Interpretation of Chinese biotin export market trends

The real turning point of Chinese biotin production came in 2001 and 2002. Chinese researchers first invented the "d-biological factors asymmetric synthesis of a new process" in the international market, since then, broken the long time leading position of big Western companies in biotin synthesis process. China take the new technology to produce biotin, the production cost is less than 1/3 of the Western companies’ biotin production costs. This new biotin production process firmly established the "pricing power" of Chinese biotin products in the international pharmaceutical market (like Chinese researchers invented vitamin C “2 -step synthesis of new process” in the 1970s). The development of Chinese biotin synthesis new processes have become one of the world's largest biotin manufacturer, It is reported that China's production capacity is about 50% of the total capacity of the world, export volume ranking first in the world, the 2007 export volume accounting for 70% of the actual sales of the biotin international market.

China is a biotin producing country, the products produced by biotin manufacturers are very popular in the international market. Since the beginning of 2008, the international market prices of biotin enter into the rising channel. The experts believe that the biotin export volume in recent years will continue to rise, have good export prospects.

Biotin, also known as "Vitamin H", is belonging to one of the B vitamins. In the early 1990s, Western pharmacologists found biotin has a lot of interesting new uses, including prevent the fetus because of the abnormal development of neural tube to cause birth defects, promote the body lipolysis - weight loss, from then on, biotin attracted the attention of the medical field. Recent research demonstrates that biotin is also effective in treating the type 2 diabetes which with high incidence in the world, this discovery makes the hard sell biotin become the shopping-rush goods in the world's pharmaceutical market.

Before 1990s, the international biotin market has been monopolized by a few large companies in the West. Although China had already begun to produce biotin as early as in the late 1960s, but due to affected by backward technology and production cost and other factors, the production is always not high, only meet part of the demand of the Chinese market, need to import a large part each year. This situation in the early 1990s began to change. With the international biotin market’s price increasing, Chinese pharmaceutical companies began to actively engaging in the production of bulk drugs biotin. With the biotin manufacturers’ team rapidly expanding, China is not only end of long-term dependence on importing, but also began to flock a large number of biotin to the international market. Until 1998, Chinese biotin exported was accounted for half of the international biotin market. However, China's exported biotin is basically the lower added value feed grade biotin, and higher selling price of pharmaceutical grade or cosmetic raw materials levels biotin market is still monopolized by big Western companies. It is understood that, in the past few years, the international biotin market constitute: feed grade account for about 80%, pharmaceutical grade, cosmetic raw material and health food grade biotin accounted for the remaining 20% share.

Source:http://www.cosprm.com

Extraction methods and applications of capsaicin

Capsaicin is also known as capsicine, was the main spicy substance in pepper fruit. The earliest isolated from pepper fruit in 1876, and named capsaicin. Since then, there are some homologs of capsaicin in the pepper fruit had been found, they are collectively referred to as capsaicin series substances, now has been found more than 14 kinds of capsaicin series substances. Wherein the capsaicin and dihydrocapsaicin are accounted for about 90% of the total amount, the remaining accounted for only a small amount.

Capsaicin is an extremely spicy vanilla amide alkaloid. Its chemical structure name: -8 - methyl - (trans) -6 - nonenamide. Pure product is white flaky crystal, melting point is 65-66°C. Easy to be dissolved in methanol, ethanol, acetone, chloroform and ether, also can be dissolved in an aqueous alkaline solution, at high temperature will produce irritating gases. It can be hydrolyzed to the vanilla ylamine and capric acid, it shows subacidity because of having a phenolic hydroxyl group, and can have a colorimetric reaction with Fehling reagent.

Capsaicin manufacturer usually use the method of extracting from natural pepper to prepare capsaicin. Early methods is pulverized the dry red pepper, extracted with an organic solvent, concentrated to give an oily liquid, this oil in the international are collectively referred to as capsicum oleoresin, the main ingredient is capsaicin, dihydro capsaicin, drop-dihydro capsaicin, high-dihydro capsaicin, capsanthin, carotene, yellow pigment, as well as citric acid, tartaric acid, malic acid and other a variety of substances. Pepper oil resin through the solvent of diethyl ether, dilute ethanol, and alkaline solution, or petroleum ether, dichloroethane and other solvents to further extracted and concentrated, crystallized can be obtained crude crystals of capsaicin, capsaicin and dihydrocapsaicin content is about 76% to 96%. In recent years, in the preparation of capsaicin appears a lot of new techniques and new methods, such as ion-exchange method, supercritical fluid extraction, liquid - liquid extraction, ethanol extraction, prepared by biological cell culture system, chemical synthesis capsaicin structure analogs.

In the international market, the supply of capsaicin exist a certain gap, especially the high purity capsaicin apply in medicine, this part of product’s processing technology is difficult, but the corresponding product’s sales prices are high, with the capsaicin in the pharmaceutical, agriculture and other fields further promote using in future, the market prospects is more optimistic.

Capsaicin is widely used, currently used as an additive in the food industry were generally belong to the low-purity capsaicin products, too much impurities, heavy odor, low price, economic efficiency is no high; the high purity capsaicin has a number of physiological activity, can ease pain, diminish inflammation, circulate blood, is now widely used in the treatment of rheumatoid arthritis, bruises, frostbite, drug, analgesic, anti-itch, inflammation sterilization, and as pharmaceutical raw materials for a variety of drugs, such as chili rheumatism ointment, drug injection, capsaicin ointment and pepper analgesic ointment; in agriculture used as pesticide formulations to get rid of pests and pest control; in military, capsaicin is used as the main component of manufacturing tear gas, tear gas guns and defensive weapons; in other areas also have been reported the application of capsaicin, the United States in 1995 used the capsaicin series compounds in paints, coating the ship to prevent algae and marine organisms sticking, also can be used in wood, metal, plastic and other surface coating.

Source:http://www.cospcn.com

Application of glutathione in the food industry

The glutathione content is usually low in daily consumption of flour products, it almost wiped out after processing. In China, along with economic development and the improvement of living standards, the food structure of consumers has changed dramatically, intake of essential amino acids from the daily food, such as lysine, methionine and so on are generally not lack of, while some foods functional factors, such as glutathione is often short, added glutathione in the flour products can greatly enhance its nutritional value. Experiments by glutathione supplier found that glutathione added to the flour products processing or used in combination with the proteolytic enzymes can reduce the amount of water in kneading dough, improve the rheological properties of dough, from a large range to control the dough viscosity, reduced dough strength, make the mixing and extrusion molding becomes easy and can shorten the drying time of the product; added glutathione as a tyrosinase inhibitor in noodle processing, can prevent unpleasant color change, in cereals and beans mixed pulverizing, added glutathione peptide as a reducing agent can maintain the original and the desired color; added glutathione in protein-rich flour, soy flour can be effectively prevented the enzymatic and non-enzymatic browning; glutathione also can inhibit amino acids and glucose produce colored and harmful substances under heating.

Apply in dairy products, add glutathione and other additives in cheese production, can greatly enhance its delightful flavor and improve cheese quality and accelerate the maturity of the cheese; add glutathione in yogurt can play the antioxidants stable mass action; in casein, skim milk powder, infant milk powder adding glutathione can effectively prevent enzymatic and non-enzymatic browning.

The application of glutathione in meat, poultry, fish and seafood, glutathione have antioxidant, in fish, meat and poultry food processing add glutathione can inhibit nuclease decomposing, and strengthen the flavor of the food and greatly prolong shelf life. Such as glutathione can effectively prevent the skin of frozen fillets color fading, browning of the fish; glutathione has an important role on maintaining and enhancing the fresh seafood’s unique flavor; have a strong meat flavor while mixed coexist with glutamic acid, nucleic acid.

On fruits, vegetables, food and beverage, in the processing of foods, fruits and vegetables join glutathione can effectively prevent the browning and keep the original attractive color, flavor and nutrition. For example, apples and potatoes’ processed products, the enzymatic and non-enzymatic browning prevention of apple juice, grape juice, pineapple juice, orange juice and grapefruit juice. In the production of traditional Japanese drink sake, use strong fermentation and leakage glutathione yeast had been produced high-content glutathione products, brewing high levels of glutathione anticancer series beer, improve its nutrition and health functions, China has patents; glutathione also can be used as the reducing agent of wine.

In health features food, for the vast majority of consumers (especially in central city), the daily intake of carbohydrates and protein is sufficient or excessive, so people have gradually turned their food consumption attention to health and longevity, foods add glutathione, can repair the body cell damage caused by free radicals and other harmful substances, preventing the body from degenerative diseases and the body organ loss of function. In addition, glutathione is an indispensable cosmetic raw material in skin care products, is the key to keeping skin elasticity. So, if we want to maintain the body and skin health, supply rich glutathione is required.

Source:http://www.cosprm.com

Rapid development reasons of abamectin

Abamectin in recent years has a very good development, experts said that avermectin also has a very good development space and development prospects in the future, then why abamectin can get such a good development? The avermectin rapidly developing is based on what?

Abamectin is a natural fermentation mixture of component, occupy a more important position in Chinese pest control system. Avermectins in China, currently has more than 10 enterprises production. The currently commercially available Avermectins Series pesticide has abamectin, ivermectin, the acetamido abamectin and methyl abamectin benzoic acid salt and so on. Boutique Abamectin is a white crystalline powder, melting point is 155-157°C, due to there is not acidic or basic functional groups on its structure, its stability under normal conditions, when the PH is 5-9  will not decompose(see the light will decompose).

Avermectin is a nerve agent, its mechanism is acting on the insect neuron synapses or neuromuscular synaptic GABAA receptors, interference the information delivery of insect nerve endings, that stimulate nerve release neurotransmitter inhibitor γ- amino butyric acid (GA-BA), prompted the GABA-gated chloride channel prolong opening, to the chloride channel have activation effect, a large number of chloride ions influx cause nerve membrane potential hyperpolarization, resulting in nerve membrane in an inhibitory state, thus blocking off nerve and muscle contact, make insects benumbed, poor feeding, death. Because of its unique mechanism of action, so it’s no cross-resistance with commonly used agents.

According to reports, in addition to the chloride channel controlled by GABA receptor, avermectin also can affect other ligand-controlled chloride channel. At the same time, avermectin has good layer-shift activity, a layer shift activity refers to the avermectin can penetrate into the crop leaf tissue after spraying, forming a sachet within the parenchyma cells of the epidermis, long term storage, so the avermectin has preferable persistence period. Because of its good layer shift activity, abamectin to spider mites, leaf miner and borer pests or sucking pests and other pests which conventional agents is difficult to control have a good effect. Avermectin is easy to biodegradable in soil and water, and absorbed by soil in the soil, not leaching, no residue, will not pollute the environment; also not accumulation and persistent residue in vivo, so abamectin should belong to pollution-free pesticides.

Abamectin can also be decomposed by edaphon to be higher activity derivatives, such as the insecticidal effect on plant nematode. Chinese existing avermectin manufacturers have more than a dozen, the annual production capacity is 200-800t/Y, but the technical level of the various manufacturers are not the same, the gap is mainly the bacterial contamination rate and titer in the fermentation. The titer of Chinese manufacturers generally around in 3500μg/ml, individual manufacturers over 4000μg/ml. Bacterial contamination rate is generally below 10%, individual manufacturers below 3%. According to reports, a research institute new cultivated more active strains, the potency can be achieved 8000μg/ml, various manufacturers were highly concerned about it, if this technology industrialization will make Chinese abamectin’s overall production technology level greatly improved, and is expected to reach the international advanced level.

The China produced avermectin have 50% for the downstream products production, 30% for exporting, 20% for preparing a variety of preparations. Abamectin as a major biological pesticide varieties presented in short supply status, so that directly led to the rising price of avermectin. Now the new formulation development of avermectin become the hotspot of international research and development, its dosage form have many different types, such as the missible oil, micro-emulsion, soluble granules, microcapsules, etc., and the use of its preparations has huge increase, has been recognized by the international market, especially the developing countries, such as Thailand, Pakistan, India, those countries’ imports show a upward trend annually, it is visible that abamectin has extremely broad prospects for development.

Source:http://www.cospcn.com

How to distinguish the quality of astaxanthin

Because of natural astaxanthin has special requirements to the cultivate environment, as well as the high technical content of the extraction process and save process, so that the food-grade astaxanthin capsules in the market are quite expensive, such as the United States’ A-bioastin natural astaxanthin, the price is generally between 450 and 500RMB about 0.4 mg, while the astaxanthin produced in China is relatively cheap, but most of them farmed by fermentation method, the nutritional value is relatively lower, the content is generally 0.3mg; there are also have astaxanthin products meet formulation requirements, such as the adding coenzyme Q10 astaxanthin which is beneficial to cardiovascular, the price is about 679 RMB; super content is 0.6mg, prices are generally in the range of 700 to 800 RMB, the market products were basically imported. Containing astaxanthin cosmetics, such as sunscreen series, general price is 50ML, 480 RMB. Eye cream add natural astaxanthin have the effect of removing wrinkles. General price is about 380 RMB each.

How to distinguish the astaxanthin’s quality? Food grade natural astaxanthin should judge from the following angles. First, whether is natural breeding, whether the water quality have strictly control and meet the standard. Natural astaxanthin is the natural form astaxanthin, mainly extract from pluvialis algae, currently, the world's largest microalgae breeding base is in the United States, second is Japan, they are also the main natural astaxanthin suppliers, wherein the United States accounted for 70 percent of the natural astaxanthin market share. Use Hawaiian high-quality drinking water aquifers to produce, ensure the products natural, security, has received the U.S. FDA certification, GMP standard. The astaxanthin synthesized by fermentation, as well as obtained by animals is inedible.

Second, whether the extraction technology is the world's top. If astaxanthin extraction process is not good, easy to be oxidized when extracted, so that the efficacy and shelf life is greatly reduced. Currently the supercritical CO2 extraction process on the market can ensure its antioxidant activity do not loss, obtain the stability, efficacy, purified astaxanthin. Also the main processes of natural astaxanthin extraction.

Third, the capsule’s manufacturing technology. Not to use genetically modified algae species in production process, do not use hormones, not microbial contamination, no organic solvent residue, each stage of production can strictly monitoring and control the product quality. Whether the production enterprises have this inspection certificate and certification is essential for the safety of food grade natural astaxanthin.

Fourth, whether have the international certification authority. Such as EU certification, America FDA certification, GMP standard, the United States Department of Agriculture’s non-animal derived ingredients certification, the Jewish certification and so on.

Fifth, whether had been through rigorous clinical trials, can be used by human body. Many products were put into the marketplace after animal test. So that whether the natural astaxanthin had been through human trials, obtain a patent, is an important way to ensure its safety, efficacy.

With the continuing escalation of astaxanthin products, people can see a variety of natural astaxanthin products in the high-end department stores, international KA stores, OTC chain, import nutrition store and so on, such as the senior cosmetic which use astaxanthin as cosmetic raw material, in the country’s high-end cosmetics store have sales.

Source:http://www.cosprm.com