin diseases and hair removal. Egg proteins contain biotin and avidin protein closely. So if you are eating a lot of raw eggs, can impede the absorption of biotin, so as to cause biotin deficiency. In normal cases, intestinal bacterial synthesis of biotin adequate human needs, symptoms of biotin deficiency does not occur.

Biotin is a water soluble sulfur-containing b vitamins, is related to the carbohydrate, protein and fat metabolism, Coenzyme a, also known as Coenzyme r. Biotin is a urea-based ring contains a sulfur atom and a valeric acid side chain, now known to have 8 types of isomers, only naturally occurring α-biotin, and biological activity. Biotin is a colorless acicular Crystal, easily soluble in water, slightly soluble in water, soluble in alcohol, but insoluble in organic solvents. On thermal stability, General cooking to be significant, strong acid, alkali and oxidizer can make their destructive, ultraviolet rays can also make its progressive destruction. Biotin in the body stored mainly in liver, concentration in the blood is low.

Biotin is of every living cell contain trace amounts of growth factors, is important for fat metabolism and carboxylation reaction Coenzyme is to maintain normal growth and development, essential for maintaining healthy skin and bone marrow of a nutrient. Research report by biotin manufacturer noted that biotin to treat baldness due to lack of biotin, improve the disadvantages of poor hair breakage, hair.

In 1901, Wildiers found a substance is required for yeast growth, he called this substance as "bioi". In 1933 when studying the growth of rhizobia isolated from beans, such as Allison, from which the isolation of a nitrogen-fixing bacteria, is named "Coenzyme r". In 1937, Hungary scientist Gyorgy discovered a substance to prevent adverse effects caused by egg white, this substance named vitamin h. 1940 Gyorgy and his colleagues through experimental research confirm that Coenzyme r, biotin, vitamin h, bioi are of the same substance, and to prove that a nutrient biotin is essential in mammals. In 1942, Vigneaud made the chemical structure of biotin. It is synthesized by biotin supplier in 1943.

Food mainly in the form of free biotin exists or in conjunction with protein. And protein binding of biotin in under the effect of protease, forming biocytin, biotin by intestinal enzymes, free biotin release. Biotin near end of the main part is absorbed by the small intestine. When low concentrations, absorbed by the carrier-mediated transport initiative; when the concentration is high. Is absorbed by simple diffusion. Absorption of biotin through the portal circulation, transported to storage within the liver, kidney, other cells that contain biotin, but less. Human intestinal bacteria can be from two replaced heptanoic acid nonanoic acid synthesis of biotin, but as the direct source of biotin is not enough. Biotin in the body primarily through urine discharge, breast discharge in biotin, but the amount is very small.

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Chia seed's eating experience

Chia seed is considered to be "Indian long-distance food". And the warriors of the ancient Aztecs feed on the chia seed when in battle. I am a runner, and I consumption of chia seed to enhance stamina and endurance running in the mountains, and hang on for several hours several times. And this is the chia seed's initial function.

The 100g Hungariana promoter contains calories is 490kcal (light work of adult males need 10030kcal /day, light work of adult women need 8800kcal / day ). This shows, the daily intake of 1.5kg chia seeds/day will not get fat! The chia seed promoter contains a very high dietary fiber, 9.8 times that of rice, oats 2.6 times, 1.6 times that of wheat. Chia seed inside the cellulose absorbent function, after absorbing water volume will inflate larger. Thus, the secretion of fluid and the volume of cellulose will account for a large space in the gastrointestinal tract, enhanced satiety to the brain to convey " I'm full " message, and don't want to eat any more to achieve the purpose of control appetite.

Mixed with a tablespoon chia seed with a glass of water for 30 minutes, not only the volume swells and becomes chia seed sub-gel. This gel formation due to the soluble fiber in chia seed. The researchers believe that foods containing soluble fiber into the stomach can also occur to the same gel reaction. In this way, the gel into the stomach chia seed between its own carbohydrates and gastric secretion of digestive juice produced a physical barrier, delaying carbohydrate degradation monosaccharide digestion process, the body continues to provide energy.

Chia seed is also rich in omega-3 polyunsaturated fatty acids, it can not only lowering blood pressure can also fight against cardiovascular disease, eliminate inflammation, fight cancer, fight diabetes, the fight against neurological diseases and brain development. Omega-3 fatty acids or a way to protect the skin collagen biologically active substances, studies by chia seed supplier have shown each week to eat three times with Omega-3 food can delay the aging of the skin. Moreover, the sub-Hungariana rich in a variety of antioxidants, protease inhibitors (Pis), chlorogenic acid, caffeic acid, myricetin, quercetin, kaempferol flavonols, vitamin C, vitamin E, beta-carotene (vitamin A), selenium, etc., which can be an effective solution to skin aging, pigmentation, resistance to aging.

Omega-3 DHA, EPA has an important role in the oxygen-carrying blood, coagulation, endocrine, skin cell nutrition, nerve cell growth, for a variety of organ metabolism must. However, the body itself can not synthesize Omega-3, therefore necessary to supplement the food. chia seed in the Omega-3 polyunsaturated fatty acids and fish oil content is higher, and no heavy metal pollution. Do not have to manually add any anti-oxidant ingredients, we can guarantee one of the Omega-3 unsaturated fatty acid is oxidized.

This pharmaceutical raw material can be in any cooking recipes to replace the fat bad for your health. You can use uncooked seeds do salad sauce, dinner dishes, fruit and cream. You can also add them to cookies, cakes, muffins and other baked foods. I often add a few spoons in the fruit juice and water, and drink directly.

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The principle of the glutathione whitening skin

Three amino acids in the formation of glutathione, it is a small molecule in the body. Each cell of the body containing these amino acid products. The body's immune system benefits enormously from the glutathione.We can take use watermelons, asparagus and other fresh vegetables and meat to produce the amino caids in cell. Glutathione in addition to these effects, but also can whiten skin color safely and effectively.

If you pay attention to the photos of top models’ childhood, you will find the color of their skin dark a lot than it is now. As a mild whitening ingredient, glutathione is an integral part of the skin whitening pills. It can reduce the appearance of the skin color, making it the best skin whitening solutions. All cells of the body can work more effective because of the existence of glutathione.

As the modern human pays great attention of the appearance,the demand of glutathione pills is growing more and more. Pressure, anxiety, and environmental pollution give the skin adversely affected. In addition, the pollutants in the atmosphere will lead to dull skin and delicate texture. Therefore, skin care has become a hot topic of public concern. This is why the skin whitening cosmetics materials can be popular solutions.

These glutathione drugs are given through the mouth following the doctor’s prescription, but many people still have a query on its security. However, the drug is safe which is confirmed after a series of clinical studies, because amino acids are the key ingredient for skin whitening agents. In addition, glutathione supplements can be used as antioxidants to strengthen the immune system. It contains vitamin C can make the skin smooth, flawless and wrinkle.

There are many false advertising about skin whitening products on the market. But glutathione suppliers are convinced that consumer glutathione pills is 100 percent secure, they do not contain any bleaching agents or chemical substances, from any perspective, these products will not do harm to human health.

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Plant extracts industry development

Recent export performance of plant extract products is particularly in traditional chinese medicine products, and it is the most rapid development of such products, especially in 2011. For example, the export value of plant extracts is $ 1.13 billion, an increase of 47.0%; export volume of 42,000 tons, an increase of 14.9%; the average export price of 26.8 U.S. dollars/kg, an increase of 28.2% can be described as the volume and price both increase.  

In addition, the import growth rate of the plant extract is also very obvious that 2011 plant extracts imports amounted to $ 220,000,000, an increase of 67.8%; imports 1.8 million tons, an increase of 59.4%; the average import price of $ 12.4/kg, an increase of 5.2%. Which the essential oils of peppermint oil and other imports from Central Asia and licorice extract in resource scarce plant extracts as pharmaceutical raw material, and the import growth rate of more than 100%.  

Basically stable from the monthly statistics, the monthly import and export of plant extracts, plant extracts in December a single month import and export amount and number of ups and downs of little change; but the amount and number of year-on-year, imports rose significantly year on year, while exports rose more gentle.

As far as the market, China plant products export market is relatively stable, United States, and Japan, and Germany, and France, has been planting products major market. In recent years, Mexico, and India imports large quantities of Chinese plant products, dominated by pigment product. 2011 plant extract export markets except Latin America slightly tighten outside, other continents showed a more substantial growth in exports and export volume. In Asia, Europe and North America are still major areas of China's export of plant extracts, 2011 exports to the three parts of 82.6% per cent of China's total export of plant extracts. 

Asian markets: China plant extract exports to the Asian region was $ 440 million, accounting for 39.4 percent, exports grew by 18.8%. Among them, Japan and the ASEAN region based on Kampo is the major export markets in Asia. 

European market: the 2011 European plant extracts market trends strongly. As the world's largest herbal medicine market, the plant extract based products much local consumers. In December, the plant extracts in China exports to the EU for $ 290 million, an increase of 63.2 percent, export volume was 11,000 tons, an increase of 15.1 percent, the average export price increased by 41.8%, volume and price go up a good situation. The main exporters of plant extracts in Europe is Spain, Germany, France and Britain.

U.S. market: the North American market or the U.S. market is the Chinese plant extracts of the most important export market, since 2005, has been ranked the location of the plant extract export. Taking dietary supplements habits of most Americans, which also spawned the growth of the world's largest dietary supplement market demand for the plant extracts. The U.S. market has become a global pharmaceutical and healthcare plant extracts vane, increase or decrease in market demand will have a direct impact to the rest of the world market changes. 2011, the plant extracts in China exports to the U.S. $ 180 million, an increase of 54%; export volume of 8050 tons, an increase of 32%.

With the development of plant extract products, the number of chinese plant extract suppliers is also growing. The record of them is 1402 (excluding production and sales of classes ) in 2011. Among them, the private enterprise is the main force in the export of plant extracts, which exports accounted for more than 56%; exports of foreign-funded enterprises accounted for 32% and state-owned enterprises accounted for only 11% of the total exports. In 2011, the plant extract prior to export 10 enterprises exports accounted for 33%, the top 10 barriers to entry increased from $ 16,140,000 to $ 22,190,000. A slight increase of the overall industry.

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Antioxidant activity of astaxanthin

Oxidative damage to the organism is mainly manifested in the destruction of lipids, proteins and nucleic acids. Lipid due to the destruction of the free radical chain reaction, resulting in biofilm structure and function change; protein oxidation is very sensitive, especially the sulfur amino acid; bases and pentose in DNA molecules are easily oxidized position, the oxidation can lead to DNA breaks, base degradation and protein cross-linking, making the genetic material to mutate or cause cell death.

Carotenoids by physical quenching Singlet oxygen, singlet-oxygen additional energy transfer to carotenoid, carotenoids accept energy into triplet (3Car3), then release the extra energy through exothermic go to the ground state (1Car), which is a physical process, the structure of the carotenoid is not changed, you can continue to quench singlet oxygen. The speed of chemical reaction can be used to describe the rate constant (k), the faster the reaction, the greater the rate constant. Carotenoid quencher of singlet oxygen, the speed can be described by the rate constant (kq) kq value of carotenoids reflect the size of the potential effectiveness of its antioxidant activity, kq, higher the value, the faster the reaction with singlet oxygen carotenoids to quench singlet oxygen, kq, higher the value, the more a certain amount of carotenoids per unit time, quenching singlet oxygen;, of course, values ​​of kq, and experimental conditions (such as temperature, solvent, photosensitizer types, determination methods) are closely related, so the size of the kq value of more carotenoids, the experimental conditions must be the same.

It can be seen from the data of carotenoids singlet oxygen quenching ability and its number of conjugated double bonds, and the end of the ionone ring is not obvious. 4, 4 'carbonyl (astaxanthin and angular zeaxanthin) can improve the ability to quench singlet oxygen the astaxanthin quenching singlet oxygen capacity of the strongest, 100 times that of the α2 tocopherol, and glutathione the reaction rate of 1/125 of α2 tocopherol, but in vivo environment and experimental conditions very different from the results of chemical experiments by astaxanthin supplier does not reflect the real situation in vivo; In order to simulate the biological environment, people with liposomes, cultured cells and animal experiments, the results due to the antioxidant capacity of oxidant species in biological environments, and the interaction between the different other substances such as carotenoids in the lipid environment (such as biofilms) than water-soluble antioxidants (alpha lipoic acid, glutathione), antioxidant capacity, while the latter antioxidant in the cytoplasm plays an important role.

Astaxanthin is a widely used carotenoid as cosmetic raw material, people have been extensively studied for its antioxidant and anti-oxidation efficiency. Several carotenoids quenching singlet oxygen, the efficiency of blood cells in vitro study found that lycopene is the most effective, astaxanthin, followed by, β2 carotene worst. Astaxanthin clear that the efficiency of free radicals and angular zeaxanthin, 50% higher than the β2-carotene and zeaxanthin, clear hydrogen peroxide free radicals and prevent lipid peroxidation was significantly better than zeaxanthin, canthaxanthin, and β2 carrots. Antioxidant, astaxanthin, each individual is not the strongest, but the highest antioxidant capacity. Astaxanthin similar to vitamin E, fat-soluble antioxidant in the performance of excellent oxidation resistance of biofilm and lipid-rich tissues. Feed with vitamin E deficiency, vitamin E rich feed and w (astaxanthin prime) = 1% of the feed fed to mice two to four months, and then liver mitochondria and red blood cells in vitro antioxidant experiments, found that astaxanthin significant antioxidant activity, more effective than vitamin E.

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Red wine and heath

Along with the increasingly popularize of healthy life, red wine has becomed the tendency of world's consumption of alcohol. More and more fashional people and leader trend to taste  red wine, enjoy the healthy life which is brought by the red wine.

It is well known that the red wine can make beauty. But not all the red wine can reach the effect. The resveratrol in the red wine is the real one that can make beauty which has the antioxidant function. This is a good component to condition the skin from the inside and outside. Resveratrol, has found by resveratrol supplier in 72 kinds of plants, including mulberries, peanuts and other particularly high content of grapes,especially the highest content of high-quality red wine.

Resveratrol is a plant origin of estrogen, senile osteoporosis, acne and so there is a clear preventive effect. In addition, resveratrol also has anti-bacterial, anti-inflammatory, antithrombotic, anti- allergy effects, and atherosclerosis sclerosis, ischemic heart disease, hyperlipidemia, and others have a significant preventive effect, retard aging. The latest research shows that resveratrol can fight against fat, food help you lose weight. Resveratrol content of high and low, often become an important basis of the difference between enterprise technology level of indicators to measure the merits of red wine quality.

Red wine also contains a wonderful pharmaceutical raw material - tannins. Tannin changes with exposure to air after the rich, level change, brings surprise completely unpredictable. Good red wine due to the selection of advanced oak aging for more than 18 months, the extraction of oak within the rich tannic substances, making the wine structure to fuller, more full-bodied texture. This wonderful tannins prevent tooth decay and prevent radiation against a lot of good, and can increase the contraction of smooth muscle fibers in the intestinal muscular system, have a certain effect on the colitis.

Other nutrients in red wine are also very rich, and play a very important role in promoting human health, is better than a lot of health care products. For example, red wine contains sugar, pectin, alcohols, organic acids, inorganic substances, trace elements and dozens of amino acids and a variety of vitamins. Now known to about 600 kinds of useful elements on the human body, of which there are many substances not found in other foods. Red wine contains a lot of glucose and fructose, not only can be directly absorbed by the body but also the role of the yeast directly fermented into alcohol and carbon dioxide. The alcohol content in red wine, good health, the body's cellular respiration, can promote blood circulation and promote healthy and beautiful.

A growing number of studies have shown that red wine can almost be called the perfect "health drinks" in the "green" "low carbon" concept prevalent today, the red wine also is met with "healthy" and "quality" by more and more people to accept and loved.

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Market application of Vitamin H

Vitamin H, also known as biotin, a water-soluble B vitamins. Vitamin H is the body's fat metabolism and other important coenzyme of the reaction of carboxylic group, is also a livestock growth and development essential to a biological catalyst. It mainly used for medicine, nutritional additives, feed additives. In recent years the international market demand, its prices are also soaring, once reached more than 3000 U.S. dollars per kilogram of high-priced.

Vitamin H in the feed additive, medicine and health, cosmetic raw material products and beverages has a wide range of applications. Especially for feed additives, currently most of the global vitamin H production is used in this regard. Previous years, the world market for vitamin H, has been little demand. Europe, North America and Japan, Korea and other developed countries are processed into animal bones, viscera, and other additives added to the beverage, these items contain natural vitamin H, and thus without additional plus vitamin H. European "mad cow" incident, it was found that the cause of the BSE is animal bone meal, offal and other substances are added to the feed. Since then, Europe and the United States and other developed countries have abandoned animal bone meal, offal, switch to the chemical synthesis of a variety of vitamins as feed additives for some time even supply, prices are also rising. And foreign distribution to goods often require the manufacturer to issue a certificate, to confirm that vitamin H is indeed the chemical synthesis production, not the natural items extracted.

The amount of Vitamin H on the Chinese market is not that much, and mostly used in medicine and hygiene. A few years ago, Chinese medicine with vitamin H per year are imported from abroad, imports about 1-1.5 tons per year. Such as a pharmaceutical company in Japan in May 1998 allowed to export to China of vitamin pharmaceutical raw materials, specifications for iron cans into each to listen 100g, 500g, 1 kg, 5 kg , four kinds of packaging.

In contrast, vitamin H is rarely used in feed additives in china by biotin supplier. In the long term, as China's rapid economic development, the 1.3 billion people's living standards continue to improve, demand for meat, poultry, eggs and other food will last, a large increase. According to statistics, China 's feed annual output of about 50 million tons, per kilogram of feed add 0.15μg vitamin calculation, it needs vitamin H 7.5 t. Now feed for more than 30 years possession kilograms per capita in China, Japan, 200 kg, 300 kg in Western Europe. If it reachs the level of developed countries, China's market feed additives only vitamin h per year up to 50 to 70 tons. It can budget, vitamin h in the Chinese market in the future development of space is very great.

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