How Chinese pharmaceutical industry get out of current predicament

Chinese pharmaceutical industry has ever experienced a great period of the 1990s. In this period, China's pharmaceutical raw materials industry successfully undertakes the industrial transfer of the U.S., Japan, Switzerland, Italy, Spain and European countries. In the short span of 10 years, China's pharmaceutical industry achieves the rapid development. The pharmaceutical industry had finished the waking time that developed countries went for nearly 60 years. It has laid a solid foundation for China to become the world's largest pharmaceutical raw materials producing and exporting countries.

According to statistics, China has been able to produce over 1500 kinds of chemical raw materials. Production of pharmaceutical raw materials are up to 1.23 million tons in 2005 (excluding chemical intermediates and precursor drugs), some products still has a pivotal role in the international market. For example, penicillin industrial salt, vitamin C, cephalosporin C, too, erythromycin, tetracycline and other fermented primary products, chemical synthetic drugs, pharmaceutical raw materials such as caffeine, acetaminophen, aspirin, and quinolone The antibiotics norfloxacin, ciprofloxacin, ofloxacin, according to the production of enoxacin, also ranks first in the world.

However, production and management advantages of China's pharmaceutical industry are also subject to challenges from the rest of the world pharmaceutical raw materials glutathione in emerging countries and regions. The strongest rival is India. They are the same premium Competition of the way, and China in the international market continue to compete on price, after years of battle and fight to fight, China Pharmaceutical prices in the international market is becoming less and less, a lot of varieties in almost unprofitable proportions. Summary of the Chinese Pharmaceutical industry we have taken this journey, the Chinese Pharmaceutical industry during the golden age of gold.

In a sense, China is simply to undertake the transfer of industries in the United States, Japan, Switzerland, Italy, Spain and other developed countries and European countries, and not too high technological content and high-tech, the contrary, the Chinese also developed countries Pharmaceutical industry, pollution, garbage, or simply repeat the introduction of the developed countries purchase low price the overdraft environment to bear the expense of the bottom line capacity production of pharmaceutical raw resveratrol products at the same, yet the pollution never left China. Resulting in the China National Pharmaceutical industry in a very vulnerable position, if there are competitors from other countries and regions, China's pharmaceutical industry advantage will be depleted.

At the same time, in face of this low-cost challenge from the foreign emerging pharmaceutical raw materials production, as well as anti-dumping lawsuits from the developed countries, China's pharmaceutical industry withstands adverse state surrounded by the enemy. Therefore, China national pharmaceutical industry should assess and review about the changed from golden era to the present recession or low profits extraordinary journey. China national pharmaceutical industry need transition facing the changing and diverse international markets. Otherwise, China can only maintain low-level position in the international pharmaceutical raw materials market and will always miss the name of power country in pharmaceutical raw materials.

Source:http://www.cospcn.com

Production of hair coloring products

Hair dye has hundreds of years’ history as a cosmetic using for beautifying people's lives. As early as the Song Dynasty of China, ancient Greece, Egypt and the Roman era, people began to use plant dyes coloring hairs. With the progress pace of the times, people’s requirements are getting higher and higher. Plant hair color can not meet the requirements. Thus a variety of chemical substances appeared in the hair dyes.

According to the solid and product forms, hair products can be classified of hair as following categories. It can be divided into temporary and semi-permanent and permanent; stained solid form of the biotin product, can be divided into a liquid, emulsion, paste, powder, shampoo type and several, but are generally hair color stranded in the persistence of the time hair to classify and determine its use.

Temporary hair dye has poor firm and it is intolerant for washing. Generally only temporary adhesion as a temporary modification of the surface of the hair, wash all removed, repair hair after the hair on the temples or for actors for cosmetic use. This hair dye is often used effectively deposited on the hair surface and does not penetrate to the hair dye within the basic dyes, acid dyes, disperse dye or metal dyes, such as: azo, anthraquinone, triphenyl methane, phenazine or benzoquinone imine.

Semi-permanent hair dye ability shampoo washing several times (5-6 times), and can keep the color of 3-4 weeks. This type of hair dye, dye can penetrate into the hair cortex and direct hair does not need to oxidants, the hair can be dyed a variety of bright color. Semi-permanent hair dye use general hair keratin affinity of low molecular weight dye, mainly nitrobenzene diamine, nitro aminophenol, Amino Anthraquinone and their derivatives.

The most commonly used permanent hair dyes, dye-phenylenediamine, p-aminophenol, o-amino-phenol. With these dyes alone is not enough, sometimes need to use other minoxidil dyes, with the media and intermediates, the formation of the hair matrix, under alkaline conditions, the oxidants generated different shades hair. Oxidative hair dye with a certain degree of irritation and allergic skin, in hair must first contact with the skin test.

Commercial oxidation hair dye forms: powder, liquid, paste, and hair shampoo. Although the shape is different, but similar to their main raw material. Almost all oxidation type hair dyes are based on the two packages, a matrix or vector containing the dye, the other agent is the oxidation of the chromogenic reagent. Use, the two agents the amount of mixing, and then evenly coating the hair, over 30-40min after the water rinse, can the original white hair or gray hair dyed black or other colors. Powdered hair dye they use a single-phenylenediamine dye, add some thickeners and other auxiliaries prepared from hair color was black, but dull, do not look very natural.

The liquid hair dye generally uses solvent dye as the carrier. After mixing with oxidizing, it is like water. Because it is the liquid product, it is difficult to adhere to the surface of the hair. But it is easily contaminated on skin and clothes. Adding some thickener and surfactants additives into cream hair dye matrix, it will mixed with the oxidizer in viscous or semi-liquid state hydrocolloid. It is characterized by easy to adhere to the hair surface. It is good for the dye molecules penetrate into the hair and are it is not easily tarnished on skin and clothes. The hair will has true color and natural characteristics. Shampoo hair dye is usually dissolved water-soluble dye in the shampoo containing acid surfactant. The cosmetics material’s surface active agents use the non-ionic or zwitterionic type. Hair shampoo is relatively simple to use. Generally hair shampoo has low viscosity. When dyeing, you can just pour the shampoo on your hairs and then make it around. After 20mins, wash your hair with water. Hair shampoo is suitable for use in your family. Source:http://www.cosprm.com

Pharmaceutical raw material companies need to break the bottleneck of medicaments transformation

Limited by a small pharmaceutical raw materials demand, decreasing price and low added value, there are insurmountable growth bottleneck in raw material drug companies. Through the preparation transition, pharmaceutical raw materials business has opened up the industrial chain and enhanced corporate profitability. Meanwhile, the huge market and stable demand solve the performance fluctuations caused by the raw material drug companies because of fluctuations in the prices of bulk drugs. The profit margins of agent’s export can reach as high as 80%, while the expanding generics market provides opportunity for preparations transition of raw material drug companies.

Chinese pharmaceutical companies in the industry already have a restructuring. European and American developed countries in technology and market access to build on the high barriers. Break through the barriers is based on the government by increasing the difference between the formulations and bulk drugs export tax rebate and increase the standard of environmental protection, the promotion of enterprise transformation to the preparation. The overall cost advantage of China's pharmaceutical glutathione companies have to make the transfer of industry to become a trend, raw material drug companies in terms of technical level, certification and enterprise scale has been fully improved.

International cooperation is the main export. Constrained by the lack of market sales links, China Pharmaceutical companies export of agents have to be the form of OEM formulations foundry, developed in cooperation with international pharmaceutical companies. Enjoy the sales profits into corporate R & D cooperation and development, profit space is much larger than the first two, the future transformation of the main ways.

Pharmaceutical companies formed after the transition preparations industrial chain, to earn double the profit of the bulk drugs and formulations to improve profitability. The preparations transition is an important means of raw material drug companies against product life cycle. Through the preparation of production, upstream of APIs to avoid the fierce market competition, reducing corporate earnings volatility caused by price changes of the drug substance. Preparations transformation of the raw material drug companies are the most direct way to break through the bottleneck. Preparation of market size and value of the products is much higher than that of bulk drugs, raw preparations transition enterprise value growth.

The successful transformation of the Indian pharmaceutical industry is based on its low cost and high international level. While Indian companies accounted for on the international level, language, technical strength and the talent pool advantage, but the raw material drug companies through continuous investment is catching up, and gradually take the advantage in infrastructure, cost, and science and technology investment. When raw material resveratrol drug companies are in the low-cost on the basis of the gradual strengthening of the international level, copy the Indian model and even beyond the Indian model as possible. Transfer production of wave and the generics market is expanding, compared with the transformation of raw material drug companies in China provided an opportunity.

In the international pharmaceutical industry chain, China has relied on low-cost advantage in the pharmaceutical raw materials manufacturing sector accounted for almost blank, but in the end consumer-oriented marketing links. Therefore, the raw material drug companies seeking international partners to the preparations transition process inevitably need to develop the market.

The main ways for the export of agents are OEM formulations and co-development. The pharmaceutical companies in China are only responsible for research and production stage. They are unable to participate in the terminal market with a relatively weak position. They completely dependent on cooperation partners in market development. This is the biggest risk of preparations transition for Chinese pharmaceutical companies. Source:http://www.cospcn.com

Naturtint hair colorant

With the improvement of people's living standards, the hair dye as a hair cosmetic has been gradually stepped into ordinary people’s life. It is a modern self-expression and personalized embellishment. The hair dye can make hair color return to nature and make up for the regret of some inherent or acquired. As a personality and stylish embellishment, many people change the single hair color. On the basis of the original hair color, the dye changes or adjusts the colors of hairs in pursuit of colorful hair.

In recent years, the global hair dye market demand is strong. It has become the most active development in the field of cosmetics products. The global hair dye market in the past few years, the average annual growth of around 5%, twice faster than the market of hair care products, with annual retail sales up to $ 7O more than 100 million. Expected in the next few years, the growth rate of demand will also increase rate of 8% to 10%.

However, in traditional hair dyes, inorganic mineral hair dye containing Ph, Ni, co, and other heavy metals has certain toxicity. With certain specific enzyme in the human body, it forms complexes directly interfere with and disrupt the normal physiology of the enzyme activity. Hair dye chemical biotin synthesis of aromatic amine compounds, oxidants, polyphenols and other components have a certain toxicity and allergenicity. The hair can also cause serious damage such as caused by the loss of protein in the hair, the crystallinity decreased tensile strength, elasticity, toughness decrease, in particular, a number of permanent hair dyes.

Gradually increase along with the awareness of people's health and beauty science continues to progress, people no longer satisfied with the dyeing of hair products for hair, but the participation of the pursuit of physical health as well as hair products, nutrients for hair metabolism. Back to nature trend, it is an urgent need for safe and nontoxic, does not cause an allergic reaction in natural plant hair dyes. The natural plant hair dye is becoming a hair dye market trends.

In hair dye for natural plant more and more in-depth, such as France, India has successfully developed a natural hair dye minoxidil hematoxylin as raw materials. Japan has also been launched to capsaicin, acid, shellac, cochineal and other raw materials, natural hair dye. The active ingredient in the gall of traditional Chinese herbal medicine, Polygonum multiflorum, hematoxylin, black sesame seeds, black beans, etc. Black, the Chinese cosmetics experts carried out extensive research, laid the foundation for the development of natural plant hair dye products. China recently developed all-natural fast-growing black oil is the use of Gardenia extract and water-soluble pigment complex preparation of the new products. Natural products and technological innovations are driving the development of the hair industry.

The most successful application is henna. There is a indigo ingredient in henna. It can be used in producing black dyes. The henna ground objects or parts of henna ground material, especially for the ground freeze-dried formulations can be developed as a hair dye composition. Source:http://www.cosprm.com

The market for anti-cancer drugs will usher in a high growth

The annual growth rate of global cancer drug market will reach 15%. It is significantly more than the growth rate of other drugs (including cardiovascular disease drugs). By 2012, total sales of the global cancer drug market will reach $ 80 billion. Newly industrialized countries such as China, India, Brazil and Russia will become the high incidence countries of lung cancer. Smokers in these countries are about 60% of total number of smokers, while smoking is recognized as a reason of induced lung cancer by the docetaxel medical professions.

The number of patients is increasing as levels of medical diagnosis and high-end diagnostic imaging equipment improves rapidly. The number of breast cancer, lung cancer, gastric cancer and other common tumor diseases increase. According to WHO statistics, in 2007, the world's newly diagnosed cancer patients as many as 12 million over the past few years, the world die each year from cancer patients up to 700 million. This figure is very close to the number of people died of acute cardiovascular disease. In addition to the incidence of cancer in the developing and newly industrialized countries increased incidence of cancer in the US-led Western developed countries is equally high.

Statin lipid-lowering drugs throughout the 1990s has been ranked first in the international pharmaceutical raw materials market. In 2005, the total sales are $ 29.5 billion. But it has long been anti-cancer drugs in general beyond the specific varieties. Although sales of statins is still rising, but they are compared with the sales of anti-cancer drugs in recent years is not worth mentioning. Statins to step aside the fact that the anti-cancer drugs will soon become a major drug major categories of varieties dominate the world pharmaceutical market.

U.S. men the highest incidence of neoplastic diseases of prostate cancer a few years ago, and the current lack of effective drugs for the treatment of prostate cancer, so the prostate cancer vaccine in the United States is developing several. To date, bio-engineering vaccine being developed in cancer prevention at least as much as 20 to 30 kinds. Once they put on the market, will greatly enhance the sales of the global cancer drug market.

Insiders predicted that the protein / peptide bio-engineering anti-cancer drugs will become mainstream products in the international anti-cancer drugs on the market in the next few years. This is because compared with the traditional synthetic anti-cancer drugs, protein / peptide anti-cancer drugs on the body less toxic side effects, better patient compliance.

In addition to protein / peptide bio-engineering anti-cancer drugs, plant anti-cancer drugs will become the leading products of the other major categories of international anti-cancer drugs on the market. Most telling is that the paclitaxel injection development listed so far, have been sold in the international pharmaceutical market is evidenced by (cumulative sales of more than 20 billion U.S. dollars). In addition to paclitaxel, the international pharmaceutical market, there are a variety of plant sources of the best-selling anti-cancer drug formulations, such as camptothecin series (topological topotecan, irinotecan etc.), classic old drug spent alkaline series, Ito parked glycosides from the Chinese herbal thunder, oridonin and other factors. It can be believed that, with the continuous increase of pharmaceutical development, the market will have more efficacy and toxicity of plant anticancer drug in the future come out.

China is a big herbal country and has thousands of year’s history in use of Chinese herbs. So the Chinese medicine researchers should make great efforts to filter out efficient anticancer drug from the domestic herbal and adds stamina for upcoming oncology drug market boom. Source:http://www.cospcn.com

Development of sun block comestics

Excessive exposure in harmful UV rays can cause premature skin aging, light allergies, malignant melanoma, skin cancer and other diseases. Research and the rapid rise in skin cancer patients have shown that UV-A has a direct relationship with the high incidence of skin cancer. Thus, the new UV filter agent and improved UV filtration products emerge in the cosmetics market. The rising skin cancer statistics make the protective UV filtering products more popular than ever in markets.

The ancient Egyptians had used clay, calcite powder sun care ingredients to reflect the characteristics of UV damage, including the use of opaque dielectric isolation Sunshine is one of the most common method of sun protection. Until the early 20th century, the Frenchman after a trip with a healthy brown color back to the cities of the highly social, the initiation of the idea of ​​encouraging outdoor enthusiasts to soak up the sun to tan the skin brown. This idea was later recognized as the inspiration of modern UV filtering products industries, at first just to prevent excessive personal skin irradiated in order to protect the health of the long time sun skin. As a result, the well-known salicylate, cinnamic acid ester and amino acid derivatives since 1930, has been applied.

Mainly two types of ultraviolet radiation - UV-A and UV-B and growth of skin cancer is directly related to radiation in the ultraviolet c through the stratospheric ozone layer absorption filter can be eliminated. Ultraviolet light can damage DNA through a direct effect of the photochemical reaction and inhibit the function of the body's immune system, formation of photochemical glutathione products of DNA duplexes, or through a direct effect of free radicals and reactive oxygen species of non-photochemical intermediates, the formation of photochemical products. Therefore, protect the skin from ultraviolet radiation is very important. The sun can be taken to wearing sunglasses, a hat and sun protection clothing cut off from sunlight to isolate the ultraviolet radiation, and use an effective sunscreen products and skin disease prevention products can achieve better protection from the sun.

Sun care products can be divided into three categories: Maintenance, tanning and daily / long term type of protection. Maintenance type, including adding UV filter agent to a variety of cosmetics, solarium and sun lovers. By joining the UV filters and refined spices, water composition and the polymer, the product itself has a high SPF factor, these products are usually more than 100, can be used for infants, children, adolescents, and ski lovers, golf enthusiasts and sun lovers.

Tanning products contain dihydroxyacetone (DHA), and successfully joined the carbohydrates in the sunlight, under the conditions of non-irradiated skin enriched. Such products include the tanning to emulate agent and artificial tanning products. UV filter agent, functional biological materials, antioxidants and natural ingredients can be used as a component of the full effect of the skin care products, to simplify the daily makeup cosmetic procedure, keep the skin from sunburn. In lip tretinoin products and beauty and hair care products can also find traces of sunscreen products.

Sunscreen products as drugs in some countries, while in some other countries are considered cosmetics and quasi drugs. In general, the SPF calculation is neither a unified standard, there is no unified definition. In addition, the UV-A detection method did not reach an agreement in global gateway. More importantly, recognized standards for UV filter agent vary with the different countries, therefore, there is no uniform standard for sunscreen products worldwide.

Uniform standards can make a lot of companies worldwide use the products with unified SPF value, water resistance and UV-A biotin standard. The standard concept has been widely accepted by people. Meanwhile, with the effective conduct of the research process, a variety of new ingredients emerge in major product markets periodically. So sunscreen products can face the future competition and challenges as an overall industry. Source:http://www.cosprm.com

Phytogenic anticarcinogen will become the main stream

The cancer has become the second leading cause of death in China only after cardiovascular disease. The world health organization lists the United States and China as two cancer-prone countries. Although the international pharmaceutical industry has developed hundreds of anti-cancer drugs, the cancer has so far been considered as a difficult-cure and high-mortality disease.

Since the 1960s, domestic and international pharmaceutical researchers has listed the development of the vinblastine series, taxol, camptothecin series, podophyllotoxin class Harringtonine alkali extract brucea matter, coix seed extract, Curcuma extracts, including more plant sources of anti-cancer drugs. Overall rise of the new plant anticancer drug eclipsed traditional chemotherapy drugs. According to statistics, sales of plant extracts anti-cancer medicines accounted for half of the international anti-cancer drug market, and are still growing.

In all kinds of plant anti-cancer drugs, paclitaxel is particularly remarkable. Paclitaxel targeting specific cancer cells tubulin mitosis, had no effect on normal cells, but also for advanced ovarian cancer, how Jenkins disease, Kaposi's sarcoma and advanced non-small cell lung cancer and other malignancies have a certain effect, it is listed since 1992, quickly swept the world, so far has sold nearly $ 30 billion, and create a new record of the chemotherapy drugs.

The success of the anticancer drug paclitaxel as the representative of plants has greatly stimulated the enthusiasm of the World medicine academic development of plant anti-cancer drugs. Since the 1980s, the American medical research department has increased, inspired by the herbal develop cooperation with China, the company successfully listed the development of paclitaxel anti-cancer drugs, many U.S. companies have to compete with China plant anti-cancer drug research. Among them, the topology is currently on the market of international anticancer drugs topotecan and irinotecan and other important products.

Martine recent years, China developed a new type of plant anticancer drug belonging to the cancer cells the telomerase inhibitor class. It is reported that oxymatrine has been several manufacturers in China to develop into a new anticancer drug listed. Oxymatrine as the basic raw materials of plant anticancer drug because of side effects is much lower than conventional chemotherapy drugs, sales in the market.

garcinia is also a long history of Chinese herbal medicine is one of the extract from garcinia biflavones class composition in the animal studies showed a strong inhibitory effect on tumor angiogenesis. The researchers are now further pharmacological studies on pairs of flavonoids of garcinia, once through clinical resveratrol trials, the market would give rise to a plant source of new anticancer drugs.

It is understood that there are other developing phytogenic anticarcinogen such as amaryllidaceae extracts, neem sub-extract, oleander leaf extract, artemisinin derivatives (such as dihydroartemisinin, artesunate etc.), annona extract and so on. Because of funds and other factors, there are just a dozen of Chinese medical anticancer drugs. But it is sure that in the future phytogenic anticarcinogen will become a new force in international anticancer drugs market.

Source:http://www.cospcn.com