Consume misleading has a shock on international market of resveratrol

Global supply market value of resveratrol is $ 50.2 million. Among them, 70% is used in the U.S. dietary supplement market. Europe will continue to maintain its status of the world's second largest resveratrol market. While the Asia-Pacific region has a fastest development, especially in markets of Australia and New Zealand. However, resveratrol manufacturer declares that global market suffers the distress of misleading claims. It will have certain constraints on hot development scenarios of the whole resveratrol market.

Resveratrol is often touted as the bioactive substances in grapes and red wine, resveratrol compounds of interest in the explosive growth in 2003. Studies have shown that resveratrol can increase the life span of yeast cells, the international media fanfare of publicity, inspire the desire of the people against aging drugs. Since then, the research done for the biological nematodes, fruit flies, fish and mice resveratrol and life extension linked.

In addition, other studies have reported that resveratrol also has anti-cancer, anti-inflammatory effects beneficial to cardiovascular health, there is potential for the fight against diabetes, can enhance the energy endurance, and prevent Alzheimer's disease. Although resveratrol is most common in red wine and grapes, but it is more common source of Aster plants, resveratrol from the Aster plants will remain a major form on the market.

In every 100 mg of resveratrol in the end-user prices vary widely, for example, less than $ 0.10, while for the price as high as $ 8 or above the level of mixed-ingredient formula applied to supplements containing resveratrol. When applied to the field of food and beverage, consumer-oriented per 100 mg of resveratrol costs will be higher, this is because in the preparation of the food matrix has a higher water activity, the technical difficulty caused by the high cost.

The media widely reported health benefits of resveratrol, as well as in Asia to its interest in increasing the development of the market is being propelled. Wide publicity in the media, the market for the high demand for resveratrol supplements, undoubtedly inspires many dietary supplement manufacturers to enter this market. The doses and forms of the product developed by pharmaceutical raw materials suppliers are different.

However, current international market due to an adequate supply will continue to be the price of resveratrol formation of downward pressure. Identify suppliers, customers concerned about product quality and supply capacity is greater than the focus on price. Sought the face of the heat of consumers on the labels of some products of the resveratrol concentration, source and purity of the introduction has made a misleading claim, no doubt, poured cold water on a hot market. Which also affect the dose and efficacy in patients with end-use.

Therefore, the entire market has suffered the distress of misleading claims. And this situation is likely to continue. Negative reaction from customers may have a bad influence on this rapidly developing market. The supplement manufacturers must aware that it will restrict development of the entire market.

Source:http://www.cospcn.com

Severe acne may increase incidence rate of suicide

Acne is a common problem among the groups of younger age. Acne not only affects the cosmetic situation. Experts claims that severe acne can also lead to double suicide risk in patients. Therefore, people need to take measures to ensure a healthy lifestyle and have a prevention of acnes in their daily lives. While people buy tretinoin to treat acnes, they should pay attention to its side effects.

It has long been known that acne patients are more prone to depression. Although most patients were young people, many adults also occur acne. Acne is a big incentive is the pressure. The new study found that 6 months after treatment of severe acne in patients 93% increased risk of suicidal thoughts or suicidal tendencies.

The researchers believe that some patients feel that the acne condition significantly improved, but their social life has not the slightest improvement. In addition, sometimes, drugs do not work for some patients, but also lead to a major cause of increased suicide risk in patients. Three years before receiving isotretinoin therapy, patients with severe acne attempt suicide rate have started to rise. A year before receiving isotretinoin treatment, these patients attempted suicide rate is one-third higher than their peers.

Accept the three years after the drug treatment, the patient tried to commit suicide rate reduced to normal levels, indicating that the acne drug actually saved the lives of patients tried to commit suicide increased risk may be one of the isotretinoin side effects, but a more reasonable explanation is that severe acne itself is the biggest hidden dangers of increased suicide risk.

Study permit retinoic acid is not only used for the treatment of acne, but also helps to avoid diabetic skin ulcers. Diabetic complications such as nerve and vascular damage will increase the possibility of skin ulcers, serious and even lead to amputation. Retinoic acid is a vitamin A derivative retinoic acid-containing component of conventional dermatology pharmaceutical for the treatment of skin ulcers.

The cosmetic raw material suppliers also note that retinoic acid is contributed to rapid healing of skin ulcers on rats with diabetes-like disease. Within a week after the treatment, 85% of wounds are healed. And for the groups without using retinoic acid in treatment of skin ulcers, the healing rate is only 41% at the same period. In addition, with the use of retinoic acid, there are fewer scars and the skins become smoother.

Source:http://www.cosprm.com

Plant extract becomes the first good category whose export figures exceed 10 billion dollars

Plant extracts develops fastest in export of Chinese medicine industry. It can be regarded as an eternal sunrise industry. In 2011, exports figures of plant extract are 1.13 billion in China. It becomes the first category whose exports figures are over 1 billion dollars. After years of development in plant extracts, its exports values exceed $ 1,000,000,000 in first time. It means Chinese plant industry reaches a new height.

In view of the export situation, the export of planting extract has the obvious characteristics of industrial clusters. The first five provinces and plant extract manufacturer are in Shandong, Yunnan, Shanghai, Hebei and Zhejiang. The ranking of provinces and cities has the advantages of industrial clusters and regional trade advantage. Because of the particular plant resources and climatic conditions, such as Yunnan in the plant pigments and flavor and fragrance products plant processing area occupies a distinct advantage; Shandong stevia extract, and flavorings industry with resources advantages, coupled with the port trade advantage, so a number of The companies are ranked in the export leader. Similarly, Hebei has been formed to dawn biological pigment industry cluster, with the advantage of cluster development. This can be seen, China planting extract industry is growing with a leading trends of the industrial clusters with large enterprises. The development of plant extracts industry is becoming increasingly health.

Press the zoning, plant extracts can be divided into pharmaceutical and health category, food additives, flavors and fragrances, cosmetics use category. Among them, extracts of food additives in recent years has been on the momentum of growth development, mainly due to global natural source pigment products in recent years gradually heated, the synthetic pigment is gradually replaced by natural pigment, such as capsanthin, leaf flavin curcumin become the best-selling products in the global food additives. Pharmaceutical and health category of the advantages of traditional products, stable demand in recent years, steady growth momentum. In addition, the export of flavors and fragrances class had become a dark horse posture, based enterprises in the export of such products in recent years has climbed rapidly. So it deserves special attention.

Stevia extract is single specie which is deserved to be mentioned for pharmaceutical raw materials suppliers. With rapid growth in recent years, stevia has developed into one of the most important plant extracts. And a few large enterprises that are based on stevia extract have ranked in the forefront for many years. Drops in abroad demand have many causes. For example, EU market allows using stevia extract as a food additive, but the related laws and regulations in the field do not have timely specification. So in a short period of time, it is failed to stimulate demand. Extract industry will usher in a new period of adjustment. And the competent departments may improve industry access threshold by the period of adjustment. It will strengthen quality supervision and the industry may have a new round of reshuffle.

Source:http://www.cospcn.com

Astaxanthin becomes a new favorite in pharmaceutical raw materials industry

With the constant pursuit of functions on cosmetics and health products, constant attention to health and constantly bad current living environment, astaxanthin products will be the new favorite of cosmetic raw material suppliers and pharmaceutical raw materials industry. Astaxanthin is a most powerful antioxidant. Its effect of anti-aging, enhancing physical ability and withstanding harsh environments will bring gospel for diabetes patients.

Astaxanthin is the most powerful antioxidant hormone. And it is also a good anti-inflammatory agent. The discovery of astaxanthin is equivalent to discovery of the penicillin in 20 century. Due to the discovery and application of penicillin and other antibiotics, it leads to the troubled era of human pneumonia. The meningitis and high-onset disease can be controlled effectively.

Today, the scientific community is finally clear: many chronic diseases to afflict humanity: such as high cholesterol, diabetes, coronary heart disease, atherosclerosis, cerebrovascular disease, gout and other metabolic diseases, as well as the pathogenesis of chronic poisoning are oxidative stress cause. If the onset of the beginning can effectively prevent oxidative damage, is expected to terminate and delay the occurrence and development of such diseases. Astaxanthin cellular antioxidant like penicillin resistance to bacterial infection, which can be inferred: With the awareness and application of astaxanthin, chronic diseases will also be expected to be effectively controlled in this century.

Astaxanthin with its unique molecular structure, its material absorption peak close to UVA wavelengths, the small amount of astaxanthin can absorb a large amount of UVA, just like the most perfect and unique natural sunscreen on Earth, as a natural anti-parasol bedding body, efficient protection against ultraviolet radiation, quenching of UV-induced free radicals, reduce UV damage to the skin to prevent. The astaxanthin factors can effectively inhibit melanin produce up to 40%, and can significantly reduce the precipitation of melanin, allowing you to stay away from the bleak colorless as well as spots on the skin.

The fundamental reason not to eat is oxidized to prevent skin collagen, experimental data indicate that oral collagen does not work, because the molecule is too large, absorption can not. The most fundamental way, is an antioxidant. Astaxanthin is the most powerful antioxidants ever discovered.

Islet beta cell damage, so the lack of insulin secretion, and therefore used in the treatment of sulfonylurea drugs to stimulate the pancreatic β cells increase insulin secretion, or exogenous insulin, the two effects results are islet cells completely were destroyed, which has called into question the concept. Oxidative stress has been involved in the occurrence of diabetes development, as well as complications and deterioration of the whole process. Therefore, a method to solve oxidative stress is the early use of antioxidants such as astaxanthin, vitamin E and so on.

Astaxanthin is the most powerful antioxidants and a good anti-inflammatory agent. The astaxanthin supplement is benefit for the pathogenesis of coronary heart disease and can be very effective to curb the process of atherosclerosis to reverse atherosclerosis. In addition, astaxanthin can also play effective roles in gout, dyslipidemia, hypertension and cerebral infarction.
Source:http://www.cosprm.com

Allergic mechanism of docetaxel and its treatment

Docetaxel is insoluble in water. But it is soluble in a mixed solvent of polyoxyethylene castor oil and ethanol. Polyoxyethylene castor oil can release histamine in the degradation. It may cause allergic reactions. Allergic reactions occurred in the first or the second medication for most of patients. Almost all of them occur within 30 minutes after administration. Timely anti-allergy treatment can quickly relieve symptoms and will not cause serious consequences. So although docetaxel cost is reasonable and welcomes, patients should be cautious when using it in curing diseases.

The severities of allergic reactions caused by docetaxel are different. The light manifested as flushing, itching, urticaria, drug fever, a severe allergic reaction mainly hypotension, bronchospasm, asthma, and anaphylactic shock. Serious allergic reactions to the rate of 25% to 30%, pre-treatment routine to the glucocorticoid, diphenhydramine and H2 blockers by the incidence dropped to 1.5% ~ 3.0%. But the main symptoms of an allergic reaction to laryngospasm is not mentioned in the instructions of the class of drugs, clinicians should be alert to allergic reactions in the use of taxane chemotherapy. They should not just depend on drug manual guidance.

The laryngospasm is dangerous. Quickly diagnosis and differential diagnosis are particularly important. The following adverse reactions to docetaxel due to laryngospasm instant attack shortly after the start of the chemotherapy inspiratory dyspnea characterized with chemotherapy-induced phase identification; often before the onset of palpitations, shortness of breath, the main complaint, with blood pressure, migraine low heart rate and other symptoms; ECG manifested as sinus tachycardia, arrhythmia with ECG for identification; acute laryngeal edema: allergy caused by acute upper airway obstruction caused by difficulty in breathing, but the incidence of slow. In addition, the differential diagnosis should also be noted that patients with or without a history of other respiratory and circulatory system.

Anti-histamine treatment or slow down the infusion rate before chemotherapy of taxol pharmaceutical raw materials can significantly reduce allergic reaction, but still can not completely avoid a severe allergic reaction. To prevent an allergic reaction, should do the following aspects: asked in detail about the history of allergies, confirm whether the patient is allergic, do a history of record in the use of docetaxel chemotherapy; medication half an hour before intramuscular injection of diphenhydramine 20mg and intravenous cimetidine 800mg dexamethasone 10mg; ready to rescue medicines and equipment to respond rapidly to serious allergic reactions may occur; infusion bottles and infusion tube using non-PVC materials, and through the connected filters and then I slow intravenous infusion; chemotherapy during the close observation of patients with signs of change, especially within 30 minutes after the chemotherapy, more with the exchange of patient and psychological counseling. Once there are the suspects and allergic reactions, the drugs should be discontinued immediately and people should have symptomatic treatment.

The laryngospasm is abrupt onset. It will obstruct the upper respiratory tract and affect the respiratory function in short time. And the panic state will exacerbate hypoxia. If it is handled improperly, it will cause hypoxia or even death. If breathing difficulties and other symptoms occur in medication process, it should be distinguish with other serious adverse reactions. It needs a quickly diagnosis. Once the diagnosis of laryngospasm is clear, people should immediately stop the importation of all drugs and cut off the allergens. At the same time, the monitoring of vital signs should be closed. High-dose dexamethasone intravenous will inhibit allergic reactions. If there are serious wheeze, the merging bronchospasm should be considered and patients need to be injected with 0.25g of aminophylline and calcium gluconate intravenous to relieve the spasm of airway smooth muscle.

Source:http://www.cospcn.com

Glutathione involves in metabolism of protein and biochemical reactions

The protein is a main ingredient of cells, such as human blood, skin, hair, muscles and bones. It is a component in manufacturing hormones, enzymes, nucleic acids, immune system and cellular messenger. It can repair human cells. Cells of human issues are always in new lives and continue to be disrupted. The newborn raw material for repairing cells is protein. If the protein synthesis is equivalent to decomposition, the protein is in a constant state in human body.

The amino acid balance in the endocrine secretion of various hormones can change the organization of protein and recycling; growth hormone and insulin increases the formation of tissue protein. Anabolic, protein for tissue growth and repair. Amino acids into the cell membrane, through a different transport mechanism glutathione promote the formation of intracellular protein amino acid peptide connection quickly.

Catabolism in vivo glucocorticoid need to increase the concentration of amino acids in the blood, glutathione promotes cell proteins into amino acids across the membrane into the blood to maintain plasma amino acids, protein, and the balance between proteins. Glutathione is also involved in the delivery of sweet fat, cholesterol, phospholipids and fat-soluble vitamins, to maintain the liquid penetration of the body in different parts of the relationship between maintaining the stability of the internal and external environment. Glutathione products produced by cosmetic raw material suppliers play an important role in a variety of metabolic, structural and physiological processes of protein.

Aging is the inevitable law of the development process of human life, under normal circumstances, the three-year-old began aging. Nucleus of human chromosomes, a DNA material called telomeres in the chromosomes of the terminal, it is like a life clock, regulating cell growth and apoptosis. Growing with age, telomere due to the continuous mitotic cells become shorter and shorter; every cell division time, the telomeres shorten that when reduced to not, to stop cell division, the life of the cell to stop a. Human aging is caused by the shortening of telomeres and telomerase close.

The glycation of proteins, protein denaturation and condensation. After protein denaturation, likely to cause congestion, disappearance of the activity within the cell, the whole cell life is shortened. The damaging effects of free radicals, damage the mitochondria, free radical damage within the cell mitochondria, the cells in the metabolic processes, the ability of the cell metabolism weakened or disappeared. Therefore, the lack of cellular energy, disappears, the cells do not have the energy metabolism. Then the cells die.

Patients buy glutathione to improve or promote secretion interleukin. The interleukin can regulate to slow down telomere shortening and extend life of cells. And thus it extends the life. Glutathione is a powerful antioxidant. It can fight against with damage of mitochondrial DNA from free radicals. It will repair the damage to extend the cell cycle and cell life. Elevating glutathione and neutralizing or eliminating free radicals will enhance glycolysis of the sugar and oxidative phosphorylation. It also inhibits the saccharification of protein and fat. Gluconeogenesis of glucose has been alleviated so that the protein will have invariance.

Source:http://www.cosprm.com

Chinese plant extract market needs standardized management

As a new emerging industry in nearly 10 years, Chinese plant extracts industry lacks of a complete set of policies and regulations. The entire industry lacks of supports from scientific research strength. The majority of plant extracts products do not have uniform quality standards. Meanwhile, the national pharmacopoeia and industry standards have not yet been equivalent with developed countries. The plant extract manufacturer has an unclear understanding of quality standards. They are mainly reflected in unclear understanding of standard in effectiveness composition and content standard. Simply use index components as the standing while ignoring the other index components result in the imbalance among the compositions of various indicators.

GEP’s literally meaning is good drug extraction standard. It has become the management practices to ensure the quality of herbal medicine and Chinese medicine extraction production, involving extraction, concentration, chromatography, crystallization, filtration, drying unit operation. The main target of the Chinese plant extract is an herbal medicine, plant extracts, to some extent can also be known as the Chinese herb extracts. Quality standardization of plant extracts has been a controversial topic. Broad standardization should be involved in the management and operation of the production process of herbal plant extracts every aspect in order to ensure product consistency.

Plant extracts in the quality of the initial raw materials and therefore should be stressed that the origin of raw materials, species selection and research, and strive to do the linking with GAP from the source control of toxic and hazardous substances. Should also strengthen the research and application of the fingerprint pattern on the effectiveness of the composition of raw materials. In short, tube production, learning the various fields, actively coordinate with the establishment of GEP, it is bound to effectively promote the standardization and regulation of quality control for plant extracts.

Botanicals often complex composition, the pharmacodynamic material basis and mechanism of action blur, often in the process of extraction and separation of functional components into degradation and interaction is different from the chemical drug extraction and separation, and the current lack of quality control standards. Chinese plant extracts in all aspects of the development, production, circulation, from macro to micro, yet lack the necessary management practices, products and miscellaneous specifications, small manufacturing enterprises operating channels chaos, product quality varied. The establishment of the GEP, from the hardware and software technology sectors for enterprise, higher demands, improve industry access threshold, which play to clean up the market, standardize enterprise behavior, eliminate fake and shoddy products and inferior role of enterprises, so that the limited social resources concentrated flows to some enterprises in the competition. The pattern of plant extract industry will change.

The Chinese plant extracts is the emerging field differentiated from the traditional Chinese medicine industry in recent years. The GEP establishment promotes the standardization and industrialization of the whole plant extract industry, thus contributing to the production and differentiation of proprietary Chinese medicines for the production of raw materials and preparations production. Through this specialization, it will promote the level of concentration and standardization for traditional Chinese pharmaceutical raw materials suppliers.

At present, Chinese plant extract industry is still short of appropriate policies and regulations. The establishment of GEP is still in the research and exploration stage. The product quality standardization has a long way to go. It is believed that, with the gradually implementations of relating regulations and policies, and development of research and technology, GEP is bound to link with GAP and GMP regulations. It will become the bridge for herbal medicines importing and exporting. At that time, modernization and internationalization of Chinese medicine in real sense will be acheived.

Source:http://www.cospcn.com

Research and application progress of biotin in animal production

Biotin is a necessary water-soluble vitamin for growth of human and animals. In 1901, scientists isolated biotin from the yeast culture medium and proved that it can promote the growth of microorganisms. In past, people generally believed that biotin was widely present in the feed and can be synthesized by bacteria in animal gut, so it was sufficient to meet the needs of the animal growth. It was no necessary to add it in dietary. In production practice, they are many biotin deficiency situations, and it even leads to death in severe cases. Supplemental biotin can make the symptoms disappeared. Therefore, biotin is one of the key ingredients of animal feed. And it is becoming the most popular vitamin supplement.

Biotin is widely present in plants and animals, naturally occurring biotin combined with other molecules in the form of existence. Its chemical structure, including one containing five carbon atoms of carboxyl side chains and two five-membered heterocyclic rings. It plays a coenzyme role in the body by the side chain carboxylic acid and enzyme protein ε-lysine residues. Biotin has a total of eight different stereoisomers. According to the study from biotin supplier, only the D (+) biotin has biological activity.

Supplemental biotin for the role of fat metabolism of growing and finishing pigs to reduce backfat and improve carcass quality. It has been confirmed that biotin can eliminate the adverse effects of high levels of copper pig backfat. It has been reported that, feeding the lack of biotin in the diet will lead to saturated fatty acids are converted to unsaturated fatty acids result in lower body fat quality, added biotin can increase lean meat and improve meat and flesh.

Biotin can promote the development of immune organs, improve the immune organ weight index; with the increased levels of biotin added, the better the development of immune organs. The addition of biotin can significantly increase the expression levels of proliferating cell nuclear antigen gene. Spleen as a peripheral immune organ in the body's immune response play a very important role, so add biological factors may promote the increase PCNA levels of PCNA gene mRNA expression and to promote DNA replication to promote spleen cells in the proliferation and differentiation, to improve the spleen of metabolic conditions and promote the play of the spleen, thus improving the immune function. In addition, biotin can also promote the cellular immune response and humoral immune responses, increase in serum globulin levels and newcastle disease antibody titers and IgG levels. It significantly increased the conversion rate of T, B lymphocytes in the blood.

Animal biotin demand not only with the animal species and different by animal age, the impact of physiological state, feed ingredients, feed traits, genetic strain caused by the differences and breeding patterns. In addition, based on different assessment criteria are also different requirements.

Biotin is a vitamin which arouses great concern in recent years. As a coenzyme of carboxylase system, it plays an important role in the metabolism of carbohydrates, lipids and proteins. Biotin is widely used in human cosmetic and hair loss treatment by cosmetic raw material suppliers. Study of biotin on animals stays in the level of the requirement. Its physiological function, mode action, pathological mechanisms and metabolic pathways all lacks of a systematic and in-depth discussion. As people have gradual deepening understanding of biotin, it has become an indispensable additive in animal nutrition. Its functions will gradually be revealed.

Source:http://www.cosprm.com

Clinical studies of resveratrol

Resveratrol is an effective antioxidant produced by some plants. It can resist the pressure and influence of the environment. Perhaps the producer of resveratrol is the grapes. Grape skin can produce a lot of resveratrol and fight against fungal diseases and sunlight damage. Therefore, the wines have highest content of resveratrol which are incomparable in any other natural food. Resveratrol manufacturer is optimistic about its further prospect.

Adding resveratrol in the diet of yeast, fruit flies, worms and fish, their life span  increased by 70%, 29%, 24% and 50%. Resveratrol for fat-related deaths decreased by 31% in the obese mice, obese mice were fed resveratrol had not fed in the test of movement and flexibility to perform better. Feeding resveratrol in mice fed 100% more endurance. Resveratrol inhibits platelet aggregation, can lead to dangerous clots may cause heart attacks and strokes.

Resveratrol is an effective antioxidant. It can help prevent free radical cell damage, resveratrol has been shown in all three stages of the in vitro anti-cancer: Start to promote progress. Perhaps resveratrol in the most exciting research in the field of life extension. The growth trend of the resveratrol research reveal resveratrol has diverse biological activity, indicating that resveratrol is widely used in the processing of human health problems. It has been claimed that resveratrol has anti-aging effects. It can improve heart health, prevent cancer, and prevent the diseases of nervous system. There are other advantages.

Inflammation after injury of the human body has been a natural process, this damage can be caused by bacterial infection or virus, or resulting from. A large number of studies have shown that inflammation play a contributing factor in the pile of fat deposition in the arterial wall. The accumulation of fat can clog arteries and cause heart attack or stroke. Platelets are irregularly shaped cell fragments, and to contribute to the formation of blood clots; blood clots can partially or completely block the coronary or cerebral arteries, causing heart attack or stroke. Several studies show that resveratrol inhibits platelet aggregation.

Many researchers believe that resveratrol will at least partially reduce the impact of cholesterol in the red wine. Resveratrol antioxidant activity is thought to prevent cholesterol oxidation. It shows resveratrol can induce cell death of a priority. However, radiotherapy and chemotherapy can cause cancer cells to release their material inside the human body, causing inflammation of the adjacent cells, induced by resveratrol in white blood cells to consume the debris of death of cancer cells.

According to the different scientific research, they show that resveratrol may help treat and prevent the following diseases: breast cancer, pancreatic cancer and prostate cancer. Resveratrol can prevent the startup process of estrogen can cause breast cancer, the first step in resveratrol strongly inhibited tumor growth of mutant pancreatic cancer: resveratrol to kill pancreatic cancer cells through the resveratrol destruction of the mitochondria of cancer cells, protecting healthy cells in radiation therapy. Weekly drinking red wine 4-7 cups of the men, only half is likely to be diagnosed with prostate cancer.

Pharmaceutical raw materials resveratrol can be applied to acute jaundice, infectious hepatitis, blood stasis amenorrhea, rheumatic joint pain, bronchitis, damp, cholelithiasis and liver variability. At the same time, resveratrol can also be used for high blood cholesterol and triglycerides. It is an anti-aging antioxidant. Resveratrol might overall improve the health and survival.

Source:http://www.cospcn.com

Algae bloom of cyanobacteria produce a teratogenic substance tretinoin

Since the 1990s, phenomenon of frog deformities has aroused great attention from eco-environmental scientists and social public. Frog growth and teratogenicity studies have shown that excessive or insufficient dose of vitamin A substance in the frog body is an important reason leading to frog deformity. Scientists found frog deformities often occur in lakes and water bodies with severe eutrophication. But there are no any direct evidence showing that tretinoin exists in the water to lead to human and animal teratogenicity. So the cause of frog deformity makes ecological environmental scientists embarrassed.

Retinoic acid and retinoic acid substances are active substances for metabolisms of vitamin A in animals and human. Cheap tretinoin has a wide range of physiological and pharmacological activity. In vertebrate growth, development and cell differentiation, especially during the embryonic development, they have an important role in regulating vertebrate embryogenesis much morphogenetic process. Scientists have discovered that it can activate the regeneration gene and it is an essential material in the process of limb regeneration for animals.

The study found that algal blooms can produce high concentrations of retinoic acid substances. Further analysis of the 39 kinds of algae, found that 32 kinds of them can produce retinoic acid and its analogues, and microcystis aeruginosa water bloom of Microcystis species produce retinoic acid substances. The traditional view is that the retinoic acid substances can only be generated by people or animals, retinoic acid substances in the environment can only come from human and animal excretion.

The first study found that bacteria can also produce retinoic acid substances, this discovery not only has important biological significance, but also aroused greater attention of the ecological and health hazards caused by eutrophication. Eutrophication is a global problem of water environment, particularly in the areas of lakes and reservoirs as drinking water sources. The retinoic acids produced by cyanobacteria may bring health risks through drinking water or freshwater for local populations.

With the help of related departments, the scientists find out that algae blooms of cyanobacteria can produce a tretinoin substance with strong teratogenic effect. And it overturned the traditional understanding that cosmetics material tretinoin is unique to vertebrates. Ecologists noted that the study opens up a new field of study and the study will help to explain the phenomenon of frog’s distortion in the wetland environment.

Source:http://www.cosprm.com

Production of paclitaxel will enter a new stage in three years

There are at least 8 to 9 species of anti-cancer drugs in international market. But none of them reach 200 million U.S. dollars sales in the next year after they are listed in market like paclitaxel. The cumulative sales of paclitaxel have exceeded $ 20 billion so far since 1992. It is estimated that its total global sales were approximately $ 4.5 billion last year.

Production and export of taxol bulk drugs is growing rapidly in recent years. The international market makes the paclitaxel price from $ 600,000 per kilogram dropped to $ 400,000. If the Chinese yew tree plantations completed and put into Taxol, paclitaxel on the international market prices to fall further in the future. China is expected to become the world's largest producer and exporter of paclitaxel.

European medical researchers from Europe, widely cultivated in Europe, the tender foliage ornamental yew extract taxol intermediate raw materials, the synthesis and the benzoyl group, paclitaxel analogue docetaxel. Docetaxel is not only excellent water-soluble and clinical studies have shown that the bioavailability and anti-cancer effect is even better than paclitaxel. Since then, docetaxel quickly became the best-selling variety of international anti-cancer drugs on the market. So docetaxel cost is always rising. At present, sales of semi-synthetic paclitaxel are overwhelming sales of paclitaxel. Since 2000, many countries including China have adopted a semi-synthetic method for production of paclitaxel.

United States is still trial taxus cell culture method to produce paclitaxel, but not the formation of large-scale production, the production of paclitaxel was estimated at most tens of liters per year. So far, the use of global production of paclitaxel stills Both of yew bark extraction, yew branches extraction and semi-synthetic method, the yield of the latter.

Taxol is a drug commonly used to the world medical community for cancer treatment, not only doctors willing to use, and patients to its tolerance are also very good, the only drawback is its higher retail price. China and the United States, like the world cancer of high incidence countries, estimated national lung cancer and breast cancer patients together there are at least hundreds of thousands of the public, specifically paclitaxel for the treatment of lung and breast cancer will become China's top-selling drugs. Insiders predicted that China paclitaxel in the future retail price dropped to less than 200 RM for each one. The paclitaxel market sales will be increased by 5 to 10 times in this year.

Pharmaceutical raw materials suppliers have predicted that there will no anti-cancer drugs found which are better than paclitaxe in the next few years. So paclitaxel will remain its position of backbone product in international anticancer drugs market. Its dominant market position is unshakable.

Source:http://www.cospcn.com

Situation of biotin supply changes

Calculating by pure products, currently the global market demand of biotin is about 125 tons. Among them, the demand for food and cosmetic medicine is about 20 tons. And the demand for feed is approximately 105 tons. A total Chinese export of biotin was about 115 tons in 2010. Due to the reasons of cost pressures, international biotin supplier has discontinued or reduced its production, while the production capacity of Chinese biotin has reached more than 200 tons.

Biotin demands are small. But there are large fluctuations in market demand and price elasticity. In 2007, the price of biotin with other vitamins prices rose sharply. Production pattern is relatively stable, only a few manufacturers, easy to form a tacit agreement on price. Dropped since the end of 2008, the biotin price long-term at low levels, the trade is generally a loss of 2009-2010 and into the new business of biotin are negative gross margin. Currently, the cost of raw material rises. So pressures on companies are also increasing. There is a strong will for manufactures to raise prices and absorb the cost.

Biotin workshop of Zhejiang province in China has the gas leakage. For production safety reasons, the future of the enterprise may biotin workshop moved to more remote areas from the staff living quarters. And security incidents, and all enterprises have to stop the purchase of biotin will change in the expected market supply, market supply of biotin will change the price of biotin may rebounded sharply.

As the VE prices rise, recently biotin price is rose from 88 RMB / kg to 160 RMB / kg in mid-September. And biotin prices depend on the attitude of the major vendors. From the present situation, the attitudes of major cosmetic raw material suppliers are from grabbing share to dispute profits. Biotin is small specie and its prices are very flexible. So in the marketm, there may be a repeat of the myth of riboflavin prices.

In view of the trend, raising prices of biotin will be maintained in a long time. In a short-term, there is a drive for price rising. But the uneven distribution of market share will make the rise time and space shorter. At same time, the price elasticity of vitamin H is large and there may be unexpected increases. Due to a substantial rise of biotin price, it is recommended to configure it as a transactional variety.

Source:http://www.cosprm.com

Chia seed is abundant in minerals

Minerals constitute a human bone and maintain muscle and organization health (such as calcium, phosphorus, etc.). It also maintains normal cardiovascular conditions (such as magnesium, potassium, etc.). It is an essential substance for protein and hormone synthesis (such as iron, zinc, etc.). Chia seed is a green plan which has most balanced mineral contents. So chia seeds purchase becomes more and more popular.

Chia seed is rich in calcium, phosphorus, magnesium, potassium, iron, zinc, copper and other minerals and vitamins. And it has highest content in plant foods. The content of some elements (such as calcium, phosphorus, etc.) are equivalent to shrimp, goat liver and other animal food. In addition, the sodium content of chia seed is almost negligible, which is better than animal foods, synthetic foods, a major advantage, eliminating the worries for patients with hypertension. Minerals and enzymes to help metabolism. The enzyme is indispensable in the new metabolic process protein, leaving the activity of the minerals. If the lack of minerals, the enzyme does not work, the metabolic activity ceases. Minerals can not be synthesized in the human body. It must be supplemented from the diets.

Calcium can promote robust bones and teeth, maintaining the normal function of the neuromuscular and cardiac muscle contraction also requires the involvement of calcium. Calcium is particularly important for the health of children and the elderly. Chia seed can promote the body's absorption of calcium, thus further contributing to bone health. 100 Kg chia seed’s calcium content is the same amount of wheat, rice, barley, oats and corn ranged from 13-354 times, six times the milk. Phosphorus necessary to constitute the bone phosphate, providing the body to promote calcium may be better absorbed by the body, while beneficial to the health of the kidney to maintain normal levels of body fluids. The phosphorus content 100 kg Chia seed are the same amount of wheat, rice, barley, oats and corn ranged from 2 to12 times. It is 2 times of the shrimp and 12 times of milk.

Magnesium can adjust the heart rate, prevention of blood clots, so as to maintain a healthy heart. In addition, it can promote the body's absorption of calcium for strong bones and teeth play an important role. Chia seed in magnesium content of broccoli 15 times. Potassium helps to regulate human blood pressure stability, to maintain the balance of fat and muscle tissue water content, while ensuring the normal functioning of the tissue. The potassium content 100kg chia seed were times ranging from 1.6 to 9 of the same amount of wheat, rice, barley, oats and corn, banana, milk, 4.6 times.

Iron is a necessary component of many proteins is particularly important for the formation of hemoglobin, the protein is transported to the lungs of oxygen to body organs and muscle tissue of the carrier. Compare the chia seed and iron-rich tradition foods, iron content of 100 grams of edible chia seed is 6 times, 8 times and 2.4 times respectively than the same amount of spinach, lentils and beef liver.

Zinc is the catalyst of many enzymes and hormones in the body. Copper can promote the metabolism and absorption of iron. They are essential part of diet and health. Closely related to the sodium and human hypertension. Hypertensive patients often ingested an overdose of sodium. Hypertension does great harm to human. If unchecked, it will increase the chance of suffering from stroke, heart attack, kidney failure and other diseases.

Pharmaceutical raw materials such as chia seed contain rich nutrient vitamin B. Recent studies indicate that too low vitamin B content in human blood will increase levels of homocysteine in human body. And it will stimulate the lining of the arteries, cause platelet deposition and eventually lead to greatly enhancement of the prevalence of coronary heart disease and stroke.

Source:http://www.cospcn.com

Explanations for frequently asked questions of 5% minoxidil

How long will minoxild play its effect? Generally, after about 2-3 months, fluffs emerge on site of hair loss. In four months, people will achieve significant results. It is best to use it in more than eight months to achieve the purpose of consolidating. Hair growth is relatively slow and it requires a process, including growth phase, catagen and telogen. In a few years later, the hair enters into stage of catagen and gradually falls off. It will grow new hair in another 3 to 4 months telogen period.

The original hairs have entered the catagen and become shedding after using 5% minoxidil in the first month. But the new hair is still in telogen and the symptom seems to be more serious. But stick use it in 3to 4 months, there will be relatively good results. So patients need to have some patience for the treatment of hair loss. 5% minoxidil will not promote existing hair thicker, longer. It ends the old hair growth cycle and grows new hair.

When using minoxidil, can the hair be colored or permed? These practices if they change the efficacy of minoxidil, research and information in this regard. However, in order to avoid the stimulation of hair may try to avoid hair color, perm. Minoxidil germinal water can not wash your hair, after swimming or rain. In order to achieve optimal drug efficacy should enable the drug to the scalp for at least four hours.

How about the effect of minoxidil tonic on female patients? Some people think that hair loss is male patent. But minoxidil supplier claims that the actual situation is that many women's hair loss situation is much more serious than men. Menstruation, childbirth and menopause and other women's unique physiological processes are the main factors leading to hair loss. Other genetic and male hormones, although not make women like men in the head and temples as the formation of hair loss, but will lead to female hair part of the shedding or hair becoming more and more thin and short, the symptoms are generally 25-30 years of age starting to show, then timely treatment for women, hair is a young and dynamic signs negligent treatment will seriously affect the image.

The minoxidil tonic has effects on the skin blood flow. It is suggested that minoxidil tincture prompts the hair growth because it promote the scalp skin vasodilation, stimulate microcirculation around the hair follicles. It also plays roles in immune function: the researchers found that the degree of alopecia areata parts of the hair follicle of the hair regrowth after the application of minoxidil Seoul tincture positive correlation between the surrounding lymphocyte infiltrations disappeared. Role in epidermal cells: experiment prompted minoxidil tincture can prolong the survival of cultured human epidermal cells. Cultured in cell aging and hair from growing season to telogen transition is different, but both may be motivated by the same signal, while minoxidil tincture may inhibit this signal.

The part component of cosmetics material minoxidil is the ethanol. With the rapid evaporation of active ingredients, it enters into the scalp and has not smell. There are crystallizations on the scalp in the application of high concentrations of minoxidil solution. In market, there are 5% concentration solution, in clinical use, there are no nuisance odor nuisances.

Source:http://www.cosprm.com

Anticancer drug irinotecan is not suitable for everyone

Drugs need to be metabolized through a series of enzymes in the body. Some drugs have low activity after the enzyme metabolism. And some drugs transform into the active form after metabolism. Among them, transfering enzymes of uridine diphosphate glucuronyl are responsible for reducing toxicity of some toxic substances or drugs with a transporter and excreting it. The activity of this enzyme is not the same in different people. Some enzyme activities are strong and the speed of excreting poison is fast. On the contrary, some enzyme activities are weak. So the concentration of poison in the body will maintain at a high level.

Different metabolic types between different people are due to the different gene encoding of this enzyme, so that the pharmaceutical raw materials will play different roles or produce different adverse effects of the medication of people with different Irinotecan is an anticancer drug used in clinical trials. Its active ingredient SN-38 is an active enzyme. It becomes SN-38G with adding a G. Then the toxicity is reduced and excreted. UGT1A1 enzyme activity in patients with normal timely metabolism, the drug not only plays the role of anti-tumor. It does not produce excessive toxicity for the human body;

Patients with low UGT1A1 activity, SN-38 in the body to maintain a higher level will give drug users a strong toxicity. Under normal circumstances, the instructions given by doctors dose is the most suitable dose distribution are relatively small, less activity is not considered. However, in the application of anticancer drugs, people can not ignore the adverse drug reaction in this part. In fact, in our daily life, people are really concerned about irinotecan price.

Some patients with irinotecan, given the normal recommended dose of time will happen after very severe neutropenia and diarrhea. The patient can not tolerate the very painful and even fatal treatment process. Therefore, before applying irinotecan, it is best to UGT1A1 genotype to predict the enzyme activity, decreased activity of patients should be appropriate to reduce the dose, while a number of patients with genotypes (enzyme has a particularly low activity) should try to avoid using this drug.

Irinotecan is used in the treatment of adult metastatic colorectal cancer. And for the patients with failures of 5-Fu chemotherapy, it can be used as a second-line treatment. At the same time, phased observations of a variety of clinical trials in gastric cancer, esophageal cancer, extensive stage small cell lung cancer are underway. In the point of view of interim observations, irinotecan has a good clinical application prospect and it is worth close attention.

Source:http://www.cospcn.com

Characteristics of glutathione

Glutathione can inhibit activity of tyrosinase. Once the metabolism of tyrosinase activity has been inhibited, it will synthesize phaeomelanin rather than eumelanin which causes black and darkness on skin. L-gltathione can increase the metabolism of melanin, it is easy to rapidly change the skin and maintain white, tender and delicate. So people are interested in finding out it and want to buy glutathione to achieve their whitening proposes.

The ultra-fine cell whitening ingredient glutathione is smoothly through the cell membrane and has rapid infiltration. It enters into the cell so that the whitening becomes quickly and safe. Glutathione has a lasting role. It can reduce melanin content, disrupting the pigment-producing procedures and dilute pigment. The skin changes instantly.

Glutathione supply a large number of cell nutrition, nourish the skin, and better help fix the cell internal structure of the suppressor cells produce abnormal pigment, the skin showing a steady Whitening and smooth texture. The harm caused against poison kept the body, glutathione open up blood vessels, lymphatic detoxification pipeline from various quarters of the meridians, the organs of Contact pipeline, the competent Road - the digestive tract, urinary tract toxins from the body, and through The combination of fill, lift properly, sophisticated prescription, conditioning the human disorder of metabolism, blood flow, air-structured and the balance.

Natural component of glutathione, skin whitening, long-term to maintain skin moisture balance and seal in moisture, supplementary nutrition to skin, dry skin regains its luster, promote cell metabolism to maintain the skin healthy and moist. Glutathione can enhance skin elasticity, and restore the elastic structure and function, firm skin, evens-out complexion, supple moisture. The collapse of melanin, eliminate wrinkles, and a full range of anti-wrinkle moisturizer, body deep whitening, lasting whitening. It improves the roughness for skin surface and the moisturizing nutrient function.

Cosmetic raw material glutathione can regulate the body and increas skin blood supply. It promotes metabolism, endorse conditioning occurs in the skin, thus toxins impede the appearance of acne, skin pigmentation, facial pigmentation such as various skin diseases get good treatment. The skin will be delicate, moist and flexible. It shows a healthy and beautiful face.

The results show that after the use of glutathione in one month, all kinds of stains will be completely eliminated. The skin becomes compact and flexible. The glory is reborn. Skin supple degree is about 60% and the silky degree of skin is 75%. The total efficiency of relieving skin is 95%. The white index is up to 95 percent. The white glossy index is larger than 90 percent while the compact index is bout 90%.

Source:http://www.cosprm.com

Health effects of chia seed

Chia seed is a health ingredient with very high value. It provides adequate calcium and protein for human tissue. This seed is also rich in boron and can help absorption and utilization of calcium. The nutrition also helps to maintain brain function. Chia seed contains more than 20 kinds of amino acids. 8 kinds of them are essential but the body can not synthesize itself. Proportion of amino acid in proteins of chia seed is very close to the content that human body needs. It has a high utilization rate. Enzymes and various organs have very harsh requirements about amino acids. If it is short of an amino acid, other amino acids would be unable to play the roles and draining away.

People can buy chia seed and place it in a glass of water. Then stir it. In a few hours, chia seed’s rich dietary fiber can absorb water in more than 10 times of its own weight. This feature makes it possible to maintain the electrolyte balance, prevent dehydration, when strenuous exercise is particularly useful sub Hungariana so long-distance food reputation. When the seeds in your body, the same physical process can help you lasting moisture and maintain electrolyte balance of fluids.

Even the chia seed swallowed whole shell is also very easy to digest. This is compared with flax seed, an improved, easier to digest had to flax seeds are crushed, if the whole to eat flax seed, it will be directly discharged. Super absorbent capacity of chia seed can absorb moisture up to 10 times than its own weight, thus inflated, heavier, and stimulates intestinal peristalsis. Also to avoid the intestinal absorption of toxic substances or damage, reduce the risk of suffering from intestinal cancer. Detoxifies but also played a role. Chia seed has the most immediate effect.

Unlike other seeds, chia seed’s taste is very light. Its light taste, fit into the soup, made milkshakes, bread stuffing, mix the pudding, as well as the seasoning of food you want. It will not change the taste, but increase you more nutrition. Into the stomach, chia seed is generated by a physical barrier between its own carbohydrates and gastric secretion of digestive juices, delaying carbohydrate degradation to provide energy for the body to continuing the digestive process of monosaccharide.

Chia seed is considered to be Indian’s long-distance food by pharmaceutical raw materials suppliers. And in the ancient, the warriors of Aztecs eat the chia seed in battle. After eating, the nutrients easily digested and absorbed, it is easy to enter the cell. When you want to build and restore the health of body tissues, and eat them. And its high content of omega-3 to allow each cell to do a health to adjust the body's immune system.

DHA and EPA in Omega-3 have an important role in oxygen-carrying blood, coagulation, endocrine, skin cell nutrition and nerve cell growth. It is necessary for metabolisms of a variety of organs. However, the body can not synthesize Omega-3 by itself. Therefore, it is necessary to use the food supplement. Compared to fish oil, content of Omega-3 polyunsaturated fatty acids in chia seed is higher and has no heavy metal pollution. It is no necessary to manually add any anti-oxidant ingredients to guarantee that Omega-3 unsaturated fatty acid will not be oxidized.

Source:http://www.cospcn.com

Desthiobiotin

The desthiobiotin is a water-soluble vitamin. It is widely distributed in animal and plant tissue. It is isolated from the liver extract and egg yolk. It becomes a composition of multiple carboxylase cofactor and usually known as biocytin.

Biotin carboxyl carrier needs ATP in the carboxylation reaction. Carboxyl temporarily combined with a nitrogen atom on the biotin bicyclic systems, such as pyruvate carboxylase pyruvate carboxylase into oxaloacetate reaction. Animals lack of biotin can cause skin disorders and hair removal. Eggs contain protein avidin and biotin closely integrated. Such as a large number of eating raw eggs, and hinder the absorption of biotin can lead to human biotin deficiency. Under normal circumstances, biotin is sufficient for the needs. The biotin deficiency will not occur.

Desthiobiotin is one of the complexes of vitamin B. It is the necessary material for many animal and growth and development of plant. And vitamin H, coenzyme R, bios II b, microbial growth factor SWX d isomers are naturally occurring L-type biological activity. Cofactor in vivo, which are almost as biotin and protein lysine ε-amino group to form a covalent bond. Its physiological role in carbon sequestration is caused by biotin and carboxyl group transfer reactions. Propionyl coenzyme A carboxylase, acetyl CoA carboxylase, methyl malonyl CoA carboxyl transfer enzymes and reactions involved in the metabolism of sugar and fat. In these enzymatic reactions in the formation of the N-carboxyl group of biotin as an intermediate product.

In addition, although biotin supplier declares that the mechanism is unclear, it may be involved in synthesis, purine synthesis and oleic acid biosynthesis. For yeast, Lactobacillus genus Rhizobium genus bacteria such as reproduction is required. The use of these microorganisms can for the quantitative determination of biotin. Animals because of their gut bacteria can be synthesized, it will not cause deficiency. If a large number of raw OVA mice, due to the avidin biotin and egg protein in the combination of inactivation, and thus give rise to hair removal and skin inflammation. Oxo-biotin, the formation of oxygen replaced by sulfur in the biotin molecules to the sulfur desulfurization biological factors can be microbes use.

The vitamin H and enzymes are involved carbon dioxide fixed and carboxylation process in the body. In the body's important metabolic processes such as pyruvate carboxylation, it is transformed into oxaloacetate and acetyl coenzyme A carbonyl become malonyl coenzyme A in sugar and fat metabolism’s main biochemical reactions. It is also certain microbial growth factor. Just a trace amount of it can test bacterial growth.

Cosmetics material vitamin H is a key regulatory element for glycogen gluconeogenesis, fatty acids and amino acid metabolism. It plays a role in promoting synthesis of certain proteins though energy production. Meanwhile, it helps to promote cells growth and manufacture fatty acids, carbohydrates, fat and protein. It is contribute to the use of vitamin B group and can promote the health of sweat glands, nerve tissue, bone marrow and male gonads. It will maintain the normal operation and growth of skin and hair, relieve eczema and dermatitis symptoms. It plays roles in the prevention of white hair and hair loss or treating baldness. It can also ease the muscle pain and be helpful for depression and insomnia. It is involved in metabolisms of vitamin B12, folic acid and pantothenic acid. In addition, biotin promotes urea synthesis and excretion to improve the body's immune function.

Source:http://www.cosprm.com

Market of pharmaceutical raw materials and its investment prospects

Pharmaceutical raw materials are prepared by technologies of chemical synthesis, plant extracts or biotechnology. They are medicinal powder, crystallization, extract, etc. But the substances can not be taken directly by patients. These powders, crystalline, extracts are made to facilitate the patients. The dosage form is known as the drug formulation.

Division of pharmaceutical raw materials from the source can be divided into mineral resource, food resource, the former pharmaceutical raw materials such as chemical synthesis, such as traditional antibiotics, semi-synthetic penicillins, nutritional, and pharmaceutical excipients. Chinese pharmaceutical raw materials are mainly antibiotics, vitamins, steroid hormone, antipyretic analgesics, amino acids, and cardiovascular and cerebrovascular medication such as irinotecan price. In addition, now irinotecan is popular in international markets and irinotecan price is increasing higher.

Global Pharmaceutical market size in 2004 is about $ 68 billion. It is more than 90 billion U.S. dollars in 2008. Among them, generic pharmaceutical raw materials are growing rapidly. On the market in the world's bulk drugs, generic bulk drugs from $ 12 billion in 2004 to grow to $ 17 billion in 2008, average annual growth rate of 9.1%.

In 2008, global pharmaceutical raw materials retail market is mainly dominated by North America. Generic bulk drugs market is another situation, the Asia-Pacific region to lead the entire generic API market with 34.8 percent market share, while the North American market share is less than 25%. China has become the important role of the world's API market, the market share of 19.2 percent in 2008, while only 15.1% market share in 2004. In addition, after the United States the world's second largest generic raw material drug consuming countries.

China and India are the generic bulk drugs market grew the fastest of the two countries, the growth rate of 11.8% and 15.8%, respectively, these two countries account for about 1/4 share of the global generic bulk drugs market. Other developing countries, the rapid development in this area, including Latin America and Eastern Europe. The average annual growth rate is more than 9.4%.

However, people are not optimistic about the medical development of Western European countries. Compared to the United States, pharmaceutical industry in the regions is losing competitiveness. In addition, pharmaceutical raw materials market is more dynamic than the innovative pharmaceutical raw materials. The growth rate in this field of Western European countries is still low. It s is mainly because the government and pharmaceutical raw materials suppliers are failed to keep up with the pace in policy and hardware upgrading of market development. It is also coupled with expensive labor costs and shortage of competition sense. Pharmaceutical raw materials markets in Western Europe are gradually lost their former prestige.

Source:http://www.cospcn.com

Detailed introduction of astaxanthin

Red foods such as wolfberry fruit, cherries, strawberries, pomegranates, pumpkins, and carrots have good oxidation resistance. They are beneficial to cardiovascular because of anthocyanins, lutein and other carotenoids. Astaxanthin is the product at the final stage in carotenoids synthesis. So it has the strongest antioxidant activity and it is particularly beneficial for the heart, brain and blood vessels. Because of its multifunction, astaxanthin price is becoming higher and higher.

In order to have better absorption it is recommended to take astaxanthin within 30 minutes after breakfast. Taking it after breakfast can better motivate gastric motility than irregular taking. And intake of certain fats will promote the secretion of bile, which is conducive to astaxanthin Esters emulsification, to promote better absorption. The study confirmed that the plasma peak after meal is the preprandial taking 2.4-3.0 times to remind that breakfast does not have any fat, can not promote the secretion of bile. It may have bad absorption.

Often smoking and drinking, it is strongly recommended that the use of astaxanthin, but requires a doubled dose. The study confirmed that taking astaxanthin smoking prawn astaxanthin absorption around 2.5 times the same people do not smoke. Generally speaking, astaxanthin with other drugs taken together, while astaxanthin derived from the pure breeding of freshwater algae. It does not contain shellfish allergens.

For women, resist wrinkles, aging years the ravages of the most important thing in life. Singlet oxygen activity is the main cause of aging, it is most destructive skin, the collagen in the dermis layer of the UV event of trouble will cause damage in the human enzyme can resist the damage to the skin, necessary to rely on astaxanthin This super antioxidant capacity to resist, is once and for all.

Astaxanthin has two most important features. They are the super antioxidant and anti-inflammatory: Astaxanthin’s effect is only for the two kinds of diseases, one is a number of chronic diseases caused by oxidative stress, such as diabetes, cardiovascular disease, gout, parkinson disease, senile dementia, etc. Another one is the non-bacterial inflammatory diseases such as systemic lupus erythematosus.

Cosmetic raw material astaxanthin is extracted from haematococcus pluvialise. Every   ton of haematococcus pluvialis solution can only extract 50cc astaxanthin stock solution. Astaxanthin to emphasize the natural, not artificial gene transfer, to be effective, it has been the high price of, you know an astaxanthin soft capsule astaxanthin content is equivalent to content of astaxanthin in1 kg of wild salmon,.

Long-term use of natural astaxanthin can continue to effectively expand microvascular. But the mechanism is not the same to general expansion of blood vessels to lower blood pressure. The general antihypertensive drugs are rapid and in a short-term. Astaxanthin becomes slow, long-term and sustainable to dilate blood vessels. So after taking astaxanthin in approximately 2-4 months, it can generally reduce dosage or frequency of blood pressure drugs. But astaxanthin can not be sustained to reduce the normal blood pressure. It is not relaxing blood vessels. It lowers blood pressure through the treatment of atherosclerosis. So there is no risk of hypotension.

Source:http://www.cosprm.com

Chinese plant extracts industry enters into a regulatory era

It has been nearly 40 years since development of Chinese plant extracts industry begins. In the past, there were only 5 or 6 companies in the industry. Now there are thousands of companies. They have been marginalized from the field of medicine, food, health care to the gradual formation of a sub-sector with distinct features. Plants extracts’ downstream target audiences include manufacturers in health products, dietary supplements, functional foods or beverages, herbal medicine and cosmetics industry. Its natural characteristics lead the global health industry. Natural and green now has become common practices in the various fields. And the ultimate beneficiaries are the global consumers who advocate of natural health and buy herbal extract.

With traditional herbal medicine industry, the plant extract industry is not only relying on the part of the Chinese herbal medicine, more part is based on the food material, such as lycopene extracted from tomatoes, rutin extracted from sophora japonica, extract of turmeric factors, resveratrol extracted from grapes, allicin extracted from garlic, garlic and capsaicin etc. Extract industry gives a modern high-tech development for traditional food material. And the purification of concentrated active ingredients will maximize the health effects for the dietary components.

Meanwhile, China will begin to have regulatory system on extract industry. The situations without regulatory in Chinese plant extract industry for many years will come to an end. The relevant departments will begin supervisions for the plant extracts. For how to have specific implementation and what impact it will have on Chinese plant extract industry, the relevant departments of China will pay great efforts in its study.

Chinese extract industry has been relying on development requirements of international nutrition and health industry. Pharmaceutical raw materials suppliers export many extract products to other countries every year. With the economic crisis rewrite the global economic situation, China is becoming one of the health markets and has caught the attention from the world. Markets of plant extracts industry with high-techs are not only the United States, Spain, Canada and other international markets, but also the Chinese market. More and more extract manufacturers of China have been aware of the problem. How to apply the QS production certificate as soon as possible now becomes one of the topics lying in front of Chinese plant extract industry.

Source:http://www.cospcn.com

Interpretation of biotin

Stiffing upper lip in front of mirror, some people may touch the hard muscles at rear chin. Those people have square jaws because of strong masseter. They can use the biotin to correct square jaw. Unused muscles will naturally degrade to smaller. So the biotin is used in paralysis of over-developed muscles and shrinking the muscles. In view of the effects of biotin in treatment of chin, muscle size has an average reduction of about 24%. And at this time, the bones and fleshes in masseter muscles will be reduced by 30%. So what is biotin? How does it have such a quickly effect?

Biotin supplier finds that biotin is a kind of botulinum in rotten ham or cans. Because biotin’s inhibition in muscle contraction, weakening the muscle strength, as a non-surgical injection therapy, used in the surgical correction of wrinkles and remove the jaw muscles, etc. Biotin is divided into 8 types of A, B, C1, C2, D, E, F and G. the A, B and F types can be injected into the body. Currently, only type A biotin achieves certification. It is widely used around the world. Biotin is mainly produced in Ireland and the UK.

In the wrinkles parts along the wrinkle lines mark the site of the injection of biotin. Along the marked good parts of the injection of a certain amount of biotin. However, injection in the lower eyelid area, may cause eyelid drooping, in principle, will be injected in this place. With a simple injection stretch wrinkles, restoring skin elasticity. Biotin injection after 3-2 days within the wrinkles will disappear. After surgery, without prejudice to their daily lives.

Without any side effects that drug safety is a lie. Aspirin is one of the best human inventions of the three pharmaceuticals, eat it there from the allergy. That is, all drugs have side effects, according to the severity of their side effects are divided into the safety of drugs or dangerous drugs. Biotin as a new wrinkle drug developed, but in the 1980s to get permission for the person's license is not in the field of nerve - muscle disorders using the 15-year-old drug. Although most of the side effects of biotin have been made public, but it is still regarded as a safe drug.

Biotin is a kind of botulinum toxin. Does it really have no side effects? People with first time injection may have the doubt. But in view of its results, cosmetic raw material suppliers declare that its security is not in doubt. For a 70 kg person, a single injection of 30 bottles can be fatal. With a single injection of 5 bottles or more, there are only some slight reactions. In other words, if half a bottle of drugs are used in the body for removing wrinkles, it will not be dangerous.

Source:http://www.cosprm.com

Docetaxel is used in the treatment of lung cancer

As a new generation of anti-cancer drugs, docetaxel has been widely used in chemotherapy of lung cancer and cancers which lost the chance of operation in recent years. Due to lack of clinical experience in docetaxel use, individual patients have adverse reactions. It causes much inconvenience for the treatment. In order to have successfully chemotherapy in patients, in the application of docetaxel with the cisplatin or carboplatin on lung cancer patients, it needs nursing care. Cisplatin and carboplatin have been applied in clinical trials for many years. Health care workers have mastered their medication care Docetaxel was a new class of anticancer drugs in 1990s. Clinical uses of the pharmaceutical raw materials lack of nursing experience. So workers need to take effective care measures according to medication instructions to avoid its adverse reactions. It will reduce the incidence of adverse events and make successful implementation of chemotherapy.

Medical staff should provide psychosocial support to patients and their families. Through a variety of ways, they need to assess patient’s mental state and understanding of the diagnosis and treatment, and more cases of lung cancer patients survive longer time introduced to the patients, so that patients will overcome despair, psychological, and enhance confidence in the treatment of disease. They need to maintain a positive attitude in the treatment. 

First, the implementation of pharmacological nurses should carefully read the instructions of the drug, to master of drug usage, dosage, adverse reactions and precautions, strict prescribed medication. Because of dexamethasone for long-acting preparations, and the prevention of chemotherapy drugs and allergic reactions, reduce the anti-cancer drugs for a variety of cell damage, reduce the incidence of fluid retention. Given docetaxel, patients first received chemotherapy drip rate should be slow, and available multi-function ECG monitoring vital signs. Docetaxel cost is relative high. In order to prevent waste and achieve an effective therapeutic dose, dispensing nurses should strictly follow the cautiousness spirit dispensing docetaxel plug corresponding to the solution to all injected corresponding uniform at room temperature, and then check the liquid evenly and clarify. According to the calculation of dosage, it is added to the solution to prevent liquid residual.

Parts of the correct choice of medication to prevent extravasation: venipuncture should be straight, easy to puncture, fixed position, in principle, from distal to proximal, small blood vessels to large vessels, puncture first with ordinary liquid puncture Remove the needle, is successful, determine the infusion smooth, no extravasation, then put on a docetaxel liquid bottle, disconnect the needle before the application of liquid the rinse liquid in the bottle and the infusion tube to avoid chemotherapy drug extravasation on skin and subcutaneous tissue damage. 

In the past 20 years, the incidence of lung cancer rate was 11%. The mortality is increased by 111.85%. The lung cancer is the third largest cause for cancer deaths. In recent years, about 70% to 80% of lung cancer cases have lost the opportunity to have surgery. They require the chemotherapy to control the disease. As a new generation of anti-cancer drug, docetaxel gets more and more attention in the treatment of lung cancer. It has broader application. In course of treatment, with intensive care and assessment of possible adverse reactions, the workers take effective interventions to reduce the incidence of adverse reactions and improve the patient's symptoms. It prolongs life for patients and plays a crucial role in improving the quality of life.

Source:http://www.cospcn.com

Astaxanthin play roles in prevention and suppression of cancers

People understand that a lot of fruits and vegetables help to prevent cancer. So if they know that natural astaxanthin has the effectiveness and features, it is no necessary for them to be so surprised. Natural astaxanthin is a concentrated plant extracts, so if the effect of it is stronger than fruits and vegetables, it is not surprising. If people are clear about where to buy astaxanthin, they can use it to maintain heath condition.

Nature astaxanthin is produced by algae, bacteria and phytoplankton material. Some aquatic species, including crustaceans, including shrimp, crab eat the algae and plankton, and this pigment is stored in the shell, so they look red. Shellfish and fish and birds chicken, duck hunt, and then store the pigment in the skin and fatty tissue. This is the salmon and other animals showing the red cause. Professors from Huazhong agricultural university in China has confirmed: the red component of natural red duck egg is also the natural astaxanthin.

Intake of salmon or crab, lobster and shrimp, otherwise the body's blood may not contain too much astaxanthin often in the diet. This detection of astaxanthin epidemiological effectiveness of the role is even more difficult. It is noteworthy that the population whose diet contains a large number of salmon, such as Eskimos and people from coastal cities of North American, the probability for them to suffer from cancers is very small

Astaxanthin significantly inhibited tumor cell growth, stimulate the immune system against tumor cells antibodies. What are the principles for astaxanthin to prevent cancer and shrink the tumor? There are three main mechanisms principles: effective biological antioxidant; strengthening the role of immune system function and regulation of gene expression

The free radicals attack the DNA within the cell will lead to DNA mutations in the formation of cancer cells. Potent antioxidant activity of astaxanthin to protect cell DNA from damage or repair the damage. Astaxanthin and chemotherapy drugs, astaxanthin make the tumor smaller capacity is not due to its toxic effects. The content in the diet is 2% and it will not induce the body to produce toxicity. Study from cosmetic raw material suppliers and medical researchers once declared that anticancer active mechanism of astaxanthin is related to the enhancement of immune ability in body.

The communications through gap junction are not enough for tumor cells. The improvement of communication among the cells will be reduced proliferations of tumor cells. Astaxanthin can improve communication between such cells. Taking astaxanthin at the early stage of tumor development has better effect than that of late stage.

Source:http://www.cosprm.com

Ginseng is a protagonist in export of Chinese plant extracts

At the first quarter of 2012, ginseng record highest exporting price in history. Plant extracts become a goods category whose export value is over $ 1 billion in China. Both of then have outstanding performances. But in the overall look of Chinese exports during the year, there are still pressures. At the first quarter, import and export volume of Chinese medicine are about $ 758 million with an increase of 9.42%. The imports value amounts to $ 169,000,000 with an increase of 20.46%.Chinese exports value is $ 589 million with an increase of 6.62%.

Compared to the exports, imports of traditional Chinese medicine sharply increased. It is mainly due to surging imports of licorice and its extracts. Licorice is an important resource product. It is one of commodity with national export quota management and is widely used in medicines, food, cosmetics, cigarettes and other industries by plant extract manufacturer. The global demands are increasingly intensify. Imports of Chinese licorice to ease the strain on the resources of the contradictions, since 2008 the licorice import enterprises to take certain incentives, increasing year by year, a record high in 2011. The first quarter of this year, licorice demand is still very strong increase in imports of Chinese licorice has far exceeded the growth rate of exports. Wild licorice of Uzbekistan, Kazakhstan and other countries rich in resources, better quality, accounting for more than 80% of the total imports of Chinese licorice.

In 2011, Chinese ginseng export price of $ 36,770 / ton, up 84% from a year earlier, the export price of the first quarter of this year reached $ 43,000 / ton, reaching record highs. Chinese ginseng exports of the main areas for the increasing demand of the market since 2011, Japan, Italy, Germany, the Netherlands, China, Hong Kong and Chinese Taiwan, Italy, Germany and the Netherlands, export prices continue to rise, but the ginseng prices are still much lower Korea (South Korea ginseng export prices up to $ 179,603 / ton). Korean ginseng business for many years vigorously open up international markets, exporters of Chinese ginseng is basically the same, but its brand value, to occupy high-end market in the major export markets, South Korea ginseng. Chinese ginseng is only occupying a low-end market.

The first quarter of this year, Chinese ginseng export prices increased sharply, on the one hand, product upgrades, such as ginseng crude processing to extract, or begin operation of organic products, the increase of the value-added products, not only more vigorous market demand, the price after rising accepted by the customer. The other hand, Chinese ginseng brand recognition of the continuous improvement of the previous brand of ginseng main origin of Jilin Province, registered more than 30 but not more than the output of products for each brand, the market coverage of narrow, there is no formation of a national of big brands. Corresponding, the most famous brand of Korean ginseng’s annual production value is over 2 billion U.S. dollars. It has an absolute advantage in the Korean ginseng brand, the lack of big brands of ginseng products. It lacks of international competitiveness in the ginseng industry.

Chinese ginseng promote, but raised the price from the source within the policy has achieved initial success. Past Chinese regulations ginseng can only be used for drugs and not for the food, the policy restricts the development of the Chinese ginseng health food. In South Korea and the United States and other developed countries, ginseng can be used for food, ginseng food markets of these countries is very popular. At present, ginseng in China can also be used directly as raw materials of food and beverage.

The plant extract industry is the fastest growing industry in Chinese exports. The pharmaceutical raw materials are always a sunrise industry. At the first quarter, exports value continues to maintain a steady growth. The class with largest export in plant extracts industry is natural pigment product, such as capsanthin, lutein and other food coloring. In addition, flavors and fragrances extract are varieties whose export value increase significantly.

Source:http://www.cospcn.com